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ATOS - Signal transduction histidine-protein kinase AtoS
UniProt: Q06067 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11667
Length: 608 (594)
Sequences: 1152
Seq/Len: 1.94

ATOS
Paralog alert: 0.44 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: ATOS BAES BASS CPXA CREC CUSS DCUS DPIB ENVZ GLRK NTRB PHOQ PHOR QSEC RSTB YEDV ZRAS
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
279_D 283_D 3.378 1.00
539_D 543_G 3.286 1.00
90_E 93_T 3.108 1.00
572_Q 576_N 2.991 1.00
503_V 574_I 2.925 1.00
584_V 594_F 2.897 1.00
586_S 592_A 2.643 1.00
574_I 578_H 2.639 1.00
305_Q 309_M 2.438 1.00
538_E 593_T 2.346 1.00
553_F 582_I 2.337 1.00
553_F 594_F 2.326 1.00
85_L 114_Y 2.272 1.00
551_K 554_D 2.219 1.00
290_A 293_V 2.206 1.00
553_F 584_V 2.185 1.00
227_T 231_N 2.16 0.99
460_L 535_I 2.073 0.99
575_I 582_I 1.96 0.99
411_V 430_V 1.954 0.99
586_S 589_G 1.878 0.98
469_V 523_I 1.871 0.98
402_N 514_A 1.85 0.98
549_Q 586_S 1.809 0.97
544_I 552_I 1.788 0.97
571_S 582_I 1.772 0.97
522_R 538_E 1.759 0.97
475_G 521_I 1.756 0.97
159_M 173_W 1.678 0.96
543_G 591_G 1.671 0.95
107_M 111_I 1.652 0.95
503_V 578_H 1.648 0.95
408_R 435_D 1.647 0.95
507_I 537_I 1.64 0.95
11_R 14_N 1.64 0.95
287_M 302_L 1.635 0.95
152_R 157_N 1.618 0.94
276_I 291_A 1.61 0.94
586_S 590_Y 1.571 0.93
306_P 309_M 1.568 0.93
392_L 402_N 1.552 0.92
62_L 85_L 1.549 0.92
539_D 591_G 1.547 0.92
284_V 310_L 1.541 0.92
520_K 540_N 1.527 0.92
535_I 596_L 1.526 0.92
514_A 558_T 1.52 0.91
483_I 520_K 1.505 0.91
412_Q 555_P 1.502 0.91
475_G 482_F 1.499 0.91
123_N 126_V 1.482 0.90
395_G 402_N 1.463 0.89
461_N 525_T 1.457 0.89
513_Q 560_K 1.455 0.89
52_S 158_S 1.436 0.88
392_L 397_A 1.43 0.88
397_A 514_A 1.428 0.88
485_E 524_Q 1.425 0.87
400_V 440_V 1.391 0.86
544_I 594_F 1.382 0.85
163_E 168_I 1.368 0.84
265_D 276_I 1.367 0.84
112_I 152_R 1.366 0.84
128_I 159_M 1.366 0.84
400_V 403_P 1.364 0.84
506_N 565_G 1.361 0.84
413_I 558_T 1.359 0.84
246_I 253_L 1.357 0.84
377_Q 381_A 1.353 0.83
402_N 559_T 1.35 0.83
112_I 150_Q 1.345 0.83
545_D 548_L 1.344 0.83
115_A 157_N 1.342 0.83
397_A 400_V 1.339 0.83
508_L 523_I 1.338 0.83
112_I 115_A 1.332 0.82
289_P 293_V 1.331 0.82
395_G 514_A 1.31 0.81
515_I 540_N 1.309 0.81
536_S 593_T 1.308 0.81
484_S 488_N 1.293 0.79
13_R 212_R 1.291 0.79
514_A 559_T 1.282 0.79
348_V 365_V 1.28 0.79
232_I 257_L 1.279 0.78
544_I 548_L 1.278 0.78
393_M 405_T 1.274 0.78
15_Q 31_I 1.27 0.78
296_G 563_G 1.269 0.78
474_A 478_A 1.266 0.77
148_G 152_R 1.264 0.77
12_L 43_V 1.263 0.77
