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CUSC - Cation efflux system protein CusC
UniProt: P77211 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14233
Length: 457 (448)
Sequences: 7957
Seq/Len: 17.76

CUSC
Paralog alert: 0.84 [within 20: 0.16] - ratio of genomes with paralogs
Cluster includes: CUSC MDTP MDTQ TOLC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
70_A 169_V 3.624 1.00
194_Q 225_R 3.225 1.00
187_E 232_Q 3.084 1.00
201_E 218_R 3.001 1.00
69_E 248_S 2.822 1.00
402_Q 433_R 2.789 1.00
201_E 205_L 2.765 1.00
403_I 406_Q 2.594 1.00
183_L 228_I 2.58 1.00
190_L 221_I 2.525 1.00
297_I 359_Q 2.422 1.00
418_S 421_E 2.376 1.00
187_E 228_I 2.372 1.00
304_F 352_L 2.342 1.00
176_Q 235_L 2.334 1.00
195_Q 198_A 2.327 1.00
86_E 358_R 2.303 1.00
83_K 361_Q 2.272 1.00
82_L 357_I 2.245 1.00
208_S 416_A 2.234 1.00
76_D 368_Q 2.213 1.00
89_A 350_A 2.167 1.00
409_R 413_Q 2.164 1.00
211_V 403_I 2.159 1.00
204_L 214_L 2.153 1.00
190_L 228_I 2.142 1.00
180_Y 235_L 2.122 1.00
79_M 365_N 2.116 1.00
157_A 285_E 2.102 1.00
181_A 184_Q 2.096 1.00
308_I 338_I 2.094 1.00
90_Q 354_I 2.037 1.00
68_S 72_V 1.975 1.00
182_Q 434_Q 1.963 1.00
402_Q 406_Q 1.957 1.00
91_Y 151_Y 1.946 1.00
146_A 296_N 1.939 1.00
202_K 410_A 1.917 1.00
194_Q 221_I 1.91 1.00
156_E 284_M 1.885 1.00
222_E 225_R 1.869 1.00
194_Q 198_A 1.863 1.00
150_N 296_N 1.836 1.00
183_L 232_Q 1.835 1.00
222_E 396_R 1.828 1.00
179_A 238_A 1.804 1.00
179_A 231_R 1.795 1.00
149_Q 288_H 1.777 1.00
191_R 195_Q 1.766 1.00
153_A 289_A 1.761 1.00
344_N 348_N 1.753 1.00
387_L 439_L 1.71 1.00
178_L 441_Y 1.701 1.00
436_L 440_N 1.692 1.00
156_E 159_R 1.68 1.00
190_L 225_R 1.676 1.00
285_E 289_A 1.669 1.00
183_L 235_L 1.661 1.00
82_L 364_V 1.658 1.00
150_N 292_A 1.653 1.00
388_N 443_R 1.647 1.00
82_L 360_Q 1.635 1.00
424_D 427_R 1.629 1.00
375_K 379_D 1.628 1.00
178_L 437_L 1.625 1.00
358_R 361_Q 1.619 1.00
294_N 359_Q 1.615 1.00
395_Q 436_L 1.604 1.00
62_Q 65_T 1.592 1.00
188_E 433_R 1.589 1.00
66_L 169_V 1.574 1.00
409_R 426_E 1.564 1.00
78_R 364_V 1.542 1.00
143_M 299_A 1.538 1.00
215_E 403_I 1.534 1.00
84_V 158_Q 1.526 1.00
64_K 68_S 1.522 1.00
146_A 299_A 1.516 1.00
152_L 155_E 1.513 1.00
85_Q 88_R 1.507 1.00
391_I 436_L 1.506 1.00
67_I 71_L 1.49 1.00
287_E 366_Y 1.486 1.00
169_V 242_L 1.486 1.00
93_L 354_I 1.486 1.00
65_T 68_S 1.481 1.00
67_I 170_A 1.478 1.00
180_Y 239_N 1.474 1.00
139_R 307_S 1.465 1.00
359_Q 363_V 1.46 1.00
288_H 291_M 1.46 1.00
153_A 292_A 1.459 1.00
197_Y 221_I 1.451 1.00
218_R 396_R 1.446 1.00
184_Q 187_E 1.445 1.00
206_T 414_H 1.442 1.00
311_T 335_I 1.44 1.00
204_L 211_V 1.434 1.00
69_E 246_L 1.42 1.00
429_L 433_R 1.42 1.00
186_A 224_T 1.418 1.00
171_Q 445_V 1.417 1.00
77_L 165_L 1.412 1.00
71_L 166_V 1.409 1.00
197_Y 218_R 1.407 0.99
360_Q 363_V 1.404 0.99
235_L 239_N 1.403 0.99
89_A 353_D 1.392 0.99
142_N 145_E 1.388 0.99
197_Y 201_E 1.374 0.99
185_I 437_L 1.364 0.99
193_Y 224_T 1.358 0.99
353_D 356_E 1.343 0.99
86_E 361_Q 1.34 0.99
219_G 401_L 1.338 0.99
85_Q 360_Q 1.337 0.99
240_N 379_D 1.335 0.99
170_A 448_I 1.333 0.99
212_L 408_A 1.331 0.99
297_I 352_L 1.328 0.99
291_M 294_N 1.327 0.99
368_Q 372_N 1.326 0.99
351_N 354_I 1.326 0.99
56_T 64_K 1.321 0.99
98_R 144_S 1.321 0.99
198_A 201_E 1.319 0.99
