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CUSS - Sensor kinase CusS
UniProt: P77485 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13642
Length: 480 (468)
Sequences: 6825
Seq/Len: 14.58

CUSS
Paralog alert: 0.78 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: ATOS BAES BASS CPXA CREC CUSS DCUS DPIB ENVZ GLRK NTRB PHOQ PHOR QSEC RSTB YEDV ZRAS
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
414_N 418_P 4.578 1.00
453_K 457_V 4.297 1.00
413_E 473_R 4.217 1.00
92_D 96_K 3.641 1.00
452_V 463_V 3.607 1.00
424_L 467_S 3.547 1.00
379_A 455_I 3.434 1.00
391_T 415_P 3.316 1.00
281_I 309_T 3.312 1.00
461_G 478_L 3.297 1.00
465_V 474_F 3.295 1.00
428_F 463_V 3.294 1.00
284_T 304_N 3.26 1.00
456_V 461_G 3.159 1.00
456_V 476_I 3.021 1.00
391_T 395_E 3.014 1.00
426_R 429_D 2.772 1.00
264_N 268_D 2.691 1.00
371_G 459_H 2.653 1.00
407_L 477_T 2.633 1.00
48_I 149_R 2.632 1.00
371_G 376_L 2.623 1.00
419_I 427_L 2.587 1.00
420_A 423_H 2.522 1.00
464_A 475_V 2.465 1.00
467_S 472_T 2.451 1.00
379_A 456_V 2.436 1.00
466_T 475_V 2.41 1.00
400_R 413_E 2.398 1.00
400_R 411_I 2.38 1.00
396_T 415_P 2.355 1.00
411_I 475_V 2.335 1.00
398_V 413_E 2.329 1.00
379_A 476_I 2.291 1.00
231_R 253_E 2.272 1.00
462_T 477_T 2.257 1.00
409_Q 477_T 2.239 1.00
455_I 459_H 2.238 1.00
411_I 473_R 2.233 1.00
334_K 373_P 2.193 1.00
336_L 371_G 2.158 1.00
427_L 465_V 2.146 1.00
353_A 388_L 2.141 1.00
361_R 398_V 2.14 1.00
428_F 474_F 2.08 1.00
380_L 410_V 2.064 1.00
231_R 256_E 2.033 1.00
13_A 207_H 2.013 1.00
382_N 452_V 2.007 1.00
466_T 473_R 1.998 1.00
424_L 465_V 1.992 1.00
395_E 415_P 1.989 1.00
359_E 396_T 1.981 1.00
423_H 432_Y 1.976 1.00
335_M 368_Q 1.954 1.00
465_V 472_T 1.919 1.00
288_L 302_Y 1.906 1.00
385_S 389_R 1.906 1.00
281_I 312_A 1.9 1.00
456_V 463_V 1.88 1.00
285_E 305_L 1.845 1.00
447_I 451_I 1.824 1.00
335_M 370_A 1.819 1.00
421_P 424_L 1.812 1.00
281_I 305_L 1.809 1.00
390_Y 433_R 1.781 1.00
345_V 384_L 1.75 1.00
91_A 97_T 1.746 1.00
222_N 227_D 1.742 1.00
337_N 340_D 1.732 1.00
337_N 366_K 1.718 1.00
344_K 373_P 1.71 1.00
268_D 430_R 1.707 1.00
423_H 426_R 1.697 1.00
89_S 168_Y 1.667 1.00
293_S 296_E 1.663 1.00
344_K 377_R 1.659 1.00
223_I 251_M 1.651 1.00
262_Q 266_S 1.647 1.00
342_V 380_L 1.637 1.00
346_F 399_V 1.606 1.00
428_F 465_V 1.594 1.00
435_D 438_R 1.583 1.00
419_I 472_T 1.581 1.00
336_L 376_L 1.58 1.00
256_E 260_T 1.577 1.00
423_H 434_V 1.567 1.00
280_L 308_L 1.556 1.00
361_R 396_T 1.555 1.00
404_V 409_Q 1.537 1.00
152_N 168_Y 1.536 1.00
383_L 452_V 1.529 1.00
383_L 474_F 1.517 1.00
414_N 472_T 1.516 1.00
468_D 471_G 1.505 1.00
280_L 304_N 1.503 1.00
349_F 381_S 1.498 1.00
202_V 206_V 1.495 1.00
338_L 408_V 1.491 1.00
284_T 308_L 1.488 1.00
284_T 301_L 1.488 1.00
90_L 167_L 1.486 1.00
223_I 252_I 1.485 1.00
402_Q 411_I 1.483 1.00
11_S 14_T 1.48 1.00
428_F 453_K 1.47 1.00
424_L 428_F 1.468 1.00
410_V 476_I 1.462 1.00
233_D 249_N 1.458 1.00
181_N 185_N 1.448 1.00
402_Q 409_Q 1.435 1.00
461_G 479_P 1.435 1.00
229_D 256_E 1.435 1.00
312_A 316_S 1.434 1.00
