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ATOB - Acetyl-CoA acetyltransferase
UniProt: P76461 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11672
Length: 394 (392)
Sequences: 7209
Seq/Len: 18.39

ATOB
Paralog alert: 0.73 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: ATOB FADA FADI PAAJ YQEF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
182_H 186_K 3.481 1.00
181_L 226_A 3.442 1.00
264_A 268_A 3.27 1.00
175_M 329_K 3.21 1.00
3_N 262_E 3.16 1.00
36_A 39_E 3.033 1.00
189_A 193_S 3.001 1.00
362_L 374_G 2.939 1.00
107_A 110_I 2.937 1.00
95_V 359_L 2.867 1.00
262_E 266_L 2.852 1.00
182_H 185_R 2.843 1.00
300_A 304_A 2.798 1.00
5_V 265_A 2.782 1.00
264_A 267_A 2.761 1.00
37_A 258_V 2.687 1.00
176_Q 241_T 2.626 1.00
300_A 389_V 2.599 1.00
102_I 259_I 2.562 1.00
34_I 111_V 2.507 1.00
102_I 261_E 2.334 1.00
174_E 178_E 2.274 1.00
2_K 263_S 2.224 1.00
366_M 371_K 2.223 1.00
278_S 304_A 2.222 1.00
9_A 360_V 2.211 1.00
313_L 340_V 2.198 1.00
167_K 237_D 2.188 1.00
197_T 215_S 2.182 1.00
10_V 40_R 2.158 1.00
192_E 222_A 2.155 1.00
229_L 245_G 2.112 1.00
255_A 356_A 2.06 1.00
172_T 175_M 2.046 1.00
44_D 47_H 2.039 1.00
219_F 249_G 2.034 1.00
191_I 220_P 2.025 1.00
306_L 373_L 2.008 1.00
197_T 216_Q 1.985 1.00
98_A 110_I 1.977 1.00
278_S 300_A 1.97 1.00
109_S 260_M 1.952 1.00
260_M 265_A 1.946 1.00
312_D 371_K 1.924 1.00
273_L 367_Q 1.917 1.00
7_V 260_M 1.862 1.00
32_T 203_V 1.851 1.00
274_A 363_L 1.824 1.00
30_G 53_M 1.821 1.00
297_T 377_T 1.819 1.00
30_G 69_A 1.813 1.00
191_I 200_I 1.793 1.00
311_I 373_L 1.758 1.00
341_N 365_A 1.753 1.00
165_V 171_I 1.752 1.00
188_A 192_E 1.739 1.00
20_S 214_F 1.735 1.00
306_L 311_I 1.716 1.00
367_Q 392_R 1.704 1.00
47_H 268_A 1.694 1.00
365_A 369_R 1.69 1.00
159_G 236_F 1.681 1.00
37_A 41_A 1.677 1.00
34_I 69_A 1.677 1.00
182_H 335_S 1.67 1.00
188_A 220_P 1.66 1.00
98_A 259_I 1.657 1.00
311_I 314_I 1.641 1.00
178_E 182_H 1.63 1.00
298_Q 302_Q 1.629 1.00
328_G 335_S 1.619 1.00
275_R 391_E 1.616 1.00
36_A 201_V 1.592 1.00
328_G 338_V 1.591 1.00
108_Q 261_E 1.566 1.00
228_A 231_A 1.566 1.00
308_L 314_I 1.563 1.00
334_D 337_K 1.541 1.00
191_I 216_Q 1.536 1.00
108_Q 264_A 1.528 1.00
32_T 201_V 1.519 1.00
260_M 264_A 1.515 1.00
53_M 113_G 1.512 1.00
370_D 392_R 1.507 1.00
311_I 389_V 1.507 1.00
195_A 365_A 1.506 1.00
36_A 40_R 1.485 1.00
82_F 97_L 1.483 1.00
375_L 389_V 1.474 1.00
313_L 365_A 1.473 1.00
204_N 211_T 1.472 1.00
175_M 178_E 1.463 1.00
181_L 185_R 1.449 1.00
306_L 389_V 1.446 1.00
8_S 37_A 1.426 1.00
195_A 341_N 1.419 1.00
3_N 275_R 1.416 1.00
204_N 213_V 1.413 1.00
257_L 356_A 1.413 1.00
198_A 367_Q 1.406 0.99
101_A 107_A 1.405 0.99
261_E 264_A 1.404 0.99
365_A 368_A 1.404 0.99
117_N 120_L 1.383 0.99
298_Q 330_N 1.374 0.99
185_R 223_N 1.373 0.99
363_L 367_Q 1.366 0.99
35_K 39_E 1.361 0.99
33_V 256_A 1.361 0.99
