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ARNF - Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF
UniProt: P76474 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14094
Length: 128 (120)
Sequences: 494
Seq/Len: 4.12

ARNF
Paralog alert: 0.75 [within 20: 0.35] - ratio of genomes with paralogs
Cluster includes: ARNE ARNF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
23_A 50_L 2.149 1.00
101_F 106_L 2.138 1.00
110_A 114_S 1.883 1.00
111_C 114_S 1.817 1.00
24_A 65_Y 1.712 0.99
111_C 118_L 1.689 0.99
16_A 80_L 1.647 0.99
17_Q 81_S 1.613 0.99
56_G 59_L 1.611 0.99
71_L 76_A 1.608 0.99
13_A 80_L 1.59 0.99
9_S 80_L 1.588 0.99
88_W 105_A 1.536 0.98
103_L 107_L 1.527 0.98
6_G 71_L 1.499 0.98
82_M 85_V 1.483 0.97
13_A 16_A 1.421 0.97
9_S 67_T 1.42 0.97
13_A 61_V 1.395 0.96
9_S 13_A 1.384 0.96
89_I 93_V 1.314 0.94
17_Q 64_W 1.307 0.94
90_A 94_L 1.283 0.93
64_W 77_Y 1.279 0.93
23_A 105_A 1.271 0.92
60_S 80_L 1.267 0.92
56_G 119_I 1.264 0.92
21_G 118_L 1.25 0.92
79_L 84_Y 1.242 0.91
3_L 7_L 1.231 0.91
13_A 83_S 1.215 0.90
23_A 53_G 1.189 0.89
88_W 116_L 1.186 0.89
51_L 59_L 1.169 0.88
104_K 107_L 1.169 0.88
20_L 83_S 1.162 0.87
93_V 107_L 1.155 0.87
13_A 67_T 1.152 0.87
102_S 105_A 1.141 0.86
94_L 98_E 1.107 0.84
51_L 98_E 1.101 0.83
84_Y 119_I 1.097 0.83
88_W 91_S 1.096 0.83
6_G 60_S 1.091 0.82
82_M 91_S 1.086 0.82
21_G 78_A 1.08 0.81
9_S 84_Y 1.077 0.81
6_G 79_L 1.076 0.81
21_G 24_A 1.053 0.79
23_A 84_Y 1.052 0.79
9_S 57_Y 1.049 0.79
13_A 60_S 1.042 0.78
64_W 79_L 1.028 0.77
109_V 113_M 1.022 0.76
18_L 22_F 1.022 0.76
13_A 20_L 1.018 0.76
10_V 14_S 1.016 0.76
13_A 71_L 1.013 0.75
17_Q 77_Y 1.01 0.75
27_L 73_L 1.009 0.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2i68A20.843899.70.488Contact Map0.033
3b5dA20.843899.70.488Contact Map0.07
2gfpA20.96881.70.948Contact Map0.208
3j01B10.437510.954Contact Map0.19
3ar4A10.76560.90.956Contact Map0.568
4hg6A10.69530.80.958Contact Map0.147
2lk9A10.22660.80.958Contact Map0.026
3o7qA10.99220.70.958Contact Map0.344
2l9uA20.29690.70.96Contact Map0.084
1q90A10.33590.60.96Contact Map0.759

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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