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ABGA - p-aminobenzoyl-glutamate hydrolase subunit A
UniProt: P77357 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13352
Length: 436 (385)
Sequences: 11687
Seq/Len: 30.36

ABGA
Paralog alert: 0.88 [within 20: 0.19] - ratio of genomes with paralogs
Cluster includes: ABGA ABGB ALLC ARGE DAPE PEPT YGEY
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
234_H 293_S 3.156 1.00
101_T 176_K 3.106 1.00
40_A 44_H 3.076 1.00
240_A 249_G 3.068 1.00
353_S 429_N 2.833 1.00
236_T 329_G 2.829 1.00
316_Q 320_Q 2.825 1.00
313_D 317_Q 2.694 1.00
255_A 328_V 2.693 1.00
357_Q 429_N 2.664 1.00
234_H 295_L 2.632 1.00
234_H 331_E 2.616 1.00
312_F 316_Q 2.526 1.00
235_F 259_A 2.519 1.00
129_S 408_K 2.491 1.00
21_D 38_L 2.434 1.00
232_D 295_L 2.423 1.00
357_Q 425_R 2.42 1.00
110_V 174_V 2.408 1.00
42_E 45_Q 2.396 1.00
232_D 333_R 2.389 1.00
40_A 52_L 2.321 1.00
256_A 281_M 2.311 1.00
356_A 362_N 2.306 1.00
236_T 331_E 2.299 1.00
236_T 293_S 2.236 1.00
41_E 45_Q 2.216 1.00
256_A 294_A 2.201 1.00
103_D 174_V 2.162 1.00
43_L 100_A 2.155 1.00
257_A 260_T 2.118 1.00
144_M 410_D 2.107 1.00
256_A 296_L 2.094 1.00
37_T 41_E 2.065 1.00
425_R 428_L 2.059 1.00
33_F 37_T 2.057 1.00
352_Q 356_A 2.041 1.00
21_D 34_R 2.01 1.00
232_D 297_K 1.967 1.00
283_A 294_A 1.953 1.00
282_Q 295_L 1.95 1.00
163_T 424_A 1.922 1.00
130_H 141_N 1.884 1.00
34_R 37_T 1.881 1.00
39_V 117_M 1.875 1.00
190_R 194_D 1.867 1.00
38_L 42_E 1.86 1.00
46_L 162_H 1.857 1.00
351_L 426_T 1.807 1.00
259_A 319_I 1.794 1.00
112_A 201_V 1.772 1.00
234_H 333_R 1.766 1.00
37_T 52_L 1.755 1.00
314_R 317_Q 1.751 1.00
163_T 167_F 1.75 1.00
24_H 140_C 1.731 1.00
110_V 176_K 1.686 1.00
14_K 162_H 1.686 1.00
238_T 250_H 1.682 1.00
21_D 24_H 1.652 1.00
101_T 174_V 1.648 1.00
280_V 297_K 1.642 1.00
354_Q 429_N 1.636 1.00
358_V 425_R 1.635 1.00
320_Q 324_T 1.626 1.00
44_H 52_L 1.625 1.00
252_A 294_A 1.625 1.00
309_Q 313_D 1.61 1.00
13_P 17_H 1.604 1.00
40_A 98_I 1.602 1.00
15_L 420_V 1.6 1.00
36_A 117_M 1.593 1.00
17_H 21_D 1.585 1.00
381_M 391_A 1.584 1.00
15_L 159_G 1.582 1.00
49_S 103_D 1.579 1.00
48_Y 102_L 1.547 1.00
131_R 138_A 1.542 1.00
250_H 255_A 1.539 1.00
156_I 419_A 1.532 1.00
41_E 44_H 1.525 1.00
162_H 166_Q 1.524 1.00
253_L 281_M 1.522 1.00
239_A 292_A 1.504 1.00
258_Q 261_L 1.485 1.00
112_A 178_I 1.485 1.00
349_A 352_Q 1.48 1.00
269_H 314_R 1.48 1.00
250_H 328_V 1.473 1.00
152_G 411_F 1.458 1.00
258_Q 326_Y 1.458 1.00
307_I 310_Y 1.447 1.00
42_E 46_L 1.443 1.00
257_A 261_L 1.443 1.00
15_L 155_A 1.426 1.00
143_G 414_Q 1.42 1.00
235_F 256_A 1.419 1.00
40_A 50_L 1.412 1.00
38_L 41_E 1.408 1.00
191_A 194_D 1.394 0.99
319_I 330_V 1.392 0.99
44_H 50_L 1.391 0.99
