GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
7tm_3 - 7 transmembrane sweet-taste receptor of 3 GCPR
Pfam: PF00003 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 238
Sequences: 1334
Seq/Len: 5.61
HH_delta: 0.928 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
119_I123_L0.246673.053
41_Y224_T0.197372.443
118_I122_I0.181552.247
115_I119_I0.168062.080
108_L112_V0.161421.998
231_F234_K0.157461.949
56_C143_C0.145671.803
196_W222_C0.138671.717
61_W65_L0.137421.701
131_D142_S0.135741.680
78_T185_I0.132071.635
196_W199_F0.129551.604
131_D134_I0.126381.564
186_A190_Y0.125021.548
3_I12_I0.123681.531
166_F186_A0.121311.502
7_I38_L0.11881.471
47_F59_R0.118361.465
7_I11_I0.115891.435
4_L8_F0.115391.428
10_L14_I0.114371.416
7_I10_L0.111241.377
215_I223_A0.110791.371
46_L55_L0.110641.370
99_N102_L0.10791.336
11_I14_I0.107681.333
56_C173_R0.107571.332
30_L181_E0.106061.313
163_L167_F0.105961.312
61_W117_L0.105621.307
87_N213_L0.105511.306
11_I15_R0.104421.293
198_I202_L0.103761.284
228_G232_I0.102971.275
127_T144_S0.102111.264
6_T9_I0.101541.257
113_Q158_N0.100251.241
103_L107_L0.099851.236
169_A173_R0.099441.231
149_I153_L0.098891.224
199_F203_Y0.097821.211
87_N90_R0.097791.210
122_I153_L0.097511.207
12_I164_I0.097511.207
173_R181_E0.097351.205
119_I122_I0.097321.205
18_N27_P0.096251.191
51_P126_P0.09611.190
77_K234_K0.0941.164
25_S172_T0.093631.159
223_A228_G0.093241.154
169_A182_A0.09311.152
180_N190_Y0.09281.149
26_S30_L0.092531.145
5_F52_S0.092481.145
65_L95_L0.092451.144
225_V229_L0.091981.139
129_V132_I0.091971.138
54_I58_L0.091781.136
46_L62_L0.09141.131
52_S55_L0.090931.126
44_V65_L0.090611.122
212_F216_S0.089441.107
202_L218_G0.089411.107
12_I121_L0.089371.106
93_R96_I0.089241.105
8_F11_I0.08921.104
122_I152_I0.089161.104
4_L163_L0.088611.097
24_A176_P0.088581.096
137_N150_W0.088521.096
180_N183_R0.088241.092
111_L115_I0.087641.085
202_L217_F0.086921.076
70_I182_A0.086661.073
78_T81_I0.08651.071
34_L39_L0.086391.069
78_T85_F0.086311.068
46_L107_L0.086211.067
117_L156_G0.085681.061
77_K181_E0.085571.059
70_I210_W0.085531.059
75_L78_T0.085341.056
119_I228_G0.085291.056
176_P181_E0.085251.055
85_F176_P0.084871.051
76_A105_L0.084751.049
52_S210_W0.084211.042
88_P92_R0.08411.041
3_I6_T0.08411.041
29_L181_E0.084031.040
21_I34_L0.083621.035
80_R83_R0.083071.028
210_W213_L0.082841.025
5_F12_I0.082771.025
128_P141_L0.082771.025
65_L114_V0.082721.024
16_N23_R0.08271.024
122_I218_G0.082481.021
62_L116_I0.082361.019
73_A77_K0.082331.019
7_I107_L0.082151.017
105_L139_I0.081931.014
35_L130_S0.081831.013
115_I153_L0.081771.012
33_L230_L0.08141.008
219_I222_C0.081371.007
201_P214_I0.081241.006
8_F18_N0.08121.005
53_D128_P0.08111.004
21_I179_F0.081011.003
115_I232_I0.080841.001
183_R231_F0.080811.000
