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FADM - Long-chain acyl-CoA thioesterase FadM
UniProt: P77712 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13251
Length: 132 (130)
Sequences: 3499
Seq/Len: 26.92

FADM
Paralog alert: 0.65 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: FADM YBGC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
55_N 59_N 3.77 1.00
64_A 70_L 2.6 1.00
27_L 102_A 2.591 1.00
64_A 99_V 2.419 1.00
62_R 97_Q 2.309 1.00
57_N 103_L 2.299 1.00
4_Q 69_L 2.271 1.00
61_R 101_D 2.23 1.00
73_T 89_V 2.214 1.00
2_Q 71_T 2.188 1.00
22_R 25_E 2.175 1.00
77_Q 87_S 2.119 1.00
110_D 113_T 2.037 1.00
24_L 56_I 2.029 1.00
24_L 58_I 2.019 1.00
2_Q 73_T 2.009 1.00
4_Q 71_T 1.849 1.00
27_L 100_A 1.849 1.00
63_P 114_Q 1.834 1.00
88_Q 104_I 1.757 1.00
75_Q 87_S 1.737 1.00
30_A 74_S 1.689 1.00
121_G 125_E 1.648 1.00
92_L 95_E 1.624 1.00
58_I 100_A 1.611 1.00
59_N 101_D 1.576 1.00
89_V 98_V 1.561 1.00
8_R 11_H 1.538 1.00
6_K 36_E 1.516 1.00
89_V 101_D 1.507 1.00
91_T 98_V 1.506 1.00
73_T 91_T 1.492 1.00
78_Q 85_I 1.486 1.00
18_V 26_F 1.478 1.00
28_E 31_R 1.465 1.00
82_K 116_A 1.448 1.00
30_A 72_I 1.434 1.00
72_I 90_I 1.42 1.00
68_D 92_L 1.414 1.00
85_I 103_L 1.408 1.00
80_N 83_S 1.389 0.99
10_Y 25_E 1.378 0.99
6_K 69_L 1.35 0.99
27_L 90_I 1.327 0.99
50_A 111_L 1.236 0.98
120_E 123_L 1.224 0.98
7_V 26_F 1.219 0.98
4_Q 93_E 1.213 0.98
83_S 105_T 1.21 0.98
11_H 25_E 1.183 0.98
6_K 33_D 1.172 0.98
52_V 109_I 1.171 0.98
85_I 105_T 1.165 0.97
124_R 128_E 1.163 0.97
75_Q 89_V 1.152 0.97
56_I 104_I 1.149 0.97
33_D 37_N 1.104 0.96
55_N 105_T 1.102 0.96
43_W 46_A 1.102 0.96
21_A 25_E 1.099 0.96
7_V 18_V 1.097 0.96
20_N 56_I 1.096 0.96
77_Q 103_L 1.088 0.96
36_E 67_S 1.066 0.95
71_T 93_E 1.059 0.95
12_L 16_Q 1.056 0.95
61_R 98_V 1.043 0.94
109_I 114_Q 1.036 0.94
122_E 125_E 1.012 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2essA10.99241000.203Contact Map0.647
2ownA20.99241000.205Contact Map0.779
1njkA4199.90.219Contact Map0.854
2hljA1199.90.222Contact Map0.71
4gakA10.984899.90.225Contact Map0.776
2aliA10.969799.90.229Contact Map0.732
4i4jA8199.90.234Contact Map0.883
2xemA40.992499.90.237Contact Map0.864
3ck1A20.992499.90.239Contact Map0.786
2o5uA30.992499.90.24Contact Map0.732

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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