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YDCT - Uncharacterized ABC transporter ATP-binding protein YdcT
UniProt: P77795 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13763
Length: 337 (328)
Sequences: 8908
Seq/Len: 27.16

YDCT
Paralog alert: 0.85 [within 20: 0.14] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
217_D 221_D 4.507 1.00
34_S 202_S 4.398 1.00
120_E 125_G 4.029 1.00
31_E 204_R 3.803 1.00
60_A 67_P 3.724 1.00
214_E 228_T 3.619 1.00
6_E 26_A 3.201 1.00
275_G 291_L 3.133 1.00
8_D 60_A 3.041 1.00
112_H 116_Q 3.001 1.00
107_N 110_Q 2.847 1.00
9_N 22_G 2.843 1.00
278_Q 292_K 2.72 1.00
119_L 128_H 2.703 1.00
127_V 130_R 2.668 1.00
9_N 24_S 2.597 1.00
94_L 129_Q 2.591 1.00
21_D 212_R 2.59 1.00
114_M 152_E 2.526 1.00
94_L 98_A 2.471 1.00
94_L 115_A 2.44 1.00
206_A 213_I 2.426 1.00
179_K 183_S 2.426 1.00
94_L 116_Q 2.425 1.00
33_F 206_A 2.392 1.00
64_F 154_R 2.358 1.00
49_L 61_I 2.326 1.00
118_A 150_V 2.316 1.00
274_N 320_Q 2.313 1.00
218_S 221_D 2.305 1.00
276_T 320_Q 2.29 1.00
20_V 49_L 2.212 1.00
94_L 112_H 2.201 1.00
63_I 68_A 2.174 1.00
5_V 155_V 2.133 1.00
7_F 10_V 2.126 1.00
66_K 154_R 2.101 1.00
206_A 216_V 2.068 1.00
50_I 189_I 2.065 1.00
18_R 21_D 2.051 1.00
77_D 154_R 2.049 1.00
209_N 214_E 2.017 1.00
98_A 115_A 1.996 1.00
28_K 31_E 1.983 1.00
6_E 62_S 1.974 1.00
316_T 319_Q 1.903 1.00
11_S 22_G 1.889 1.00
158_L 188_F 1.872 1.00
113_A 117_E 1.867 1.00
62_S 67_P 1.856 1.00
229_P 255_S 1.837 1.00
48_R 54_E 1.829 1.00
122_V 146_A 1.803 1.00
274_N 322_M 1.781 1.00
8_D 62_S 1.776 1.00
95_D 102_M 1.774 1.00
13_L 18_R 1.761 1.00
88_F 100_G 1.761 1.00
110_Q 113_A 1.752 1.00
97_V 146_A 1.751 1.00
123_A 172_Q 1.744 1.00
276_T 292_K 1.742 1.00
11_S 58_G 1.735 1.00
11_S 18_R 1.728 1.00
7_F 50_I 1.727 1.00
12_R 49_L 1.717 1.00
207_V 231_V 1.688 1.00
66_K 71_L 1.665 1.00
111_R 115_A 1.66 1.00
98_A 111_R 1.652 1.00
229_P 233_G 1.595 1.00
12_R 54_E 1.591 1.00
49_L 56_L 1.586 1.00
33_F 216_V 1.576 1.00
109_K 113_A 1.555 1.00
223_Y 261_E 1.549 1.00
244_L 253_T 1.541 1.00
92_S 95_D 1.52 1.00
106_V 110_Q 1.512 1.00
20_V 46_C 1.51 1.00
106_V 111_R 1.505 1.00
68_A 71_L 1.5 1.00
97_V 119_L 1.489 1.00
116_Q 128_H 1.487 1.00
41_S 208_F 1.481 1.00
100_G 151_N 1.455 1.00
7_F 25_I 1.449 1.00
62_S 65_G 1.439 1.00
229_P 240_V 1.436 1.00
238_S 257_A 1.435 1.00
