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BGLA - 6-phospho-beta-glucosidase BglA
UniProt: Q46829 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13079
Length: 479 (468)
Sequences: 3212
Seq/Len: 6.86

BGLA
Paralog alert: 0.69 [within 20: 0.13] - ratio of genomes with paralogs
Cluster includes: ASCB BGLA BGLB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
30_G 109_E 5.024 1.00
393_N 463_K 4.146 1.00
119_D 171_K 4.107 1.00
408_M 419_L 3.463 1.00
115_D 171_K 3.358 1.00
74_K 120_E 3.296 1.00
108_E 112_K 3.228 1.00
68_D 71_G 3.221 1.00
81_A 124_Y 3.168 1.00
132_L 164_V 3.156 1.00
108_E 167_R 3.123 1.00
120_E 123_K 3.068 1.00
112_K 116_D 3.066 1.00
29_K 71_G 3.023 1.00
115_D 167_R 2.975 1.00
407_E 410_K 2.968 1.00
316_Y 404_H 2.96 1.00
251_S 256_D 2.782 1.00
162_E 166_E 2.739 1.00
78_K 124_Y 2.644 1.00
77_I 117_M 2.642 1.00
401_L 424_P 2.575 1.00
461_R 465_F 2.555 1.00
16_G 85_F 2.526 1.00
98_F 163_V 2.509 1.00
229_A 238_V 2.482 1.00
74_K 116_D 2.444 1.00
227_K 231_R 2.419 1.00
151_R 300_D 2.405 1.00
446_Y 460_S 2.373 1.00
69_F 88_F 2.362 1.00
139_L 143_Q 2.335 1.00
87_C 423_T 2.311 1.00
363_C 415_D 2.302 1.00
359_R 415_D 2.292 1.00
395_D 463_K 2.291 1.00
399_D 403_A 2.278 1.00
109_E 112_K 2.271 1.00
299_G 302_D 2.156 1.00
155_D 224_L 2.155 1.00
450_H 454_T 2.115 1.00
35_S 95_T 2.06 1.00
69_F 113_F 2.058 1.00
122_L 171_K 2.015 1.00
18_V 23_V 2.014 1.00
115_D 119_D 2.006 1.00
90_T 118_F 1.991 1.00
119_D 122_L 1.982 1.00
162_E 228_A 1.97 1.00
127_E 173_K 1.968 1.00
158_V 228_A 1.963 1.00
216_H 279_Y 1.957 1.00
470_E 478_K 1.921 1.00
27_W 34_P 1.865 1.00
469_K 473_A 1.863 1.00
90_T 117_M 1.845 1.00
316_Y 357_G 1.837 1.00
118_F 122_L 1.832 1.00
118_F 168_Y 1.818 1.00
14_W 475_N 1.807 1.00
120_E 124_Y 1.786 1.00
121_L 126_I 1.784 1.00
77_I 124_Y 1.779 1.00
176_M 311_Y 1.773 1.00
278_Y 305_R 1.772 1.00
224_L 303_V 1.772 1.00
387_E 391_S 1.754 1.00
26_G 29_K 1.749 1.00
39_V 143_Q 1.744 1.00
359_R 363_C 1.742 1.00
39_V 139_L 1.742 1.00
362_L 417_V 1.727 1.00
78_K 120_E 1.72 1.00
248_Y 360_Y 1.716 1.00
302_D 306_E 1.705 1.00
146_G 150_N 1.704 1.00
92_I 130_I 1.702 1.00
356_V 407_E 1.694 1.00
374_F 420_M 1.685 1.00
233_N 236_M 1.682 1.00
386_V 460_S 1.676 1.00
281_S 285_N 1.658 1.00
448_N 456_D 1.657 1.00
127_E 174_Y 1.656 1.00
26_G 30_G 1.647 1.00
33_G 101_G 1.638 1.00
229_A 236_M 1.626 1.00
77_I 120_E 1.603 1.00
87_C 129_V 1.584 1.00
359_R 410_K 1.58 1.00
34_P 39_V 1.575 1.00
162_E 232_I 1.574 1.00
129_V 423_T 1.57 1.00
470_E 473_A 1.569 1.00
111_L 163_V 1.524 0.99
158_V 224_L 1.516 0.99
73_Y 116_D 1.51 0.99
153_V 156_F 1.507 0.99
165_F 229_A 1.505 0.99
77_I 121_L 1.505 0.99
152_K 155_D 1.504 0.99
467_W 471_V 1.501 0.99
68_D 72_H 1.496 0.99
145_Y 156_F 1.495 0.99
80_F 85_F 1.471 0.99
90_T 130_I 1.467 0.99
72_H 75_E 1.467 0.99
227_K 306_E 1.458 0.99
170_H 233_N 1.457 0.99
80_F 445_I 1.452 0.99
18_V 90_T 1.44 0.99
165_F 225_A 1.438 0.99
278_Y 284_L 1.43 0.99
102_D 144_Q 1.427 0.99
215_L 270_F 1.427 0.99
82_E 465_F 1.417 0.99
362_L 408_M 1.417 0.99