409_Q 475_V 1.433 1.00
342_V 401_C 1.421 1.00
342_V 410_V 1.419 1.00
237_V 242_E 1.413 1.00
456_V 478_L 1.402 0.99
288_L 305_L 1.391 0.99
408_V 480_A 1.387 0.99
294_Q 297_L 1.386 0.99
265_F 269_I 1.385 0.99
427_L 474_F 1.376 0.99
398_V 415_P 1.372 0.99
457_V 462_T 1.353 0.99
426_R 432_Y 1.353 0.99
464_A 477_T 1.347 0.99
288_L 298_E 1.34 0.99
369_V 408_V 1.338 0.99
440_R 443_E 1.334 0.99
337_N 368_Q 1.332 0.99
36_I 184_M 1.326 0.99
372_D 375_M 1.313 0.99
414_N 471_G 1.313 0.99
375_M 378_R 1.313 0.99
282_T 286_I 1.308 0.99
421_P 467_S 1.302 0.99
404_V 477_T 1.297 0.99
221_Q 243_Q 1.287 0.99
403_T 480_A 1.283 0.99
239_I 242_E 1.279 0.99
217_S 243_Q 1.279 0.99
33_W 37_H 1.278 0.99
358_V 397_I 1.271 0.99
390_Y 417_T 1.268 0.99
220_I 247_S 1.265 0.99
213_I 244_L 1.256 0.99
192_S 196_I 1.253 0.99
231_R 249_N 1.241 0.98
353_A 358_V 1.238 0.98
284_T 305_L 1.236 0.98
313_K 374_L 1.23 0.98
216_V 245_V 1.229 0.98
379_A 452_V 1.216 0.98
413_E 468_D 1.215 0.98
39_V 183_L 1.214 0.98
231_R 252_I 1.21 0.98
232_L 249_N 1.209 0.98
213_I 241_L 1.208 0.98
419_I 424_L 1.185 0.98
214_R 217_S 1.185 0.98
433_R 444_G 1.184 0.98
238_P 242_E 1.184 0.98
467_S 470_R 1.183 0.98
463_V 474_F 1.182 0.98
407_L 462_T 1.182 0.98
339_A 343_G 1.173 0.98
220_I 248_F 1.173 0.98
217_S 247_S 1.171 0.98
333_K 370_A 1.163 0.97
367_C 408_V 1.16 0.97
375_M 459_H 1.157 0.97
380_L 384_L 1.151 0.97
454_S 457_V 1.149 0.97
418_P 472_T 1.147 0.97
287_A 301_L 1.143 0.97
414_N 417_T 1.141 0.97
375_M 455_I 1.14 0.97
281_I 308_L 1.139 0.97
255_I 258_V 1.139 0.97
227_D 230_V 1.137 0.97
383_L 476_I 1.134 0.97
367_C 401_C 1.131 0.97
348_F 377_R 1.126 0.97
429_D 453_K 1.122 0.97
293_S 297_L 1.12 0.96
419_I 465_V 1.11 0.96
305_L 309_T 1.101 0.96
277_I 308_L 1.097 0.96
353_A 397_I 1.096 0.96
222_N 230_V 1.094 0.96
92_D 98_V 1.087 0.96
353_A 360_L 1.087 0.96
392_P 415_P 1.085 0.96
55_S 59_E 1.083 0.96
220_I 224_T 1.08 0.95
384_L 399_V 1.073 0.95
281_I 285_E 1.072 0.95
419_I 425_P 1.063 0.95
331_P 372_D 1.059 0.95
417_T 472_T 1.056 0.95
203_L 207_H 1.055 0.95
404_V 407_L 1.051 0.94
427_L 432_Y 1.05 0.94
321_L 325_D 1.05 0.94
292_R 297_L 1.047 0.94
208_K 211_A 1.047 0.94
454_S 458_A 1.042 0.94
317_D 375_M 1.037 0.94
387_A 397_I 1.037 0.94
199_V 203_L 1.031 0.94
363_V 400_R 1.028 0.94
223_I 231_R 1.023 0.93
221_Q 250_H 1.023 0.93
380_L 412_V 1.023 0.93
273_I 311_M 1.022 0.93
216_V 248_F 1.021 0.93
307_E 310_R 1.017 0.93
304_N 308_L 1.017 0.93
342_V 399_V 1.008 0.93
421_P 468_D 1.007 0.93
251_M 255_I 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4i5sA20.63961000.439Contact Map0.805
2btzA10.63331000.548Contact Map0.57
4ew8A20.52291000.552Contact Map0.799
3jz3A20.44371000.56Contact Map0.671
2q8gA10.65621000.57Contact Map0.568
2c2aA10.49581000.572Contact Map0.738
4e01A10.71881000.572Contact Map0.63
2e0aA20.63961000.572Contact Map0.61
3d36A20.46461000.581Contact Map0.77
1y8oA10.67921000.581Contact Map0.576

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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