GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Metallophos - Calcineurin-like phosphoesterase
Pfam: PF00149 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0163
Length: 200
Sequences: 14060
Seq/Len: 70.3
HH_delta: 0.119 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
5_V38_L1.522153.981
36_I155_F1.254953.282
3_I34_F1.175833.075
9_L37_F1.005162.629
5_V193_L0.99542.604
156_T192_V0.954042.495
7_S38_L0.87552.290
153_I191_L0.874682.288
4_L32_P0.788722.063
34_F69_Y0.788442.062
138_L142_L0.785892.056
152_V190_D0.755991.977
38_L155_F0.741011.938
6_I37_F0.723011.891
151_P190_D0.691551.809
181_E185_K0.668831.749
37_F41_L0.661711.731
139_W143_L0.661321.730
136_W139_W0.656241.716
74_N196_H0.632691.655
154_V189_V0.631611.652
38_L71_I0.623131.630
23_L27_A0.614131.606
141_L145_E0.612821.603
38_L193_L0.584051.528
116_F120_S0.580211.518
2_R33_D0.555771.454
140_L144_L0.553821.449
20_F24_D0.550561.440
7_S10_H0.549311.437
25_E29_E0.547671.432
10_H43_D0.547081.431
155_F193_L0.539151.410
59_I62_L0.535621.401
26_I29_E0.535391.400
37_F70_F0.534451.398
22_K25_E0.53271.393
6_I67_P0.532651.393
157_H196_H0.518921.357
59_I63_N0.509981.334
182_E186_K0.508431.330
154_V192_V0.50711.326
40_D74_N0.504271.319
24_D28_A0.496941.300
117_W121_G0.495451.296
21_R25_E0.492221.287
27_A32_P0.475851.245
183_L187_Y0.470841.231
72_L76_D0.470141.230
40_D198_H0.469511.228
112_D116_F0.467881.224
118_F122_N0.466531.220
133_Q136_W0.457731.197
134_Q138_L0.455921.192
26_I30_N0.454231.188
114_D118_F0.453591.186
139_W142_L0.452181.183
36_I69_Y0.448611.173
160_P194_S0.446721.168
22_K26_I0.445751.166
49_E53_A0.440451.152
38_L195_G0.438231.146
71_I155_F0.431931.130
115_N118_F0.428481.121
132_A136_W0.427171.117
176_G179_A0.427121.117
115_N119_N0.425681.113
116_F119_N0.423241.107
112_D117_W0.422941.106
25_E28_A0.417621.092
136_W140_L0.415491.087
135_E138_L0.414231.083
6_I35_I0.413931.083
137_W140_L0.41291.080
64_P67_P0.410141.073
180_L184_L0.40781.067
7_S195_G0.405211.060
147_K152_V0.400771.048
182_E185_K0.398091.041
113_N117_W0.397021.038
139_W144_L0.385931.009
27_A30_N0.384811.006
147_K150_D0.384671.006
35_I65_K0.3820.999
152_V189_V0.381550.998
134_Q137_W0.381250.997
159_P194_S0.380130.994
37_F68_V0.379320.992
91_F95_Y0.378770.991
35_I66_I0.378740.991
120_S123_N0.37850.990
184_L187_Y0.375430.982
93_D96_G0.374270.979
24_D27_A0.37380.978
138_L141_L0.372990.976
142_L145_E0.37260.975
179_A182_E0.368780.965
153_I193_L0.36850.964
137_W141_L0.368140.963
96_G99_N0.366990.960
96_G100_Y0.365140.955
113_N116_F0.363280.950
59_I64_P0.361750.946
34_F67_P0.361570.946
114_D117_W0.358130.937
46_N49_E0.356520.932
8_D74_N0.356140.931
135_E140_L0.353410.924
94_Y97_N0.353270.924
119_N123_N0.352130.921
74_N157_H0.350410.917
60_R64_P0.348250.911
112_D118_F0.344180.900
40_D75_H0.343710.899
51_W55_F0.343520.898
141_L186_K0.341430.893
135_E139_W0.340040.889
112_D115_N0.339840.889
183_L186_K0.339070.887
131_E135_E0.338830.886
42_V76_D0.336110.879
40_D196_H0.335790.878
149_D152_V0.334350.875
122_N125_Y0.334160.874
176_G182_E0.333930.873
177_R181_E0.333520.872
143_L146_A0.331670.867
30_N33_D0.331170.866
8_D40_D0.328690.860
85_G89_Y0.328240.859
97_N100_Y0.328130.858
175_K179_A0.326870.855