114_M 117_E 1.434 1.00
72_P 75_E 1.417 1.00
33_F 204_R 1.415 1.00
12_R 57_S 1.409 1.00
110_Q 114_M 1.404 0.99
23_V 46_C 1.404 0.99
117_E 152_E 1.397 0.99
243_G 254_G 1.379 0.99
242_D 253_T 1.364 0.99
181_Q 186_I 1.345 0.99
67_P 70_N 1.335 0.99
221_D 225_R 1.33 0.99
118_A 149_L 1.327 0.99
25_I 206_A 1.323 0.99
6_E 65_G 1.32 0.99
92_S 131_K 1.317 0.99
291_L 323_V 1.308 0.99
28_K 204_R 1.305 0.99
286_A 302_S 1.295 0.99
233_G 240_V 1.289 0.99
60_A 69_S 1.289 0.99
117_E 120_E 1.286 0.99
162_L 177_L 1.265 0.99
262_H 329_V 1.259 0.99
7_F 46_C 1.253 0.99
102_M 108_K 1.252 0.99
25_I 216_V 1.25 0.99
20_V 23_V 1.248 0.99
13_L 58_G 1.246 0.98
56_L 61_I 1.245 0.98
79_N 151_N 1.238 0.98
240_V 255_S 1.233 0.98
181_Q 188_F 1.226 0.98
209_N 230_F 1.217 0.98
215_Q 231_V 1.216 0.98
116_Q 120_E 1.216 0.98
220_R 224_M 1.215 0.98
56_L 69_S 1.211 0.98
99_Y 103_V 1.194 0.98
264_R 324_S 1.187 0.98
162_L 190_F 1.187 0.98
32_F 181_Q 1.187 0.98
13_L 19_A 1.186 0.98
152_E 183_S 1.182 0.98
178_K 201_M 1.176 0.98
108_K 112_H 1.17 0.97
116_Q 125_G 1.164 0.97
280_V 289_F 1.163 0.97
32_F 201_M 1.162 0.97
11_S 21_D 1.162 0.97
204_R 216_V 1.155 0.97
35_M 206_A 1.145 0.97
217_D 222_L 1.131 0.97
277_I 289_F 1.128 0.97
10_V 56_L 1.119 0.96
242_D 255_S 1.102 0.96
10_V 49_L 1.077 0.95
9_N 58_G 1.07 0.95
85_Y 164_A 1.07 0.95
95_D 98_A 1.061 0.95
266_N 322_M 1.058 0.95
263_I 325_W 1.055 0.95
88_F 151_N 1.051 0.94
224_M 282_Y 1.05 0.94
71_L 75_E 1.049 0.94
119_L 124_L 1.041 0.94
97_V 115_A 1.036 0.94
123_A 176_E 1.035 0.94
326_S 329_V 1.03 0.94
192_T 198_A 1.023 0.93
117_E 183_S 1.02 0.93
8_D 24_S 1.016 0.93
46_C 208_F 1.016 0.93
275_G 321_V 1.01 0.93
29_D 64_F 1.01 0.93
158_L 190_F 1.009 0.93
32_F 188_F 1.006 0.93
195_Q 234_F 1.005 0.93
79_N 188_F 1.003 0.93
97_V 118_A 1.003 0.93
258_L 263_I 1.001 0.92
225_R 331_V 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2it1A20.97631000.175Contact Map0.871
1oxxK10.97331000.175Contact Map0.738
1v43A10.97631000.176Contact Map0.85
3rlfA20.97921000.187Contact Map0.828
1g29120.97631000.192Contact Map0.877
3fvqA20.97921000.193Contact Map0.746
2yyzA10.97631000.195Contact Map0.785
3d31A20.95851000.199Contact Map0.739
1z47A20.97331000.22Contact Map0.84
3gd7A40.94361000.286Contact Map0.708

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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