GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Aldedh - Aldehyde dehydrogenase family
Pfam: PF00171 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0099
Length: 462
Sequences: 18072
Seq/Len: 39.12
HH_delta: -0.034 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
279_E381_D3.088135.377
223_K227_K2.08483.630
279_E379_P1.81993.169
251_D288_A1.814353.159
246_P278_H1.645912.866
314_K318_E1.587072.764
39_R205_D1.585352.761
360_P363_M1.571432.736
282_Y379_P1.568452.731
65_E98_R1.559012.715
325_E329_A1.546922.694
246_P280_S1.492592.599
255_E292_R1.483582.583
326_D364_P1.47452.568
171_L174_E1.471622.562
286_V377_V1.441122.509
67_R70_E1.43112.492
403_S409_A1.359082.367
324_I351_I1.353882.357
311_L320_V1.34062.334
177_E183_P1.287132.241
39_R207_D1.272762.216
411_R415_R1.239982.159
27_T30_D1.221582.127
290_K294_A1.220112.125
68_R91_D1.186562.066
60_F176_L1.176532.049
333_K358_D1.174552.045
383_L411_R1.171762.040
321_K325_E1.163282.026
383_L408_R1.143541.991
36_E205_D1.100371.916
326_D330_E1.095451.907
328_V334_V1.09541.907
56_I181_L1.092721.903
284_E288_A1.092151.902
287_E291_E1.086571.892
63_L178_E1.084861.889
276_L386_A1.082061.884
164_Q313_S1.077481.876
69_D87_R1.074011.870
356_L365_I1.073681.870
242_V257_I1.060441.847
275_V375_L1.058221.843
335_L357_E1.049481.827
394_E441_Q1.042511.815
62_D66_E1.037671.807
63_L66_E1.034481.801
321_K351_I1.024731.784
70_E171_L1.020631.777
97_L148_A1.019661.776
247_D408_R1.0181.773
125_E460_K1.017181.771
32_D199_A1.016821.771
124_R457_T1.016311.770
381_D385_E1.01291.764
202_S224_A1.009621.758
198_E202_S1.009021.757
333_K357_E1.007721.755
67_R178_E0.996871.736
32_D36_E0.995211.733
283_D379_P0.99161.727
63_L175_L0.987851.720
364_P368_E0.98361.713
293_V355_V0.966371.683
219_R441_Q0.964091.679
385_E388_A0.96181.675
42_F46_S0.960921.673
384_D415_R0.957041.666
276_L389_L0.947741.650
417_E440_K0.935041.628
246_P408_R0.934621.627
62_D98_R0.933931.626
290_K335_L0.93231.623
361_P389_L0.926921.614
399_A418_A0.925491.612
282_Y286_V0.922481.606
173_A188_V0.920531.603
58_E98_R0.919581.601
334_V356_L0.915711.595
69_D73_E0.915131.593
220_A223_K0.904851.576
156_T185_V0.904261.575
278_H380_Y0.90061.568
284_E287_E0.898711.565
49_P52_E0.897451.563
63_L179_A0.894961.558
292_R295_K0.89221.554
74_L171_L0.891311.552
256_A402_F0.886621.544
124_R454_D0.882181.536
366_M378_V0.879181.531
257_I285_F0.874841.523
59_R62_D0.874821.523
65_E94_I0.873741.521
278_H382_D0.85621.491
297_R305_S0.84581.473
52_E55_R0.845391.472
387_I412_L0.843831.469
250_L288_A0.843761.469
288_A291_E0.838671.460
47_K415_R0.836771.457
332_A356_L0.828741.443
19_V22_E0.828441.443
32_D203_H0.823271.434
245_D408_R0.819421.427
322_A364_P0.817481.423
277_V285_F0.817451.423
291_E295_K0.807051.405
314_K349_F0.803181.399
325_E328_V0.801451.396
382_D385_E0.800661.394
174_E178_E0.800111.393
257_I275_V0.785191.367
318_E322_A0.780381.359
73_E77_L0.777771.354
42_F156_T0.775191.350
254_A288_A0.77111.343
61_A98_R0.768121.338
262_F293_V0.765991.334
282_Y357_E0.761091.325
18_E347_N0.761091.325
73_E302_L0.760981.325
103_A106_K0.757391.319
132_I157_V0.757011.318
