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ALLB - Allantoinase
UniProt: P77671 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13619
Length: 453 (442)
Sequences: 8711
Seq/Len: 19.71

ALLB
Paralog alert: 0.87 [within 20: 0.21] - ratio of genomes with paralogs
Cluster includes: ALLB CODA GUAD IADA NAGA PHNM PHYDA SSNA YAHJ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
7_I 46_A 4.944 1.00
426_I 431_V 4.73 1.00
379_R 384_K 4.417 1.00
49_L 423_T 4.347 1.00
26_K 31_A 4.09 1.00
10_G 46_A 3.959 1.00
424_K 431_V 3.832 1.00
46_A 390_F 3.78 1.00
380_I 388_F 3.576 1.00
377_K 385_D 3.376 1.00
356_S 359_M 3.345 1.00
23_I 51_V 3.34 1.00
32_A 382_P 3.278 1.00
52_S 391_I 3.236 1.00
51_V 390_F 3.177 1.00
381_A 384_K 3.17 1.00
42_E 434_D 3.15 1.00
10_G 51_V 3.082 1.00
359_M 362_K 3.048 1.00
6_I 24_A 2.997 1.00
25_V 388_F 2.862 1.00
8_K 43_V 2.84 1.00
5_L 426_I 2.77 1.00
396_S 417_T 2.75 1.00
52_S 389_V 2.711 1.00
28_G 385_D 2.693 1.00
54_G 86_T 2.663 1.00
385_D 428_R 2.647 1.00
392_Q 423_T 2.522 1.00
29_K 385_D 2.5 1.00
8_K 22_D 2.497 1.00
12_V 23_I 2.422 1.00
232_K 258_E 2.38 1.00
425_T 433_Y 2.368 1.00
49_L 390_F 2.366 1.00
12_V 21_V 2.35 1.00
9_N 45_D 2.323 1.00
367_N 370_D 2.251 1.00
388_F 426_I 2.242 1.00
362_K 366_T 2.182 1.00
23_I 380_I 2.163 1.00
33_I 382_P 2.162 1.00
366_T 370_D 2.113 1.00
239_H 263_T 2.102 1.00
294_L 298_K 2.068 1.00
374_L 377_K 2.057 1.00
7_I 25_V 2.03 1.00
4_D 26_K 1.998 1.00
51_V 388_F 1.964 1.00
397_Y 421_R 1.962 1.00
370_D 379_R 1.918 1.00
361_G 365_A 1.911 1.00
224_I 248_G 1.89 1.00
266_S 270_Y 1.845 1.00
52_S 55_M 1.838 1.00
175_K 178_E 1.828 1.00
81_A 118_I 1.826 1.00
10_G 390_F 1.821 1.00
46_A 51_V 1.804 1.00
250_E 254_R 1.778 1.00
24_A 32_A 1.778 1.00
4_D 24_A 1.736 1.00
81_A 432_I 1.718 1.00
229_Y 233_V 1.709 1.00
56_V 369_A 1.7 1.00
21_V 33_I 1.683 1.00
389_V 422_I 1.681 1.00
400_T 403_D 1.68 1.00
267_C 270_Y 1.66 1.00
431_V 434_D 1.647 1.00
220_E 223_A 1.646 1.00
399_L 418_I 1.636 1.00
25_V 426_I 1.627 1.00
6_I 22_D 1.612 1.00
44_M 426_I 1.609 1.00
56_V 368_A 1.604 1.00
5_L 25_V 1.604 1.00
362_K 367_N 1.604 1.00
301_W 305_F 1.593 1.00
376_Q 384_K 1.592 1.00
7_I 388_F 1.586 1.00
49_L 392_Q 1.583 1.00
366_T 379_R 1.578 1.00
424_K 434_D 1.573 1.00
401_N 414_V 1.57 1.00
58_A 372_F 1.562 1.00
3_F 24_A 1.553 1.00
11_T 18_A 1.53 1.00
171_K 174_Q 1.517 1.00
18_A 21_V 1.502 1.00
396_S 419_G 1.482 1.00
427_L 432_I 1.479 1.00
9_N 20_V 1.467 1.00
28_G 428_R 1.46 1.00
23_I 33_I 1.46 1.00
11_T 20_V 1.423 1.00
176_L 183_V 1.42 1.00
58_A 311_C 1.414 1.00
311_C 371_I 1.389 0.99
309_I 370_D 1.388 0.99
13_I 361_G 1.387 0.99
302_E 306_N 1.386 0.99
50_V 393_P 1.383 0.99
294_L 297_Q 1.38 0.99
390_F 426_I 1.379 0.99
18_A 358_P 1.377 0.99
