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CSDA - Cysteine sulfinate desulfinase
UniProt: Q46925 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13082
Length: 401 (378)
Sequences: 33645
Seq/Len: 89.01

CSDA
Paralog alert: 0.90 [within 20: 0.48] - ratio of genomes with paralogs
Cluster includes: AAT ALAA ALAC ARNB AVTA CSDA HIS8 ISCS MALY RFFA SERC SUFS TYRB YBDL YDCR YJIR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
307_L 386_D 3.963 1.00
154_P 188_S 3.569 1.00
311_A 389_V 3.482 1.00
348_Y 394_R 3.431 1.00
40_Q 44_S 3.331 1.00
307_L 382_K 2.968 1.00
71_K 287_E 2.951 1.00
303_S 382_K 2.942 1.00
33_E 37_E 2.83 1.00
387_A 391_A 2.727 1.00
178_D 181_R 2.718 1.00
111_E 136_K 2.601 1.00
111_E 138_V 2.502 1.00
111_E 158_T 2.461 1.00
37_E 41_Q 2.434 1.00
302_R 306_T 2.4 1.00
381_T 384_D 2.37 1.00
87_T 93_S 2.365 1.00
344_L 347_E 2.357 1.00
319_R 332_D 2.346 1.00
284_A 287_E 2.303 1.00
152_L 155_E 2.281 1.00
150_V 185_F 2.276 1.00
110_D 162_R 2.259 1.00
307_L 311_A 2.256 1.00
152_L 156_L 2.254 1.00
311_A 314_K 2.19 1.00
234_G 239_L 2.187 1.00
154_P 189_A 2.104 1.00
387_A 390_N 2.103 1.00
71_K 283_S 2.08 1.00
111_E 161_S 2.064 1.00
306_T 310_D 2.048 1.00
183_I 193_V 2.035 1.00
337_H 340_D 2.006 1.00
275_N 278_G 2.006 1.00
116_V 141_P 2.004 1.00
311_A 386_D 1.991 1.00
70_E 74_Q 1.974 1.00
348_Y 391_A 1.958 1.00
106_L 135_A 1.927 1.00
36_V 40_Q 1.921 1.00
184_T 188_S 1.903 1.00
180_A 184_T 1.896 1.00
311_A 393_D 1.896 1.00
181_R 184_T 1.874 1.00
23_L 388_L 1.872 1.00
141_P 152_L 1.865 1.00
149_D 152_L 1.838 1.00
163_I 194_M 1.826 1.00
183_I 187_H 1.791 1.00
218_F 231_V 1.783 1.00
97_V 215_F 1.779 1.00
344_L 395_A 1.752 1.00
111_E 160_R 1.74 1.00
154_P 185_F 1.732 1.00
70_E 81_D 1.721 1.00
186_A 193_V 1.709 1.00
315_R 393_D 1.705 1.00
37_E 40_Q 1.701 1.00
197_G 216_Y 1.672 1.00
140_L 156_L 1.669 1.00
186_A 191_M 1.665 1.00
300_W 303_S 1.645 1.00
374_A 388_L 1.641 1.00
150_V 181_R 1.637 1.00
382_K 386_D 1.632 1.00
164_L 191_M 1.631 1.00
314_K 393_D 1.624 1.00
67_A 283_S 1.62 1.00
310_D 314_K 1.619 1.00
220_G 282_L 1.611 1.00
187_H 212_D 1.608 1.00
300_W 304_L 1.605 1.00
41_Q 45_L 1.601 1.00
72_V 231_V 1.579 1.00
311_A 390_N 1.578 1.00
309_E 313_A 1.577 1.00
299_S 303_S 1.571 1.00
185_F 189_A 1.564 1.00
151_D 155_E 1.556 1.00
151_D 181_R 1.543 1.00
90_T 217_A 1.541 1.00
71_K 290_A 1.539 1.00
164_L 186_A 1.533 1.00
154_P 158_T 1.527 1.00
340_D 344_L 1.524 1.00
66_E 70_E 1.523 1.00
229_I 282_L 1.521 1.00
95_N 99_Q 1.513 1.00
36_V 44_S 1.498 1.00
390_N 394_R 1.483 1.00
82_K 236_S 1.478 1.00
295_N 299_S 1.477 1.00
34_A 284_A 1.467 1.00
39_T 281_G 1.467 1.00
151_D 154_P 1.461 1.00
88_R 92_E 1.451 1.00
38_A 284_A 1.45 1.00
168_Q 200_G 1.441 1.00
157_I 185_F 1.437 1.00
116_V 139_K 1.435 1.00
