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ASTC - Succinylornithine transaminase
UniProt: P77581 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13999
Length: 406 (390)
Sequences: 9666
Seq/Len: 24.78

ASTC
Paralog alert: 0.89 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: ARGD ASTC BIOA GABT GSA PAT PUUE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
65_N 69_S 4.607 1.00
361_A 395_A 4.312 1.00
210_R 214_N 4.189 1.00
32_R 40_E 3.818 1.00
314_W 387_T 3.629 1.00
173_I 208_G 3.475 1.00
303_E 306_N 3.343 1.00
89_K 297_E 3.268 1.00
27_R 34_W 3.187 1.00
62_E 66_E 3.012 1.00
234_E 240_H 2.998 1.00
314_W 383_E 2.885 1.00
382_S 385_E 2.86 1.00
325_R 394_A 2.769 1.00
59_E 301_T 2.756 1.00
307_G 311_R 2.706 1.00
59_E 294_K 2.559 1.00
294_K 297_E 2.506 1.00
310_Q 383_E 2.503 1.00
211_E 215_R 2.415 1.00
208_G 211_E 2.376 1.00
318_R 390_L 2.346 1.00
357_E 360_K 2.333 1.00
44_F 389_G 2.303 1.00
89_K 300_N 2.297 1.00
26_V 36_Q 2.283 1.00
59_E 298_L 2.261 1.00
57_H 298_L 2.216 1.00
313_D 317_E 2.211 1.00
169_A 175_S 2.2 1.00
361_A 399_H 2.148 1.00
188_I 221_I 2.142 1.00
32_R 385_E 2.139 1.00
177_S 215_R 2.086 1.00
363_V 392_R 2.04 1.00
34_W 40_E 1.979 1.00
357_E 399_H 1.977 1.00
86_L 292_A 1.912 1.00
81_E 85_R 1.902 1.00
89_K 293_G 1.893 1.00
316_V 320_N 1.887 1.00
326_Y 394_A 1.877 1.00
26_V 70_K 1.875 1.00
388_T 392_R 1.873 1.00
357_E 361_A 1.856 1.00
88_K 92_D 1.855 1.00
61_R 65_N 1.852 1.00
64_L 291_V 1.85 1.00
130_G 183_S 1.831 1.00
318_R 387_T 1.829 1.00
176_A 209_L 1.816 1.00
98_R 267_E 1.808 1.00
189_V 209_L 1.783 1.00
35_D 39_K 1.776 1.00
102_C 261_G 1.773 1.00
318_R 321_T 1.772 1.00
318_R 391_D 1.767 1.00
29_E 58_P 1.743 1.00
187_V 213_C 1.739 1.00
267_E 271_R 1.722 1.00
298_L 302_P 1.719 1.00
134_F 205_F 1.711 1.00
39_K 362_G 1.697 1.00
64_L 68_A 1.684 1.00
130_G 166_R 1.652 1.00
87_A 101_F 1.6 1.00
32_R 388_T 1.6 1.00
40_E 388_T 1.594 1.00
316_V 334_G 1.589 1.00
109_N 249_T 1.586 1.00
307_G 310_Q 1.575 1.00
234_E 309_K 1.57 1.00
204_A 207_Q 1.562 1.00
89_K 92_D 1.559 1.00
250_T 262_A 1.544 1.00
306_N 310_Q 1.527 1.00
174_N 177_S 1.522 1.00
326_Y 398_E 1.52 1.00
311_R 386_V 1.508 1.00
85_R 293_G 1.479 1.00
250_T 264_L 1.476 1.00
255_G 260_V 1.469 1.00
311_R 314_W 1.465 1.00
62_E 65_N 1.458 1.00
222_F 238_Y 1.457 1.00
66_E 70_K 1.454 1.00
112_A 249_T 1.452 1.00
116_A 221_I 1.447 1.00
177_S 181_D 1.443 1.00
97_D 267_E 1.442 1.00
25_P 33_L 1.434 1.00
58_P 62_E 1.43 1.00
180_I 218_A 1.423 1.00
210_R 220_L 1.417 1.00
357_E 396_A 1.414 1.00
330_S 344_N 1.407 0.99
210_R 213_C 1.402 0.99
35_D 41_Y 1.393 0.99
31_S 385_E 1.384 0.99
63_A 294_K 1.383 0.99
168_A 179_L 1.382 0.99
254_L 260_V 1.38 0.99
189_V 206_L 1.378 0.99
234_E 239_M 1.372 0.99
111_A 263_L 1.368 0.99