392_Q 395_S 1.377 0.99
299_G 302_E 1.371 0.99
433_Y 438_G 1.371 0.99
423_T 435_I 1.37 0.99
106_E 110_D 1.367 0.99
31_A 382_P 1.367 0.99
52_S 361_G 1.364 0.99
82_K 433_Y 1.361 0.99
261_D 371_I 1.353 0.99
7_I 51_V 1.351 0.99
350_V 360_F 1.348 0.99
231_A 238_L 1.333 0.99
5_L 42_E 1.33 0.99
9_N 47_S 1.311 0.99
253_T 306_N 1.302 0.99
254_R 257_Q 1.301 0.99
228_L 262_V 1.299 0.99
170_F 174_Q 1.298 0.99
165_N 168_Q 1.295 0.99
10_G 388_F 1.292 0.99
256_R 310_D 1.29 0.99
389_V 425_T 1.289 0.99
44_M 424_K 1.284 0.99
119_D 428_R 1.284 0.99
370_D 375_Q 1.283 0.99
110_D 113_K 1.281 0.99
138_D 181_Q 1.274 0.99
9_N 46_A 1.271 0.99
74_E 78_R 1.27 0.99
7_I 426_I 1.27 0.99
22_D 36_D 1.269 0.99
42_E 431_V 1.267 0.99
355_M 363_L 1.253 0.99
89_I 372_F 1.252 0.99
62_I 76_G 1.249 0.99
24_A 41_K 1.248 0.99
23_I 388_F 1.238 0.98
7_I 390_F 1.228 0.98
246_P 295_E 1.222 0.98
55_M 364_M 1.221 0.98
81_A 425_T 1.209 0.98
395_S 423_T 1.203 0.98
107_L 111_A 1.201 0.98
24_A 31_A 1.201 0.98
58_A 368_A 1.201 0.98
8_K 45_D 1.199 0.98
390_F 424_K 1.195 0.98
11_T 50_V 1.193 0.98
348_E 352_K 1.184 0.98
22_D 34_G 1.183 0.98
62_I 88_M 1.17 0.97
133_R 136_E 1.169 0.97
170_F 233_V 1.159 0.97
279_E 306_N 1.158 0.97
184_L 241_C 1.156 0.97
82_K 405_E 1.156 0.97
398_V 417_T 1.153 0.97
56_V 377_K 1.142 0.97
11_T 19_R 1.14 0.97
9_N 48_G 1.12 0.96
359_M 363_L 1.116 0.96
6_I 43_V 1.115 0.96
55_M 342_M 1.113 0.96
10_G 48_G 1.112 0.96
287_C 335_I 1.11 0.96
227_V 238_L 1.11 0.96
303_K 308_E 1.109 0.96
242_H 315_D 1.105 0.96
345_M 364_M 1.1 0.96
395_S 421_R 1.09 0.96
44_M 431_V 1.081 0.95
254_R 258_E 1.079 0.95
80_A 88_M 1.072 0.95
302_E 305_F 1.071 0.95
135_H 179_L 1.067 0.95
13_I 50_V 1.063 0.95
311_C 367_N 1.061 0.95
46_A 424_K 1.061 0.95
364_M 368_A 1.059 0.95
58_A 286_K 1.052 0.95
379_R 382_P 1.05 0.94
271_F 300_M 1.043 0.94
56_V 87_T 1.043 0.94
87_T 387_D 1.042 0.94
210_D 227_V 1.042 0.94
21_V 380_I 1.04 0.94
85_I 341_C 1.038 0.94
225_R 229_Y 1.038 0.94
71_E 76_G 1.033 0.94
276_D 279_E 1.022 0.93
50_V 357_L 1.022 0.93
221_V 225_R 1.021 0.93
59_H 242_H 1.021 0.93
245_S 248_G 1.017 0.93
369_A 378_G 1.016 0.93
4_D 41_K 1.013 0.93
293_D 296_N 1.013 0.93
40_A 43_V 1.01 0.93
387_D 428_R 1.009 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2ftyA40.98011000.202Contact Map0.805
3e74A40.99341000.202Contact Map0.839
3dc8A20.97351000.217Contact Map0.82
1nfgA40.97571000.223Contact Map0.814
1gkrA40.98681000.224Contact Map0.792
2ftwA10.98231000.225Contact Map0.777
4bknA20.98231000.229Contact Map0.827
2vm8A40.98231000.229Contact Map0.861
4b90A20.98231000.23Contact Map0.802
4gz7A10.98231000.233Contact Map0.806

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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