72_S113_Q0.080730.999
77_K231_F0.080620.998
3_I7_I0.080570.997
102_L165_G0.080550.997
72_S75_L0.080540.997
109_L157_Y0.080510.997
4_L160_L0.079920.989
16_N111_L0.079850.988
205_V208_G0.079740.987
11_I38_L0.079620.986
13_F30_L0.079490.984
169_A180_N0.079430.983
195_I202_L0.079410.983
160_L164_I0.079310.982
114_V128_P0.07930.982
80_R99_N0.079140.980
28_E99_N0.078930.977
5_F160_L0.078930.977
118_I163_L0.078920.977
70_I73_A0.07890.977
30_L179_F0.078670.974
4_L7_I0.078560.972
3_I38_L0.078480.971
9_I13_F0.07830.969
42_S200_I0.078270.969
162_L192_I0.078130.967
26_S84_I0.078070.966
43_S70_I0.077950.965
30_L33_L0.077940.965
46_L68_T0.077830.963
78_T169_A0.077760.963
108_L160_L0.077760.963
185_I200_I0.077690.962
26_S78_T0.077630.961
175_V181_E0.07740.958
78_T179_F0.07720.956
187_F199_F0.077080.954
116_I219_I0.077020.953
51_P199_F0.0770.953
54_I65_L0.076920.952
211_R223_A0.076870.952
59_R73_A0.076730.950
49_L59_R0.076570.948
12_I122_I0.076530.947
160_L163_L0.076320.945
18_N23_R0.076220.943
129_V144_S0.076210.943
196_W203_Y0.076140.942
200_I218_G0.076090.942
115_I130_S0.076090.942
113_Q155_L0.075810.938
55_L63_F0.075730.937
52_S163_L0.07570.937
72_S106_V0.075610.936
178_N184_Y0.075460.934
4_L145_S0.075450.934
192_I220_L0.075430.934
67_F73_A0.075290.932
202_L221_L0.075270.932
53_D118_I0.075190.931
180_N185_I0.075080.929
138_E160_L0.075070.929
38_L95_L0.074870.927
189_I193_T0.07480.926
213_L217_F0.074760.925
77_K185_I0.074550.923
93_R168_L0.074460.922
33_L45_F0.07440.921
112_V197_I0.074360.920
63_F151_L0.074240.919
7_I18_N0.074150.918
6_T227_L0.074080.917
17_R71_F0.073880.915
148_N163_L0.073730.913
102_L110_V0.073730.913
176_P180_N0.07360.911
35_L217_F0.073340.908
5_F38_L0.07330.907
32_I173_R0.07330.907
74_L185_I0.073210.906
81_I90_R0.073180.906
105_L118_I0.073180.906
8_F132_I0.073180.906
116_I144_S0.073070.904
31_Y191_N0.073020.904
36_G103_L0.073020.904
5_F114_V0.072950.903
108_L149_I0.072860.902
7_I132_I0.072730.900
35_L160_L0.072670.900
73_A80_R0.072340.895
179_F230_L0.072140.893
122_I132_I0.072050.892
168_L184_Y0.072040.892
36_G69_L0.072040.892
15_R149_I0.071960.891
105_L109_L0.071930.890
28_E103_L0.071920.890
95_L156_G0.071810.889
8_F12_I0.071690.887
7_I129_V0.071480.885
95_L102_L0.07140.884
147_S155_L0.071380.884
84_I120_W0.071310.883
8_F111_L0.071260.882
106_V161_L0.071260.882
16_N129_V0.071080.880
12_I16_N0.071080.880
89_S102_L0.071070.880
102_L178_N0.071030.879
114_V118_I0.0710.879
66_G79_W0.070970.878
68_T202_L0.070940.878
181_E231_F0.070620.874
83_R86_R0.070550.873
115_I197_I0.070520.873
135_S210_W0.070510.873
47_F219_I0.070480.872
215_I219_I0.070350.871
39_L61_W0.070340.871
59_R63_F0.07030.870
14_I174_N0.070260.870
141_L228_G0.070240.869
46_L53_D0.070180.869
35_L89_S0.070180.869
42_S49_L0.070170.869
