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ARNE - Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE
UniProt: Q47377 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14344
Length: 111 (110)
Sequences: 503
Seq/Len: 4.57

ARNE
Paralog alert: 0.76 [within 20: 0.36] - ratio of genomes with paralogs
Cluster includes: ARNE ARNF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
23_A 40_L 2.057 1.00
89_V 94_W 1.876 1.00
98_A 102_G 1.853 1.00
99_F 102_G 1.709 0.99
9_A 70_L 1.708 0.99
24_T 55_L 1.677 0.99
99_F 106_I 1.66 0.99
79_L 83_K 1.634 0.99
6_L 61_V 1.55 0.99
17_Q 71_S 1.517 0.98
61_V 66_A 1.51 0.98
13_S 70_L 1.486 0.98
78_T 93_H 1.472 0.98
9_A 57_V 1.438 0.97
17_Q 54_W 1.389 0.97
46_C 49_L 1.388 0.97
91_P 95_C 1.361 0.96
16_G 70_L 1.354 0.96
72_L 75_V 1.353 0.96
13_S 51_M 1.334 0.96
13_S 16_G 1.329 0.95
18_L 22_Q 1.328 0.95
90_S 93_H 1.303 0.95
9_A 13_S 1.295 0.94
83_K 95_C 1.23 0.92
69_M 74_F 1.217 0.92
54_W 67_Y 1.215 0.92
50_A 70_L 1.2 0.91
92_R 95_C 1.188 0.90
3_W 7_V 1.163 0.89
23_A 43_A 1.154 0.89
78_T 81_A 1.148 0.88
74_F 107_L 1.147 0.88
17_Q 72_L 1.141 0.88
42_L 45_A 1.138 0.88
80_A 84_L 1.127 0.87
77_V 81_A 1.121 0.87
41_G 49_L 1.118 0.86
32_R 80_A 1.11 0.86
72_L 81_A 1.101 0.85
17_Q 21_K 1.098 0.85
13_S 73_N 1.094 0.85
23_A 93_H 1.079 0.84
10_S 14_V 1.079 0.84
21_K 106_I 1.078 0.84
31_K 52_V 1.071 0.83
41_G 86_H 1.065 0.83
63_V 107_L 1.061 0.82
13_S 20_Q 1.046 0.81
54_W 72_L 1.046 0.81
20_Q 73_N 1.038 0.80
54_W 69_M 1.037 0.80
105_V 109_S 1.035 0.80
46_C 107_L 1.028 0.79
23_A 74_F 1.021 0.79
3_W 6_L 1.018 0.79
42_L 49_L 1.013 0.78
97_V 101_I 1.011 0.78
13_S 57_V 1.011 0.78
35_H 45_A 1.008 0.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2i68A20.927999.70.428Contact Map0.016
3b5dA20.927999.70.432Contact Map0.071
4gx0A40.83781.10.947Contact Map0.477
3ar4A10.819810.949Contact Map0.526
2lk9A10.22520.70.953Contact Map0.031
4h44F10.19820.70.955Contact Map0.263
2wscL10.57660.70.955Contact Map0.061
4kjrA20.54950.60.955Contact Map0.252
3j01B10.45950.60.956Contact Map0.186
2ri9A20.31530.60.957Contact Map0.468

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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