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DPIB - Sensor histidine kinase DpiB
UniProt: P77510 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13646
Length: 552 (526)
Sequences: 4449
Seq/Len: 8.46

DPIB
Paralog alert: 0.72 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: ATOS BAES BASS CPXA CREC CUSS DCUS DPIB ENVZ GLRK NTRB PHOQ PHOR QSEC RSTB YEDV ZRAS
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
474_A 532_L 4.964 1.00
436_I 513_Y 4.248 1.00
511_A 515_T 4.154 1.00
523_L 533_F 4.146 1.00
525_D 531_T 3.936 1.00
475_D 479_G 3.885 1.00
360_L 372_V 3.878 1.00
448_S 476_Q 3.721 1.00
510_I 521_I 3.377 1.00
514_V 535_I 3.364 1.00
485_R 525_D 3.318 1.00
526_N 529_C 2.998 1.00
448_S 456_K 2.932 1.00
357_N 377_Q 2.853 1.00
102_D 106_I 2.842 1.00
519_G 537_I 2.837 1.00
522_T 534_S 2.82 1.00
514_V 519_G 2.781 1.00
489_F 521_I 2.77 1.00
468_D 536_Y 2.737 1.00
485_R 523_L 2.725 1.00
459_E 474_A 2.673 1.00
487_K 490_E 2.67 1.00
489_F 533_F 2.65 1.00
513_Y 517_C 2.644 1.00
464_D 539_K 2.626 1.00
481_P 484_L 2.586 1.00
461_F 472_E 2.553 1.00
472_E 534_S 2.435 1.00
471_I 535_I 2.43 1.00
416_V 461_F 2.409 1.00
470_V 536_Y 2.388 1.00
412_K 457_I 2.382 1.00
456_K 476_Q 2.37 1.00
524_E 534_S 2.366 1.00
428_L 433_F 2.35 1.00
457_I 476_Q 2.34 1.00
520_V 536_Y 2.33 1.00
239_D 243_Y 2.304 1.00
406_A 458_V 2.301 1.00
469_V 539_K 2.283 1.00
461_F 474_A 2.28 1.00
514_V 521_I 2.278 1.00
448_S 458_V 2.277 1.00
436_I 535_I 2.254 1.00
416_V 459_E 2.225 1.00
428_L 517_C 2.194 1.00
480_V 488_I 2.166 1.00
414_I 457_I 2.14 1.00
436_I 514_V 2.14 1.00
472_E 532_L 2.12 1.00
525_D 529_C 2.115 1.00
447_A 494_S 2.088 1.00
414_I 459_E 2.044 1.00
480_V 484_L 2.033 1.00
524_E 532_L 2.016 1.00
484_L 493_V 1.996 1.00
432_E 435_A 1.972 1.00
394_Q 397_G 1.912 1.00
484_L 487_K 1.895 1.00
437_V 441_L 1.878 1.00
525_D 528_P 1.875 1.00
459_E 476_Q 1.87 1.00
429_D 432_E 1.827 1.00
437_V 473_V 1.78 1.00
399_L 437_V 1.779 1.00
481_P 527_D 1.771 1.00
475_D 530_G 1.771 1.00
488_I 533_F 1.755 1.00
519_G 538_P 1.755 1.00
424_L 462_L 1.744 1.00
514_V 537_I 1.734 1.00
394_Q 423_Q 1.713 1.00
440_L 510_I 1.7 1.00
406_A 445_F 1.684 1.00
437_V 471_I 1.674 1.00
360_L 373_Q 1.667 1.00
436_I 517_C 1.665 1.00
406_A 413_M 1.664 1.00
198_S 202_A 1.663 1.00
426_P 469_V 1.64 1.00
480_V 531_T 1.637 1.00
442_D 446_E 1.622 1.00
482_E 485_R 1.62 1.00
151_P 161_G 1.619 1.00
463_S 470_V 1.605 1.00
344_T 491_Q 1.548 1.00
381_Q 431_T 1.541 1.00
349_H 379_Q 1.539 1.00
522_T 536_Y 1.536 1.00
484_L 495_T 1.53 1.00
482_E 526_N 1.521 1.00
356_L 372_V 1.506 1.00
97_Y 166_G 1.502 1.00
465_E 470_V 1.5 1.00
360_L 369_L 1.497 1.00
440_L 535_I 1.495 1.00
100_I 163_V 1.494 1.00
515_T 520_V 1.493 1.00
380_Q 384_D 1.49 1.00
393_R 428_L 1.485 1.00
215_K 218_A 1.474 1.00
440_L 533_F 1.468 0.99
375_E 378_A 1.463 0.99
470_V 534_S 1.455 0.99
505_I 509_L 1.449 0.99
402_K 438_G 1.445 0.99
