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ABGR - HTH-type transcriptional regulator AbgR
UniProt: P77744 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13353
Length: 302 (293)
Sequences: 37318
Seq/Len: 127.37

ABGR
Paralog alert: 0.88 [within 20: 0.50] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
74_L 78_E 3.7 1.00
19_Q 28_M 3.374 1.00
164_E 294_R 2.529 1.00
235_V 242_S 2.508 1.00
100_G 145_L 2.403 1.00
24_G 27_R 2.357 1.00
71_H 85_D 2.346 1.00
170_Q 246_E 2.249 1.00
18_R 73_S 2.207 1.00
15_E 28_M 2.171 1.00
98_N 127_R 2.16 1.00
96_Q 125_K 2.129 1.00
96_Q 127_R 2.109 1.00
186_S 189_Q 2.082 1.00
179_H 193_Y 2.08 1.00
17_A 61_L 2.078 1.00
75_I 79_L 2.074 1.00
165_K 168_E 2.062 1.00
168_E 271_A 2.046 1.00
71_H 78_E 2.021 1.00
12_A 39_S 1.993 1.00
14_V 69_Y 1.978 1.00
22_I 40_I 1.977 1.00
232_I 252_P 1.967 1.00
49_A 64_A 1.949 1.00
69_Y 73_S 1.925 1.00
15_E 19_Q 1.881 1.00
165_K 271_A 1.873 1.00
116_R 296_E 1.858 1.00
14_V 73_S 1.856 1.00
14_V 18_R 1.855 1.00
12_A 36_L 1.831 1.00
15_E 18_R 1.827 1.00
68_F 82_A 1.806 1.00
53_F 60_T 1.799 1.00
116_R 292_Q 1.791 1.00
236_A 257_G 1.769 1.00
175_C 261_L 1.767 1.00
136_M 148_T 1.753 1.00
117_F 124_V 1.747 1.00
172_A 246_E 1.738 1.00
17_A 69_Y 1.733 1.00
236_A 252_P 1.729 1.00
63_D 66_E 1.678 1.00
13_F 69_Y 1.668 1.00
117_F 289_L 1.658 1.00
14_V 72_A 1.656 1.00
18_R 28_M 1.652 1.00
23_R 33_Q 1.648 1.00
67_S 85_D 1.648 1.00
196_T 240_F 1.645 1.00
194_S 222_G 1.608 1.00
12_A 31_M 1.607 1.00
205_Y 209_S 1.593 1.00
32_S 35_A 1.592 1.00
19_Q 24_G 1.585 1.00
21_S 24_G 1.583 1.00
172_A 260_M 1.572 1.00
138_N 142_Q 1.57 1.00
14_V 76_L 1.551 1.00
92_Q 123_Q 1.542 1.00
168_E 269_K 1.496 1.00
163_F 273_Y 1.486 1.00
139_E 144_E 1.473 1.00
71_H 81_A 1.455 1.00
15_E 29_L 1.452 1.00
75_I 82_A 1.451 1.00
9_Q 39_S 1.446 1.00
9_Q 42_E 1.445 1.00
107_R 229_S 1.427 1.00
50_Q 53_F 1.42 1.00
9_Q 46_G 1.413 1.00
193_Y 241_L 1.4 0.99
196_T 231_C 1.396 0.99
116_R 120_Q 1.379 0.99
68_F 83_Q 1.371 0.99
66_E 70_Q 1.368 0.99
147_F 286_T 1.352 0.99
7_I 79_L 1.35 0.99
6_K 9_Q 1.336 0.99
162_T 276_Q 1.326 0.99
94_A 123_Q 1.317 0.99
71_H 74_L 1.316 0.99
41_Q 45_E 1.311 0.99
282_Q 286_T 1.306 0.99
274_L 290_I 1.305 0.99
116_R 119_Q 1.3 0.99
250_C 254_H 1.296 0.99
162_T 278_R 1.283 0.99
175_C 241_L 1.281 0.99
288_S 291_T 1.279 0.99
231_C 242_S 1.269 0.99
38_K 41_Q 1.264 0.99
115_S 119_Q 1.26 0.99
252_P 257_G 1.26 0.99
13_F 17_A 1.235 0.98
131_G 135_S 1.234 0.98
290_I 294_R 1.229 0.98
177_P 257_G 1.228 0.98
140_L 148_T 1.227 0.98
117_F 292_Q 1.22 0.98
98_N 129_M 1.213 0.98
16_V 40_I 1.208 0.98
78_E 81_A 1.208 0.98
13_F 52_F 1.203 0.98
70_Q 74_L 1.197 0.98
139_E 145_L 1.197 0.98
46_G 83_Q 1.193 0.98
71_H 82_A 1.193 0.98
164_E 276_Q 1.189 0.98
97_I 289_L 1.188 0.98
31_M 35_A 1.187 0.98
118_H 222_G 1.186 0.98
61_L 65_G 1.186 0.98
184_A 189_Q 1.186 0.98
16_V 25_A 1.181 0.98
37_S 41_Q 1.18 0.98
17_A 52_F 1.172 0.98
147_F 274_L 1.169 0.97
118_H 194_S 1.168 0.97
225_C 231_C 1.167 0.97
233_S 236_A 1.167 0.97
22_I 59_V 1.167 0.97
13_F 51_L 1.163 0.97
120_Q 292_Q 1.163 0.97
180_P 193_Y 1.162 0.97
67_S 70_Q 1.16 0.97
55_R 60_T 1.155 0.97
141_R 160_E 1.148 0.97
246_E 250_C 1.147 0.97
11_R 80_R 1.142 0.97
169_K 247_E 1.129 0.97
15_E 25_A 1.118 0.96
150_N 275_I 1.106 0.96
39_S 42_E 1.095 0.96
232_I 236_A 1.085 0.96
246_E 260_M 1.082 0.96
233_S 237_K 1.08 0.95
8_H 11_R 1.08 0.95
212_L 217_Q 1.079 0.95
165_K 273_Y 1.078 0.95
276_Q 290_I 1.078 0.95
38_K 42_E 1.069 0.95
106_S 130_E 1.068 0.95
117_F 121_H 1.067 0.95
10_I 72_A 1.062 0.95
173_I 241_L 1.062 0.95
291_T 294_R 1.059 0.95
177_P 259_V 1.057 0.95
175_C 179_H 1.055 0.95
287_A 291_T 1.054 0.95
67_S 71_H 1.053 0.95
251_D 255_G 1.052 0.95
163_F 275_I 1.048 0.94
174_F 249_G 1.042 0.94
120_Q 295_R 1.042 0.94
31_M 36_L 1.04 0.94
176_R 238_S 1.035 0.94
75_I 78_E 1.033 0.94
277_R 280_S 1.031 0.94
121_H 288_S 1.028 0.94
17_A 65_G 1.026 0.94
115_S 237_K 1.026 0.94
74_L 81_A 1.019 0.93
80_R 84_E 1.017 0.93
52_F 59_V 1.011 0.93
68_F 72_A 1.007 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3fxqA20.99011000.109Contact Map0.785
2esnA411000.11Contact Map0.763
3fzvA40.98681000.113Contact Map0.72
1uthA10.99341000.115Contact Map0.752
1ixcA20.96031000.125Contact Map0.768
1al3A10.98011000.133Contact Map0.781
2h98A20.96691000.133Contact Map0.774
2h9bA20.96691000.139Contact Map0.764
3szpA20.9571000.151Contact Map0.766
3hhgA80.97351000.152Contact Map0.921

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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