13_N16_T0.755031.315
123_R414_R0.750991.308
97_L144_V0.748161.303
68_R87_R0.746941.301
31_V196_V0.746191.299
35_V203_H0.743351.294
317_R351_I0.743241.294
291_E294_A0.74091.290
384_D411_R0.740121.289
176_L186_V0.739641.288
110_E450_P0.739131.287
323_L370_I0.734131.278
385_E389_L0.734091.278
317_R321_K0.731831.274
294_A336_C0.729471.270
245_D380_Y0.727351.267
327_A356_L0.726861.266
71_L171_L0.723961.261
222_A444_I0.723281.259
36_E40_A0.721461.256
330_E364_P0.721171.256
242_V272_P0.717471.249
48_L52_E0.717451.249
30_D33_R0.707421.232
380_Y389_L0.702171.223
76_A86_A0.697811.215
276_L380_Y0.697521.215
198_E220_A0.694061.209
83_I87_R0.692481.206
59_R63_L0.691841.205
67_R171_L0.691621.204
245_D412_L0.690451.202
21_G167_L0.689091.200
198_E224_A0.687711.197
208_L233_V0.686611.196
60_F97_L0.685811.194
143_A159_L0.680011.184
296_L308_V0.678411.181
60_F175_L0.678161.181
314_K317_R0.676781.178
300_D303_D0.674781.175
451_E454_D0.670231.167
220_A224_A0.665851.159
367_Q394_E0.664941.158
71_L175_L0.664931.158
123_R462_V0.664171.157
367_Q392_D0.660571.150
61_A65_E0.659951.149
132_I210_S0.656811.144
173_A186_V0.654771.140
387_I391_N0.654051.139
362_D367_Q0.653621.138
399_A421_V0.651041.134
35_V205_D0.650251.132
286_V290_K0.649331.131
387_I415_R0.648091.129
243_I386_A0.646291.125
110_E451_E0.643971.121
67_R175_L0.643291.120
58_E105_R0.640551.115
413_A462_V0.636331.108
37_A184_G0.635811.107
383_L412_L0.633331.103
320_V372_G0.633131.102
13_N300_D0.631291.099
121_Y410_E0.631231.099
124_R459_I0.629721.097
17_G349_F0.62941.096
17_G347_N0.629391.096
289_L375_L0.626721.091
283_D287_E0.626061.090
76_A301_P0.624651.088
409_A423_I0.62261.084
361_P392_D0.622441.084
217_T220_A0.618131.076
285_F289_L0.6181.076
147_I186_V0.616161.073
281_I284_E0.6131.067
243_I412_L0.611661.065
48_L56_I0.610841.064
60_F181_L0.608891.060
384_D388_A0.607551.058
297_R307_D0.605471.054
184_G187_N0.604671.053
219_R229_L0.603621.051
328_V356_L0.601721.048
245_D278_H0.599751.044
290_K336_C0.598321.042
163_E194_S0.597961.041
405_D408_R0.597471.040
450_P454_D0.597131.040
138_F268_S0.595481.037
66_E178_E0.595191.036
294_A352_P0.594791.036
278_H281_I0.593911.034
131_L206_V0.593831.034
222_A232_V0.592271.031
43_K388_A0.591731.030
252_K404_R0.59121.029
286_V335_L0.590351.028
73_E83_I0.588291.024
13_N77_L0.587671.023
214_S217_T0.584661.018
322_A326_D0.584431.018
446_R458_Q0.584141.017
386_A389_L0.583271.016
58_E101_A0.581631.013
37_A187_N0.581011.012
326_D329_A0.58081.011
283_D286_V0.580351.011
451_E459_I0.580131.010
247_D405_D0.579681.009
199_A203_H0.577131.005
170_L190_P0.57621.003
388_A392_D0.576011.003
127_L155_N0.573810.999
58_E102_D0.573490.999
216_A220_A0.570650.994
286_V357_E0.570030.993
249_D404_R0.568660.990
202_S227_K0.567930.989
129_V206_V0.566220.986
147_I157_V0.564740.983
241_P399_A0.563150.981
131_L200_L0.562190.979
13_N18_E0.561880.978
40_A43_K0.560220.975
250_L254_A0.558870.973
330_E363_M0.558350.972
327_A370_I0.557680.971
219_R223_K0.557470.971
254_A292_R0.556680.969
245_D383_L0.555840.968
64_L93_A0.555360.967
337_G354_T0.55340.964
299_G306_T0.55160.960
207_D417_E0.550920.959
