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YGEW - Uncharacterized protein YgeW
UniProt: Q46803 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13053
Length: 396 (349)
Sequences: 1530
Seq/Len: 4.38

YGEW
Paralog alert: 0.50 [within 20: 0.15] - ratio of genomes with paralogs
Cluster includes: OTC1 OTC2 PYRB YGEW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
190_K 221_D 4.024 1.00
256_S 259_E 3.759 1.00
56_K 59_N 3.578 1.00
225_A 260_A 3.548 1.00
234_P 238_E 3.446 1.00
258_E 319_L 3.355 1.00
326_L 356_A 2.995 1.00
314_E 348_G 2.985 1.00
114_F 359_K 2.808 1.00
327_Y 345_V 2.782 1.00
192_A 264_A 2.779 1.00
228_E 255_T 2.672 1.00
82_L 87_L 2.587 1.00
328_M 356_A 2.554 1.00
176_L 266_I 2.485 1.00
315_E 318_E 2.435 1.00
242_N 245_K 2.417 1.00
43_A 174_A 2.413 1.00
173_L 218_F 2.412 1.00
190_K 223_T 2.291 1.00
314_E 318_E 2.281 1.00
173_L 214_L 2.273 1.00
317_M 354_R 2.26 1.00
221_D 252_R 2.161 1.00
243_N 247_S 2.137 1.00
43_A 177_R 2.11 1.00
267_V 312_C 2.021 1.00
179_H 356_A 2.006 1.00
46_K 178_E 1.972 1.00
317_M 325_A 1.971 1.00
169_S 214_L 1.929 1.00
238_E 241_K 1.906 1.00
226_H 231_D 1.901 1.00
36_K 177_R 1.897 1.00
325_A 354_R 1.892 1.00
40_D 177_R 1.855 1.00
26_L 164_D 1.854 1.00
221_D 250_S 1.851 1.00
22_K 34_E 1.773 1.00
257_M 316_M 1.769 1.00
237_V 253_Q 1.763 1.00
267_V 325_A 1.724 0.99
265_D 322_D 1.722 0.99
118_A 157_V 1.695 0.99
266_I 326_L 1.691 0.99
114_F 362_S 1.675 0.99
192_A 225_A 1.657 0.99
211_I 268_Y 1.649 0.99
311_H 346_T 1.634 0.99
179_H 359_K 1.629 0.99
241_K 245_K 1.62 0.99
180_F 324_E 1.602 0.99
83_N 88_A 1.6 0.99
32_P 247_S 1.599 0.99
314_E 354_R 1.576 0.99
180_F 189_K 1.56 0.99
238_E 242_N 1.559 0.99
215_M 222_V 1.539 0.98
236_V 240_A 1.514 0.98
44_A 48_L 1.513 0.98
64_I 116_A 1.497 0.98
181_G 188_G 1.484 0.98
314_E 317_M 1.477 0.98
111_M 361_A 1.471 0.98
225_A 264_A 1.441 0.97
269_P 312_C 1.422 0.97
258_E 316_M 1.421 0.97
254_V 260_A 1.42 0.97
271_S 333_A 1.419 0.97
239_V 242_N 1.411 0.97
259_E 262_K 1.386 0.96
35_L 217_R 1.382 0.96
47_A 51_E 1.375 0.96
93_D 96_K 1.366 0.96
320_T 325_A 1.365 0.96
75_R 79_A 1.363 0.96
77_S 115_C 1.357 0.96
32_P 187_K 1.357 0.96
110_N 351_E 1.356 0.96
178_E 363_W 1.354 0.96
267_V 317_M 1.353 0.96
314_E 352_K 1.347 0.95
190_K 263_D 1.345 0.95
106_R 351_E 1.341 0.95
191_I 215_M 1.327 0.95
39_L 367_I 1.318 0.95
46_K 363_W 1.312 0.95
28_W 239_V 1.305 0.94
234_P 241_K 1.303 0.94
192_A 223_T 1.299 0.94
106_R 110_N 1.294 0.94
24_F 170_M 1.279 0.94
63_G 82_L 1.279 0.94
24_F 30_Q 1.27 0.93
39_L 170_M 1.265 0.93
32_P 36_K 1.264 0.93
42_A 170_M 1.257 0.93
167_T 368_I 1.248 0.92
182_S 187_K 1.247 0.92
228_E 231_D 1.233 0.92
37_Q 374_S 1.233 0.92
43_A 178_E 1.23 0.92
130_G 133_Y 1.206 0.91
230_Y 306_Q 1.203 0.90
27_T 35_L 1.197 0.90
263_D 321_R 1.193 0.90
151_P 155_A 1.185 0.90
70_N 98_Q 1.181 0.89
32_P 217_R 1.172 0.89
72_T 108_T 1.17 0.89
119_I 154_P 1.168 0.89
69_D 160_Q 1.167 0.89
362_S 366_Y 1.163 0.88
54_S 85_L 1.156 0.88
28_W 243_N 1.155 0.88
215_M 224_L 1.144 0.87
66_V 99_I 1.14 0.87
38_V 374_S 1.134 0.87
305_A 308_K 1.133 0.87
182_S 189_K 1.132 0.87
157_V 371_M 1.13 0.86
301_L 305_A 1.115 0.85
26_L 213_G 1.109 0.85
31_T 34_E 1.098 0.84
192_A 260_A 1.078 0.83
36_K 218_F 1.076 0.83
113_S 149_V 1.075 0.82
231_D 255_T 1.073 0.82
225_A 257_M 1.069 0.82
48_L 53_I 1.067 0.82
265_D 321_R 1.063 0.81
231_D 253_Q 1.052 0.81
337_G 341_K 1.05 0.80
214_L 218_F 1.041 0.80
223_T 252_R 1.03 0.79
57_V 373_L 1.028 0.78
39_L 218_F 1.025 0.78
120_G 159_L 1.013 0.77
39_L 177_R 1.009 0.77
237_V 241_K 1.008 0.76
260_A 316_M 1.007 0.76
180_F 356_A 1.006 0.76
241_K 315_E 1.005 0.76
89_Q 97_S 1.002 0.76
312_C 327_Y 1.002 0.76
176_L 189_K 1.001 0.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3q98A111000.167Contact Map0.591
2yfkA20.99751000.191Contact Map0.613
1pvvA10.79551000.252Contact Map0.726
1duvG30.8031000.256Contact Map0.793
2i6uA30.77531000.259Contact Map0.713
1dxhA10.81311000.259Contact Map0.756
4amuA40.84091000.262Contact Map0.794
4h31A30.84341000.262Contact Map0.789
1vlvA10.81821000.263Contact Map0.664
2w37A30.8511000.265Contact Map0.762

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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