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ARCL - Carbamate kinase-like protein YqeA
UniProt: Q46807 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13057
Length: 310 (308)
Sequences: 629
Seq/Len: 2.04

ARCL
Paralog alert: 0.46 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: ARCC ARCL ARCM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
256_E 281_R 5.093 1.00
135_E 139_E 4.898 1.00
238_N 243_N 3.446 1.00
250_L 255_A 3.425 1.00
37_A 100_R 2.856 1.00
4_K 41_E 2.816 1.00
236_A 246_W 2.745 1.00
32_I 42_V 2.729 1.00
257_R 261_E 2.6 1.00
134_T 137_E 2.6 1.00
234_K 248_D 2.519 1.00
75_S 205_S 2.48 1.00
45_T 214_S 2.264 1.00
55_I 81_S 2.238 1.00
135_E 156_Y 2.193 1.00
247_L 250_L 2.133 0.99
34_D 100_R 2.094 0.99
280_A 288_A 2.07 0.99
259_I 270_L 2.008 0.99
295_K 298_E 1.922 0.99
187_V 217_L 1.895 0.98
7_L 32_I 1.837 0.98
146_Y 158_R 1.83 0.98
140_Q 143_K 1.826 0.98
256_E 260_E 1.801 0.98
234_K 246_W 1.795 0.98
238_N 263_H 1.752 0.97
245_Q 254_D 1.75 0.97
291_T 299_G 1.727 0.97
30_Q 96_E 1.723 0.97
124_N 149_K 1.718 0.97
287_E 307_V 1.714 0.97
90_Q 108_T 1.698 0.96
255_A 308_I 1.693 0.96
251_S 254_D 1.692 0.96
33_V 93_L 1.688 0.96
237_I 245_Q 1.684 0.96
298_E 303_K 1.681 0.96
249_R 309_C 1.679 0.96
229_L 296_A 1.668 0.96
132_F 154_R 1.664 0.96
114_E 167_D 1.661 0.96
164_K 278_S 1.657 0.96
215_A 219_E 1.65 0.95
227_I 296_A 1.646 0.95
238_N 241_K 1.618 0.95
273_V 288_A 1.61 0.95
222_D 286_R 1.605 0.94
254_D 257_R 1.602 0.94
216_R 220_M 1.586 0.94
237_I 263_H 1.566 0.93
74_M 78_V 1.542 0.93
139_E 142_T 1.524 0.92
234_K 304_T 1.508 0.92
175_K 179_D 1.506 0.92
233_E 236_A 1.448 0.89
76_V 88_D 1.425 0.88
9_L 13_A 1.421 0.88
197_E 202_R 1.407 0.87
176_A 180_A 1.402 0.87
133_F 141_L 1.399 0.87
57_Q 133_F 1.399 0.87
187_V 213_A 1.381 0.86
54_M 58_A 1.373 0.86
58_A 84_Y 1.368 0.85
150_E 154_R 1.345 0.84
173_T 182_Q 1.342 0.84
167_D 171_K 1.328 0.83
90_Q 112_Q 1.304 0.81
18_L 76_V 1.298 0.81
18_L 88_D 1.296 0.81
15_G 20_G 1.295 0.81
128_P 149_K 1.294 0.81
139_E 156_Y 1.279 0.80
128_P 265_A 1.276 0.79
58_A 80_L 1.27 0.79
265_A 270_L 1.268 0.79
34_D 297_K 1.267 0.79
59_F 80_L 1.264 0.79
256_E 274_E 1.253 0.78
164_K 274_E 1.253 0.78
258_F 261_E 1.25 0.78
233_E 304_T 1.241 0.77
133_F 148_L 1.237 0.76
96_E 100_R 1.232 0.76
283_R 286_R 1.205 0.74
34_D 37_A 1.204 0.74
112_Q 201_L 1.2 0.73
18_L 58_A 1.198 0.73
167_D 196_R 1.197 0.73
132_F 152_A 1.19 0.72
215_A 278_S 1.188 0.72
54_M 59_F 1.181 0.72
43_I 221_I 1.176 0.71
225_M 289_L 1.175 0.71
121_A 129_I 1.164 0.70
168_I 217_L 1.164 0.70
96_E 99_S 1.158 0.70
13_A 229_L 1.157 0.69
99_S 199_N 1.157 0.69
43_I 178_V 1.155 0.69
18_L 75_S 1.153 0.69
276_A 280_A 1.152 0.69
5_I 293_L 1.151 0.69
97_L 106_V 1.149 0.69
280_A 283_R 1.143 0.68
38_Q 301_E 1.143 0.68
174_V 187_V 1.139 0.68
238_N 245_Q 1.137 0.68
289_L 299_G 1.135 0.67
114_E 169_I 1.133 0.67
227_I 289_L 1.131 0.67
266_K 270_L 1.129 0.67
15_G 54_M 1.123 0.66
132_F 150_E 1.117 0.65
54_M 84_Y 1.116 0.65
129_I 233_E 1.115 0.65
235_V 290_I 1.114 0.65
80_L 84_Y 1.113 0.65
219_E 278_S 1.108 0.65
112_Q 169_I 1.106 0.64
7_L 278_S 1.104 0.64
291_T 304_T 1.102 0.64
9_L 293_L 1.102 0.64
212_W 274_E 1.096 0.63
216_R 219_E 1.095 0.63
69_S 88_D 1.094 0.63
55_I 77_C 1.09 0.63
295_K 304_T 1.089 0.63
128_P 132_F 1.086 0.62
29_S 92_A 1.078 0.61
167_D 220_M 1.074 0.61
56_N 75_S 1.073 0.61
22_M 92_A 1.071 0.61
22_M 91_N 1.068 0.60
81_S 84_Y 1.066 0.60
36_I 42_V 1.059 0.59
15_G 56_N 1.057 0.59
129_I 161_A 1.047 0.58
14_L 54_M 1.041 0.57
276_A 288_A 1.041 0.57
6_V 223_A 1.033 0.57
214_S 226_L 1.022 0.55
57_Q 131_S 1.013 0.54
233_E 295_K 1.01 0.54
107_A 173_T 1.01 0.54
103_N 172_E 1.002 0.53
59_F 69_S 1 0.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1e19A20.99351000.482Contact Map0.746
2e9yA20.98711000.489Contact Map0.705
4axsA10.99681000.495Contact Map0.601
4jz8A40.98711000.497Contact Map0.744
2we5A30.98711000.507Contact Map0.699
2bufA120.81611000.716Contact Map0.539
2rd5A20.83231000.718Contact Map0.481
3l86A10.77741000.719Contact Map0.431
2ap9A60.81941000.722Contact Map0.433
2btyA30.80971000.723Contact Map0.55

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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