135_D 138_G 1.319 0.99
405_L 429_L 1.315 0.99
92_R 350_A 1.314 0.99
191_R 194_Q 1.308 0.99
140_L 144_S 1.308 0.99
228_I 232_Q 1.304 0.99
184_Q 188_E 1.302 0.99
183_L 187_E 1.288 0.99
218_R 222_E 1.277 0.99
159_R 162_H 1.273 0.99
398_L 429_L 1.272 0.99
67_I 166_V 1.271 0.99
96_A 347_R 1.271 0.99
91_Y 148_R 1.269 0.99
176_Q 239_N 1.267 0.99
171_Q 449_S 1.262 0.99
395_Q 399_A 1.261 0.99
83_K 86_E 1.26 0.99
286_A 362_S 1.257 0.99
396_R 399_A 1.251 0.99
402_Q 429_L 1.248 0.99
69_E 73_N 1.246 0.98
412_Y 419_Y 1.245 0.98
149_Q 291_M 1.244 0.98
233_G 383_L 1.243 0.98
197_Y 214_L 1.241 0.98
438_D 442_A 1.24 0.98
229_A 389_D 1.236 0.98
164_L 168_N 1.231 0.98
398_L 433_R 1.227 0.98
190_L 194_Q 1.224 0.98
361_Q 365_N 1.224 0.98
408_A 417_V 1.223 0.98
395_Q 440_N 1.214 0.98
290_L 366_Y 1.214 0.98
84_V 151_Y 1.214 0.98
84_V 155_E 1.211 0.98
348_N 352_L 1.21 0.98
188_E 191_R 1.209 0.98
398_L 436_L 1.206 0.98
198_A 202_K 1.205 0.98
290_L 363_V 1.205 0.98
89_A 357_I 1.204 0.98
244_L 375_K 1.203 0.98
82_L 85_Q 1.202 0.98
53_G 56_T 1.196 0.98
202_K 205_L 1.196 0.98
79_M 364_V 1.196 0.98
221_I 225_R 1.196 0.98
280_R 376_E 1.194 0.98
297_I 356_E 1.191 0.98
367_E 370_I 1.19 0.98
81_T 158_Q 1.177 0.98
21_A 142_N 1.176 0.98
290_L 359_Q 1.175 0.98
343_F 346_G 1.174 0.98
410_A 413_Q 1.171 0.98
384_R 443_R 1.168 0.97
387_L 446_N 1.164 0.97
156_E 288_H 1.163 0.97
182_Q 438_D 1.161 0.97
90_Q 93_L 1.159 0.97
215_E 218_R 1.156 0.97
405_L 409_R 1.147 0.97
366_Y 370_I 1.147 0.97
392_S 396_R 1.146 0.97
301_R 352_L 1.139 0.97
152_L 288_H 1.138 0.97
158_Q 162_H 1.136 0.97
91_Y 95_D 1.123 0.97
65_T 69_E 1.123 0.97
187_E 191_R 1.121 0.97
411_L 417_V 1.12 0.96
377_V 450_L 1.116 0.96
237_Q 383_L 1.115 0.96
300_A 303_A 1.113 0.96
283_I 373_A 1.111 0.96
341_P 344_N 1.108 0.96
70_A 165_L 1.107 0.96
394_Q 439_L 1.105 0.96
211_V 215_E 1.103 0.96
181_A 440_N 1.1 0.96
280_R 373_A 1.1 0.96
390_Q 442_A 1.098 0.96
443_R 447_E 1.091 0.96
354_I 358_R 1.09 0.96
175_N 445_V 1.087 0.96
287_E 291_M 1.086 0.96
220_V 223_S 1.083 0.96
183_L 231_R 1.081 0.95
66_L 246_L 1.08 0.95
157_A 289_A 1.079 0.95
174_F 448_I 1.075 0.95
145_E 295_A 1.075 0.95
110_W 122_R 1.073 0.95
154_T 157_A 1.069 0.95
282_D 373_A 1.062 0.95
355_A 358_R 1.061 0.95
237_Q 382_A 1.061 0.95
160_A 164_L 1.06 0.95
93_L 351_N 1.054 0.95
149_Q 295_A 1.051 0.94
406_Q 410_A 1.05 0.94
447_E 451_Y 1.048 0.94
280_R 453_A 1.044 0.94
233_G 386_S 1.043 0.94
24_Y 27_P 1.041 0.94
63_V 170_A 1.036 0.94
222_E 400_S 1.032 0.94
200_V 217_A 1.029 0.94
80_A 161_V 1.019 0.93
55_R 64_K 1.016 0.93
168_N 171_Q 1.014 0.93
313_G 333_N 1.01 0.93
391_I 439_L 1.01 0.93
347_R 351_N 1.009 0.93
372_N 376_E 1.009 0.93
179_A 182_Q 1.006 0.93
295_A 298_G 1.005 0.93
250_G 253_P 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4k7rA10.96281000.214Contact Map0.652
3pikA10.96281000.214Contact Map0.67
3d5kA30.95621000.239Contact Map0.805
1yc9A10.93441000.261Contact Map0.628
1ek9A30.86211000.357Contact Map0.743
4dk0A10.330456.90.955Contact Map0.607
3zbiC140.10540.20.959Contact Map0
3fppA20.3282400.959Contact Map0.655
2f1mA40.293217.30.966Contact Map0.757
3lnnA20.363216.50.966Contact Map0.552

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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