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CAAL - Carboxylate-amine ligase YbdK
UniProt: P77213 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13644
Length: 372 (362)
Sequences: 1203
Seq/Len: 3.32

CAAL
Paralog alert: 0.16 [within 20: 0.03] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
293_E 308_T 2.776 1.00
357_S 360_G 2.632 1.00
28_Y 363_K 2.553 1.00
16_I 72_A 2.473 1.00
175_D 349_R 2.314 1.00
25_P 93_E 2.283 1.00
64_D 75_Q 2.277 1.00
238_V 257_I 2.25 1.00
68_D 71_Q 2.239 1.00
199_S 203_Q 2.212 1.00
256_L 314_L 2.186 1.00
66_C 71_Q 2.185 1.00
73_A 251_V 2.177 1.00
147_A 229_P 2.042 1.00
295_V 306_P 1.965 1.00
344_E 348_M 1.934 1.00
24_N 27_G 1.931 1.00
143_S 146_D 1.863 0.99
200_N 203_Q 1.86 0.99
15_G 19_E 1.854 0.99
244_P 253_M 1.83 0.99
165_S 253_M 1.815 0.99
323_H 328_S 1.785 0.99
74_G 85_Q 1.753 0.99
69_I 255_G 1.71 0.99
360_G 363_K 1.681 0.99
151_L 236_V 1.675 0.99
179_A 346_Q 1.674 0.99
135_Q 250_A 1.653 0.98
342_L 350_D 1.635 0.98
282_F 286_Q 1.608 0.98
22_V 92_L 1.588 0.98
144_G 205_E 1.557 0.97
211_L 223_L 1.556 0.97
264_L 317_K 1.553 0.97
13_T 140_G 1.54 0.97
40_A 89_D 1.536 0.97
286_Q 290_Y 1.522 0.97
160_H 307_L 1.52 0.97
100_H 108_Q 1.511 0.97
98_G 243_T 1.51 0.97
73_A 248_S 1.509 0.97
346_Q 350_D 1.505 0.97
167_A 344_E 1.501 0.96
97_G 167_A 1.498 0.96
320_P 324_K 1.482 0.96
312_L 339_V 1.481 0.96
73_A 330_A 1.464 0.96
319_A 335_H 1.463 0.96
305_R 313_R 1.446 0.95
295_V 304_R 1.436 0.95
342_L 347_L 1.435 0.95
117_Q 121_E 1.431 0.95
319_A 323_H 1.423 0.95
141_C 236_V 1.405 0.94
16_I 254_A 1.397 0.94
63_T 66_C 1.396 0.94
167_A 343_N 1.396 0.94
100_H 103_Q 1.395 0.94
343_N 346_Q 1.387 0.94
279_L 297_T 1.384 0.94
112_D 117_Q 1.383 0.94
66_C 75_Q 1.382 0.94
33_D 36_M 1.376 0.93
336_R 340_S 1.373 0.93
21_Q 133_F 1.366 0.93
67_R 71_Q 1.36 0.93
246_T 249_H 1.346 0.92
100_H 195_M 1.339 0.92
256_L 318_I 1.325 0.92
96_G 243_T 1.317 0.91
13_T 65_V 1.303 0.91
355_G 360_G 1.298 0.91
351_F 361_L 1.287 0.90
360_G 364_K 1.28 0.90
259_A 321_S 1.275 0.90
199_S 206_A 1.273 0.89
347_L 351_F 1.273 0.89
77_S 247_L 1.27 0.89
342_L 345_A 1.267 0.89
53_D 60_E 1.256 0.89
95_C 366_C 1.256 0.89
82_V 85_Q 1.255 0.89
337_Q 341_G 1.253 0.88
309_E 312_L 1.252 0.88
348_M 365_H 1.25 0.88
73_A 247_L 1.243 0.88
73_A 77_S 1.232 0.87
16_I 134_G 1.225 0.87
259_A 322_A 1.222 0.87
350_D 360_G 1.222 0.87
26_P 91_H 1.221 0.87
305_R 309_E 1.207 0.86
171_M 176_T 1.206 0.86