165_K 168_E 1.386 0.99
25_Y 38_L 1.369 0.99
127_D 138_A 1.369 0.99
39_V 154_T 1.369 0.99
20_R 413_E 1.367 0.99
310_Y 314_R 1.366 0.99
354_Q 425_R 1.356 0.99
23_H 147_A 1.356 0.99
112_A 204_F 1.349 0.99
229_T 308_N 1.349 0.99
323_A 330_V 1.345 0.99
12_A 417_A 1.339 0.99
21_D 25_Y 1.32 0.99
231_F 298_V 1.319 0.99
113_F 157_G 1.318 0.99
49_S 101_T 1.301 0.99
18_W 38_L 1.298 0.99
102_L 165_K 1.285 0.99
310_Y 313_D 1.278 0.99
274_S 311_V 1.276 0.99
235_F 255_A 1.275 0.99
355_A 422_T 1.265 0.99
425_R 429_N 1.26 0.99
253_L 283_A 1.258 0.99
417_A 421_E 1.251 0.99
233_A 296_L 1.247 0.99
18_W 42_E 1.245 0.98
33_F 96_T 1.244 0.98
20_R 24_H 1.243 0.98
254_L 265_A 1.234 0.98
262_A 321_G 1.229 0.98
353_S 357_Q 1.227 0.98
24_H 138_A 1.224 0.98
233_A 332_T 1.216 0.98
6_Q 10_S 1.215 0.98
418_I 421_E 1.207 0.98
254_L 264_H 1.206 0.98
317_Q 321_G 1.194 0.98
9_N 421_E 1.194 0.98
17_H 20_R 1.194 0.98
104_T 174_V 1.189 0.98
258_Q 325_M 1.186 0.98
313_D 316_Q 1.184 0.98
312_F 334_L 1.176 0.98
160_L 424_A 1.175 0.98
20_R 139_S 1.174 0.98
7_F 11_L 1.173 0.98
260_T 296_L 1.169 0.97
29_G 185_G 1.166 0.97
235_F 296_L 1.162 0.97
349_A 353_S 1.16 0.97
113_F 427_A 1.16 0.97
262_A 318_A 1.156 0.97
36_A 98_I 1.154 0.97
191_A 195_A 1.149 0.97
350_W 354_Q 1.144 0.97
350_W 429_N 1.143 0.97
312_F 336_G 1.143 0.97
14_K 17_H 1.123 0.97
281_M 294_A 1.12 0.96
316_Q 332_T 1.115 0.96
109_P 202_D 1.115 0.96
22_F 38_L 1.113 0.96
354_Q 358_V 1.112 0.96
37_T 40_A 1.11 0.96
233_A 259_A 1.103 0.96
353_S 356_A 1.102 0.96
11_L 14_K 1.1 0.96
152_G 209_I 1.095 0.96
34_R 38_L 1.094 0.96
385_Q 390_Q 1.089 0.96
345_P 349_A 1.084 0.96
232_D 335_M 1.08 0.95
414_Q 418_I 1.076 0.95
125_E 408_K 1.076 0.95
50_L 100_A 1.074 0.95
152_G 416_L 1.068 0.95
106_R 172_H 1.065 0.95
42_E 162_H 1.062 0.95
211_T 404_H 1.059 0.95
16_S 20_R 1.057 0.95
128_V 136_G 1.053 0.95
260_T 281_M 1.039 0.94
157_G 177_L 1.038 0.94
102_L 177_L 1.033 0.94
263_L 315_A 1.032 0.94
27_E 35_T 1.031 0.94
260_T 278_V 1.028 0.94
317_Q 320_Q 1.027 0.94
18_W 159_G 1.027 0.94
319_I 332_T 1.026 0.94
203_Y 430_F 1.022 0.93
126_Q 138_A 1.021 0.93
233_A 319_I 1.011 0.93
351_L 394_V 1.009 0.93
318_A 322_A 1.005 0.93
24_H 139_S 1.001 0.92
350_W 426_T 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3io1A20.98851000.239Contact Map0.724
3pfoA20.90371000.301Contact Map0.705
4ewtA40.86931000.309Contact Map0.766
1xmbA10.86241000.317Contact Map0.679
1ysjA20.8671000.322Contact Map0.784
1cg2A40.86241000.333Contact Map0.672
4g1pA10.91061000.344Contact Map0.701
2zogA20.88761000.347Contact Map0.677
1vgyA20.8441000.349Contact Map0.706
3rzaA20.85091000.351Contact Map0.744

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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