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COPA - Copper-exporting P-type ATPase A
UniProt: Q59385 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13246
Length: 834 (791)
Sequences: 5032
Seq/Len: 6.36

COPA
Paralog alert: 0.76 [within 20: 0.09] - ratio of genomes with paralogs
Cluster includes: ATKB ATMA ATZN COPA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
677_P 681_N 4.952 1.00
366_A 399_V 4.447 1.00
556_L 593_G 4.431 1.00
360_E 402_R 3.888 1.00
227_L 264_W 3.797 1.00
584_R 592_S 3.598 1.00
700_G 703_E 3.58 1.00
673_T 680_A 3.58 1.00
677_P 695_G 3.578 1.00
704_A 707_H 3.472 1.00
668_R 691_E 3.427 1.00
598_H 638_D 3.423 1.00
637_V 642_V 3.411 1.00
709_Q 730_Q 3.312 1.00
537_A 630_A 3.294 1.00
654_D 756_S 3.268 1.00
518_D 713_R 3.267 1.00
346_L 400_L 3.097 1.00
355_V 368_L 3.093 1.00
589_L 610_E 3.081 1.00
366_A 394_V 3.07 1.00
549_A 643_A 2.949 1.00
546_E 575_M 2.927 1.00
535_V 645_L 2.864 1.00
716_A 735_I 2.853 1.00
361_I 399_V 2.847 1.00
363_Q 400_L 2.845 1.00
346_L 362_T 2.792 1.00
663_H 690_D 2.74 1.00
324_T 335_S 2.733 1.00
326_R 335_S 2.701 1.00
517_L 716_A 2.698 1.00
582_G 594_E 2.679 1.00
346_L 402_R 2.666 1.00
327_L 334_K 2.659 1.00
357_V 403_A 2.633 1.00
528_L 687_A 2.609 1.00
271_N 286_Y 2.593 1.00
535_V 571_K 2.518 1.00
388_V 401_F 2.504 1.00
196_G 294_G 2.479 1.00
706_K 730_Q 2.458 1.00
602_L 635_L 2.407 1.00
586_L 607_L 2.404 1.00
329_T 334_K 2.4 1.00
521_V 705_I 2.39 1.00
571_K 575_M 2.364 1.00
668_R 713_R 2.305 1.00
684_A 692_V 2.299 1.00
632_P 644_L 2.288 1.00
341_V 357_V 2.283 1.00
361_I 368_L 2.267 1.00
552_L 600_L 2.256 1.00
693_I 704_A 2.237 1.00
530_E 653_S 2.22 1.00
773_N 826_R 2.22 1.00
110_C 113_C 2.218 1.00
600_L 637_V 2.217 1.00
498_A 766_I 2.201 1.00
681_N 685_K 2.2 1.00
106_S 160_G 2.193 1.00
328_V 400_L 2.136 1.00
739_G 755_H 2.136 1.00
530_E 650_P 2.134 1.00
608_L 636_A 2.131 1.00
592_S 599_A 2.131 1.00
326_R 353_D 2.122 1.00
635_L 643_A 2.117 1.00
656_V 660_Q 2.073 1.00
261_G 265_L 2.063 1.00
622_I 634_L 2.063 1.00
403_A 406_V 2.061 1.00
451_S 470_I 2.052 1.00
238_Y 261_G 2.049 1.00
536_V 630_A 2.041 1.00
521_V 708_L 2.038 1.00
665_A 765_A 2.037 1.00
707_H 711_E 2.027 1.00
657_A 758_M 2.025 1.00
327_L 336_V 2.017 1.00
672_L 704_A 1.949 1.00
633_V 647_V 1.945 1.00
545_D 548_Q 1.904 1.00
114_V 134_L 1.894 1.00
235_G 239_R 1.89 1.00
598_H 637_V 1.882 1.00
554_A 572_A 1.871 1.00
681_N 692_V 1.862 1.00
