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TAUB - Taurine import ATP-binding protein TauB
UniProt: Q47538 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13299
Length: 255 (212)
Sequences: 68420
Seq/Len: 322.74

TAUB
Paralog alert: 0.94 [within 20: 0.84] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
31_V 196_A 3.237 1.00
3_Q 23_T 2.977 1.00
121_A 124_R 2.899 1.00
28_E 198_E 2.882 1.00
57_S 64_R 2.797 1.00
5_S 57_S 2.76 1.00
6_H 19_D 2.732 1.00
30_L 200_V 2.62 1.00
15_P 18_E 2.619 1.00
71_E 148_Q 2.583 1.00
3_Q 59_Q 2.546 1.00
114_K 119_E 2.518 1.00
18_E 208_R 2.323 1.00
25_E 28_E 2.304 1.00
203_S 206_P 2.235 1.00
10_D 15_P 2.174 1.00
8_Y 19_D 2.153 1.00
108_I 146_N 2.153 1.00
4_I 7_L 2.133 1.00
9_A 46_L 2.128 1.00
61_A 148_Q 2.107 1.00
198_E 212_R 2.071 1.00
87_V 129_L 2.051 1.00
8_Y 15_P 2.049 1.00
110_H 122_E 2.012 1.00
8_Y 55_H 1.997 1.00
113_L 122_E 1.958 1.00
88_Q 123_K 1.902 1.00
5_S 59_Q 1.824 1.00
88_Q 122_E 1.783 1.00
200_V 209_V 1.763 1.00
173_K 177_E 1.747 1.00
88_Q 110_H 1.747 1.00
26_S 148_Q 1.702 1.00
28_E 197_T 1.699 1.00
6_H 21_N 1.685 1.00
146_N 180_K 1.675 1.00
11_Y 16_A 1.655 1.00
115_K 173_K 1.631 1.00
9_A 54_Q 1.61 1.00
88_Q 109_A 1.59 1.00
200_V 212_R 1.503 1.00
111_Q 115_K 1.496 1.00
108_I 111_Q 1.494 1.00
106_L 110_H 1.484 1.00
101_E 104_Q 1.48 1.00
77_Q 131_G 1.479 1.00
124_R 128_Q 1.449 1.00
115_K 178_T 1.445 1.00
59_Q 64_R 1.398 0.99
9_A 51_V 1.396 0.99
10_D 54_Q 1.381 0.99
88_Q 106_L 1.355 0.99
44_L 185_I 1.355 0.99
88_Q 92_A 1.336 0.99
5_S 23_T 1.327 0.99
107_E 111_Q 1.319 0.99
61_A 71_E 1.317 0.99
92_A 109_A 1.315 0.99
46_L 53_Y 1.312 0.99
92_A 105_R 1.312 0.99
17_L 46_L 1.311 0.99
119_E 122_E 1.31 0.99
24_L 30_L 1.293 0.99
4_I 47_I 1.288 0.99
115_K 177_E 1.287 0.99
8_Y 18_E 1.274 0.99
22_L 200_V 1.27 0.99
175_W 197_T 1.255 0.99
152_L 171_L 1.244 0.98
91_V 144_A 1.211 0.98
4_I 22_L 1.2 0.98
7_L 53_Y 1.2 0.98
86_N 89_D 1.19 0.98
87_V 137_V 1.189 0.98
108_I 112_M 1.188 0.98
110_H 114_K 1.17 0.97
186_T 192_A 1.168 0.97
121_A 133_Q 1.164 0.97
30_L 212_R 1.156 0.97
90_N 141_R 1.156 0.97
5_S 21_N 1.154 0.97
25_E 198_E 1.141 0.97
110_H 119_E 1.126 0.97
164_R 191_E 1.11 0.96
47_I 183_L 1.109 0.96
29_L 182_V 1.104 0.96
44_L 151_L 1.095 0.96
45_N 51_V 1.091 0.96
4_I 43_L 1.085 0.96
92_A 106_L 1.085 0.96
170_L 173_K 1.08 0.95
112_M 144_A 1.072 0.95
11_Y 42_T 1.07 0.95
20_I 43_L 1.061 0.95
148_Q 180_K 1.059 0.95
175_W 182_V 1.051 0.94
26_S 61_A 1.05 0.94
64_R 67_G 1.041 0.94
116_V 140_A 1.035 0.94
203_S 210_L 1.034 0.94
30_L 198_E 1.031 0.94
29_L 175_W 1.028 0.94
152_L 182_V 1.025 0.93
46_L 58_I 1.022 0.93
43_L 202_L 1.013 0.93
146_N 178_T 1.013 0.93
125_Y 128_Q 1.008 0.93
9_A 42_T 1.007 0.93
168_Q 191_E 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1v43A10.98431000.054Contact Map0.828
2it1A20.98431000.055Contact Map0.871
2yyzA10.98431000.057Contact Map0.814
1g29120.98431000.058Contact Map0.906
3tuiC40.98431000.058Contact Map0.879
1oxxK10.97651000.062Contact Map0.817
1z47A20.98431000.062Contact Map0.826
3rlfA20.98431000.064Contact Map0.833
3fvqA20.98431000.064Contact Map0.764
3d31A20.96081000.078Contact Map0.814

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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