33_R37_A0.550680.959
77_L302_L0.549940.958
144_V172_L0.549680.957
317_R349_F0.54940.957
249_D252_K0.549140.956
338_G354_T0.547620.954
43_K47_K0.545850.950
243_I390_A0.542120.944
323_L326_D0.541820.943
197_G201_V0.541720.943
125_E414_R0.541480.943
254_A258_V0.5410.942
242_V402_F0.540150.941
67_R174_E0.539890.940
413_A423_I0.537390.936
222_A226_A0.537360.936
58_E62_D0.536880.935
244_V285_F0.535960.933
50_A54_A0.534860.931
131_L209_V0.532660.928
406_E409_A0.532160.927
70_E73_E0.531580.926
28_A199_A0.530350.923
320_V374_V0.526530.917
251_D284_E0.526320.916
260_G272_P0.524040.912
258_V292_R0.523570.912
130_V208_L0.523460.911
437_G446_R0.522670.910
318_E321_K0.520080.906
54_A101_A0.519180.904
41_A156_T0.51760.901
127_L231_P0.51740.901
239_K273_S0.516020.899
380_Y386_A0.513960.895
77_L167_L0.512510.892
401_V412_L0.512340.892
383_L387_I0.512330.892
127_L208_L0.510850.890
150_A157_V0.510150.888
288_A292_R0.509420.887
35_V206_V0.508560.886
332_A363_M0.507540.884
104_A152_A0.506870.883
15_A301_P0.506150.881
247_D403_S0.505840.881
31_V131_L0.504740.879
61_A101_A0.504210.878
254_A289_L0.502110.874
174_E177_E0.501940.874
181_L186_V0.501740.874
64_L94_I0.498140.867
33_R36_E0.497840.867
81_K89_E0.497570.866
170_L188_V0.4970.865
261_A273_S0.496940.865
323_L364_P0.494570.861
29_E32_D0.494530.861
55_R59_R0.493060.859
253_A285_F0.492030.857
253_A257_I0.490690.854
93_A140_L0.490460.854
164_Q315_A0.490030.853
93_A144_V0.487560.849
282_Y377_V0.486930.848
222_A229_L0.486890.848
337_G352_P0.486610.847
129_V156_T0.485620.846
359_V363_M0.485430.845
38_A187_N0.485280.845
28_A32_D0.483230.841
47_K414_R0.481350.838
29_E33_R0.481260.838
125_E439_F0.481220.838
218_G234_L0.480850.837
209_V221_I0.479910.836
378_V389_L0.479040.834
63_L67_R0.478710.834
25_S195_E0.478590.833
380_Y385_E0.478140.833
127_L458_Q0.475610.828
45_W185_V0.475470.828
41_A185_V0.474930.827
26_A189_V0.474270.826
303_D306_T0.47250.823
361_P378_V0.471980.822
231_P458_Q0.471640.821
382_D388_A0.471380.821
146_K447_E0.470570.819
426_P429_G0.469160.817
46_S417_E0.468960.817
439_F458_Q0.46730.814
225_A232_V0.467090.813
156_T187_N0.465730.811
26_A34_A0.463630.807
43_K417_E0.46340.807
26_A30_D0.463350.807
20_I77_L0.461660.804
400_S426_P0.460910.803
323_L368_E0.460570.802
218_G236_L0.460040.801
320_V370_I0.459650.800
31_V35_V0.459430.800
65_E91_D0.458740.799
54_A58_E0.45850.798
252_K256_A0.45810.798
28_A195_E0.457210.796
293_V336_C0.454270.791
54_A105_R0.454170.791
300_D306_T0.453560.790
56_I179_A0.453060.789
158_V187_N0.452850.789
59_R179_A0.451830.787
254_A285_F0.449990.784
211_F217_T0.448170.780
87_R304_E0.447680.780
209_V225_A0.447340.779
399_A416_L0.447150.779
65_E68_R0.446880.778
72_A76_A0.444230.774
15_A350_F0.444150.773
282_Y358_D0.443680.773
159_L169_A0.443460.772
410_E414_R0.441990.770
252_K255_E0.441790.769
191_G196_V0.441510.769
322_A325_E0.441450.769
72_A83_I0.437050.761
367_Q393_S0.436980.761
240_N273_S0.436090.759
404_R407_S0.434660.757
140_L168_T0.434110.756
278_H383_L0.433720.755
39_R43_K0.433610.755
406_E410_E0.433230.754
336_C355_V0.431930.752
170_L174_E0.431670.752
