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ANSP - L-asparagine permease
UniProt: P77610 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13776
Length: 499 (449)
Sequences: 9689
Seq/Len: 21.58

ANSP
Paralog alert: 0.80 [within 20: 0.33] - ratio of genomes with paralogs
Cluster includes: ADIC ANSP ARCD AROP CADB CYCA FRLA GABP GADC LYSP MMUP PHEP PLAP POTE PROY PUUP YBAT YCAM YGJI YIFK YJEH YJEM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
342_F 354_A 4.04 1.00
394_A 430_L 3.821 1.00
156_G 360_L 3.347 1.00
334_A 344_A 3.274 1.00
31_G 247_K 3.071 1.00
188_G 274_L 3.048 1.00
149_L 367_V 2.925 1.00
402_R 406_A 2.862 1.00
251_T 255_K 2.825 1.00
71_G 265_G 2.734 1.00
397_I 429_T 2.726 1.00
345_K 354_A 2.712 1.00
248_D 251_T 2.605 1.00
427_W 431_L 2.546 1.00
337_G 341_S 2.543 1.00
357_L 361_V 2.423 1.00
302_Y 306_I 2.421 1.00
246_C 252_M 2.325 1.00
342_F 345_K 2.3 1.00
347_S 353_Y 2.258 1.00
72_L 428_L 2.218 1.00
331_R 335_M 2.213 1.00
62_A 222_A 2.115 1.00
80_A 397_I 2.104 1.00
111_G 333_M 2.103 1.00
343_M 358_A 2.097 1.00
32_N 252_M 2.076 1.00
36_Q 259_S 2.071 1.00
186_V 190_V 2.068 1.00
32_N 259_S 2.048 1.00
452_A 456_I 2.047 1.00
244_G 335_M 2.037 1.00
283_A 297_K 2.007 1.00
99_R 107_A 2.003 1.00
31_G 34_Q 1.976 1.00
102_L 402_R 1.952 1.00
99_R 104_E 1.935 1.00
95_V 336_G 1.933 1.00
280_P 283_A 1.91 1.00
105_K 465_W 1.908 1.00
26_Y 346_M 1.894 1.00
463_I 467_G 1.845 1.00
398_V 430_L 1.839 1.00
402_R 405_K 1.832 1.00
431_L 435_S 1.821 1.00
35_V 246_C 1.813 1.00
160_M 357_L 1.808 1.00
115_F 359_T 1.805 1.00
424_F 428_L 1.804 1.00
83_E 404_R 1.759 1.00
80_A 426_S 1.749 1.00
72_L 76_F 1.744 1.00
156_G 356_I 1.736 1.00
160_M 353_Y 1.723 1.00
178_V 182_V 1.713 1.00
245_E 328_R 1.707 1.00
164_K 168_E 1.704 1.00
157_T 161_I 1.703 1.00
55_R 63_L 1.702 1.00
66_V 225_L 1.697 1.00
68_L 269_V 1.682 1.00
102_L 398_V 1.68 1.00
248_D 255_K 1.665 1.00
421_G 425_T 1.66 1.00
175_L 179_L 1.65 1.00
255_K 259_S 1.643 1.00
453_A 456_I 1.631 1.00
455_P 459_I 1.627 1.00
32_N 36_Q 1.596 1.00
110_A 395_F 1.595 1.00
400_Q 426_S 1.591 1.00
401_M 427_W 1.573 1.00
86_L 416_S 1.572 1.00
189_T 193_G 1.564 1.00
152_L 363_Y 1.557 1.00
459_I 463_I 1.556 1.00
327_G 356_I 1.54 1.00
30_M 34_Q 1.539 1.00
133_M 147_F 1.532 1.00
76_F 428_L 1.507 1.00
249_P 254_P 1.506 1.00
262_W 266_L 1.502 1.00
248_D 252_M 1.481 1.00
293_T 297_K 1.474 1.00
354_A 358_A 1.47 1.00
149_L 364_V 1.467 1.00
56_L 63_L 1.455 1.00
36_Q 263_R 1.444 1.00
34_Q 171_F 1.436 1.00
98_A 395_F 1.434 1.00
98_A 110_A 1.434 1.00
293_T 296_S 1.409 1.00
347_S 351_V 1.404 0.99
305_S 309_I 1.397 0.99
326_T 359_T 1.388 0.99
73_F 432_F 1.387 0.99
430_L 434_L 1.377 0.99
185_L 270_G 1.376 0.99
449_Y 452_A 1.37 0.99
438_V 442_F 1.369 0.99
423_P 427_W 1.366 0.99
258_N 262_W 1.365 0.99
330_L 355_G 1.364 0.99
102_L 106_A 1.351 0.99
341_S 345_K 1.338 0.99
179_L 183_T 1.337 0.99
101_F 399_C 1.336 0.99
456_I 459_I 1.335 0.99
153_T 364_V 1.323 0.99
32_N 255_K 1.321 0.99
103_G 106_A 1.312 0.99
148_A 367_V 1.307 0.99
250_Q 416_S 1.305 0.99
88_R 100_E 1.298 0.99
341_S 344_A 1.297 0.99
447_G 451_I 1.29 0.99
467_G 470_K 1.286 0.99
77_I 397_I 1.283 0.99
407_I 410_G 1.283 0.99
