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ALLC - Allantoate amidohydrolase
UniProt: P77425 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13623
Length: 411 (388)
Sequences: 12259
Seq/Len: 31.60

ALLC
Paralog alert: 0.89 [within 20: 0.18] - ratio of genomes with paralogs
Cluster includes: ABGA ABGB ALLC ARGE DAPE PEPT YGEY
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
219_T 280_K 3.345 1.00
44_K 48_A 3.337 1.00
65_R 119_E 3.222 1.00
221_N 316_G 3.132 1.00
225_N 235_R 3.126 1.00
303_E 307_R 3.019 1.00
219_T 282_T 3.003 1.00
340_E 408_A 2.916 1.00
300_Q 304_N 2.912 1.00
344_R 408_A 2.906 1.00
220_L 245_I 2.888 1.00
241_A 315_I 2.813 1.00
219_T 318_D 2.743 1.00
217_T 282_T 2.697 1.00
299_T 303_E 2.651 1.00
344_R 404_L 2.637 1.00
46_R 49_A 2.62 1.00
44_K 56_F 2.514 1.00
221_N 280_K 2.504 1.00
75_V 117_T 2.5 1.00
217_T 320_D 2.468 1.00
242_F 281_T 2.445 1.00
242_F 267_V 2.394 1.00
45_K 49_A 2.389 1.00
221_N 318_D 2.379 1.00
343_E 348_N 2.373 1.00
242_F 283_F 2.361 1.00
404_L 407_L 2.278 1.00
243_S 246_C 2.23 1.00
67_N 117_T 2.222 1.00
339_T 343_E 2.213 1.00
217_T 284_T 2.196 1.00
41_Q 45_K 2.192 1.00
50_S 105_D 2.17 1.00
106_W 403_M 2.136 1.00
38_E 41_Q 2.11 1.00
37_L 41_Q 2.067 1.00
47_M 64_G 2.053 1.00
268_E 282_T 2.024 1.00
42_Q 46_R 1.994 1.00
269_P 281_T 1.976 1.00
338_L 405_Y 1.966 1.00
106_W 110_Q 1.954 1.00
139_K 143_G 1.944 1.00
41_Q 56_F 1.935 1.00
43_F 82_I 1.932 1.00
245_I 306_M 1.926 1.00
219_T 320_D 1.911 1.00
296_R 300_Q 1.875 1.00
15_W 18_S 1.85 1.00
341_L 408_A 1.829 1.00
223_E 236_R 1.8 1.00
301_Q 304_N 1.794 1.00
65_R 117_T 1.791 1.00
19_F 42_Q 1.79 1.00
53_E 67_N 1.759 1.00
48_A 56_F 1.746 1.00
52_L 66_L 1.745 1.00
45_K 48_A 1.723 1.00
238_T 281_T 1.696 1.00
224_S 279_G 1.694 1.00
99_A 396_G 1.694 1.00
75_V 119_E 1.693 1.00
236_R 241_A 1.673 1.00
266_K 284_T 1.662 1.00
244_R 247_H 1.662 1.00
40_Q 82_I 1.661 1.00
14_P 18_S 1.66 1.00
336_A 339_T 1.658 1.00
307_R 311_D 1.652 1.00
15_W 42_Q 1.642 1.00
105_D 109_T 1.63 1.00
364_A 369_T 1.629 1.00
77_L 121_V 1.625 1.00
294_V 297_D 1.615 1.00
220_L 242_F 1.61 1.00
11_E 15_W 1.61 1.00
44_K 62_L 1.605 1.00
44_K 54_T 1.597 1.00
297_D 301_Q 1.59 1.00
243_S 247_H 1.585 1.00
310_C 317_I 1.571 1.00
78_S 100_A 1.541 1.00
236_R 315_I 1.535 1.00
46_R 50_S 1.529 1.00
140_N 143_G 1.528 1.00
239_V 267_V 1.525 1.00
42_Q 45_K 1.518 1.00
244_R 313_M 1.504 1.00
7_Q 11_E 1.499 1.00
341_L 404_L 1.49 1.00
48_A 54_T 1.481 1.00
70_E 115_L 1.459 1.00
394_A 398_K 1.453 1.00
214_R 295_L 1.453 1.00
395_E 398_K 1.429 1.00
297_D 300_Q 1.426 1.00
260_L 298_F 1.421 1.00
306_M 317_I 1.412 1.00
66_L 108_K 1.395 0.99
220_L 241_A 1.379 0.99