26_G 71_G 1.414 0.99
424_P 444_F 1.411 0.99
115_D 168_Y 1.407 0.99
405_I 408_M 1.4 0.99
403_A 406_E 1.399 0.99
100_K 103_E 1.397 0.99
461_R 466_N 1.392 0.99
364_E 368_R 1.389 0.99
151_R 217_H 1.387 0.99
468_Y 472_I 1.375 0.98
18_V 88_F 1.36 0.98
228_A 231_R 1.358 0.98
176_M 241_M 1.357 0.98
276_R 370_Q 1.356 0.98
296_M 301_L 1.346 0.98
13_L 87_C 1.345 0.98
140_H 144_Q 1.344 0.98
115_D 170_H 1.34 0.98
9_P 412_V 1.337 0.98
269_V 283_V 1.326 0.98
378_N 422_Y 1.324 0.98
297_E 300_D 1.321 0.98
173_K 235_E 1.317 0.98
42_G 64_H 1.311 0.98
132_L 157_F 1.31 0.98
265_R 282_Y 1.303 0.98
466_N 469_K 1.288 0.97
249_P 257_V 1.286 0.97
8_L 412_V 1.277 0.97
164_V 168_Y 1.275 0.97
439_S 451_D 1.274 0.97
158_V 162_E 1.271 0.97
155_D 158_V 1.261 0.97
178_F 218_Q 1.256 0.97
118_F 171_K 1.255 0.97
470_E 474_S 1.249 0.97
205_E 210_T 1.246 0.97
278_Y 281_S 1.242 0.97
257_V 260_A 1.238 0.96
363_C 417_V 1.237 0.96
386_V 392_I 1.236 0.96
53_K 59_K 1.233 0.96
301_L 304_L 1.231 0.96
161_A 228_A 1.229 0.96
278_Y 370_Q 1.227 0.96
240_C 274_Q 1.224 0.96
111_L 167_R 1.219 0.96
33_G 140_H 1.211 0.96
358_L 419_L 1.208 0.96
27_W 32_K 1.203 0.96
21_H 63_N 1.199 0.96
115_D 122_L 1.198 0.96
149_T 210_T 1.185 0.95
148_W 153_V 1.185 0.95
111_L 115_D 1.182 0.95
358_L 408_M 1.18 0.95
224_L 228_A 1.178 0.95
226_V 230_R 1.175 0.95
349_W 381_G 1.175 0.95
271_T 312_L 1.165 0.95
67_V 428_I 1.151 0.94
69_F 117_M 1.15 0.94
78_K 82_E 1.149 0.94
409_K 477_E 1.14 0.94
448_N 458_S 1.138 0.94
8_L 409_K 1.137 0.94
92_I 97_I 1.136 0.94
53_K 61_Y 1.134 0.94
184_Q 218_Q 1.131 0.93
207_P 210_T 1.131 0.93
92_I 164_V 1.124 0.93
229_A 233_N 1.123 0.93
409_K 413_T 1.122 0.93
33_G 99_P 1.116 0.93
152_K 156_F 1.116 0.93
244_M 361_A 1.115 0.93
129_V 374_F 1.107 0.92
158_V 225_A 1.101 0.92
386_V 391_S 1.099 0.92
298_D 301_L 1.098 0.92
174_Y 237_K 1.097 0.92
118_F 130_I 1.096 0.92
358_L 375_I 1.086 0.91
178_F 221_A 1.078 0.91
32_K 95_T 1.068 0.91
97_I 163_V 1.067 0.90
144_Q 152_K 1.065 0.90
150_N 156_F 1.064 0.90
170_H 236_M 1.061 0.90
129_V 174_Y 1.056 0.90
137_M 147_S 1.056 0.90
31_G 107_N 1.054 0.90
72_H 457_M 1.053 0.90
449_K 457_M 1.043 0.89
98_F 106_P 1.041 0.89
78_K 81_A 1.04 0.89
65_E 449_K 1.036 0.89
128_P 173_K 1.031 0.88
163_V 167_R 1.028 0.88
162_E 233_N 1.028 0.88
390_G 460_S 1.022 0.88
239_G 313_G 1.021 0.88
80_F 126_I 1.02 0.88
348_D 383_Y 1.02 0.88
165_F 238_V 1.017 0.87
366_Y 418_D 1.013 0.87
111_L 164_V 1.011 0.87
17_A 423_T 1.005 0.87
72_H 458_S 1.003 0.86
244_M 314_F 1.003 0.86
356_V 360_Y 1.001 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4ddeA20.98751000.094Contact Map0.806
3qomA10.98331000.095Contact Map0.793
4iplA20.9771000.096Contact Map0.844
2xhyA40.99161000.103Contact Map0.796
2dgaA10.94571000.109Contact Map0.758
1v02A50.94781000.11Contact Map0.774
3ptmA20.93531000.114Contact Map0.76
1v08A20.94781000.116Contact Map0.785
2jf7A20.94361000.117Contact Map0.706
4atdA20.93531000.121Contact Map0.737

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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