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SSNA - Protein SsnA
UniProt: Q46812 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13062
Length: 442 (423)
Sequences: 9788
Seq/Len: 23.14

SSNA
Paralog alert: 0.79 [within 20: 0.28] - ratio of genomes with paralogs
Cluster includes: ALLB CODA GUAD IADA NAGA PHNM PHYDA SSNA YAHJ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
404_M 409_M 5.043 1.00
4_L 49_M 4.863 1.00
362_L 367_Y 4.354 1.00
402_S 409_M 4.13 1.00
26_E 31_V 4.015 1.00
57_G 120_T 3.995 1.00
52_R 401_H 3.891 1.00
49_M 373_I 3.755 1.00
7_V 49_M 3.574 1.00
364_E 367_Y 3.405 1.00
32_A 365_A 3.349 1.00
336_L 339_D 3.08 1.00
55_M 374_C 3.045 1.00
23_I 54_V 3.036 1.00
5_K 46_F 2.961 1.00
368_K 406_N 2.955 1.00
3_I 24_A 2.789 1.00
54_V 373_I 2.716 1.00
363_L 371_L 2.693 1.00
55_M 372_T 2.676 1.00
25_I 371_L 2.654 1.00
251_A 279_R 2.525 1.00
371_L 404_M 2.52 1.00
6_N 48_E 2.515 1.00
339_D 342_A 2.478 1.00
28_D 368_K 2.462 1.00
23_I 363_L 2.439 1.00
45_S 412_E 2.438 1.00
306_N 350_E 2.402 1.00
2_L 404_M 2.376 1.00
5_K 22_D 2.371 1.00
216_A 219_A 2.33 1.00
29_V 368_K 2.309 1.00
403_V 411_Y 2.281 1.00
7_V 54_V 2.246 1.00
33_I 365_A 2.171 1.00
347_N 350_E 2.142 1.00
29_V 359_K 2.138 1.00
4_L 25_I 2.122 1.00
346_T 362_L 2.105 1.00
115_I 410_V 2.105 1.00
18_Q 21_V 2.085 1.00
342_A 346_T 2.077 1.00
28_D 406_N 2.073 1.00
54_V 371_L 2.049 1.00
379_P 392_A 2.038 1.00
375_D 401_H 1.998 1.00
52_R 375_D 1.993 1.00
52_R 373_I 1.964 1.00
34_G 37_L 1.913 1.00
24_A 32_A 1.903 1.00
372_T 400_V 1.888 1.00
9_A 23_I 1.887 1.00
49_M 54_V 1.872 1.00
360_F 368_K 1.848 1.00
172_E 175_R 1.837 1.00
13_H 364_E 1.836 1.00
9_A 21_V 1.805 1.00
99_D 102_S 1.801 1.00
4_L 371_L 1.8 1.00
211_E 252_Q 1.786 1.00
116_K 420_C 1.775 1.00
116_K 411_Y 1.756 1.00
359_K 368_K 1.732 1.00
104_Y 108_L 1.722 1.00
409_M 412_E 1.717 1.00
59_V 348_G 1.709 1.00
217_V 224_L 1.684 1.00
23_I 371_L 1.647 1.00
265_G 283_L 1.641 1.00
55_M 58_I 1.634 1.00
215_E 219_A 1.633 1.00
285_H 289_S 1.616 1.00
3_I 22_D 1.598 1.00
61_S 284_V 1.589 1.00
308_A 351_L 1.587 1.00
282_F 351_L 1.581 1.00
358_A 367_Y 1.566 1.00
402_S 412_E 1.564 1.00
274_T 278_Q 1.563 1.00
284_V 308_A 1.56 1.00
61_S 308_A 1.552 1.00
25_I 404_M 1.543 1.00
405_V 410_V 1.535 1.00
4_L 404_M 1.534 1.00
244_K 252_Q 1.526 1.00
31_V 365_A 1.526 1.00
2_L 25_I 1.518 1.00
211_E 215_E 1.513 1.00
271_D 274_T 1.512 1.00
2_L 45_S 1.495 1.00
174_I 219_A 1.494 1.00
108_L 145_K 1.482 1.00
356_F 360_F 1.476 1.00
270_K 303_D 1.469 1.00
236_S 240_H 1.469 1.00
350_E 357_G 1.467 1.00
373_I 404_M 1.461 1.00
21_V 33_I 1.45 1.00
24_A 44_A 1.444 1.00
149_R 406_N 1.434 1.00
308_A 347_N 1.425 1.00