155_N457_T0.431340.751
132_I146_K0.43120.751
324_I374_V0.430680.750
143_A169_A0.430660.750
32_D205_D0.428010.745
245_D403_S0.425360.741
90_V140_L0.424640.739
338_G352_P0.423120.737
46_S415_R0.422940.736
421_V460_K0.422170.735
277_V281_I0.422080.735
357_E379_P0.421690.734
222_A234_L0.421640.734
127_L207_D0.419810.731
268_S271_A0.419360.730
57_L152_A0.418830.729
81_K85_E0.418260.728
76_A83_I0.418040.728
164_Q312_I0.413170.719
43_K46_S0.413110.719
257_I289_L0.41280.719
181_L185_V0.412750.719
324_I356_L0.412180.718
161_P190_P0.412120.718
45_W56_I0.410080.714
68_R94_I0.409930.714
75_I78_E0.409650.713
38_A156_T0.408380.711
173_A177_E0.406890.709
356_L359_V0.406310.707
222_A225_A0.405620.706
219_R227_K0.403310.702
387_I411_R0.403270.702
320_V351_I0.402830.701
250_L281_I0.401920.700
334_V337_G0.401440.699
298_V308_V0.401230.699
315_A318_E0.401060.698
44_E47_K0.400440.697
241_P390_A0.400350.697
251_D292_R0.399880.696
194_S198_E0.398970.695
258_V289_L0.398640.694
223_K226_A0.39770.693
40_A44_E0.396820.691
71_L140_L0.395160.688
201_V221_I0.394770.687
31_V199_A0.394360.687
79_T165_A0.39420.686
177_E184_G0.393650.685
163_E319_R0.393150.685
289_L377_V0.392560.684
38_A158_V0.390930.681
13_N302_L0.389490.678
319_R322_A0.38920.678
250_L284_E0.388970.677
79_T312_I0.388310.676
201_V209_V0.38780.675
324_I354_T0.386840.674
74_L167_L0.386790.674
60_F63_L0.386770.673
24_P190_P0.386730.673
331_G363_M0.385850.672
72_A87_R0.385550.671
91_D94_I0.38550.671
70_E74_L0.384660.670
258_V296_L0.384290.669
276_L361_P0.382510.666
276_L366_M0.381650.665
61_A94_I0.381530.664
366_M389_L0.380320.662
35_V158_V0.378160.658
23_V166_P0.377070.657
176_L181_L0.376630.656
200_L209_V0.37560.654
121_Y462_V0.37510.653
64_L97_L0.374740.653
119_R410_E0.374630.652
359_V366_M0.374230.652
46_S126_P0.374170.652
293_V296_L0.373680.651
290_K355_V0.372850.649
62_D65_E0.372020.648
403_S408_R0.370840.646
153_A457_T0.369430.643
69_D83_I0.369140.643
149_P452_G0.368970.642
252_K402_F0.368930.642
141_Y145_W0.368630.642
383_L415_R0.367630.640
335_L358_D0.3670.639
120_N461_T0.366480.638
159_L186_V0.365870.637
279_E283_D0.365740.637
64_L172_L0.365330.636
248_A253_A0.365320.636
44_E48_L0.365280.636
296_L307_D0.365110.636
201_V224_A0.364440.635
409_A413_A0.363270.633
163_E220_A0.362880.632
251_D255_E0.361560.630
244_V248_A0.358650.625
130_V155_N0.358370.624
311_L316_Q0.358290.624
91_D95_D0.357760.623
315_A319_R0.357750.623
361_P366_M0.35750.623
76_A302_L0.357180.622
247_D404_R0.357020.622
289_L355_V0.356610.621
51_A105_R0.35640.621
84_A307_D0.355530.619
194_S216_A0.354760.618
143_A147_I0.354560.617
321_K324_I0.354120.617
37_A183_P0.353810.616
407_S410_E0.353490.616
163_E216_A0.353470.615
56_I60_F0.353030.615
195_E198_E0.352880.614
417_E439_F0.352510.614
242_V400_S0.35140.612
193_G197_G0.350980.611
321_K328_V0.350650.611
387_I416_L0.349480.609
200_L206_V0.349310.608
233_V455_E0.348440.607
449_G452_G0.348170.606
231_P455_E0.34770.605
287_E290_K0.347490.605
358_D379_P0.347010.604
407_S411_R0.346940.604
83_I302_L0.346520.603
131_L197_G0.346340.603
90_V94_I0.345280.601
34_A37_A0.344660.600
215_T441_Q0.3440.599