779_L 783_I 1.855 1.00
621_E 624_A 1.852 1.00
671_M 680_A 1.851 1.00
521_V 672_L 1.834 1.00
490_S 824_A 1.828 1.00
663_H 669_L 1.824 1.00
522_F 528_L 1.819 1.00
658_A 761_A 1.811 1.00
435_K 439_V 1.811 1.00
518_D 714_Q 1.809 1.00
601_L 611_Q 1.8 1.00
383_G 386_D 1.797 1.00
670_V 691_E 1.794 1.00
452_A 471_A 1.787 1.00
703_E 706_K 1.786 1.00
571_K 574_D 1.784 1.00
519_T 670_V 1.779 1.00
151_V 161_A 1.77 1.00
773_N 824_A 1.77 1.00
604_N 607_L 1.75 1.00
223_G 226_T 1.744 1.00
651_L 687_A 1.737 1.00
239_R 243_K 1.737 1.00
624_A 628_Q 1.735 1.00
226_T 230_M 1.714 1.00
327_L 345_M 1.71 1.00
329_T 332_G 1.705 1.00
341_V 347_L 1.695 1.00
192_A 233_A 1.689 1.00
660_Q 664_K 1.681 1.00
668_R 690_D 1.673 1.00
659_L 669_L 1.672 1.00
121_L 139_A 1.667 1.00
370_E 382_K 1.665 1.00
600_L 642_V 1.664 1.00
362_T 402_R 1.66 1.00
417_R 421_Q 1.659 1.00
193_L 294_G 1.658 1.00
551_R 596_E 1.648 1.00
226_T 229_V 1.633 1.00
238_Y 257_A 1.633 1.00
661_R 765_A 1.623 1.00
561_S 585_T 1.619 1.00
557_E 565_A 1.612 1.00
665_A 768_R 1.612 1.00
348_R 400_L 1.611 1.00
519_T 713_R 1.601 1.00
568_I 645_L 1.594 1.00
580_V 593_G 1.585 0.99
188_Q 236_H 1.585 0.99
520_V 716_A 1.584 0.99
601_L 607_L 1.576 0.99
369_D 395_Q 1.574 0.99
257_A 261_G 1.572 0.99
583_F 591_V 1.572 0.99
347_L 401_F 1.569 0.99
592_S 601_L 1.567 0.99
530_E 534_Q 1.561 0.99
497_R 501_F 1.558 0.99
706_K 709_Q 1.557 0.99
368_L 399_V 1.552 0.99
754_R 759_G 1.55 0.99
528_L 651_L 1.546 0.99
446_V 450_V 1.541 0.99
673_T 694_A 1.539 0.99
153_A 157_A 1.528 0.99
709_Q 732_D 1.526 0.99
735_I 760_V 1.52 0.99
776_Q 823_N 1.519 0.99
333_E 348_R 1.512 0.99
407_G 410_T 1.51 0.99
490_S 773_N 1.505 0.99
359_G 401_F 1.504 0.99
129_Q 142_M 1.5 0.99
702_A 730_Q 1.499 0.99
447_I 793_A 1.499 0.99
531_G 649_D 1.495 0.99
494_G 770_T 1.491 0.99
556_L 600_L 1.487 0.99
594_E 599_A 1.487 0.99
152_Q 156_K 1.482 0.99
501_F 762_D 1.479 0.99
505_V 750_I 1.472 0.99
361_I 364_G 1.468 0.99
373_L 389_H 1.464 0.99
533_P 564_L 1.464 0.99
553_A 635_L 1.457 0.99
555_A 580_V 1.444 0.99
360_E 404_S 1.441 0.99
372_M 392_T 1.434 0.99
146_S 149_D 1.433 0.99
242_W 246_L 1.418 0.99
535_V 647_V 1.416 0.99
365_E 381_Q 1.413 0.99
656_V 686_E 1.408 0.99
132_V 139_A 1.396 0.98
347_L 403_A 1.393 0.98
230_M 238_Y 1.391 0.98
398_S 559_G 1.384 0.98
234_G 293_I 1.384 0.98
556_L 602_L 1.381 0.98
544_V 642_V 1.381 0.98
387_S 405_A 1.379 0.98
551_R 555_A 1.378 0.98