55_M 341_F 1.419 1.00
61_S 348_G 1.405 0.99
212_M 215_E 1.405 0.99
342_A 347_N 1.402 0.99
346_T 350_E 1.395 0.99
24_A 31_V 1.387 0.99
341_F 345_L 1.381 0.99
149_R 370_D 1.373 0.99
275_L 278_Q 1.368 0.99
104_Y 141_D 1.367 0.99
47_K 404_M 1.356 0.99
216_A 220_T 1.355 0.99
115_I 405_V 1.354 0.99
59_V 121_S 1.338 0.99
380_T 399_S 1.337 0.99
7_V 373_I 1.335 0.99
382_L 393_F 1.331 0.99
282_F 306_N 1.328 0.99
372_T 403_V 1.327 0.99
30_I 363_L 1.322 0.99
206_P 209_G 1.315 0.99
346_T 367_Y 1.314 0.99
275_L 279_R 1.311 0.99
47_K 402_S 1.309 0.99
401_H 413_D 1.303 0.99
137_S 141_D 1.294 0.99
13_H 16_K 1.29 0.99
354_R 360_F 1.284 0.99
123_I 352_M 1.282 0.99
207_D 211_E 1.282 0.99
115_I 403_V 1.276 0.99
22_D 37_L 1.275 0.99
53_I 376_Y 1.275 0.99
225_H 263_A 1.274 0.99
400_V 403_V 1.274 0.99
59_V 349_N 1.27 0.99
114_A 122_V 1.265 0.99
6_N 20_G 1.265 0.99
4_L 47_K 1.253 0.99
141_D 145_K 1.248 0.99
286_N 289_S 1.234 0.98
373_I 402_S 1.233 0.98
353_S 357_G 1.229 0.98
59_V 360_F 1.228 0.98
21_V 35_D 1.226 0.98
374_C 400_V 1.222 0.98
411_Y 416_F 1.217 0.98
6_N 50_H 1.206 0.98
223_G 353_S 1.199 0.98
308_A 348_G 1.196 0.98
6_N 49_M 1.196 0.98
138_T 142_A 1.192 0.98
221_G 259_K 1.183 0.98
210_L 226_I 1.182 0.98
248_A 252_Q 1.171 0.98
268_L 304_I 1.162 0.97
276_L 283_L 1.155 0.97
30_I 371_L 1.152 0.97
237_Y 240_H 1.151 0.97
375_D 378_S 1.149 0.97
262_V 265_G 1.142 0.97
115_I 411_Y 1.141 0.97
6_N 51_G 1.132 0.97
23_I 33_I 1.131 0.97
65_F 122_V 1.127 0.97
8_T 18_Q 1.124 0.97
120_T 403_V 1.121 0.97
8_T 20_G 1.118 0.96
153_C 198_G 1.112 0.96
64_H 312_D 1.108 0.96
251_A 275_L 1.107 0.96
4_L 54_V 1.107 0.96
168_E 172_E 1.107 0.96
419_D 422_S 1.106 0.96
138_T 141_D 1.106 0.96
344_A 348_G 1.103 0.96
362_L 365_A 1.096 0.96
218_K 259_K 1.088 0.96
21_V 34_G 1.087 0.96
422_S 426_Q 1.085 0.96
121_S 151_M 1.075 0.95
349_N 361_G 1.066 0.95
121_S 360_F 1.061 0.95
65_F 110_C 1.061 0.95
207_D 252_Q 1.056 0.95
217_V 222_R 1.054 0.95
5_K 48_E 1.045 0.94
169_G 172_E 1.04 0.94
227_H 312_D 1.037 0.94
270_K 300_H 1.018 0.93
288_R 324_F 1.015 0.93
276_L 280_D 1.009 0.93
149_R 405_V 1.008 0.93
370_D 405_V 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4dzhA10.95251000.233Contact Map0.754
3ls9A20.9571000.259Contact Map0.786
4gbdA20.9481000.262Contact Map0.791
3lnpA10.9571000.263Contact Map0.798
4f0rA10.95251000.275Contact Map0.818
2pajA10.97291000.28Contact Map0.732
3h4uA20.96381000.283Contact Map0.764
4f0lA20.93891000.312Contact Map0.606
1p1mA10.89371000.312Contact Map0.756
3mduA10.94121000.32Contact Map0.623

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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