244_V253_A0.342950.597
42_F185_V0.342810.597
107_L453_L0.34240.596
313_S316_Q0.3420.596
131_L158_V0.341750.595
72_A86_A0.341460.595
250_L253_A0.340910.594
43_K415_R0.340190.592
286_V355_V0.340140.592
298_V307_D0.339960.592
327_A365_I0.338910.590
114_S120_N0.338870.590
172_L176_L0.338650.590
162_S165_A0.338570.590
39_R42_F0.338180.589
241_P418_A0.337760.588
400_S427_P0.337520.588
64_L71_L0.33710.587
158_V200_L0.336660.586
199_A202_S0.335910.585
143_A172_L0.335720.585
45_W151_L0.335610.584
351_I354_T0.334580.583
275_V285_F0.334430.582
81_K138_F0.334390.582
277_V377_V0.333760.581
277_V282_Y0.333470.581
194_S220_A0.333410.581
215_T219_R0.333350.580
122_T435_P0.333210.580
51_A55_R0.332990.580
265_S308_V0.332640.579
398_T422_W0.332240.579
158_V189_V0.332220.578
75_I168_T0.33220.578
134_T143_A0.328340.572
426_P430_D0.328230.572
73_E76_A0.327890.571
412_L415_R0.327620.570
34_A189_V0.327330.570
71_L90_V0.327240.570
146_K210_S0.32710.570
50_A104_A0.326970.569
147_I159_L0.326660.569
254_A281_I0.32650.569
370_I374_V0.326420.568
153_A453_L0.326250.568
32_D35_V0.325590.567
366_M376_P0.325170.566
242_V275_V0.324810.566
107_L457_T0.324230.565
64_L140_L0.323880.564
224_A227_K0.323850.564
250_L285_F0.322950.562
36_E39_R0.322580.562
418_A421_V0.321740.560
401_V409_A0.321630.560
425_D428_T0.320690.558
171_L175_L0.320280.558
75_I89_E0.319860.557
240_N398_T0.319690.557
246_P380_Y0.319610.557
20_I167_L0.318830.555
235_E397_L0.31780.553
50_A152_A0.317430.553
334_V354_T0.3170.552
275_V377_V0.316390.551
278_H381_D0.315890.550
147_I151_L0.315880.550
401_V423_I0.315320.549
46_S125_E0.315310.549
102_D106_K0.313290.546
68_R72_A0.313030.545
287_E294_A0.312630.544
359_V365_I0.312610.544
330_E362_D0.312550.544
290_K293_V0.311310.542
224_A228_N0.310870.541
38_A129_V0.310580.541
389_L392_D0.310460.541
316_Q320_V0.309560.539
135_P142_L0.309450.539
454_D457_T0.309450.539
439_F446_R0.309330.539
75_I140_L0.308970.538
208_L455_E0.30840.537
92_R141_Y0.308310.537
417_E458_Q0.308280.537
55_R62_D0.308250.537
52_E56_I0.30720.535
260_G271_A0.307170.535
39_R129_V0.306810.534
144_V148_A0.306620.534
327_A334_V0.306530.534
442_S445_G0.306450.534
365_I370_I0.306190.533
17_G314_K0.306130.533
168_T171_L0.305580.532
89_E138_F0.305420.532
249_D253_A0.305360.532
35_V199_A0.304770.531
34_A187_N0.304560.530
161_P169_A0.304450.530
37_A40_A0.304050.529
316_Q319_R0.30370.529
216_A395_Y0.30360.529
427_P430_D0.303560.529
216_A315_A0.303430.528
229_L441_Q0.302450.527
129_V207_D0.302080.526
297_R303_D0.301930.526
191_G197_G0.301730.525
140_L172_L0.300860.524
327_A364_P0.300790.524
76_A300_D0.300320.523
37_A41_A0.300050.522
34_A158_V0.299390.521
215_T395_Y0.299210.521
130_V157_V0.298980.521
56_I156_T0.298790.520
210_S456_F0.298580.520
41_A184_G0.297950.519
279_E282_Y0.297760.518
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
2wmeA0.9978100-0.034
3ed6A0.9978100-0.008
3rh9A0.9913100-0.008
3ifgA0.9913100-0.007
2o2pA0.9913100-0.005
4f3xA0.9892100-0.005
3ek1A0.987100-0.004
3qanA0.9892100-0.001
3k2wA0.9978100-0.001
3prlA0.9805100-0.001

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