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CITG - 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase
UniProt: P77231 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13539
Length: 292 (276)
Sequences: 413
Seq/Len: 1.50

CITG
Paralog alert: 0.18 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
185_A 188_P 2.515 1.00
68_W 98_C 2.456 1.00
220_M 240_L 2.443 1.00
51_K 273_N 2.332 0.99
233_G 236_G 2.323 0.99
228_V 240_L 2.268 0.99
91_L 124_A 2.194 0.99
75_F 94_I 2.152 0.99
36_S 44_R 2.063 0.98
46_N 266_D 2.036 0.98
36_S 45_I 1.988 0.98
252_G 258_D 1.943 0.97
29_M 115_S 1.925 0.97
177_T 181_G 1.879 0.97
232_G 236_G 1.846 0.96
251_G 258_D 1.729 0.94
53_M 58_F 1.689 0.93
36_S 43_D 1.685 0.93
166_A 170_L 1.669 0.93
151_G 184_E 1.659 0.92
255_T 258_D 1.654 0.92
232_G 274_L 1.64 0.92
219_L 223_N 1.637 0.92
43_D 262_L 1.633 0.92
176_L 229_A 1.618 0.91
103_F 113_K 1.609 0.91
247_L 258_D 1.604 0.91
49_A 270_I 1.596 0.90
123_C 127_G 1.581 0.90
219_L 232_G 1.54 0.88
240_L 269_C 1.538 0.88
121_L 183_A 1.534 0.88
34_N 44_R 1.509 0.87
236_G 274_L 1.508 0.87
214_D 251_G 1.507 0.87
194_A 286_T 1.5 0.86
34_N 59_H 1.475 0.85
189_L 223_N 1.439 0.83
65_I 69_L 1.425 0.82
166_A 230_S 1.378 0.79
33_V 55_L 1.367 0.78
30_L 62_A 1.365 0.78
217_L 262_L 1.363 0.78
220_M 269_C 1.359 0.78
197_H 201_L 1.352 0.77
65_I 98_C 1.345 0.77
56_E 121_L 1.344 0.77
143_S 147_S 1.339 0.76
214_D 252_G 1.337 0.76
183_A 187_Y 1.323 0.75
117_F 227_N 1.321 0.75
252_G 255_T 1.307 0.74
43_D 266_D 1.307 0.74
215_T 286_T 1.301 0.73
91_L 228_V 1.298 0.73
237_L 241_Q 1.283 0.72
229_A 237_L 1.276 0.71
69_L 91_L 1.274 0.71
92_R 117_F 1.274 0.71
181_G 185_A 1.271 0.71
266_D 273_N 1.268 0.70
21_Y 127_G 1.239 0.68
36_S 46_N 1.239 0.68
112_H 227_N 1.238 0.68
142_C 191_I 1.227 0.67
212_L 287_W 1.215 0.66
262_L 266_D 1.211 0.65
216_L 220_M 1.204 0.65
25_G 119_L 1.203 0.65
170_L 226_T 1.201 0.64
87_V 128_R 1.196 0.64
265_F 269_C 1.187 0.63
228_V 274_L 1.178 0.62
149_C 183_A 1.171 0.62
228_V 269_C 1.167 0.61
189_L 229_A 1.158 0.60
108_G 122_L 1.157 0.60
142_C 145_A 1.157 0.60
33_V 62_A 1.146 0.59
277_G 281_D 1.142 0.59
46_N 270_I 1.139 0.58
102_M 112_H 1.135 0.58
102_M 116_I 1.133 0.58
141_V 147_S 1.125 0.57
26_W 65_I 1.124 0.57
179_A 226_T 1.123 0.57
109_V 118_S 1.12 0.56
76_G 124_A 1.118 0.56
75_F 87_V 1.115 0.56
52_D 281_D 1.111 0.55
110_N 281_D 1.109 0.55
88_L 117_F 1.107 0.55
32_E 42_V 1.104 0.55
67_G 101_D 1.104 0.55
30_L 33_V 1.097 0.54
179_A 223_N 1.09 0.53
38_K 187_Y 1.088 0.53
239_W 272_R 1.088 0.53
139_T 249_Q 1.087 0.53
88_L 156_E 1.083 0.53
74_E 78_C 1.078 0.52
200_T 203_D 1.077 0.52
52_D 110_N 1.076 0.52
266_D 270_I 1.067 0.51
64_A 105_A 1.067 0.51
35_L 38_K 1.065 0.51
43_D 217_L 1.064 0.51
53_M 109_V 1.063 0.51
76_G 127_G 1.063 0.51
92_R 227_N 1.061 0.50
40_G 269_C 1.058 0.50
212_L 215_T 1.054 0.50
101_D 113_K 1.041 0.48
149_C 152_L 1.039 0.48
54_A 246_T 1.038 0.48
71_R 97_A 1.036 0.48
214_D 258_D 1.036 0.48
29_M 119_L 1.035 0.48
121_L 179_A 1.025 0.47
42_V 52_D 1.025 0.47
35_L 236_G 1.024 0.47
170_L 230_S 1.022 0.46
202_L 208_P 1.02 0.46
102_M 231_R 1.019 0.46
25_G 65_I 1.019 0.46
112_H 116_I 1.019 0.46
22_A 62_A 1.012 0.45
120_G 124_A 1.01 0.45
102_M 281_D 1.01 0.45
168_Q 189_L 1.007 0.45
195_L 286_T 1.006 0.45
38_K 118_S 1.006 0.45
38_K 43_D 1.005 0.45
219_L 282_L 1.003 0.44
113_K 171_Y 1 0.44
49_A 274_L 1 0.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3h9pA30.76371000.454Contact Map0.493
4a4zA10.366420.40.971Contact Map0.06
3l9oA10.36648.20.975Contact Map0.011
2xgjA20.36647.70.976Contact Map0.175
2xc7A10.23976.40.977Contact Map0.269
2d1lA20.29796.40.977Contact Map0.195
2w4sA40.23634.40.978Contact Map0.236
1z3eB10.24324.30.978Contact Map0.145
4c2tA40.30484.10.979Contact Map0.073
1rfzA40.219240.979Contact Map0.233

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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