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ARCM - Carbamate kinase-like protein YahI
UniProt: P77624 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13593
Length: 316 (313)
Sequences: 633
Seq/Len: 2.02

ARCM
Paralog alert: 0.46 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: ARCC ARCL ARCM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
262_T 287_E 5.2 1.00
138_D 142_D 4.884 1.00
244_H 249_Q 3.537 1.00
256_V 261_M 3.385 1.00
42_A 104_H 2.893 1.00
242_C 252_A 2.777 1.00
37_V 47_I 2.77 1.00
4_L 46_D 2.764 1.00
263_R 267_E 2.711 1.00
137_S 140_Q 2.584 1.00
240_K 254_D 2.521 1.00
79_A 211_D 2.443 1.00
50_T 220_T 2.282 1.00
138_D 161_Y 2.257 1.00
60_D 85_T 2.178 1.00
253_L 256_V 2.176 1.00
39_E 104_H 2.104 0.99
286_L 293_V 2.066 0.99
300_C 303_A 2.032 0.99
265_M 276_L 1.989 0.99
7_V 37_V 1.971 0.99
192_A 223_L 1.921 0.99
240_K 252_A 1.837 0.98
143_E 148_N 1.832 0.98
251_Q 260_T 1.828 0.98
151_W 163_R 1.784 0.97
292_E 312_H 1.767 0.97
262_T 266_Q 1.747 0.97
303_A 308_E 1.73 0.97
244_H 269_H 1.726 0.97
255_R 314_I 1.72 0.97
296_T 304_A 1.716 0.96
257_D 260_T 1.698 0.96
127_H 154_V 1.69 0.96
169_E 284_T 1.688 0.96
228_H 291_K 1.688 0.96
94_Q 111_T 1.687 0.96
35_D 100_R 1.677 0.96
221_A 225_R 1.668 0.96
261_M 313_I 1.665 0.96
235_T 301_L 1.662 0.96
135_F 159_R 1.661 0.96
243_I 251_Q 1.66 0.96
233_V 301_L 1.659 0.96
117_E 172_R 1.659 0.96
244_H 247_K 1.656 0.95
38_L 97_L 1.646 0.95
260_T 263_R 1.64 0.95
279_I 293_V 1.608 0.94
243_I 269_H 1.608 0.94
239_E 242_C 1.563 0.93
78_L 82_V 1.546 0.93
180_K 184_Q 1.525 0.92
222_L 226_E 1.515 0.92
240_K 309_T 1.502 0.91
9_I 13_S 1.482 0.91
142_D 147_A 1.439 0.89
181_A 185_Q 1.431 0.88
192_A 219_S 1.416 0.88
62_R 136_F 1.404 0.87
146_K 153_F 1.393 0.87
178_A 187_F 1.363 0.85
202_T 208_Q 1.358 0.85
80_N 92_L 1.341 0.84
59_L 63_R 1.34 0.84
155_E 159_R 1.334 0.83
131_P 154_V 1.319 0.82
172_R 176_A 1.317 0.82
239_E 309_T 1.292 0.80
63_R 88_G 1.292 0.80
142_D 161_Y 1.292 0.80
131_P 271_P 1.29 0.80
94_Q 115_Q 1.286 0.80
169_E 280_I 1.278 0.79
286_L 289_G 1.277 0.79
19_A 29_A 1.268 0.79
136_F 153_F 1.262 0.78
172_R 201_R 1.26 0.78
48_V 227_I 1.248 0.77
39_E 302_P 1.244 0.77
100_R 104_H 1.243 0.77
63_R 84_D 1.241 0.77
136_F 145_Q 1.237 0.76
135_F 157_A 1.235 0.76
271_P 276_L 1.229 0.76
23_I 80_N 1.224 0.75
179_I 192_A 1.223 0.75
264_Y 267_E 1.22 0.75
132_I 239_E 1.212 0.74
23_I 92_L 1.204 0.73
231_I 294_I 1.2 0.73
221_A 284_T 1.198 0.73
225_R 284_T 1.197 0.73
64_A 84_D 1.193 0.72
115_Q 207_Y 1.193 0.72
282_S 286_L 1.185 0.72
244_H 251_Q 1.185 0.72
39_E 42_A 1.182 0.71
117_E 174_V 1.171 0.70
124_G 132_I 1.167 0.70
222_L 225_R 1.153 0.69
48_V 183_I 1.149 0.68
173_I 223_L 1.144 0.68
101_L 109_A 1.142 0.68
233_V 294_I 1.142 0.68
294_I 304_A 1.139 0.67
59_L 64_A 1.138 0.67
34_A 96_A 1.135 0.67
172_R 226_E 1.132 0.67
100_R 103_R 1.126 0.66
16_K 19_A 1.124 0.66
135_F 155_E 1.123 0.66
272_P 276_L 1.123 0.66
43_S 306_R 1.121 0.66
241_V 295_I 1.12 0.66
23_I 63_R 1.12 0.66
13_S 235_T 1.117 0.65
296_T 309_T 1.11 0.64
262_T 280_I 1.108 0.64
218_L 280_I 1.106 0.64
9_I 298_P 1.105 0.64
131_P 135_F 1.101 0.64
115_Q 174_V 1.092 0.63
5_V 298_P 1.089 0.62
21_Q 25_H 1.075 0.61
23_I 79_A 1.075 0.61
84_D 88_G 1.074 0.61
27_A 96_A 1.064 0.60
27_A 95_Q 1.062 0.59
60_D 81_C 1.059 0.59
282_S 293_V 1.058 0.59
85_T 88_G 1.051 0.58
15_I 26_Q 1.048 0.58
59_L 88_G 1.044 0.57
73_L 92_L 1.033 0.56
119_D 171_K 1.031 0.56
46_D 186_G 1.016 0.54
18_N 25_H 1.014 0.54
6_V 229_A 1.014 0.54
154_V 157_A 1.013 0.54
30_V 96_A 1.012 0.54
110_V 178_A 1.011 0.54
231_I 301_L 1.009 0.54
146_K 161_Y 1.007 0.53
61_L 79_A 1.004 0.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1e19A20.99051000.485Contact Map0.75
2e9yA20.99051000.49Contact Map0.703
4jz8A40.98731000.501Contact Map0.752
4axsA10.97151000.51Contact Map0.602
2we5A30.97151000.518Contact Map0.695
2bufA120.80061000.72Contact Map0.547
2rd5A20.81961000.724Contact Map0.479
3l86A10.76271000.727Contact Map0.431
2ap9A60.8071000.727Contact Map0.43
2btyA30.79751000.729Contact Map0.568

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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