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ADPP - ADP-ribose pyrophosphatase
UniProt: Q93K97 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12184
Length: 209 (191)
Sequences: 2506
Seq/Len: 13.12

ADPP
Paralog alert: 0.40 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: ADPP NUDE NUDK
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
61_V 94_M 3.178 1.00
123_R 147_E 2.75 1.00
106_E 110_R 2.735 1.00
66_D 71_E 2.664 1.00
122_K 148_V 2.565 1.00
92_L 169_H 2.565 1.00
26_R 30_S 2.465 1.00
22_E 33_L 2.405 1.00
125_K 147_E 2.4 1.00
176_A 194_L 2.373 1.00
76_E 167_R 2.327 1.00
104_S 107_D 2.322 1.00
105_V 142_S 2.287 1.00
178_Q 182_E 2.276 1.00
114_I 120_I 2.263 1.00
71_E 172_S 2.238 1.00
73_V 170_V 2.169 1.00
71_E 170_V 2.096 1.00
77_Q 93_E 2.095 1.00
103_E 111_R 2.082 1.00
110_R 124_T 1.986 1.00
129_S 140_R 1.974 1.00
126_P 142_S 1.94 1.00
126_P 129_S 1.936 1.00
17_E 39_R 1.91 1.00
99_I 108_V 1.894 1.00
62_L 109_A 1.888 1.00
21_R 32_D 1.87 1.00
175_Q 178_Q 1.822 1.00
39_R 45_M 1.817 1.00
123_R 148_V 1.793 1.00
129_S 142_S 1.767 1.00
63_L 193_A 1.758 1.00
76_E 169_H 1.717 1.00
23_T 26_R 1.712 1.00
171_V 179_W 1.706 1.00
106_E 124_T 1.684 1.00
172_S 175_Q 1.681 1.00
27_G 52_E 1.658 1.00
73_V 119_L 1.65 1.00
55_E 138_S 1.647 1.00
127_V 145_V 1.574 1.00
179_W 184_K 1.572 1.00
66_D 170_V 1.56 1.00
107_D 110_R 1.539 1.00
131_L 186_D 1.51 1.00
94_M 193_A 1.481 1.00
18_I 80_I 1.472 1.00
108_V 111_R 1.46 1.00
177_Y 198_Q 1.452 1.00
113_A 121_V 1.442 1.00
195_Q 199_L 1.37 0.99
180_V 191_V 1.322 0.99
122_K 150_A 1.311 0.99
103_E 108_V 1.292 0.99
178_Q 181_E 1.282 0.99
34_Y 80_I 1.278 0.99
37_R 45_M 1.276 0.99
91_L 134_P 1.259 0.99
73_V 168_V 1.243 0.98
89_P 186_D 1.223 0.98
130_F 192_I 1.22 0.98
79_R 93_E 1.217 0.98
21_R 34_Y 1.2 0.98
133_S 139_E 1.198 0.98
66_D 119_L 1.182 0.98
105_V 144_M 1.18 0.98
74_L 171_V 1.167 0.97
82_A 91_L 1.16 0.97
61_V 141_S 1.141 0.97
32_D 55_E 1.14 0.97
68_V 71_E 1.133 0.97
131_L 140_R 1.126 0.97
17_E 37_R 1.123 0.97
24_L 31_L 1.119 0.96
132_A 136_G 1.102 0.96
110_R 114_I 1.09 0.96
82_A 89_P 1.081 0.95
70_D 173_R 1.079 0.95
41_F 165_D 1.074 0.95
143_I 193_A 1.073 0.95
63_L 197_L 1.055 0.95
171_V 176_A 1.053 0.95
56_R 139_E 1.036 0.94
120_I 150_A 1.036 0.94
82_A 131_L 1.028 0.94
176_A 185_I 1.027 0.94
58_H 99_I 1.027 0.94
130_F 143_I 1.023 0.93
130_F 191_V 1.013 0.93
176_A 180_V 1.012 0.93
23_T 30_S 1.007 0.93
33_L 50_R 1.003 0.93
126_P 144_M 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1g0sA211000.261Contact Map0.861
2dscA20.90911000.376Contact Map0.744
1vhzA20.89471000.394Contact Map0.769
1mk1A10.891000.421Contact Map0.784
3o6zA20.90911000.428Contact Map0.834
2yvpA10.85171000.472Contact Map0.765
1v8yA10.7991000.5Contact Map0.78
3q91A40.891000.523Contact Map0.719
2w4eA20.684299.90.574Contact Map0.749
2fvvA10.856599.90.619Contact Map0.611

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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