27_H 350_H 1.282 0.99
153_T 360_L 1.277 0.99
108_Y 112_W 1.273 0.99
201_N 206_H 1.273 0.99
62_A 215_F 1.273 0.99
408_K 412_A 1.271 0.99
91_S 244_G 1.27 0.99
30_M 167_A 1.269 0.99
447_G 452_A 1.267 0.99
462_V 466_F 1.267 0.99
215_F 222_A 1.251 0.99
452_A 455_P 1.249 0.99
39_A 260_V 1.246 0.98
394_A 398_V 1.246 0.98
180_A 310_V 1.245 0.98
103_G 466_F 1.242 0.98
346_M 350_H 1.24 0.98
40_I 263_R 1.233 0.98
159_N 320_N 1.231 0.98
122_G 363_Y 1.227 0.98
33_R 168_E 1.221 0.98
50_L 128_A 1.22 0.98
252_M 255_K 1.212 0.98
85_V 97_Y 1.21 0.98
30_M 35_V 1.205 0.98
242_A 324_Y 1.199 0.98
112_W 339_A 1.198 0.98
87_H 416_S 1.194 0.98
155_V 319_L 1.193 0.98
126_I 152_L 1.193 0.98
129_V 312_L 1.19 0.98
149_L 153_T 1.186 0.98
394_A 434_L 1.184 0.98
398_V 402_R 1.183 0.98
142_V 146_V 1.182 0.98
156_G 160_M 1.177 0.98
361_V 365_V 1.174 0.98
234_A 389_I 1.173 0.98
64_A 273_V 1.169 0.97
335_M 344_A 1.168 0.97
76_F 425_T 1.167 0.97
156_G 357_L 1.164 0.97
65_L 222_A 1.164 0.97
160_M 351_V 1.162 0.97
126_I 319_L 1.16 0.97
105_K 462_V 1.159 0.97
449_Y 453_A 1.158 0.97
345_K 353_Y 1.157 0.97
451_I 456_I 1.153 0.97
287_G 293_T 1.152 0.97
451_I 455_P 1.15 0.97
145_W 149_L 1.148 0.97
43_A 264_I 1.144 0.97
189_T 274_L 1.144 0.97
157_T 160_M 1.142 0.97
465_W 469_R 1.141 0.97
163_V 324_Y 1.141 0.97
223_L 435_S 1.138 0.97
33_R 37_M 1.137 0.97
354_A 357_L 1.137 0.97
26_Y 331_R 1.135 0.97
401_M 423_P 1.12 0.96
160_M 347_S 1.119 0.96
421_G 424_F 1.112 0.96
55_R 59_A 1.11 0.96
68_L 72_L 1.11 0.96
161_I 349_Q 1.107 0.96
31_G 164_K 1.107 0.96
169_M 173_F 1.106 0.96
78_L 261_I 1.106 0.96
270_G 274_L 1.105 0.96
397_I 430_L 1.104 0.96
154_I 316_L 1.1 0.96
412_A 416_S 1.099 0.96
36_Q 39_A 1.098 0.96
289_S 293_T 1.095 0.96
349_Q 353_Y 1.093 0.96
424_F 427_W 1.093 0.96
243_A 253_V 1.092 0.96
87_H 412_A 1.09 0.96
87_H 410_G 1.086 0.96
237_E 241_T 1.084 0.96
296_S 301_P 1.081 0.95
193_G 202_T 1.08 0.95
112_W 461_L 1.08 0.95
70_C 229_V 1.076 0.95
405_K 408_K 1.074 0.95
330_L 339_A 1.074 0.95
78_L 257_I 1.072 0.95
296_S 304_G 1.071 0.95
401_M 426_S 1.07 0.95
95_V 332_S 1.063 0.95
152_L 360_L 1.062 0.95
408_K 411_K 1.061 0.95
384_F 388_G 1.058 0.95
98_A 399_C 1.053 0.95
451_I 454_L 1.053 0.95
463_I 466_F 1.052 0.95
182_V 186_V 1.044 0.94
29_A 164_K 1.042 0.94
34_Q 168_E 1.04 0.94
79_R 420_P 1.04 0.94
331_R 346_M 1.034 0.94
117_N 389_I 1.028 0.94
219_L 222_A 1.027 0.94
38_I 242_A 1.025 0.93
80_A 419_L 1.023 0.93
435_S 439_L 1.02 0.93
266_L 270_G 1.02 0.93
444_Y 447_G 1.017 0.93
98_A 106_A 1.015 0.93
450_T 455_P 1.012 0.93
133_M 312_L 1.011 0.93
96_S 100_E 1.011 0.93
90_S 96_S 1.009 0.93
409_E 412_A 1.003 0.93
441_A 445_P 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4djkA20.92991000.432Contact Map0.595
3l1lA10.87981000.451Contact Map0.683
3giaA10.87581000.459Contact Map0.588
2jlnA10.887898.70.897Contact Map0.416
3dh4A40.905898.50.902Contact Map0.4
2xq2A10.909898.10.912Contact Map0.48
4m48A10.895896.30.935Contact Map0.309
2a65A10.869794.50.942Contact Map0.38
2m20A20.1042250.97Contact Map0.414
1fftB20.172318.30.972Contact Map0.248

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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