8_D75_H0.326130.853
47_P51_W0.325180.851
156_T194_S0.32490.850
32_P35_I0.3240.847
10_H40_D0.323320.846
137_W142_L0.322590.844
140_L143_L0.32240.843
2_R30_N0.320790.839
113_N118_F0.320760.839
4_L27_A0.320040.837
41_L70_F0.319780.836
184_L189_V0.319720.836
21_R24_D0.319130.835
135_E142_L0.317810.831
47_P50_E0.317480.830
50_E53_A0.314060.821
9_L41_L0.314020.821
99_N102_Y0.313490.820
51_W54_Q0.311810.816
23_L30_N0.311740.815
42_V45_G0.31080.813
86_F89_Y0.310490.812
48_S52_R0.308940.808
20_F23_L0.308640.807
73_G76_D0.308310.806
42_V49_E0.308130.806
175_K178_E0.30510.798
69_Y72_L0.302670.792
144_L148_N0.302560.791
136_W144_L0.302250.791
153_I157_H0.300010.785
143_L147_K0.30.785
141_L187_Y0.299450.783
133_Q137_W0.298540.781
4_L26_I0.297890.779
125_Y128_Y0.297530.778
35_I68_V0.295970.774
8_D198_H0.295680.773
4_L33_D0.293880.769
61_L64_P0.293790.768
123_N127_D0.293130.767
97_N101_Y0.292390.765
158_H197_T0.291670.763
142_L146_A0.29110.761
72_L77_Y0.290970.761
6_I9_L0.29080.761
3_I36_I0.289850.758
32_P66_I0.289660.758
5_V194_S0.289220.756
129_G132_A0.286660.750
42_V50_E0.285870.748
114_D121_G0.284120.743
129_G133_Q0.283690.742
9_L76_D0.282810.740
39_G70_F0.280580.734
10_H196_H0.28040.733
75_H198_H0.279820.732
117_W122_N0.279310.731
20_F25_E0.277850.727
43_D46_N0.277480.726
82_S86_F0.27670.724
22_K27_A0.276540.723
40_D157_H0.276330.723
130_M133_Q0.276220.722
44_G49_E0.274250.717
27_A35_I0.272990.714
178_E182_E0.27230.712
23_L26_I0.270190.707
37_F67_P0.268780.703
181_E184_L0.267530.700
113_N119_N0.26730.699
134_Q139_W0.266130.696
74_N198_H0.266080.696
20_F27_A0.263930.690
113_N120_S0.262340.686
21_R27_A0.262330.686
115_N121_G0.261860.685
9_L42_V0.260610.682
116_F121_G0.260460.681
45_G49_E0.260030.680
98_Y102_Y0.259690.679
132_A135_E0.259350.678
152_V155_F0.259120.678
131_E139_W0.258740.677
145_E148_N0.258510.676
120_S124_E0.258320.676
50_E54_Q0.256160.670
157_H198_H0.25570.669
132_A139_W0.255570.668
35_I67_P0.25530.668
77_Y80_G0.255260.668
182_E187_Y0.255230.668
7_S11_G0.255120.667
12_G16_D0.255120.667
121_G125_Y0.254550.666
40_D195_G0.254360.665
113_N121_G0.253370.663
31_K65_K0.250620.656
98_Y101_Y0.248960.651
162_S197_T0.24890.651
122_N126_P0.248880.651
43_D75_H0.246770.645
151_P154_V0.246160.644
83_F86_F0.245840.643
146_A149_D0.245770.643
5_V36_I0.244410.639
94_Y98_Y0.243570.637
50_E55_F0.24340.637
95_Y99_N0.240440.629
2_R31_K0.239990.628
118_F121_G0.239150.626
114_D119_N0.237860.622
159_P197_T0.237660.622
81_N85_G0.236790.619
124_E129_G0.235990.617
31_K66_I0.235840.617
128_Y131_E0.235130.615
94_Y99_N0.234620.614
121_G124_E0.234420.613
85_G88_D0.234320.613
8_D196_H0.233990.612
129_G134_Q0.232790.609
152_V188_N0.232790.609
136_W141_L0.232470.608
160_P180_L0.23240.608
112_D119_N0.232180.607
63_N66_I0.231450.605
4_L35_I0.23130.605
144_L147_K0.231090.604
119_N125_Y0.230350.602
33_D37_F0.229370.600
176_G180_L0.229170.599
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3tghA0.96599.80.119
3ib7A0.9499.80.193
1uteA0.9899.80.199
1xzwA0.94599.70.216
3d03A0.93599.70.216
2xmoA0.9999.70.216
2nxfA0.9899.70.226
2qfpA0.9599.70.228
2q8uA0.96599.60.283
2yvtA0.92599.60.293

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