69_I 251_V 1.203 0.86
27_G 36_M 1.202 0.85
21_Q 58_M 1.197 0.85
80_Q 83_V 1.194 0.85
99_T 171_M 1.194 0.85
12_F 262_H 1.194 0.85
204_F 208_F 1.192 0.85
84_L 93_E 1.181 0.84
162_I 229_P 1.174 0.84
160_H 314_L 1.172 0.83
129_Q 224_H 1.172 0.83
351_F 364_K 1.168 0.83
163_A 166_A 1.167 0.83
319_A 332_E 1.167 0.83
184_N 187_S 1.162 0.83
155_S 195_M 1.159 0.83
226_D 284_R 1.156 0.82
318_I 321_S 1.153 0.82
15_G 60_E 1.151 0.82
305_R 310_D 1.146 0.82
299_P 303_D 1.141 0.81
157_F 260_T 1.138 0.81
219_S 222_D 1.138 0.81
170_Y 352_V 1.129 0.80
341_G 348_M 1.126 0.80
264_L 314_L 1.126 0.80
308_T 341_G 1.125 0.80
44_K 89_D 1.122 0.80
35_S 52_H 1.118 0.79
160_H 311_T 1.115 0.79
132_V 186_F 1.113 0.79
137_V 238_V 1.113 0.79
315_L 335_H 1.11 0.79
214_T 324_K 1.108 0.78
61_L 74_G 1.107 0.78
22_V 94_I 1.104 0.78
72_A 137_V 1.098 0.78
167_A 322_A 1.098 0.78
20_M 61_L 1.097 0.77
69_I 260_T 1.094 0.77
211_L 220_I 1.093 0.77
286_Q 306_P 1.085 0.76
255_G 331_I 1.083 0.76
229_P 236_V 1.081 0.76
40_A 90_H 1.078 0.76
159_P 242_D 1.077 0.76
59_L 81_K 1.074 0.75
307_L 310_D 1.073 0.75
166_A 343_N 1.072 0.75
41_V 50_V 1.071 0.75
49_E 78_A 1.07 0.75
349_R 353_A 1.07 0.75
192_N 226_D 1.07 0.75
137_V 258_Q 1.067 0.75
51_K 62_A 1.065 0.75
102_F 359_I 1.061 0.74
308_T 312_L 1.06 0.74
315_L 338_V 1.058 0.74
256_L 331_I 1.056 0.74
293_E 346_Q 1.055 0.74
361_L 364_K 1.052 0.73
129_Q 189_F 1.051 0.73
50_V 83_V 1.046 0.73
150_L 261_A 1.045 0.73
316_E 335_H 1.037 0.72
353_A 356_G 1.036 0.72
259_A 318_I 1.033 0.71
193_G 226_D 1.032 0.71
154_L 236_V 1.031 0.71
70_N 74_G 1.028 0.71
138_H 235_T 1.021 0.70
100_H 235_T 1.02 0.70
281_K 285_F 1.02 0.70
329_S 332_E 1.018 0.70
178_F 289_R 1.017 0.70
110_V 120_L 1.016 0.69
364_K 367_E 1.014 0.69
136_H 140_G 1.012 0.69
22_V 31_S 1.01 0.69
150_L 236_V 1.01 0.69
221_K 224_H 1.009 0.69
294_G 320_P 1.007 0.68
235_T 283_N 1.005 0.68
54_I 207_L 1.001 0.68
306_P 309_E 1.001 0.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1r8gA211000.182Contact Map0.631
2gwdA10.9571000.256Contact Map0.563
3nztA10.97041000.373Contact Map0.432
1va6A20.97311000.395Contact Map0.442
3ln6A10.95431000.414Contact Map0.346
3ln7A20.95161000.429Contact Map0.398
3ig5A10.98661000.551Contact Map0.51
2d3aA100.5591980.912Contact Map0.513
4hppA10.7823980.912Contact Map0.407
4baxA100.5672980.913Contact Map0.486

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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