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SUFC - Probable ATP-dependent transporter SufC
UniProt: P77499 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13964
Length: 248 (233)
Sequences: 73136
Seq/Len: 313.89

SUFC
Paralog alert: 0.94 [within 20: 0.88] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
28_E 215_Y 3.324 1.00
3_S 23_D 3.25 1.00
31_A 213_P 3.152 1.00
6_D 19_G 3.063 1.00
5_K 59_T 3.049 1.00
59_T 66_D 3.012 1.00
30_H 217_H 2.912 1.00
15_A 18_R 2.74 1.00
3_S 61_E 2.729 1.00
25_H 28_E 2.687 1.00
215_Y 227_S 2.674 1.00
137_L 140_R 2.633 1.00
79_G 165_E 2.603 1.00
18_R 223_R 2.591 1.00
8_H 19_G 2.395 1.00
9_V 46_T 2.335 1.00
4_I 7_L 2.295 1.00
10_S 15_A 2.27 1.00
8_H 15_A 2.242 1.00
63_K 165_E 2.22 1.00
8_H 57_G 2.164 1.00
123_L 163_E 2.126 1.00
5_K 61_E 2.106 1.00
26_P 165_E 1.978 1.00
217_H 224_I 1.962 1.00
95_N 146_F 1.957 1.00
128_I 138_L 1.88 1.00
217_H 227_S 1.83 1.00
11_V 16_I 1.825 1.00
129_A 134_P 1.807 1.00
28_E 214_D 1.754 1.00
6_D 21_S 1.748 1.00
163_E 196_R 1.745 1.00
125_E 138_L 1.715 1.00
44_S 201_V 1.71 1.00
130_L 194_G 1.635 1.00
229_D 232_L 1.633 1.00
121_Q 125_E 1.631 1.00
130_L 190_S 1.617 1.00
96_Q 138_L 1.613 1.00
96_Q 139_T 1.611 1.00
123_L 126_E 1.609 1.00
9_V 56_T 1.553 1.00
126_E 130_L 1.551 1.00
44_S 168_I 1.548 1.00
10_S 56_T 1.532 1.00
24_V 30_H 1.462 1.00
94_S 97_F 1.46 1.00
17_L 46_T 1.452 1.00
5_K 23_D 1.441 1.00
192_R 214_D 1.427 1.00
129_A 135_E 1.399 0.99
61_E 66_D 1.397 0.99
22_L 217_H 1.393 0.99
4_I 47_L 1.392 0.99
85_Q 148_G 1.37 0.99
96_Q 125_E 1.368 0.99
116_D 119_D 1.362 0.99
8_H 18_R 1.359 0.99
11_V 42_T 1.354 0.99
4_I 22_L 1.339 0.99
169_L 188_V 1.329 0.99
71_S 74_D 1.319 0.99
122_D 126_E 1.317 0.99
228_G 232_L 1.315 0.99
46_T 55_V 1.295 0.99
43_L 219_L 1.278 0.99
94_S 98_F 1.259 0.99
228_G 233_V 1.253 0.99
66_D 69_A 1.251 0.99
96_Q 124_M 1.245 0.98
189_N 192_R 1.24 0.98
5_K 21_S 1.231 0.98
96_Q 100_Q 1.23 0.98
29_V 192_R 1.22 0.98
25_H 215_Y 1.211 0.98
9_V 42_T 1.211 0.98
63_K 79_G 1.208 0.98
48_A 82_M 1.199 0.98
123_L 127_K 1.197 0.98
30_H 227_S 1.178 0.98
98_F 158_Q 1.172 0.98
7_L 55_V 1.164 0.97
202_T 208_L 1.137 0.97
127_K 161_V 1.13 0.97
29_V 198_F 1.128 0.97
30_H 215_Y 1.127 0.97
100_Q 124_M 1.122 0.97
26_P 63_K 1.116 0.96
165_E 196_R 1.103 0.96
100_Q 120_F 1.092 0.96
96_Q 121_Q 1.092 0.96
6_D 57_G 1.088 0.96
83_A 169_L 1.084 0.96
191_L 196_R 1.077 0.95
99_L 161_V 1.076 0.95
220_Y 225_V 1.074 0.95
95_N 98_F 1.07 0.95
20_L 43_L 1.068 0.95
185_A 207_I 1.066 0.95
181_L 207_I 1.066 0.95
167_C 198_F 1.06 0.95
4_I 43_L 1.06 0.95
32_I 43_L 1.059 0.95
183_V 186_D 1.05 0.94
10_S 16_I 1.049 0.94
81_F 164_P 1.045 0.94
35_P 220_Y 1.042 0.94
125_E 129_A 1.042 0.94
93_V 97_F 1.038 0.94
131_L 157_L 1.026 0.94
146_F 154_N 1.023 0.93
47_L 199_I 1.016 0.93
22_L 43_L 1.014 0.93
1_M 63_K 1.012 0.93
97_F 100_Q 1.006 0.93
95_N 154_N 1.002 0.92
48_A 168_I 1.002 0.92
128_I 133_M 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiC40.9516100-0.016Contact Map0.871
1v43A10.9395100-0.015Contact Map0.839
2it1A20.9395100-0.014Contact Map0.866
2yyzA10.9395100-0.014Contact Map0.802
1g29120.9516100-0.013Contact Map0.892
3rlfA20.9395100-0.008Contact Map0.856
1z47A20.9395100-0.008Contact Map0.846
1oxxK10.9516100-0.007Contact Map0.815
3fvqA20.9516100-0.001Contact Map0.789
3d31A20.92341000.008Contact Map0.826

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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