27_R 70_K 1.365 0.99
311_R 383_E 1.361 0.99
57_H 302_P 1.359 0.99
322_I 390_L 1.359 0.99
294_K 298_L 1.354 0.99
99_V 264_L 1.354 0.99
85_R 297_E 1.352 0.99
247_L 265_A 1.349 0.99
56_A 61_R 1.348 0.99
113_L 131_I 1.347 0.99
132_V 184_T 1.346 0.99
174_N 178_A 1.345 0.99
361_A 396_A 1.335 0.99
31_S 380_N 1.335 0.99
93_A 300_N 1.331 0.99
358_A 365_V 1.327 0.99
135_K 169_A 1.327 0.99
316_V 339_I 1.324 0.99
381_V 386_V 1.318 0.99
260_V 289_S 1.318 0.99
91_I 99_V 1.317 0.99
29_E 56_A 1.316 0.99
94_T 264_L 1.311 0.99
148_A 165_I 1.3 0.99
171_N 202_S 1.296 0.99
394_A 398_E 1.296 0.99
383_E 387_T 1.293 0.99
207_Q 211_E 1.287 0.99
64_L 287_L 1.282 0.99
187_V 209_L 1.28 0.99
293_G 297_E 1.276 0.99
204_A 241_Y 1.267 0.99
169_A 172_D 1.267 0.99
109_N 188_I 1.265 0.99
133_A 167_H 1.259 0.99
29_E 40_E 1.259 0.99
177_S 208_G 1.254 0.99
238_Y 248_L 1.249 0.99
32_R 42_I 1.24 0.98
53_L 298_L 1.236 0.98
125_G 269_C 1.236 0.98
314_W 318_R 1.232 0.98
98_R 271_R 1.231 0.98
241_Y 335_L 1.228 0.98
235_L 239_M 1.223 0.98
222_F 243_V 1.218 0.98
317_E 321_T 1.213 0.98
260_V 292_A 1.211 0.98
244_T 266_T 1.206 0.98
209_L 220_L 1.195 0.98
66_E 69_S 1.195 0.98
320_N 323_N 1.194 0.98
219_L 269_C 1.193 0.98
65_N 68_A 1.192 0.98
128_K 217_N 1.19 0.98
92_D 300_N 1.186 0.98
318_R 394_A 1.171 0.98
391_D 395_A 1.169 0.97
385_E 388_T 1.167 0.97
361_A 392_R 1.163 0.97
297_E 301_T 1.156 0.97
148_A 188_I 1.15 0.97
61_R 68_A 1.143 0.97
61_R 69_S 1.133 0.97
26_V 38_G 1.124 0.97
254_L 262_A 1.123 0.97
240_H 335_L 1.117 0.96
387_T 391_D 1.108 0.96
131_I 186_A 1.106 0.96
247_L 263_L 1.099 0.96
230_G 305_L 1.097 0.96
211_E 214_N 1.093 0.96
207_Q 242_G 1.092 0.96
299_I 305_L 1.091 0.96
233_G 239_M 1.09 0.96
180_I 184_T 1.087 0.96
299_I 304_M 1.079 0.95
305_L 308_V 1.07 0.95
102_C 263_L 1.068 0.95
358_A 363_V 1.067 0.95
101_F 289_S 1.065 0.95
358_A 396_A 1.064 0.95
60_L 291_V 1.063 0.95
322_I 394_A 1.06 0.95
388_T 391_D 1.052 0.95
175_S 178_A 1.046 0.94
309_K 313_D 1.033 0.94
358_A 392_R 1.031 0.94
192_I 335_L 1.026 0.94
86_L 293_G 1.025 0.93
106_A 145_T 1.02 0.93
108_A 249_T 1.013 0.93
31_S 42_I 1.013 0.93
363_V 389_G 1.011 0.93
256_G 295_V 1.01 0.93
236_Y 250_T 1.008 0.93
177_S 216_H 1.007 0.93
212_L 216_H 1.004 0.93
229_V 299_I 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4a0gA40.99011000.317Contact Map0.574
3tfuA20.98521000.37Contact Map0.714
4e3qA40.99011000.387Contact Map0.78
2epjA10.96311000.39Contact Map0.706
4ffcA40.98031000.393Contact Map0.652
4atqA120.97291000.394Contact Map0.715
3nx3A20.97041000.395Contact Map0.768
1z7dA60.99261000.395Contact Map0.848
3hmuA20.99261000.396Contact Map0.808
3oksA40.97041000.396Contact Map0.731

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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