138_V 156_L 1.435 1.00
307_L 385_V 1.431 1.00
113_I 156_L 1.429 1.00
386_D 390_N 1.413 1.00
154_P 181_R 1.407 0.99
83_T 236_S 1.407 0.99
110_D 160_R 1.393 0.99
194_M 217_A 1.379 0.99
71_K 74_Q 1.379 0.99
38_A 41_Q 1.368 0.99
34_A 288_W 1.361 0.99
187_H 214_D 1.359 0.99
332_D 370_G 1.359 0.99
300_W 382_K 1.357 0.99
93_S 217_A 1.357 0.99
98_A 165_A 1.354 0.99
80_D 236_S 1.345 0.99
309_E 329_L 1.345 0.99
107_Q 110_D 1.325 0.99
113_I 161_S 1.323 0.99
180_A 210_Q 1.321 0.99
166_L 182_A 1.311 0.99
94_I 121_A 1.309 0.99
73_A 81_D 1.308 0.99
190_G 213_I 1.307 0.99
304_L 382_K 1.304 0.99
313_A 320_S 1.298 0.99
157_I 191_M 1.294 0.99
319_R 334_A 1.288 0.99
97_V 194_M 1.288 0.99
158_T 161_S 1.287 0.99
344_L 348_Y 1.284 0.99
232_L 242_M 1.282 0.99
343_T 347_E 1.281 0.99
350_I 391_A 1.271 0.99
296_Q 299_S 1.263 0.99
305_A 309_E 1.252 0.99
299_S 302_R 1.251 0.99
143_N 149_D 1.24 0.98
198_A 219_S 1.233 0.98
352_L 372_L 1.233 0.98
36_V 43_Y 1.224 0.98
393_D 397_E 1.221 0.98
207_D 210_Q 1.2 0.98
311_A 315_R 1.189 0.98
340_D 343_T 1.184 0.98
296_Q 300_W 1.179 0.98
215_F 234_G 1.165 0.97
342_V 352_L 1.165 0.97
308_A 311_A 1.159 0.97
310_D 313_A 1.156 0.97
383_S 386_D 1.154 0.97
76_L 233_Y 1.148 0.97
350_I 388_L 1.135 0.97
101_Y 192_V 1.127 0.97
331_F 374_A 1.126 0.97
67_A 71_K 1.126 0.97
345_L 352_L 1.113 0.96
72_V 86_W 1.109 0.96
295_N 298_E 1.107 0.96
315_R 389_V 1.106 0.96
77_N 207_D 1.106 0.96
37_E 44_S 1.105 0.96
23_L 385_V 1.104 0.96
33_E 36_V 1.099 0.96
307_L 310_D 1.099 0.96
309_E 322_R 1.096 0.96
345_L 392_V 1.086 0.96
138_V 158_T 1.081 0.95
184_T 187_H 1.076 0.95
143_N 147_L 1.062 0.95
114_V 137_V 1.062 0.95
113_I 140_L 1.062 0.95
153_L 182_A 1.061 0.95
284_A 288_W 1.061 0.95
308_A 376_F 1.058 0.95
33_E 44_S 1.056 0.95
94_I 194_M 1.056 0.95
67_A 287_E 1.046 0.94
185_F 191_M 1.044 0.94
74_Q 290_A 1.038 0.94
99_Q 133_T 1.036 0.94
215_F 238_L 1.032 0.94
341_M 395_A 1.03 0.94
308_A 389_V 1.027 0.94
34_A 37_E 1.027 0.94
283_S 287_E 1.025 0.93
303_S 307_L 1.019 0.93
71_K 286_L 1.019 0.93
41_Q 44_S 1.018 0.93
84_I 233_Y 1.018 0.93
341_M 372_L 1.017 0.93
308_A 385_V 1.016 0.93
391_A 394_R 1.014 0.93
308_A 388_L 1.013 0.93
74_Q 287_E 1.008 0.93
298_E 302_R 1.005 0.93
384_D 387_A 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4lw2A311000.21Contact Map0.756
1kmjA10.99251000.214Contact Map0.716
1t3iA20.99751000.238Contact Map0.729
1eluA20.94011000.275Contact Map0.71
3caiA20.94261000.279Contact Map0.73
3e9kA10.95511000.286Contact Map0.593
4hvkA10.90021000.29Contact Map0.658
1eg5A20.90271000.306Contact Map0.711
3a9zA20.94261000.306Contact Map0.744
3vaxA20.92021000.307Contact Map0.671

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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