77_E 285_P 1.358 0.99
296_A 387_A 1.348 0.99
89_G 386_I 1.343 0.99
280_A 300_A 1.34 0.99
372_T 391_E 1.336 0.99
314_I 375_L 1.329 0.99
8_S 41_A 1.317 0.99
5_V 275_R 1.308 0.99
301_L 308_L 1.307 0.99
100_Q 106_Q 1.306 0.99
340_V 369_R 1.299 0.99
299_K 302_Q 1.298 0.99
28_D 72_K 1.286 0.99
55_N 58_Q 1.285 0.99
224_S 229_L 1.283 0.99
295_P 298_Q 1.282 0.99
4_C 259_I 1.276 0.99
111_V 258_V 1.27 0.99
95_V 257_L 1.265 0.99
312_D 366_M 1.259 0.99
14_I 353_A 1.259 0.99
51_V 70_L 1.258 0.99
307_Q 310_D 1.258 0.99
14_I 347_L 1.254 0.99
284_V 291_M 1.251 0.99
168_E 288_L 1.251 0.99
49_D 108_Q 1.25 0.99
362_L 376_A 1.249 0.99
21_L 214_F 1.246 0.98
53_M 256_A 1.238 0.98
276_I 388_M 1.233 0.98
340_V 365_A 1.229 0.98
188_A 223_N 1.227 0.98
124_L 143_V 1.224 0.98
360_V 364_H 1.221 0.98
5_V 262_E 1.212 0.98
65_P 115_M 1.21 0.98
49_D 107_A 1.205 0.98
92_L 359_L 1.204 0.98
48_V 109_S 1.202 0.98
10_V 201_V 1.196 0.98
178_E 226_A 1.196 0.98
109_S 264_A 1.191 0.98
206_V 211_T 1.186 0.98
359_L 390_I 1.185 0.98
96_A 388_M 1.182 0.98
98_A 112_A 1.173 0.98
31_A 72_K 1.172 0.98
185_R 189_A 1.171 0.98
95_V 259_I 1.17 0.97
96_A 279_Y 1.147 0.97
171_I 176_Q 1.146 0.97
89_G 380_I 1.142 0.97
179_L 324_F 1.142 0.97
171_I 325_L 1.141 0.97
5_V 260_M 1.14 0.97
8_S 40_R 1.136 0.97
9_A 364_H 1.135 0.97
33_V 254_A 1.127 0.97
278_S 303_L 1.124 0.97
280_A 299_K 1.123 0.97
52_I 110_I 1.119 0.96
93_K 97_L 1.105 0.96
312_D 337_K 1.092 0.96
313_L 369_R 1.092 0.96
278_S 389_V 1.086 0.96
12_T 33_V 1.085 0.96
38_I 43_I 1.084 0.96
195_A 368_A 1.082 0.96
24_T 32_T 1.076 0.95
207_T 212_F 1.073 0.95
263_S 267_A 1.071 0.95
311_I 375_L 1.068 0.95
181_L 229_L 1.067 0.95
199_E 361_T 1.064 0.95
198_A 368_A 1.063 0.95
13_A 214_F 1.061 0.95
294_V 298_Q 1.054 0.95
297_T 375_L 1.054 0.95
333_F 338_V 1.053 0.95
207_T 211_T 1.049 0.94
38_I 75_L 1.046 0.94
288_L 291_M 1.045 0.94
189_A 192_E 1.041 0.94
304_A 389_V 1.038 0.94
226_A 230_G 1.037 0.94
291_M 294_V 1.034 0.94
357_R 361_T 1.029 0.94
277_K 391_E 1.029 0.94
34_I 75_L 1.027 0.94
168_E 287_A 1.027 0.94
173_R 243_T 1.026 0.94
181_L 223_N 1.024 0.93
316_A 377_T 1.022 0.93
160_I 237_D 1.021 0.93
277_K 373_L 1.019 0.93
159_G 235_A 1.019 0.93
291_M 330_N 1.018 0.93
33_V 36_A 1.011 0.93
6_I 390_I 1.01 0.93
25_S 28_D 1.008 0.93
182_H 336_E 1.006 0.93
282_G 299_K 1.006 0.93
282_G 295_P 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2vu1A40.99241000.185Contact Map0.822
1ulqA80.99751000.186Contact Map0.847
4dd5A10.99241000.19Contact Map0.835
3ss6A20.99241000.197Contact Map0.827
4e1lA40.99241000.204Contact Map0.881
2wu9A20.96951000.213Contact Map0.815
2ib8A40.98481000.214Contact Map0.771
1wl4A10.99241000.216Contact Map0.833
2iikA20.96951000.223Contact Map0.812
1wdkC20.96191000.229Contact Map0.785

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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