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BAMB - Outer membrane protein assembly factor BamB
UniProt: P77774 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14208
Length: 392 (362)
Sequences: 2265
Seq/Len: 6.26

BAMB
Paralog alert: 0.60 [within 20: 0.06] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
71_V 92_I 5.368 1.00
175_N 178_D 4.687 1.00
161_L 182_K 4.327 1.00
81_V 134_L 4.008 1.00
121_H 142_A 3.959 1.00
135_N 138_D 3.576 1.00
305_V 349_I 3.101 1.00
206_A 227_I 3.091 1.00
131_V 174_L 3.024 1.00
350_N 353_D 2.996 1.00
91_E 94_S 2.981 1.00
356_F 359_Q 2.905 1.00
141_V 144_Q 2.805 1.00
85_N 88_D 2.757 1.00
309_T 312_G 2.746 1.00
123_Y 176_E 2.726 1.00
71_V 83_A 2.712 1.00
220_L 223_Q 2.671 1.00
123_Y 162_V 2.643 1.00
348_W 358_A 2.581 1.00
50_T 84_L 2.381 1.00
161_L 173_A 2.343 1.00
73_Y 136_T 2.333 1.00
157_V 162_V 2.313 1.00
46_T 49_S 2.294 1.00
336_N 357_V 2.252 1.00
216_V 270_L 2.235 1.00
86_A 379_L 2.228 1.00
315_T 318_T 2.211 1.00
295_R 316_L 2.195 1.00
220_L 227_I 2.105 1.00
160_G 176_E 2.044 1.00
130_Q 144_Q 2.042 1.00
257_V 278_M 2.037 1.00
120_G 136_T 2.019 1.00
317_W 354_G 2.006 1.00
121_H 133_A 1.96 1.00
377_K 389_S 1.936 1.00
338_V 348_W 1.91 1.00
259_F 269_A 1.899 1.00
205_G 222_E 1.895 1.00
304_R 318_T 1.881 1.00
257_V 269_A 1.846 1.00
350_N 355_R 1.832 1.00
121_H 177_A 1.817 1.00
340_G 367_F 1.808 1.00
175_N 182_K 1.792 1.00
171_L 219_V 1.786 1.00
145_T 181_V 1.781 1.00
218_A 228_W 1.774 1.00
345_Y 359_Q 1.758 1.00
125_G 151_A 1.741 1.00
48_W 89_G 1.729 1.00
95_V 141_V 1.723 1.00
50_T 82_K 1.712 1.00
337_L 351_V 1.698 1.00
206_A 218_A 1.697 1.00
207_A 221_M 1.694 1.00
291_V 296_I 1.685 1.00
163_L 173_A 1.68 1.00
83_A 92_I 1.668 1.00
126_S 132_Y 1.661 1.00
228_W 275_G 1.66 1.00
216_V 258_V 1.659 1.00
208_V 218_A 1.653 1.00
205_G 220_L 1.629 1.00
117_V 122_V 1.621 1.00
183_W 224_G 1.612 1.00
181_V 184_T 1.605 1.00
373_A 378_L 1.567 0.99
230_Q 277_I 1.567 0.99
40_N 335_G 1.555 0.99
215_R 229_Q 1.531 0.99
170_Q 184_T 1.529 0.99
117_V 136_T 1.526 0.99
259_F 310_I 1.525 0.99
226_M 229_Q 1.521 0.99
46_T 390_I 1.505 0.99
208_V 272_L 1.486 0.99
332_L 351_V 1.486 0.99
307_A 317_W 1.456 0.99
163_L 207_A 1.449 0.99
66_A 115_V 1.448 0.99
71_V 137_S 1.438 0.99
67_L 72_V 1.425 0.99
68_A 117_V 1.425 0.99
269_A 279_W 1.42 0.99
295_R 307_A 1.396 0.98
202_T 221_M 1.381 0.98
314_V 355_R 1.378 0.98
279_W 313_G 1.376 0.98
82_K 94_S 1.347 0.98
36_P 39_E 1.339 0.98
156_V 202_T 1.328 0.98
66_A 117_V 1.322 0.97
339_V 349_I 1.317 0.97
67_L 372_V 1.314 0.97
70_N 86_A 1.31 0.97
81_V 115_V 1.31 0.97
123_Y 133_A 1.305 0.97
211_G 217_S 1.299 0.97
203_A 253_V 1.29 0.97
80_L 94_S 1.287 0.97
230_Q 270_L 1.284 0.97
87_D 375_D 1.278 0.97
185_V 219_V 1.264 0.96
83_A 93_W 1.263 0.96
205_G 221_M 1.256 0.96
161_L 222_E 1.255 0.96
145_T 180_A 1.252 0.96
72_V 379_L 1.247 0.96
185_V 226_M 1.239 0.96
306_M 318_T 1.239 0.96
157_V 176_E 1.236 0.96
379_L 389_S 1.235 0.96
95_V 132_Y 1.226 0.95
50_T 91_E 1.222 0.95
172_Q 181_V 1.21 0.95
133_A 142_A 1.198 0.95
277_I 280_K 1.198 0.95
185_V 217_S 1.193 0.95
133_A 179_G 1.179 0.94
201_T 253_V 1.175 0.94
84_L 387_V 1.172 0.94
271_D 274_S 1.163 0.94
85_N 90_K 1.146 0.93
341_D 347_H 1.14 0.93
32_M 36_P 1.134 0.92
204_F 208_V 1.125 0.92
331_V 373_A 1.112 0.91
36_P 40_N 1.105 0.91
135_N 142_A 1.092 0.90
73_Y 122_V 1.091 0.90
336_N 348_W 1.088 0.90
67_L 86_A 1.086 0.90
253_V 258_V 1.086 0.90
93_W 139_G 1.085 0.90
135_N 140_T 1.081 0.90
216_V 260_A 1.081 0.90
123_Y 157_V 1.078 0.90
125_G 164_I 1.077 0.90
172_Q 184_T 1.052 0.88
173_A 183_W 1.049 0.88
340_G 362_V 1.048 0.88
45_T 90_K 1.047 0.88
40_N 350_N 1.039 0.87
131_V 162_V 1.035 0.87
332_L 337_L 1.034 0.87
382_A 388_Y 1.032 0.87
175_N 271_D 1.03 0.87
175_N 180_A 1.029 0.87
297_Y 351_V 1.02 0.86
132_Y 144_Q 1.019 0.86
217_S 226_M 1.009 0.85
143_W 179_G 1.007 0.85
138_D 142_A 1.006 0.85
81_V 124_I 1.005 0.85
70_N 92_I 1.005 0.85
164_I 174_L 1.004 0.85
281_R 308_L 1.003 0.85
147_V 166_T 1.001 0.84
174_L 181_V 1.001 0.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3q7mA10.95921000.297Contact Map0.8
4hdjA10.92861000.339Contact Map0.847
1w6sA20.95921000.414Contact Map0.772
1flgA20.96431000.456Contact Map0.829
4maeA20.95151000.458Contact Map0.842
2ad6A20.95921000.483Contact Map0.818
1kb0A10.95921000.486Contact Map0.874
1kv9A10.96431000.493Contact Map0.856
1yiqA10.96431000.498Contact Map0.869
3hxjA40.79851000.594Contact Map0.604

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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