118_Q 122_Q 1.378 0.98
344_G 402_R 1.375 0.98
122_Q 130_A 1.372 0.98
329_T 345_M 1.37 0.98
258_L 445_V 1.368 0.98
659_L 663_H 1.367 0.98
367_W 381_Q 1.366 0.98
522_F 760_V 1.363 0.98
823_N 826_R 1.363 0.98
586_L 592_S 1.362 0.98
124_V 153_A 1.362 0.98
566_R 570_D 1.361 0.98
600_L 635_L 1.359 0.98
556_L 591_V 1.359 0.98
625_Q 646_A 1.358 0.98
222_I 226_T 1.356 0.98
121_L 130_A 1.356 0.98
703_E 707_H 1.351 0.98
601_L 636_A 1.348 0.98
548_Q 551_R 1.348 0.98
654_D 758_M 1.347 0.98
522_F 669_L 1.343 0.98
680_A 692_V 1.338 0.98
305_R 309_R 1.337 0.98
634_L 641_A 1.335 0.98
200_M 291_M 1.328 0.98
625_Q 630_A 1.327 0.98
387_S 404_S 1.326 0.98
349_L 401_F 1.322 0.98
452_A 456_Y 1.32 0.97
327_L 347_L 1.317 0.97
693_I 707_H 1.315 0.97
127_V 150_L 1.311 0.97
605_Q 634_L 1.309 0.97
810_G 814_A 1.302 0.97
516_T 714_Q 1.301 0.97
540_T 549_A 1.295 0.97
570_D 573_G 1.295 0.97
729_A 747_T 1.294 0.97
117_V 157_A 1.29 0.97
360_E 385_G 1.29 0.97
325_A 356_P 1.289 0.97
100_S 142_M 1.282 0.97
337_P 340_E 1.277 0.97
351_T 366_A 1.274 0.97
630_A 646_A 1.27 0.97
105_L 108_M 1.267 0.97
439_V 443_V 1.262 0.96
194_A 198_P 1.262 0.96
706_K 710_S 1.256 0.96
351_T 561_S 1.255 0.96
155_E 160_G 1.251 0.96
103_L 161_A 1.247 0.96
547_A 575_M 1.245 0.96
691_E 711_E 1.244 0.96
654_D 658_A 1.243 0.96
608_L 613_V 1.238 0.96
580_V 595_A 1.227 0.96
414_R 699_D 1.224 0.96
536_V 648_R 1.223 0.96
86_V 90_L 1.222 0.96
684_A 689_I 1.219 0.95
534_Q 570_D 1.216 0.95
228_A 232_F 1.213 0.95
672_L 693_I 1.213 0.95
538_V 645_L 1.212 0.95
23_E 119_N 1.212 0.95
292_I 810_G 1.207 0.95
328_V 333_E 1.207 0.95
361_I 386_D 1.204 0.95
102_Q 138_T 1.203 0.95
539_K 625_Q 1.203 0.95
806_P 810_G 1.202 0.95
228_A 231_V 1.194 0.95
351_T 585_T 1.192 0.95
581_N 594_E 1.189 0.95
13_S 109_S 1.188 0.95
553_A 602_L 1.184 0.94
348_R 398_S 1.183 0.94
651_L 683_I 1.181 0.94
351_T 394_V 1.18 0.94
497_R 500_E 1.18 0.94
514_A 763_A 1.179 0.94
561_S 583_F 1.179 0.94
528_L 659_L 1.177 0.94
85_A 89_A 1.176 0.94
388_V 399_V 1.172 0.94
189_A 193_L 1.169 0.94
556_L 635_L 1.168 0.94
522_F 662_L 1.167 0.94
365_E 383_G 1.165 0.94
316_K 500_E 1.162 0.94
108_M 113_C 1.161 0.94
544_V 549_A 1.159 0.94
121_L 150_L 1.158 0.94
536_V 625_Q 1.157 0.93
361_I 366_A 1.157 0.93
549_A 635_L 1.154 0.93
595_A 600_L 1.152 0.93
540_T 643_A 1.152 0.93
514_A 733_V 1.152 0.93
773_N 776_Q 1.15 0.93
605_Q 609_N 1.148 0.93
122_Q 129_Q 1.147 0.93
