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YBBL - Uncharacterized ABC transporter ATP-binding protein YbbL
UniProt: P77279 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13259
Length: 225 (214)
Sequences: 72130
Seq/Len: 337.06

YBBL
Paralog alert: 0.93 [within 20: 0.83] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
37_L 204_A 3.173 1.00
9_Q 29_S 3.108 1.00
34_E 206_K 3.024 1.00
63_T 70_D 2.884 1.00
11_Q 63_T 2.853 1.00
130_I 133_K 2.844 1.00
12_N 25_N 2.841 1.00
82_Q 157_K 2.708 1.00
21_K 24_N 2.591 1.00
9_Q 65_L 2.532 1.00
31_R 34_E 2.531 1.00
206_K 220_A 2.509 1.00
36_K 208_I 2.495 1.00
24_N 216_E 2.454 1.00
122_E 127_P 2.303 1.00
14_G 25_N 2.247 1.00
10_L 13_V 2.153 1.00
16_L 21_K 2.093 1.00
14_G 61_S 2.087 1.00
14_G 21_K 2.078 1.00
118_L 131_L 2.073 1.00
15_Y 52_I 2.053 1.00
11_Q 65_L 2.038 1.00
128_D 131_L 2.02 1.00
98_Y 132_T 1.972 1.00
116_I 155_M 1.969 1.00
67_E 157_K 1.938 1.00
97_V 138_L 1.885 1.00
155_M 189_I 1.833 1.00
121_L 131_L 1.814 1.00
208_I 217_M 1.747 1.00
208_I 220_A 1.725 1.00
34_E 205_D 1.694 1.00
32_A 157_K 1.69 1.00
98_Y 131_L 1.68 1.00
17_A 22_I 1.675 1.00
12_N 27_N 1.656 1.00
98_Y 102_I 1.618 1.00
95_D 99_D 1.601 1.00
50_L 160_L 1.548 1.00
50_L 194_V 1.503 1.00
15_Y 60_T 1.496 1.00
16_L 60_T 1.467 1.00
133_K 137_E 1.462 1.00
119_D 123_R 1.451 1.00
182_R 186_E 1.44 1.00
118_L 122_E 1.433 1.00
98_Y 118_L 1.424 1.00
30_L 36_K 1.415 1.00
123_R 182_R 1.395 0.99
88_Q 140_G 1.394 0.99
98_Y 117_F 1.375 0.99
75_K 78_I 1.369 0.99
28_F 208_I 1.367 0.99
15_Y 57_I 1.361 0.99
10_L 53_V 1.354 0.99
65_L 70_D 1.336 0.99
114_P 118_L 1.325 0.99
116_I 119_D 1.318 0.99
184_V 205_D 1.311 0.99
23_L 52_I 1.297 0.99
11_Q 29_S 1.291 0.99
52_I 59_P 1.275 0.99
7_L 67_E 1.264 0.99
14_G 24_N 1.264 0.99
161_L 180_I 1.247 0.99
10_L 28_F 1.232 0.98
123_R 187_Q 1.231 0.98
98_Y 114_P 1.226 0.98
15_Y 48_T 1.222 0.98
115_A 119_D 1.221 0.98
13_V 59_P 1.215 0.98
100_N 150_R 1.211 0.98
127_P 131_L 1.202 0.98
101_L 153_Q 1.195 0.98
96_T 99_D 1.187 0.98
67_E 82_Q 1.18 0.98
195_T 201_I 1.173 0.98
184_V 191_V 1.164 0.97
49_L 210_L 1.137 0.97
11_Q 27_N 1.136 0.97
31_R 206_K 1.131 0.97
211_Q 218_Q 1.129 0.97
84_S 156_P 1.124 0.97
10_L 49_L 1.113 0.96
102_I 113_D 1.112 0.96
53_V 192_L 1.098 0.96
97_V 146_I 1.09 0.96
177_N 200_E 1.084 0.96
54_A 85_Y 1.078 0.95
36_K 206_K 1.07 0.95
55_S 58_S 1.069 0.95
35_F 193_W 1.062 0.95
35_F 184_V 1.061 0.95
116_I 120_F 1.058 0.95
36_K 220_A 1.054 0.95
173_K 200_E 1.049 0.94
35_F 191_V 1.049 0.94
70_D 73_T 1.046 0.94
51_K 57_I 1.037 0.94
86_C 148_L 1.032 0.94
16_L 22_I 1.028 0.94
179_M 182_R 1.028 0.94
173_K 197_D 1.017 0.93
121_L 126_L 1.005 0.93
124_F 149_I 1.002 0.92
181_H 184_V 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2yyzA10.96100-0.048Contact Map0.813
3tuiC40.9867100-0.048Contact Map0.871
2it1A20.96100-0.048Contact Map0.882
1g29120.9689100-0.048Contact Map0.9
1oxxK10.9689100-0.045Contact Map0.791
3rlfA20.96100-0.044Contact Map0.854
1z47A20.9778100-0.043Contact Map0.832
1v43A10.9778100-0.041Contact Map0.824
3fvqA20.9689100-0.041Contact Map0.774
4mkiB20.9822100-0.029Contact Map0.806

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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