108_K 111_Y 1.378 0.99
244_R 312_E 1.378 0.99
77_L 186_F 1.371 0.99
404_L 408_A 1.362 0.99
218_V 283_F 1.362 0.99
80_S 93_G 1.357 0.99
100_A 120_V 1.356 0.99
258_D 291_D 1.352 0.99
342_C 399_T 1.35 0.99
53_E 65_R 1.35 0.99
11_E 14_P 1.346 0.99
345_E 404_L 1.338 0.99
38_E 42_Q 1.335 0.99
77_L 183_I 1.334 0.99
300_Q 303_E 1.333 0.99
239_V 269_P 1.323 0.99
21_A 39_T 1.315 0.99
339_T 351_V 1.307 0.99
304_N 308_A 1.305 0.99
336_A 340_E 1.305 0.99
216_Y 285_I 1.296 0.99
218_V 245_I 1.294 0.99
12_T 46_R 1.29 0.99
340_E 344_R 1.265 0.99
246_C 283_F 1.26 0.99
248_Q 308_A 1.259 0.99
218_V 319_I 1.248 0.99
78_S 406_Q 1.244 0.98
240_Y 251_E 1.235 0.98
9_I 397_V 1.223 0.98
240_Y 250_V 1.215 0.98
391_T 395_E 1.208 0.98
299_T 321_L 1.205 0.98
187_V 409_W 1.2 0.98
12_T 102_L 1.197 0.98
16_L 39_T 1.194 0.98
46_R 105_D 1.178 0.98
220_L 283_F 1.178 0.98
299_T 323_M 1.174 0.98
37_L 60_G 1.172 0.98
389_N 392_D 1.171 0.98
54_T 64_G 1.171 0.98
326_E 365_P 1.164 0.97
337_T 341_L 1.157 0.97
304_N 307_R 1.154 0.97
337_T 408_A 1.152 0.97
217_T 322_W 1.152 0.97
41_Q 44_K 1.144 0.97
267_V 281_T 1.141 0.97
68_G 117_T 1.14 0.97
248_Q 251_E 1.138 0.97
10_E 14_P 1.131 0.97
103_A 403_M 1.13 0.97
12_T 105_D 1.125 0.97
110_Q 407_L 1.12 0.96
248_Q 305_D 1.11 0.96
340_E 343_E 1.106 0.96
246_C 267_V 1.099 0.96
8_A 105_D 1.096 0.96
216_Y 299_T 1.09 0.96
188_E 371_M 1.088 0.96
185_A 409_W 1.076 0.95
212_G 327_P 1.067 0.95
104_I 120_V 1.067 0.95
40_Q 62_L 1.065 0.95
303_E 319_I 1.065 0.95
221_N 279_G 1.065 0.95
76_V 406_Q 1.062 0.95
66_L 120_V 1.059 0.95
341_L 405_Y 1.057 0.95
388_T 393_L 1.054 0.95
247_H 251_E 1.053 0.95
248_Q 309_I 1.053 0.95
70_E 73_Q 1.047 0.94
106_W 398_K 1.047 0.94
80_S 97_A 1.042 0.94
225_N 277_V 1.035 0.94
230_T 233_G 1.033 0.94
55_R 65_R 1.029 0.94
34_P 125_E 1.028 0.94
52_L 64_G 1.028 0.94
249_S 302_L 1.026 0.94
17_S 90_N 1.017 0.93
48_A 53_E 1.017 0.93
398_K 404_L 1.014 0.93
99_A 189_L 1.013 0.93
296_R 323_M 1.012 0.93
240_Y 246_C 1.012 0.93
140_N 144_L 1.012 0.93
403_M 407_L 1.008 0.93
244_R 251_E 1.007 0.93
249_S 262_L 1.006 0.93
74_E 116_R 1.004 0.93
332_K 336_A 1.004 0.93
333_E 336_A 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1z2lA20.99511000.197Contact Map0.715
3n5fA20.98541000.206Contact Map0.763
2v8hA40.9831000.279Contact Map0.733
3gb0A10.83211000.307Contact Map0.739
3rzaA20.83451000.315Contact Map0.744
3pfoA20.83451000.321Contact Map0.703
3io1A20.8541000.334Contact Map0.728
1cg2A40.84671000.336Contact Map0.691
1vgyA20.84431000.344Contact Map0.706
4ewtA40.85891000.345Contact Map0.76

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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