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ABDH - Gamma-aminobutyraldehyde dehydrogenase
UniProt: P77674 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13766
Length: 474 (469)
Sequences: 17845
Seq/Len: 38.05

ABDH
Paralog alert: 0.85 [within 20: 0.24] - ratio of genomes with paralogs
Cluster includes: ABDH ALDA ALDB ASTD BETB EUTE FEAB GABD PROA PUUC SAD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
290_K 390_D 5.416 1.00
234_S 238_S 3.634 1.00
290_K 388_P 3.187 1.00
262_E 299_K 3.131 1.00
257_D 289_Q 2.855 1.00
325_L 329_E 2.795 1.00
369_L 372_D 2.77 1.00
49_D 216_K 2.741 1.00
293_Y 388_P 2.72 1.00
336_E 340_A 2.702 1.00
20_P 32_E 2.695 1.00
351_E 361_A 2.619 1.00
257_D 291_G 2.613 1.00
337_E 373_A 2.567 1.00
77_N 80_V 2.528 1.00
266_E 303_A 2.525 1.00
183_K 186_E 2.503 1.00
297_V 386_V 2.489 1.00
75_E 109_R 2.412 1.00
8_N 50_A 2.41 1.00
322_L 331_V 2.399 1.00
335_V 360_Y 2.37 1.00
412_T 418_A 2.353 1.00
49_D 218_R 2.262 1.00
189_K 194_A 2.187 1.00
301_G 305_A 2.154 1.00
420_R 424_R 2.147 1.00
37_S 40_Q 2.141 1.00
20_P 29_V 2.098 1.00
345_K 367_G 2.053 1.00
392_E 420_R 2.047 1.00
332_G 336_E 2.002 1.00
392_E 417_R 1.999 1.00
70_L 188_A 1.986 1.00
365_L 374_I 1.953 1.00
5_L 36_A 1.947 1.00
287_Y 395_V 1.936 1.00
298_E 302_A 1.919 1.00
46_R 216_K 1.914 1.00
66_C 192_F 1.891 1.00
295_T 299_K 1.888 1.00
337_E 341_T 1.886 1.00
73_V 190_D 1.868 1.00
79_Q 97_F 1.858 1.00
339_K 346_V 1.858 1.00
286_I 384_V 1.85 1.00
6_L 189_K 1.849 1.00
345_K 366_A 1.842 1.00
176_I 324_S 1.841 1.00
72_D 76_E 1.826 1.00
332_G 352_K 1.825 1.00
347_I 366_A 1.815 1.00
253_V 268_V 1.812 1.00
136_R 465_T 1.797 1.00
137_D 468_R 1.796 1.00
73_V 76_E 1.788 1.00
258_D 417_R 1.783 1.00
209_D 213_G 1.774 1.00
403_Q 449_L 1.772 1.00
332_G 360_Y 1.761 1.00
390_D 394_Q 1.759 1.00
373_A 377_K 1.753 1.00
73_V 187_L 1.752 1.00
394_Q 397_N 1.742 1.00
42_D 210_P 1.739 1.00
78_G 102_P 1.737 1.00
80_V 183_K 1.736 1.00
294_D 388_P 1.723 1.00
213_G 235_H 1.718 1.00
42_D 46_R 1.716 1.00
52_F 56_G 1.712 1.00
77_N 190_D 1.699 1.00
304_V 364_L 1.695 1.00
230_E 449_L 1.679 1.00
346_V 365_L 1.665 1.00
393_E 424_R 1.661 1.00
426_Q 448_K 1.657 1.00
287_Y 398_W 1.651 1.00
257_D 417_R 1.647 1.00
301_G 347_I 1.628 1.00
73_V 191_I 1.627 1.00
293_Y 297_V 1.624 1.00
79_Q 83_E 1.6 1.00
370_Q 398_W 1.598 1.00
408_S 427_Y 1.597 1.00
168_C 196_V 1.586 1.00
185_A 199_I 1.582 1.00
231_H 234_S 1.558 1.00
84_L 183_K 1.552 1.00
10_E 194_A 1.551 1.00
289_Q 389_F 1.547 1.00
59_T 62_V 1.542 1.00
136_R 462_E 1.536 1.00
303_A 306_T 1.533 1.00
375_V 387_T 1.522 1.00
295_T 298_E 1.519 1.00
267_G 411_W 1.515 1.00
261_I 299_K 1.506 1.00
69_K 72_D 1.504 1.00
268_V 296_L 1.501 1.00
391_N 394_Q 1.495 1.00
289_Q 391_N 1.492 1.00
396_V 421_V 1.465 1.00
308_K 316_S 1.464 1.00
42_D 214_H 1.46 1.00
333_K 373_A 1.439 1.00
344_I 365_L 1.439 1.00
299_K 302_A 1.438 1.00
4_K 13_S 1.433 1.00
72_D 109_R 1.419 1.00
108_F 160_A 1.418 1.00
256_F 417_R 1.418 1.00
336_E 339_K 1.418 1.00
62_V 65_E 1.413 1.00
329_E 333_K 1.409 1.00
288_A 296_L 1.406 0.99
68_L 109_R 1.405 0.99
57_Q 424_R 1.401 0.99
52_F 168_C 1.379 0.99
29_V 32_E 1.371 0.99
186_E 190_D 1.371 0.99
302_A 306_T 1.37 0.99
83_E 313_D 1.353 0.99
83_E 87_R 1.351 0.99
22_Y 29_V 1.345 0.99
75_E 105_V 1.341 0.99
273_Y 304_V 1.335 0.99
268_V 286_I 1.333 0.99
45_V 214_H 1.333 0.99
293_Y 366_A 1.332 0.99
