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ACDH - Acetaldehyde dehydrogenase
UniProt: P77580 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13625
Length: 316 (307)
Sequences: 322
Seq/Len: 1.05

ACDH
Paralog alert: 0.14 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
139_M 272_V 4.345 1.00
6_V 29_L 3.995 1.00
145_R 225_S 3.161 1.00
210_V 274_L 3.027 1.00
143_V 212_V 2.75 1.00
87_D 91_R 2.441 0.99
59_V 86_N 2.412 0.99
224_A 228_E 2.316 0.99
139_M 230_A 2.224 0.98
218_S 221_D 2.202 0.98
42_D 282_Y 2.043 0.96
5_K 30_E 2.029 0.96
145_R 232_A 1.994 0.96
163_A 197_L 1.877 0.94
129_V 181_A 1.85 0.93
11_S 37_I 1.781 0.91
76_D 90_L 1.776 0.91
74_V 97_I 1.757 0.90
220_D 223_E 1.738 0.90
212_V 270_T 1.728 0.89
20_I 42_D 1.698 0.88
84_V 88_A 1.682 0.88
214_S 270_T 1.681 0.88
40_Q 45_A 1.665 0.87
22_I 298_L 1.656 0.86
126_V 300_T 1.623 0.85
63_M 89_A 1.578 0.83
130_T 171_I 1.555 0.81
277_E 285_A 1.541 0.81
85_K 88_A 1.525 0.80
280_A 285_A 1.518 0.79
183_E 190_K 1.502 0.78
6_V 22_I 1.497 0.78
53_A 67_E 1.486 0.77
87_D 99_L 1.484 0.77
23_L 57_E 1.476 0.76
219_Q 250_V 1.474 0.76
130_T 195_I 1.45 0.75
4_R 72_D 1.431 0.73
231_E 234_Q 1.43 0.73
57_E 64_N 1.428 0.73
115_V 185_V 1.423 0.73
180_R 184_V 1.415 0.72
31_M 34_M 1.406 0.71
111_C 300_T 1.401 0.71
6_V 111_C 1.39 0.70
48_R 93_A 1.389 0.70
60_I 89_A 1.382 0.69
132_G 195_I 1.361 0.68
232_A 235_A 1.339 0.66
171_I 195_I 1.33 0.65
50_M 155_I 1.325 0.65
144_S 271_A 1.322 0.64
132_G 171_I 1.305 0.63
158_I 176_E 1.296 0.62
157_S 169_A 1.294 0.62
156_A 208_D 1.282 0.61
98_R 308_L 1.279 0.61
158_I 163_A 1.276 0.60
63_M 94_K 1.274 0.60
137_I 181_A 1.265 0.59
84_V 107_I 1.263 0.59
189_A 215_D 1.25 0.58
166_G 175_T 1.247 0.58
38_D 44_L 1.241 0.57
227_N 245_R 1.236 0.57
11_S 38_D 1.232 0.56
175_T 195_I 1.227 0.56
33_V 65_M 1.221 0.55
100_I 287_A 1.213 0.55
35_V 55_T 1.21 0.54
48_R 54_T 1.205 0.54
129_V 208_D 1.205 0.54
35_V 62_L 1.202 0.54
90_L 99_L 1.2 0.53
112_V 129_V 1.195 0.53
91_R 99_L 1.189 0.52
88_A 93_A 1.173 0.51
223_E 245_R 1.164 0.50
22_I 31_M 1.164 0.50
64_N 304_M 1.159 0.50
90_L 97_I 1.159 0.50
39_P 44_L 1.158 0.49
249_E 252_P 1.158 0.49
44_L 282_Y 1.153 0.49
253_Q 262_V 1.152 0.49
86_N 111_C 1.149 0.49
61_G 76_D 1.148 0.49
110_Y 129_V 1.148 0.49
148_R 189_A 1.145 0.48
6_V 298_L 1.133 0.47
66_P 74_V 1.13 0.47
228_E 232_A 1.128 0.47
214_S 301_A 1.118 0.46
258_N 262_V 1.118 0.46
93_A 234_Q 1.116 0.46
169_A 269_K 1.115 0.45
4_R 73_I 1.113 0.45
144_S 152_A 1.109 0.45
217_A 222_I 1.102 0.44
34_M 46_R 1.1 0.44
111_C 265_F 1.099 0.44
9_I 181_A 1.09 0.43
303_K 306_Q 1.089 0.43
287_A 295_S 1.085 0.43
72_D 97_I 1.085 0.43
26_G 29_L 1.084 0.43
150_H 248_F 1.084 0.43
60_I 159_A 1.082 0.42
35_V 86_N 1.073 0.42
258_N 263_G 1.072 0.41
128_M 181_A 1.072 0.41
251_I 259_L 1.068 0.41
44_L 56_H 1.066 0.41
235_A 299_A 1.066 0.41
158_I 211_Y 1.061 0.40
157_S 247_Q 1.06 0.40
7_A 62_L 1.057 0.40
182_I 208_D 1.051 0.40
55_T 62_L 1.05 0.39
72_D 161_K 1.048 0.39
150_H 189_A 1.047 0.39
29_L 298_L 1.034 0.38
179_S 301_A 1.033 0.38
129_V 176_E 1.033 0.38
98_R 304_M 1.031 0.38
20_I 298_L 1.029 0.38
185_V 196_V 1.022 0.37
196_V 204_L 1.021 0.37
93_A 150_H 1.018 0.37
51_G 66_P 1.014 0.36
29_L 55_T 1.011 0.36
11_S 19_M 1.011 0.36
64_N 67_E 1.007 0.36
35_V 71_I 1.006 0.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4jn6B20.95251000.537Contact Map0.552
4lrtB20.95571000.539Contact Map0.544
1nvmB40.98421000.569Contact Map0.551
3dr3A10.867199.70.873Contact Map0.373
2r00A20.870399.70.879Contact Map0.334
3tz6A10.835499.70.882Contact Map0.391
2hjsA10.870399.60.89Contact Map0.358
1t4bA20.882999.60.891Contact Map0.419
3hskA20.936799.50.894Contact Map0.425
2ozpA10.892499.50.895Contact Map0.429

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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