311_F 327_G 1.262 0.77
402_N 558_T 1.261 0.77
513_Q 559_T 1.261 0.77
152_R 155_I 1.257 0.77
548_L 551_K 1.256 0.77
16_M 27_P 1.249 0.76
276_I 284_V 1.248 0.76
480_V 515_I 1.247 0.76
381_A 384_E 1.245 0.76
195_V 243_M 1.244 0.76
112_I 116_P 1.243 0.76
556_F 564_T 1.239 0.75
407_I 411_V 1.239 0.75
56_N 143_P 1.232 0.75
253_L 507_I 1.228 0.74
515_I 521_I 1.226 0.74
399_E 506_N 1.225 0.74
276_I 307_Y 1.223 0.74
471_V 505_L 1.223 0.74
46_E 207_I 1.222 0.74
393_M 396_V 1.22 0.74
481_D 520_K 1.217 0.73
117_S 123_N 1.217 0.73
480_V 521_I 1.216 0.73
115_A 152_R 1.215 0.73
394_A 400_V 1.213 0.73
271_A 275_V 1.213 0.73
568_L 594_F 1.211 0.73
23_M 270_N 1.21 0.73
503_V 575_I 1.209 0.73
402_N 443_Q 1.197 0.72
392_L 514_A 1.197 0.72
24_V 563_G 1.196 0.72
439_K 498_E 1.194 0.71
66_Y 162_I 1.193 0.71
549_Q 552_I 1.187 0.71
553_F 568_L 1.185 0.71
554_D 576_N 1.185 0.71
397_A 402_N 1.184 0.70
400_V 570_L 1.183 0.70
287_M 292_E 1.182 0.70
504_L 537_I 1.174 0.70
233_P 258_R 1.174 0.70
316_F 537_I 1.174 0.70
546_L 549_Q 1.169 0.69
527_Q 600_I 1.169 0.69
115_A 150_Q 1.166 0.69
513_Q 564_T 1.161 0.68
443_Q 448_S 1.161 0.68
536_S 595_T 1.16 0.68
527_Q 530_D 1.154 0.68
80_A 83_A 1.151 0.67
402_N 513_Q 1.15 0.67
112_I 157_N 1.146 0.67
575_I 596_L 1.144 0.67
460_L 504_L 1.144 0.67
231_N 235_R 1.141 0.66
587_L 590_Y 1.14 0.66
161_P 170_G 1.14 0.66
565_G 568_L 1.139 0.66
575_I 580_G 1.138 0.66
392_L 558_T 1.138 0.66
512_V 515_I 1.137 0.66
246_I 250_V 1.137 0.66
241_G 244_G 1.136 0.66
544_I 549_Q 1.135 0.66
227_T 234_T 1.133 0.66
277_A 362_G 1.132 0.65
260_T 267_I 1.13 0.65
58_L 172_I 1.13 0.65
510_N 539_D 1.129 0.65
395_G 513_Q 1.126 0.65
225_L 402_N 1.126 0.65
11_R 33_Y 1.126 0.65
534_A 597_I 1.126 0.65
464_V 523_I 1.126 0.65
228_L 534_A 1.125 0.65
392_L 443_Q 1.123 0.65
11_R 15_Q 1.12 0.64
225_L 558_T 1.12 0.64
10_R 14_N 1.12 0.64
511_A 521_I 1.118 0.64
402_N 451_R 1.116 0.64
242_E 246_I 1.116 0.64
397_A 566_L 1.114 0.64
458_V 495_A 1.114 0.64
218_I 246_I 1.113 0.64
499_L 578_H 1.113 0.64
362_G 367_F 1.111 0.63
390_G 397_A 1.11 0.63
390_G 395_G 1.11 0.63
506_N 511_A 1.108 0.63
24_V 203_S 1.107 0.63
394_A 502_Q 1.107 0.63
400_V 433_E 1.106 0.63
552_I 594_F 1.105 0.63
491_S 533_Q 1.103 0.63
155_I 175_N 1.099 0.62
108_L 168_I 1.097 0.62
392_L 395_G 1.096 0.62
59_N 112_I 1.095 0.62
389_L 397_A 1.095 0.62
143_P 160_L 1.094 0.62
553_F 563_G 1.093 0.61
115_A 153_G 1.092 0.61
506_N 510_N 1.092 0.61
129_A 132_H 1.091 0.61
502_Q 570_L 1.088 0.61
205_L 218_I 1.088 0.61
407_I 430_V 1.086 0.61
235_R 251_N 1.084 0.61