325_L 358_Y 1.329 0.99
81_F 183_K 1.325 0.99
394_Q 398_W 1.323 0.99
265_V 299_K 1.32 0.99
12_V 43_A 1.319 0.99
144_S 169_V 1.31 0.99
135_R 423_A 1.309 0.99
328_L 332_G 1.309 0.99
114_A 117_C 1.304 0.99
341_T 373_A 1.294 0.99
28_D 356_N 1.29 0.99
302_A 305_A 1.289 0.99
334_A 379_V 1.286 0.99
307_L 319_L 1.285 0.99
256_F 389_F 1.281 0.99
41_V 207_V 1.28 0.99
68_L 116_R 1.279 0.99
338_A 365_L 1.279 0.99
23_N 26_T 1.276 0.99
311_A 314_D 1.271 0.99
188_A 197_I 1.268 0.99
86_S 96_A 1.263 0.99
305_A 348_T 1.262 0.99
46_R 50_A 1.26 0.99
233_I 452_Y 1.242 0.98
69_K 73_V 1.236 0.98
108_F 156_A 1.235 0.98
328_L 360_Y 1.223 0.98
393_E 420_R 1.216 0.98
70_L 187_L 1.214 0.98
40_Q 43_A 1.209 0.98
93_L 97_F 1.208 0.98
253_V 283_A 1.207 0.98
389_F 398_W 1.205 0.98
219_M 244_H 1.204 0.98
58_T 62_V 1.201 0.98
325_L 328_L 1.198 0.98
71_A 75_E 1.193 0.98
287_Y 389_F 1.189 0.98
376_Q 401_D 1.185 0.98
155_A 171_L 1.176 0.98
185_A 197_I 1.176 0.98
256_F 421_V 1.173 0.98
396_V 424_R 1.173 0.98
77_N 183_K 1.165 0.97
71_A 109_R 1.163 0.97
77_N 187_L 1.161 0.97
31_L 179_L 1.16 0.97
144_S 221_S 1.159 0.97
45_V 216_K 1.158 0.97
135_R 470_V 1.155 0.97
459_Y 462_E 1.152 0.97
254_I 395_V 1.148 0.97
81_F 187_L 1.143 0.97
23_N 311_A 1.141 0.97
396_V 400_N 1.139 0.97
422_S 470_V 1.137 0.97
6_L 11_L 1.13 0.97
209_D 235_H 1.129 0.97
78_G 97_F 1.127 0.97
231_H 235_H 1.127 0.97
408_S 430_T 1.126 0.97
294_D 298_E 1.125 0.97
376_Q 403_Q 1.124 0.97
331_V 381_G 1.124 0.97
121_L 459_Y 1.123 0.97
18_K 32_E 1.117 0.96
136_R 467_V 1.115 0.96
159_L 197_I 1.113 0.96
418_A 432_V 1.101 0.96
47_A 195_G 1.099 0.96
370_Q 401_D 1.099 0.96
297_V 301_G 1.098 0.96
371_D 376_Q 1.097 0.96
339_K 365_L 1.096 0.96
296_L 300_L 1.096 0.96
254_I 421_V 1.092 0.96
294_D 297_V 1.088 0.96
395_V 398_W 1.087 0.96
228_T 231_H 1.087 0.96
328_L 352_K 1.084 0.96
133_M 419_H 1.074 0.95
86_S 312_P 1.073 0.95
209_D 231_H 1.073 0.95
121_L 458_L 1.07 0.95
300_L 384_V 1.068 0.95
414_D 417_R 1.065 0.95
70_L 192_F 1.064 0.95
70_L 108_F 1.063 0.95
292_I 295_T 1.057 0.95
289_Q 292_I 1.057 0.95
203_R 206_T 1.057 0.95
392_E 421_V 1.056 0.95
27_G 358_Y 1.056 0.95
256_F 289_Q 1.056 0.95
297_V 347_I 1.055 0.95
27_G 356_N 1.053 0.95
393_E 397_N 1.048 0.94
301_G 348_T 1.045 0.94
210_P 214_H 1.043 0.94
305_A 361_A 1.041 0.94
76_E 190_D 1.039 0.94
58_T 66_C 1.039 0.94
141_V 217_V 1.035 0.94
53_A 397_N 1.035 0.94
139_L 167_N 1.034 0.94
458_L 462_E 1.034 0.94
233_I 243_T 1.029 0.94
225_S 228_T 1.028 0.94
454_K 466_V 1.028 0.94
252_P 408_S 1.027 0.94
260_D 413_K 1.025 0.93
213_G 238_S 1.02 0.93
258_D 414_D 1.019 0.93
263_A 413_K 1.015 0.93
17_E 35_E 1.015 0.93
143_A 217_V 1.014 0.93
83_E 93_L 1.012 0.93
310_G 317_T 1.009 0.93
308_K 318_E 1.009 0.93
445_G 454_K 1.008 0.93
150_Y 279_D 1.006 0.93
333_K 337_E 1.004 0.93
331_V 383_V 1.003 0.93
230_E 240_I 1.003 0.93
195_G 198_N 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4f3xA40.9937100-0.017Contact Map0.723
1wndA40.9958100-0.017Contact Map0.749
4i8pA20.9958100-0.016Contact Map0.785
3k2wA80.9958100-0.015Contact Map0.859
3ek1A80.9916100-0.013Contact Map0.806
3ed6A20.9958100-0.01Contact Map0.782
1a4sA40.9916100-0.01Contact Map0.789
2o2pA40.9979100-0.008Contact Map0.82
1bxsA40.9958100-0.008Contact Map0.826
1o04A80.9958100-0.008Contact Map0.832

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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