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ANMK - Anhydro-N-acetylmuramic acid kinase
UniProt: P77570 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13942
Length: 369 (363)
Sequences: 973
Seq/Len: 2.68

ANMK
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
168_I 191_G 5.928 1.00
272_E 306_R 4.381 1.00
95_G 338_A 3.904 1.00
293_V 304_M 3.764 1.00
230_D 245_Y 3.71 1.00
233_F 273_L 3.106 1.00
201_R 252_E 3.046 1.00
215_R 305_A 3.025 1.00
292_M 322_V 2.954 1.00
299_R 327_D 2.908 1.00
292_M 319_T 2.724 1.00
341_T 364_I 2.673 1.00
101_V 115_I 2.466 1.00
123_A 136_R 2.462 1.00
168_I 278_I 2.422 1.00
140_L 359_T 2.414 1.00
47_A 68_Q 2.396 1.00
9_V 77_V 2.339 1.00
94_I 125_T 2.329 1.00
195_M 271_A 2.253 1.00
118_N 131_G 2.224 1.00
148_V 333_A 2.208 1.00
172_A 188_T 2.171 1.00
166_L 278_I 2.114 1.00
320_D 326_G 2.088 1.00
24_T 31_A 2.067 1.00
73_F 96_C 2.054 1.00
123_A 140_L 2.033 1.00
340_R 345_L 2.006 1.00
161_E 290_R 1.962 0.99
71_Q 124_R 1.956 0.99
93_A 342_L 1.953 0.99
195_M 267_Q 1.917 0.99
131_G 365_F 1.905 0.99
211_A 302_L 1.89 0.99
128_T 364_I 1.877 0.99
302_L 306_R 1.852 0.99
186_Y 281_Q 1.846 0.99
215_R 302_L 1.799 0.99
35_S 328_D 1.797 0.99
70_G 121_I 1.738 0.98
23_A 332_L 1.703 0.98
188_T 277_T 1.695 0.98
20_V 80_L 1.688 0.98
86_L 91_I 1.671 0.98
81_L 127_I 1.67 0.98
198_W 266_V 1.67 0.98
152_H 329_M 1.632 0.97
123_A 359_T 1.622 0.97
191_G 278_I 1.6 0.97
163_R 290_R 1.599 0.97
36_L 83_E 1.592 0.96
86_L 90_D 1.576 0.96
63_G 111_H 1.574 0.96
47_A 61_Q 1.566 0.96
220_I 261_V 1.562 0.96
217_G 265_D 1.552 0.96
164_M 176_L 1.55 0.96
73_F 121_I 1.546 0.96
211_A 301_P 1.537 0.95
216_A 264_R 1.531 0.95
171_I 193_M 1.53 0.95
18_V 76_A 1.525 0.95
15_L 48_V 1.523 0.95
132_D 363_A 1.519 0.95
211_A 215_R 1.515 0.95
9_V 20_V 1.487 0.94
151_F 336_W 1.485 0.94
275_A 306_R 1.482 0.94
210_D 301_P 1.464 0.94
25_I 339_W 1.457 0.93
166_L 293_V 1.451 0.93
17_G 37_S 1.441 0.93
275_A 307_L 1.44 0.93
199_I 203_A 1.434 0.93
17_G 40_I 1.431 0.93
219_V 268_A 1.419 0.92
66_D 116_G 1.418 0.92
166_L 291_L 1.416 0.92
318_T 326_G 1.41 0.92
6_F 93_A 1.392 0.91
198_W 267_Q 1.392 0.91
317_T 321_A 1.38 0.91
69_L 73_F 1.377 0.91
66_D 70_G 1.364 0.90
195_M 303_L 1.361 0.90
121_I 129_V 1.359 0.90
41_P 72_L 1.357 0.90
209_K 212_E 1.345 0.89
80_L 84_Q 1.336 0.89
213_W 267_Q 1.329 0.89
199_I 213_W 1.327 0.88
194_L 270_L 1.327 0.88
67_T 120_Q 1.327 0.88
96_C 116_G 1.321 0.88
282_V 291_L 1.315 0.88
275_A 310_L 1.306 0.87
226_N 257_H 1.303 0.87
112_T 138_I 1.302 0.87
198_W 202_Q 1.298 0.87
65_L 70_G 1.282 0.86
21_V 331_A 1.28 0.86
119_N 135_R 1.271 0.85
272_E 276_V 1.255 0.84
276_V 310_L 1.255 0.84
128_T 367_A 1.254 0.84
348_N 361_L 1.248 0.84
32_Q 332_L 1.243 0.84
320_D 325_S 1.235 0.83
221_L 225_Q 1.231 0.83
51_I 65_L 1.226 0.82
193_M 243_R 1.225 0.82
271_A 303_L 1.211 0.81
49_L 193_M 1.21 0.81
96_C 121_I 1.207 0.81
198_W 270_L 1.2 0.81
74_A 124_R 1.194 0.80
352_V 355_A 1.192 0.80
117_D 135_R 1.183 0.79
9_V 96_C 1.179 0.79
149_P 240_S 1.162 0.78
133_F 334_F 1.159 0.77
306_R 310_L 1.157 0.77
78_N 124_R 1.157 0.77
136_R 140_L 1.155 0.77
67_T 117_D 1.153 0.77
303_L 307_L 1.151 0.77
47_A 65_L 1.15 0.76
188_T 232_Y 1.148 0.76
291_L 311_L 1.146 0.76
140_L 357_Q 1.142 0.76
40_I 69_L 1.139 0.76
120_Q 124_R 1.139 0.76
348_N 355_A 1.135 0.75
18_V 72_L 1.132 0.75
21_V 32_Q 1.125 0.74
94_I 127_I 1.121 0.74
87_Q 90_D 1.115 0.73
54_G 57_L 1.114 0.73
136_R 359_T 1.113 0.73
307_L 311_L 1.109 0.73
347_G 361_L 1.105 0.72
20_V 77_V 1.103 0.72
200_W 206_P 1.1 0.72
123_A 357_Q 1.095 0.71
152_H 336_W 1.09 0.71
224_L 227_M 1.088 0.71
152_H 294_C 1.085 0.70
306_R 309_A 1.083 0.70
324_I 332_L 1.077 0.70
205_K 209_K 1.074 0.69
128_T 341_T 1.071 0.69
209_K 301_P 1.061 0.68
290_R 315_E 1.059 0.68
81_L 88_A 1.057 0.67
147_L 334_F 1.053 0.67
271_A 302_L 1.048 0.67
272_E 310_L 1.035 0.65
44_L 72_L 1.025 0.64
220_I 265_D 1.024 0.64
48_V 65_L 1.023 0.64
298_S 318_T 1.02 0.63
267_Q 271_A 1.015 0.63
230_D 273_L 1.012 0.63
137_D 353_T 1.01 0.62
58_T 61_Q 1.009 0.62
34_A 84_Q 1.008 0.62
164_M 282_V 1.008 0.62
191_G 274_T 1.007 0.62
96_C 244_E 1.001 0.61
271_A 275_A 1 0.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3cqyA20.99731000.057Contact Map0.806
3qbxA20.98641000.063Contact Map0.814
4bgbA20.81841000.36Contact Map0.562
1huxA20.712799.70.872Contact Map0.694
4ehuA20.718299.50.885Contact Map0.756
3enoA20.818498.20.93Contact Map0.538
2ivnA10.788697.70.938Contact Map0.514
3venA10.856497.70.938Contact Map0.441
3en9A20.815797.60.94Contact Map0.579
3zeuB20.818496.80.947Contact Map0.442

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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