440_L 473_V 1.431 0.99
433_F 517_C 1.427 0.99
357_N 376_S 1.425 0.99
488_I 523_L 1.424 0.99
473_V 514_V 1.405 0.99
403_V 407_R 1.403 0.99
523_L 531_T 1.388 0.99
525_D 532_L 1.387 0.99
396_A 462_L 1.382 0.99
432_E 436_I 1.361 0.99
479_G 530_G 1.36 0.99
479_G 531_T 1.356 0.99
361_Q 373_Q 1.353 0.99
401_G 434_A 1.351 0.99
360_L 376_S 1.34 0.99
444_A 458_V 1.317 0.99
475_D 531_T 1.314 0.99
154_D 158_K 1.31 0.99
498_D 501_G 1.309 0.99
436_I 510_I 1.307 0.99
395_V 469_V 1.301 0.98
489_F 523_L 1.3 0.98
463_S 472_E 1.292 0.98
23_F 27_L 1.275 0.98
355_T 359_L 1.274 0.98
432_E 513_Y 1.267 0.98
357_N 380_Q 1.259 0.98
535_I 538_P 1.256 0.98
465_E 536_Y 1.255 0.98
433_F 437_V 1.248 0.98
468_D 520_V 1.243 0.98
228_F 235_L 1.238 0.98
480_V 486_D 1.221 0.97
478_C 531_T 1.22 0.97
61_A 65_A 1.215 0.97
329_N 333_T 1.212 0.97
395_V 471_I 1.212 0.97
17_A 20_L 1.209 0.97
429_D 517_C 1.191 0.97
206_R 209_M 1.171 0.96
153_F 159_V 1.163 0.96
348_E 352_W 1.16 0.96
267_K 271_E 1.16 0.96
467_D 539_K 1.159 0.96
480_V 485_R 1.157 0.96
447_A 495_T 1.152 0.96
491_Q 494_S 1.152 0.96
346_R 349_H 1.151 0.96
33_V 37_L 1.142 0.96
392_D 427_G 1.142 0.96
432_E 516_R 1.139 0.96
215_K 220_V 1.137 0.96
333_T 336_K 1.135 0.96
465_E 468_D 1.135 0.96
435_A 513_Y 1.129 0.95
236_I 251_A 1.128 0.95
356_L 376_S 1.127 0.95
99_V 164_S 1.126 0.95
351_N 447_A 1.122 0.95
207_R 210_M 1.114 0.95
351_N 495_T 1.114 0.95
366_D 370_A 1.109 0.95
491_Q 505_I 1.107 0.95
61_A 150_T 1.101 0.95
385_S 432_E 1.091 0.94
19_P 23_F 1.089 0.94
351_N 446_E 1.077 0.94
194_L 198_S 1.074 0.94
216_Q 220_V 1.074 0.94
254_M 299_V 1.071 0.93
338_Y 344_T 1.07 0.93
344_T 389_A 1.07 0.93
358_G 376_S 1.068 0.93
447_A 500_P 1.064 0.93
402_K 442_D 1.063 0.93
439_N 510_I 1.061 0.93
385_S 503_H 1.059 0.93
446_E 496_R 1.05 0.93
469_V 537_I 1.049 0.93
486_D 511_A 1.046 0.92
521_I 535_I 1.045 0.92
101_G 164_S 1.042 0.92
482_E 486_D 1.042 0.92
385_S 509_L 1.041 0.92
474_A 526_N 1.037 0.92
101_G 105_S 1.037 0.92
98_V 111_P 1.026 0.91
359_L 371_M 1.026 0.91
441_L 460_L 1.024 0.91
57_A 167_Y 1.023 0.91
346_R 379_Q 1.022 0.91
376_S 379_Q 1.019 0.91
460_L 473_V 1.018 0.91
301_A 304_E 1.017 0.91
446_E 494_S 1.016 0.91
338_Y 346_R 1.015 0.91
50_T 54_R 1.015 0.91
333_T 337_Q 1.009 0.90
388_E 432_E 1.008 0.90
36_A 39_Q 1.007 0.90
338_Y 341_S 1.004 0.90
39_Q 43_A 1.004 0.90
184_A 188_V 1.001 0.90
58_M 62_K 1 0.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4i5sA20.67031000.51Contact Map0.77
3a0rA10.57611000.547Contact Map0.608
4gczA20.60141000.551Contact Map0.685
2c2aA10.4131000.646Contact Map0.741
3jz3A20.36051000.65Contact Map0.668
2btzA10.52361000.651Contact Map0.596
2q8gA10.53441000.653Contact Map0.591
3d36A20.39491000.654Contact Map0.733
4ew8A20.44381000.658Contact Map0.771
4e01A10.63591000.659Contact Map0.637

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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