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ATOC - Acetoacetate metabolism regulatory protein AtoC
UniProt: Q06065 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11668
Length: 461 (453)
Sequences: 5474
Seq/Len: 12.08

ATOC
Paralog alert: 0.75 [within 20: 0.18] - ratio of genomes with paralogs
Cluster includes: ATOC DHAR FHLA GLRR HYFR NORR NTRC PRPR PSPF RTCR TYRR YGEV ZRAR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
292_M 297_T 4.011 1.00
218_E 228_L 3.961 1.00
174_E 317_R 3.804 1.00
429_Q 439_M 3.305 1.00
203_A 255_A 3.239 1.00
232_L 267_E 3.151 1.00
234_E 268_R 3.103 1.00
291_A 295_E 3.054 1.00
288_D 291_A 2.84 1.00
159_T 182_I 2.804 1.00
32_H 49_P 2.742 1.00
266_F 277_V 2.599 1.00
265_E 274_T 2.522 1.00
265_E 276_K 2.51 1.00
207_E 252_V 2.493 1.00
62_D 65_K 2.479 1.00
333_K 366_S 2.428 1.00
345_I 369_I 2.402 1.00
421_I 425_V 2.385 1.00
429_Q 436_T 2.377 1.00
435_R 438_L 2.34 1.00
287_R 292_M 2.334 1.00
324_S 350_M 2.32 1.00
36_N 39_T 2.319 1.00
233_F 260_I 2.315 1.00
17_R 35_N 2.237 1.00
37_G 61_M 2.227 1.00
419_K 423_M 2.225 1.00
327_A 345_I 2.214 1.00
242_L 284_A 2.205 1.00
346_D 382_F 2.195 1.00
218_E 271_G 2.125 1.00
10_V 40_A 2.112 1.00
261_L 281_I 2.089 1.00
8_L 34_A 2.084 1.00
358_W 368_V 2.069 1.00
218_E 268_R 2.057 1.00
262_Q 366_S 2.05 1.00
324_S 354_T 2.045 1.00
291_A 294_K 2.024 1.00
17_R 33_C 2.023 1.00
267_E 274_T 1.992 1.00
292_M 295_E 1.956 1.00
248_E 287_R 1.907 1.00
100_F 119_A 1.903 1.00
182_I 313_L 1.884 1.00
428_Q 439_M 1.875 1.00
161_K 377_S 1.845 1.00
35_N 39_T 1.842 1.00
68_K 97_C 1.811 1.00
129_I 132_L 1.801 1.00
155_I 311_L 1.791 1.00
260_I 266_F 1.79 1.00
237_N 277_V 1.756 1.00
192_R 278_D 1.751 1.00
356_W 359_P 1.751 1.00
172_S 312_I 1.75 1.00
229_R 272_H 1.716 1.00
346_D 349_A 1.691 1.00
418_E 450_K 1.682 1.00
177_T 313_L 1.682 1.00
237_N 278_D 1.678 1.00
283_A 306_L 1.677 1.00
180_E 259_R 1.668 1.00
238_E 278_D 1.668 1.00
38_R 60_E 1.661 1.00
320_R 357_S 1.65 1.00
381_I 386_L 1.646 1.00
425_V 429_Q 1.634 1.00
51_V 116_V 1.623 1.00
148_N 325_L 1.61 1.00
349_A 353_L 1.603 1.00
69_E 72_S 1.587 1.00
217_H 222_F 1.581 1.00
6_R 30_E 1.58 1.00
128_E 133_H 1.579 1.00
21_S 33_C 1.571 1.00
271_G 275_I 1.569 1.00
149_S 321_E 1.567 1.00
329_H 333_K 1.566 1.00
247_G 285_T 1.56 1.00
348_M 383_S 1.552 1.00
155_I 313_L 1.53 1.00
445_R 449_Y 1.525 1.00
320_R 324_S 1.525 1.00
54_M 66_A 1.523 1.00
350_M 354_T 1.52 1.00
312_I 318_D 1.513 1.00
53_L 116_V 1.511 1.00
327_A 369_I 1.511 1.00
289_L 298_F 1.499 1.00
248_E 286_N 1.499 1.00
328_N 350_M 1.499 1.00
211_E 256_K 1.49 1.00
58_M 61_M 1.47 1.00
128_E 132_L 1.454 1.00
44_F 70_M 1.45 1.00
425_V 440_L 1.44 1.00
326_L 330_F 1.436 1.00
349_A 383_S 1.434 1.00
160_A 189_N 1.431 1.00
233_F 241_L 1.428 1.00
210_L 253_L 1.427 1.00
172_S 310_H 1.426 1.00
52_V 70_M 1.421 1.00
425_V 439_M 1.42 1.00
344_D 380_I 1.41 1.00
152_M 156_C 1.406 0.99
156_C 159_T 1.406 0.99
217_H 221_A 1.401 0.99
230_Q 234_E 1.397 0.99
80_I 115_I 1.392 0.99
54_M 81_L 1.387 0.99
446_A 450_K 1.386 0.99
45_A 73_H 1.386 0.99
32_H 43_L 1.377 0.99
422_I 447_L 1.374 0.99
356_W 364_E 1.37 0.99
41_L 69_E 1.368 0.99
334_F 373_V 1.362 0.99
167_A 370_E 1.362 0.99
320_R 323_I 1.361 0.99
21_S 25_A 1.36 0.99
34_A 40_A 1.359 0.99