282_G 545_D 1.083 0.60
27_P 31_I 1.081 0.60
496_D 574_I 1.081 0.60
115_A 175_N 1.08 0.60
559_T 572_Q 1.078 0.60
382_Q 433_E 1.078 0.60
11_R 21_I 1.078 0.60
101_A 176_E 1.077 0.60
304_G 346_L 1.076 0.60
510_N 541_G 1.075 0.60
539_D 567_G 1.073 0.59
394_A 399_E 1.072 0.59
392_L 401_R 1.071 0.59
329_E 352_R 1.07 0.59
150_Q 157_N 1.068 0.59
157_N 175_N 1.068 0.59
404_L 407_I 1.066 0.59
385_R 403_P 1.063 0.58
513_Q 558_T 1.061 0.58
265_D 284_V 1.061 0.58
130_A 151_V 1.059 0.58
15_Q 241_G 1.059 0.58
472_Q 509_I 1.058 0.58
167_E 537_I 1.058 0.58
510_N 567_G 1.056 0.58
504_L 535_I 1.055 0.57
217_N 241_G 1.055 0.57
511_A 592_A 1.054 0.57
278_I 310_L 1.053 0.57
393_M 570_L 1.05 0.57
200_L 435_D 1.048 0.57
405_T 445_L 1.047 0.57
196_L 364_L 1.046 0.56
402_N 509_I 1.046 0.56
274_G 367_F 1.046 0.56
36_E 193_I 1.045 0.56
511_A 565_G 1.044 0.56
496_D 499_L 1.044 0.56
397_A 401_R 1.043 0.56
470_L 514_A 1.041 0.56
402_N 437_I 1.04 0.56
394_A 505_L 1.038 0.56
393_M 410_Y 1.037 0.55
207_I 211_S 1.034 0.55
284_V 526_W 1.034 0.55
580_G 598_L 1.034 0.55
566_L 570_L 1.032 0.55
297_Y 302_L 1.032 0.55
460_L 595_T 1.031 0.55
397_A 572_Q 1.031 0.55
582_I 596_L 1.03 0.55
282_G 433_E 1.03 0.55
544_I 553_F 1.028 0.54
220_I 234_T 1.028 0.54
566_L 573_R 1.023 0.54
513_Q 542_C 1.023 0.54
239_L 244_G 1.021 0.54
91_N 181_I 1.019 0.53
558_T 564_T 1.017 0.53
20_A 23_M 1.016 0.53
394_A 403_P 1.016 0.53
272_A 349_T 1.016 0.53
286_T 444_L 1.015 0.53
59_N 175_N 1.014 0.53
231_N 234_T 1.014 0.53
137_V 141_N 1.013 0.53
511_A 568_L 1.013 0.53
405_T 410_Y 1.012 0.53
386_L 397_A 1.011 0.53
219_D 227_T 1.011 0.53
203_S 207_I 1.01 0.52
391_E 555_P 1.01 0.52
235_R 255_Q 1.01 0.52
504_L 531_S 1.01 0.52
390_G 514_A 1.009 0.52
386_L 395_G 1.008 0.52
397_A 437_I 1.007 0.52
327_G 360_M 1.007 0.52
26_V 45_S 1.006 0.52
275_V 366_I 1.006 0.52
268_I 368_S 1.006 0.52
43_V 182_R 1.005 0.52
426_Y 573_R 1.005 0.52
555_P 566_L 1.004 0.52
390_G 402_N 1.004 0.52
507_I 594_F 1.002 0.52
539_D 565_G 1.002 0.52
395_G 555_P 1.001 0.52
510_N 565_G 1.001 0.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4i5sA20.68421000.494Contact Map0.536
4gczA20.58721000.531Contact Map0.475
3a0rA10.56741000.532Contact Map0.383
3d36A20.37831000.672Contact Map0.437
4ew8A20.41281000.676Contact Map0.489
2c2aA10.39141000.679Contact Map0.494
3jz3A20.3521000.679Contact Map0.554
4e01A10.60031000.681Contact Map0.405
2btzA10.51000.682Contact Map0.388
2q8gA10.50991000.687Contact Map0.385

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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