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ALLA - Ureidoglycolate hydrolase
UniProt: P77731 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13615
Length: 160 (154)
Sequences: 322
Seq/Len: 2.09

ALLA
Paralog alert: 0.06 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
6_L 106_R 4.325 1.00
58_R 135_D 3.199 1.00
8_L 19_V 2.996 1.00
89_F 110_T 2.718 1.00
54_I 139_I 2.584 1.00
53_L 142_G 2.231 1.00
16_Y 106_R 1.832 0.98
40_D 51_C 1.722 0.97
71_L 107_A 1.711 0.97
125_H 128_F 1.662 0.96
57_N 138_T 1.653 0.96
59_A 127_L 1.629 0.95
52_T 94_A 1.607 0.95
140_D 146_N 1.559 0.94
91_V 110_T 1.548 0.93
16_Y 139_I 1.528 0.93
45_E 120_R 1.5 0.92
125_H 129_A 1.485 0.91
96_G 100_P 1.457 0.90
85_K 135_D 1.451 0.90
27_F 36_E 1.443 0.90
18_D 119_H 1.41 0.88
97_D 100_P 1.39 0.87
80_A 117_N 1.337 0.84
34_L 126_P 1.318 0.83
18_D 117_N 1.314 0.83
37_R 77_G 1.305 0.82
47_L 105_L 1.294 0.81
95_L 121_N 1.293 0.81
68_I 91_V 1.271 0.80
5_V 109_I 1.263 0.79
45_E 50_D 1.261 0.79
121_N 147_C 1.246 0.78
42_A 117_N 1.244 0.78
75_P 146_N 1.218 0.76
92_V 115_G 1.216 0.75
37_R 65_P 1.191 0.73
71_L 121_N 1.188 0.73
73_R 148_D 1.182 0.72
75_P 143_G 1.18 0.72
55_S 142_G 1.174 0.72
66_L 128_F 1.168 0.71
66_L 92_V 1.167 0.71
47_L 120_R 1.162 0.71
82_I 137_L 1.159 0.70
88_V 131_Q 1.159 0.70
34_L 71_L 1.155 0.70
105_L 147_C 1.143 0.69
105_L 121_N 1.129 0.67
44_V 139_I 1.127 0.67
44_V 54_I 1.121 0.67
141_R 146_N 1.109 0.65
28_F 147_C 1.092 0.64
84_M 137_L 1.091 0.64
77_G 140_D 1.086 0.63
39_H 42_A 1.085 0.63
25_R 139_I 1.063 0.61
8_L 110_T 1.043 0.58
28_F 32_N 1.042 0.58
96_G 99_K 1.04 0.58
10_Q 21_E 1.039 0.58
5_V 86_G 1.036 0.58
21_E 114_Q 1.029 0.57
30_I 141_R 1.023 0.56
77_G 127_L 1.02 0.56
90_V 152_I 1.019 0.56
30_I 77_G 1.016 0.55
89_F 136_F 1.008 0.55
61_P 142_G 1.005 0.54
121_N 148_D 1.004 0.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1xsqA211000.162Contact Map0.483
2bdrA211000.168Contact Map0.533
3d0jA10.7812590.938Contact Map0.449
1w74A20.30635.10.963Contact Map0.07
3ejkA10.93755.10.963Contact Map0.245
2pa7A20.78124.70.964Contact Map0.341
1x82A10.88754.40.965Contact Map0.19
4mcjA100.456240.965Contact Map0.002
2y0oA10.8753.30.967Contact Map0.081
4g63A10.4752.80.968Contact Map0.065

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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