167_A 338_N 1.356 0.99
34_A 43_L 1.35 0.99
349_A 381_I 1.34 0.99
434_T 438_L 1.338 0.99
174_E 315_P 1.336 0.99
74_E 77_T 1.326 0.99
36_N 60_E 1.325 0.99
147_T 156_C 1.315 0.99
281_I 306_L 1.308 0.99
88_V 92_V 1.303 0.99
443_S 446_A 1.301 0.99
7_I 29_F 1.299 0.99
69_E 73_H 1.294 0.99
266_F 276_K 1.291 0.99
217_H 269_I 1.29 0.99
331_L 373_V 1.288 0.99
154_D 157_K 1.278 0.99
268_R 271_G 1.274 0.99
449_Y 453_E 1.272 0.99
423_M 427_E 1.272 0.99
337_E 370_E 1.26 0.99
195_G 238_E 1.258 0.99
436_T 439_M 1.254 0.99
331_L 345_I 1.252 0.99
432_N 444_R 1.252 0.99
207_E 250_P 1.247 0.99
171_I 282_I 1.246 0.98
70_M 79_V 1.245 0.98
345_I 350_M 1.244 0.98
157_K 160_A 1.243 0.98
324_S 327_A 1.241 0.98
330_F 334_F 1.24 0.98
147_T 152_M 1.239 0.98
222_F 225_A 1.237 0.98
432_N 435_R 1.237 0.98
352_L 383_S 1.236 0.98
433_R 448_M 1.235 0.98
145_I 182_I 1.233 0.98
382_F 385_D 1.228 0.98
11_D 58_M 1.212 0.98
159_T 185_A 1.209 0.98
27_Q 113_N 1.208 0.98
43_L 49_P 1.205 0.98
434_T 444_R 1.201 0.98
371_R 375_M 1.187 0.98
415_K 453_E 1.187 0.98
445_R 448_M 1.184 0.98
9_I 31_T 1.18 0.98
443_S 449_Y 1.18 0.98
147_T 159_T 1.179 0.98
346_D 380_I 1.173 0.98
234_E 275_I 1.163 0.97
147_T 182_I 1.162 0.97
37_G 58_M 1.16 0.97
162_I 309_I 1.158 0.97
422_I 440_L 1.146 0.97
241_L 281_I 1.146 0.97
321_E 354_T 1.144 0.97
155_I 182_I 1.143 0.97
52_V 77_T 1.142 0.97
213_E 229_R 1.141 0.97
212_S 217_H 1.134 0.97
233_F 279_I 1.125 0.97
166_Q 192_R 1.123 0.97
57_R 85_Y 1.122 0.97
424_E 428_Q 1.121 0.97
268_R 275_I 1.12 0.96
264_R 276_K 1.116 0.96
64_I 94_A 1.113 0.96
147_T 325_L 1.112 0.96
37_G 66_A 1.111 0.96
53_L 112_L 1.11 0.96
330_F 369_I 1.109 0.96
23_A 109_L 1.108 0.96
90_T 102_Y 1.106 0.96
185_A 189_N 1.098 0.96
67_L 81_L 1.098 0.96
294_K 300_E 1.096 0.96
145_I 181_L 1.093 0.96
145_I 156_C 1.091 0.96
125_M 129_I 1.091 0.96
210_L 214_L 1.09 0.96
41_L 61_M 1.081 0.95
320_R 354_T 1.078 0.95
417_V 421_I 1.075 0.95
67_L 79_V 1.074 0.95
170_L 283_A 1.073 0.95
159_T 186_I 1.073 0.95
11_D 17_R 1.072 0.95
247_G 289_L 1.071 0.95
447_L 450_K 1.069 0.95
433_R 451_L 1.069 0.95
37_G 41_L 1.067 0.95
158_D 375_M 1.066 0.95
290_Q 294_K 1.064 0.95
323_I 353_L 1.058 0.95
328_N 332_Q 1.056 0.95
221_A 269_I 1.054 0.95
93_E 97_C 1.051 0.94
334_F 369_I 1.051 0.94
10_V 66_A 1.05 0.94
171_I 182_I 1.049 0.94
351_S 355_A 1.048 0.94
54_M 79_V 1.044 0.94
201_N 249_M 1.04 0.94
180_E 199_K 1.04 0.94
6_R 32_H 1.039 0.94
12_D 105_K 1.039 0.94
421_I 440_L 1.036 0.94
51_V 120_L 1.032 0.94
234_E 266_F 1.029 0.94
32_H 47_I 1.026 0.94
376_N 385_D 1.023 0.93
146_L 329_H 1.019 0.93
201_N 248_E 1.014 0.93
435_R 439_M 1.011 0.93
235_R 271_G 1.009 0.93
210_L 249_M 1.004 0.93
212_S 222_F 1.003 0.93
442_I 446_A 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4l4uA10.95881000.114Contact Map0.73
1ny5A20.83951000.242Contact Map0.79
3dzdA20.79831000.284Contact Map0.778
1ojlA60.65941000.447Contact Map0.766
4fwgA10.90891000.652Contact Map0.368
1r6bX10.8721000.665Contact Map0.344
2bjvA10.57271000.672Contact Map0.667
1qvrA30.85681000.683Contact Map0.309
1hqcA20.59871000.708Contact Map0.475
3pxiA30.83511000.712Contact Map0.378

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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