4_L130_S0.070110.868
110_V128_P0.070090.868
73_A135_S0.070060.867
32_I53_D0.06980.864
6_T10_L0.069780.864
133_D197_I0.069760.864
7_I15_R0.069750.863
119_I153_L0.069740.863
10_L35_L0.069620.862
116_I178_N0.069570.861
15_R118_I0.06950.860
124_D127_T0.069470.860
132_I232_I0.069460.860
37_C49_L0.069450.860
20_P24_A0.06940.859
9_I22_I0.069340.858
76_A158_N0.069010.854
32_I38_L0.069010.854
120_W188_A0.068830.852
18_N184_Y0.068830.852
13_F19_T0.068690.850
32_I69_L0.068640.850
82_Y168_L0.068620.849
164_I206_T0.068620.849
118_I204_F0.068520.848
77_K80_R0.06850.848
12_I17_R0.068490.848
15_R107_L0.068420.847
163_L210_W0.068340.846
122_I138_E0.068240.845
41_Y192_I0.067950.841
25_S180_N0.067840.840
33_L73_A0.067740.839
214_I225_V0.067710.838
11_I111_L0.067640.837
113_Q157_Y0.067620.837
9_I136_S0.06760.837
52_S141_L0.06760.837
18_N93_R0.067560.836
141_L198_I0.067540.836
62_L86_R0.067520.836
191_N206_T0.067470.835
19_T34_L0.067360.834
21_I93_R0.067330.833
21_I50_P0.067240.832
12_I232_I0.067220.832
202_L210_W0.06720.832
22_I34_L0.067170.831
107_L166_F0.067060.830
32_I103_L0.066810.827
171_K188_A0.066740.826
38_L132_I0.066730.826
10_L18_N0.066680.825
82_Y175_V0.066650.825
35_L112_V0.066640.825
180_N187_F0.066640.825
106_V110_V0.06660.824
212_F230_L0.066530.824
147_S200_I0.066440.822
24_A29_L0.066390.822
137_N141_L0.066360.821
3_I136_S0.066350.821
156_G160_L0.06630.821
128_P160_L0.066280.820
195_I199_F0.066210.820
137_N232_I0.066170.819
113_Q196_W0.066160.819
26_S41_Y0.066130.819
53_D228_G0.065990.817
119_I130_S0.065960.816
196_W201_P0.06590.816
103_L133_D0.065780.814
175_V208_G0.06560.812
176_P179_F0.065540.811
123_L141_L0.065490.811
4_L132_I0.065440.810
112_V136_S0.065420.810
209_E217_F0.065360.809
60_R145_S0.065270.808
138_E150_W0.06520.807
49_L155_L0.065150.806
19_T22_I0.065140.806
80_R84_I0.065130.806
63_F175_V0.065080.806
7_I130_S0.065070.805
7_I116_I0.0650.805
116_I185_I0.064960.804
203_Y236_Y0.064960.804
121_L124_D0.064930.804
96_I206_T0.064750.801
112_V237_I0.064710.801
74_L136_S0.064680.801
221_L224_T0.064580.799
42_S156_G0.064570.799
131_D187_F0.064560.799
36_G66_G0.064410.797
78_T180_N0.064370.797
18_N108_L0.064320.796
71_F119_I0.06430.796
40_L43_S0.064260.795
183_R186_A0.064260.795
181_E234_K0.064210.795
186_A225_V0.064170.794
7_I58_L0.064040.793
24_A177_S0.064020.792
165_G191_N0.0640.792
81_I84_I0.063980.792
11_I53_D0.063880.791
210_W232_I0.063870.791
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3sn6R0.953867.50.928
2z73A0.9496640.929
3rzeA0.95854.60.933
3uonA0.95847.50.935
4ea3A0.945442.80.937
3emlA0.949640.90.938
3oduA0.945433.20.941
4eiyA0.949628.70.943
4ib4A0.962227.50.943
2ks9A0.93722.70.945
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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