518_D 712_G 1.147 0.93
454_I 458_F 1.143 0.93
589_L 697_L 1.139 0.93
601_L 608_L 1.138 0.93
114_V 117_V 1.138 0.93
537_A 625_Q 1.137 0.93
223_G 227_L 1.136 0.93
657_A 661_R 1.136 0.93
507_D 749_A 1.135 0.93
338_L 341_V 1.134 0.93
250_A 254_T 1.132 0.93
138_T 420_R 1.132 0.93
603_G 607_L 1.126 0.92
586_L 589_L 1.123 0.92
360_E 387_S 1.122 0.92
363_Q 384_E 1.121 0.92
661_R 665_A 1.117 0.92
118_Q 426_K 1.116 0.92
558_Q 573_G 1.105 0.91
505_V 511_L 1.103 0.91
571_K 577_L 1.103 0.91
316_K 743_V 1.102 0.91
16_H 112_S 1.098 0.91
661_R 664_K 1.094 0.91
223_G 268_M 1.094 0.91
771_L 775_K 1.094 0.91
120_A 157_A 1.094 0.91
189_A 298_L 1.093 0.91
534_Q 650_P 1.087 0.90
326_R 350_T 1.087 0.90
477_I 788_G 1.083 0.90
18_V 38_I 1.083 0.90
655_S 658_A 1.083 0.90
223_G 264_W 1.078 0.90
222_I 225_I 1.078 0.90
709_Q 715_V 1.078 0.90
223_G 228_A 1.077 0.90
151_V 155_E 1.077 0.90
639_G 642_V 1.076 0.90
149_D 152_Q 1.071 0.89
102_Q 140_L 1.07 0.89
223_G 229_V 1.068 0.89
310_S 496_G 1.068 0.89
515_S 771_L 1.066 0.89
627_S 678_T 1.065 0.89
665_A 764_L 1.061 0.89
121_L 124_V 1.058 0.89
241_A 254_T 1.056 0.89
108_M 132_V 1.055 0.89
328_V 348_R 1.052 0.88
130_A 139_A 1.052 0.88
103_L 151_V 1.051 0.88
224_L 228_A 1.05 0.88
86_V 91_P 1.046 0.88
605_Q 626_A 1.046 0.88
20_R 116_R 1.044 0.88
534_Q 574_D 1.041 0.88
553_A 645_L 1.04 0.88
349_L 388_V 1.039 0.88
677_P 692_V 1.038 0.87
592_S 611_Q 1.038 0.87
671_M 689_I 1.037 0.87
655_S 659_L 1.026 0.87
343_P 406_V 1.024 0.86
613_V 636_A 1.024 0.86
241_A 246_L 1.022 0.86
195_V 198_P 1.021 0.86
190_I 194_A 1.017 0.86
390_A 410_T 1.017 0.86
184_R 188_Q 1.016 0.86
693_I 696_V 1.016 0.86
189_A 301_M 1.015 0.86
336_V 340_E 1.014 0.86
442_P 812_A 1.013 0.86
651_L 656_V 1.01 0.85
601_L 613_V 1.01 0.85
699_D 703_E 1.01 0.85
108_M 117_V 1.01 0.85
244_S 254_T 1.008 0.85
318_L 745_I 1.008 0.85
696_V 700_G 1.007 0.85
806_P 813_M 1.003 0.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3rfuA40.86931000.276Contact Map0.646
3j09A20.85371000.308Contact Map0.674
3j08A20.76381000.366Contact Map0.629
1mhsA20.81181000.58Contact Map0.499
3b8cA20.73381000.582Contact Map0.507
3ar4A10.7471000.606Contact Map0.673
2zxeA10.80461000.606Contact Map0.655
3ixzA10.81291000.608Contact Map0.071
3skxA10.33331000.809Contact Map0.763
3a1cA20.34051000.822Contact Map0.812

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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