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CBL - HTH-type transcriptional regulator cbl
UniProt: Q47083 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14264
Length: 316 (295)
Sequences: 36554
Seq/Len: 123.91

CBL
Paralog alert: 0.88 [within 20: 0.50] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
72_R 76_E 3.727 1.00
15_Q 25_M 3.375 1.00
234_V 241_G 2.503 1.00
98_A 143_A 2.451 1.00
21_E 24_N 2.408 1.00
69_I 83_L 2.364 1.00
161_F 292_N 2.357 1.00
14_R 71_E 2.262 1.00
167_H 245_E 2.26 1.00
176_H 192_W 2.229 1.00
185_T 188_S 2.225 1.00
96_T 125_E 2.194 1.00
11_E 25_M 2.169 1.00
73_I 77_A 2.154 1.00
94_V 123_R 2.149 1.00
94_V 125_E 2.13 1.00
13_A 59_M 2.121 1.00
162_P 165_R 2.101 1.00
19_L 37_I 2.099 1.00
69_I 76_E 2.063 1.00
10_R 67_L 2.033 1.00
165_R 269_T 2.004 1.00
8_I 36_H 1.99 1.00
67_L 71_E 1.973 1.00
114_A 294_G 1.967 1.00
46_I 62_P 1.948 1.00
11_E 15_Q 1.89 1.00
10_R 14_R 1.86 1.00
11_E 14_R 1.859 1.00
10_R 71_E 1.851 1.00
136_T 140_N 1.846 1.00
8_I 33_V 1.842 1.00
195_I 239_G 1.834 1.00
66_L 80_V 1.832 1.00
115_F 122_V 1.824 1.00
162_P 269_T 1.797 1.00
50_V 58_G 1.747 1.00
13_A 67_L 1.743 1.00
235_A 255_N 1.729 1.00
114_A 290_L 1.724 1.00
169_S 245_E 1.717 1.00
172_V 259_L 1.703 1.00
9_I 67_L 1.703 1.00
61_E 64_K 1.702 1.00
14_R 25_M 1.698 1.00
134_I 146_G 1.687 1.00
10_R 70_A 1.686 1.00
193_P 221_V 1.68 1.00
20_T 30_Q 1.671 1.00
65_A 83_L 1.648 1.00
10_R 74_L 1.616 1.00
18_N 21_E 1.611 1.00
29_S 32_G 1.595 1.00
181_I 188_S 1.595 1.00
115_F 287_F 1.591 1.00
8_I 28_T 1.578 1.00
90_D 121_E 1.578 1.00
169_S 258_R 1.573 1.00
15_Q 21_E 1.564 1.00
195_I 230_I 1.511 1.00
73_I 80_V 1.486 1.00
137_L 142_E 1.483 1.00
165_R 267_A 1.48 1.00
69_I 79_N 1.48 1.00
160_A 271_W 1.465 1.00
11_E 26_L 1.443 1.00
47_E 50_V 1.437 1.00
105_R 228_D 1.436 1.00
204_R 208_D 1.427 1.00
5_Q 36_H 1.426 1.00
5_Q 39_E 1.424 1.00
64_K 68_V 1.418 1.00
145_I 284_V 1.415 1.00
3_F 77_A 1.404 0.99
114_A 118_L 1.392 0.99
5_Q 43_E 1.382 0.99
66_L 81_R 1.37 0.99
2_N 5_Q 1.362 0.99
192_W 240_I 1.36 0.99
272_L 288_L 1.356 0.99
38_R 42_D 1.35 0.99
114_A 117_E 1.348 0.99
92_S 121_E 1.343 0.99
129_G 133_E 1.341 0.99
172_V 240_I 1.319 0.99
159_V 274_L 1.316 0.99
69_I 72_R 1.304 0.99
231_K 251_Q 1.304 0.99
174_H 255_N 1.299 0.99
230_I 241_G 1.296 0.99
12_A 37_I 1.295 0.99
137_L 143_A 1.288 0.99
113_K 117_E 1.285 0.99
159_V 276_R 1.273 0.99
224_A 230_I 1.271 0.99
43_E 81_R 1.261 0.99
95_L 287_F 1.241 0.98
9_I 13_A 1.241 0.98
116_R 193_P 1.233 0.98
35_R 38_R 1.231 0.98
177_P 192_W 1.23 0.98
280_Q 284_V 1.226 0.98
161_F 274_L 1.213 0.98
182_S 257_I 1.213 0.98
96_T 127_I 1.211 0.98
286_R 289_E 1.21 0.98
13_A 49_F 1.198 0.98
138_L 146_G 1.196 0.98
68_V 72_R 1.196 0.98
9_I 49_F 1.193 0.98
232_T 235_A 1.193 0.98
116_R 221_V 1.191 0.98
69_I 80_V 1.191 0.98
245_E 249_G 1.186 0.98
12_A 22_V 1.185 0.98
9_I 48_I 1.183 0.98
115_F 290_L 1.183 0.98
59_M 63_G 1.181 0.98
211_F 216_L 1.18 0.98
145_I 272_L 1.18 0.98
65_A 68_V 1.177 0.98
7_K 78_S 1.176 0.98
34_S 38_R 1.175 0.98
28_T 32_G 1.168 0.97
139_Q 157_Q 1.166 0.97
104_A 128_Q 1.164 0.97
184_L 188_S 1.136 0.97
249_G 252_E 1.132 0.97
173_P 237_G 1.129 0.97
76_E 79_N 1.127 0.97
11_E 22_V 1.126 0.97
4_Q 7_K 1.122 0.97
288_L 292_N 1.119 0.96
176_H 193_P 1.114 0.96
6_L 70_A 1.096 0.96
172_V 176_H 1.091 0.96
36_H 39_E 1.09 0.96
170_L 240_I 1.087 0.96
115_F 119_F 1.086 0.96
285_W 289_E 1.078 0.95
65_A 69_I 1.078 0.95
232_T 236_L 1.076 0.95
113_K 236_L 1.075 0.95
275_K 278_Q 1.074 0.95
28_T 33_V 1.073 0.95
19_L 56_L 1.072 0.95
148_A 273_G 1.072 0.95
35_R 39_E 1.071 0.95
245_E 258_R 1.071 0.95
193_P 219_D 1.071 0.95
174_H 257_I 1.067 0.95
258_R 261_T 1.067 0.95
160_A 273_G 1.05 0.94
73_I 76_E 1.05 0.94
118_L 290_L 1.05 0.94
97_I 145_I 1.049 0.94
289_E 292_N 1.046 0.94
98_A 148_A 1.043 0.94
171_L 248_S 1.042 0.94
78_S 82_R 1.037 0.94
162_P 271_W 1.033 0.94
166_W 246_Q 1.032 0.94
66_L 70_A 1.029 0.94
13_A 63_G 1.028 0.94
235_A 251_Q 1.028 0.94
274_L 288_L 1.025 0.93
72_R 79_N 1.022 0.93
52_R 58_G 1.022 0.93
118_L 293_A 1.019 0.93
125_E 223_S 1.007 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ixcA20.92411000.183Contact Map0.756
2esnA40.93671000.184Contact Map0.762
3fxqA20.95251000.185Contact Map0.777
1al3A10.99681000.186Contact Map0.755
1uthA10.94941000.186Contact Map0.754
3fzvA40.94621000.187Contact Map0.711
2h98A20.96521000.193Contact Map0.751
2h9bA20.97471000.197Contact Map0.739
3szpA20.91771000.209Contact Map0.752
3hhgA80.95251000.226Contact Map0.918

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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