GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
GST_C - Glutathione S-transferase C-terminal domain
Pfam: PF00043 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0497
Length: 95
Sequences: 6694
Seq/Len: 70.46
HH_delta: 0.208 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
48_P90_R1.901893.413
86_K90_R1.496272.685
41_E83_K1.419132.546
45_K83_K1.330672.388
23_E27_E1.208982.169
38_E81_F1.099561.973
85_K89_E0.990821.778
41_E82_P0.97471.749
55_L60_I0.959781.722
22_D25_M0.953071.710
55_L94_R0.944631.695
79_E85_K0.914621.641
48_P53_D0.889331.596
51_V56_T0.880921.581
50_L62_L0.85541.535
83_K86_K0.842281.511
27_E31_A0.80281.441
63_F91_M0.77771.395
43_R47_G0.758961.362
38_E42_K0.750561.347
28_E32_K0.749951.346
27_E30_R0.716111.285
63_F92_F0.662691.189
89_E93_A0.644361.156
39_V43_R0.620031.113
41_E45_K0.619421.111
25_M29_A0.618341.110
34_P80_K0.617691.108
34_P81_F0.615021.104
60_I94_R0.60821.091
31_A35_R0.607961.091
50_L58_A0.607881.091
49_Y91_M0.596231.070
49_Y52_G0.588081.055
34_P38_E0.586121.052
38_E80_K0.578791.039
30_R34_P0.571291.025
55_L91_M0.558331.002
66_L88_Y0.55821.002
36_Y39_V0.55540.997
87_W91_M0.544560.977
42_K46_G0.529430.950
23_E26_V0.523590.940
32_K35_R0.520990.935
64_P87_W0.509450.914
89_E92_F0.506110.908
88_Y92_F0.501140.899
57_I61_A0.498210.894
70_E88_Y0.496190.890
46_G83_K0.494510.887
37_L66_L0.4930.885
42_K45_K0.487970.876
41_E84_L0.486950.874
29_A32_K0.472380.848
28_E31_A0.472040.847
39_V42_K0.469580.843
41_E81_F0.468750.841
40_L62_L0.464450.833
52_G59_D0.464220.833
24_E27_E0.453110.813
36_Y40_L0.443570.796
35_R39_V0.441890.793
85_K88_Y0.435050.781
90_R93_A0.432220.776
43_R50_L0.431390.774
50_L87_W0.430820.773
51_V58_A0.425440.763
32_K36_Y0.419930.754
67_D88_Y0.418230.750
60_I64_P0.416860.748
62_L66_L0.407680.732
70_E85_K0.405740.728
67_D92_F0.404970.727
48_P86_K0.402810.723
63_F67_D0.394470.708
60_I91_M0.39080.701
60_I87_W0.384780.690
72_L76_F0.377340.677
49_Y90_R0.377010.676
38_E41_E0.376190.675
31_A34_P0.371010.666
24_E28_E0.368640.661
37_L81_F0.367940.660
73_G76_F0.361630.649
67_D71_R0.357310.641
66_L87_W0.357150.641
47_G90_R0.352540.633
22_D29_A0.351610.631
68_W72_L0.351210.630
26_V30_R0.347710.624
33_V37_L0.346270.621
65_M68_W0.345210.619
90_R94_R0.345050.619
40_L50_L0.343280.616
81_F84_L0.342920.615
41_E86_K0.342730.615
68_W71_R0.340080.610
76_F79_E0.338490.607
37_L84_L0.332360.596
57_I64_P0.330690.593
56_T59_D0.328630.590
43_R51_V0.328270.589
82_P86_K0.327320.587
49_Y55_L0.3260.585
40_L84_L0.322820.579
68_W73_G0.317130.569
82_P85_K0.315550.566
25_M32_K0.313580.563
86_K89_E0.31210.560
22_D28_E0.311430.559
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
4g0iA0.978999.10.208
4gciA0.936899.10.213
4fquA0.978999.10.219
4akgA0.936899.10.221
4kh7A0.9684990.222
4hojA0.9895990.222
4hi7A0.9789990.222
4kdxA0.9684990.224
3ik7A0.9684990.225
4gf0A0.9684990.226

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