GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
His_Phos_1 - Histidine phosphatase superfamily (branch 1)
Pfam: PF00300 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0071
Length: 158
Sequences: 8409
Seq/Len: 53.22
HH_delta: 0.05 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
55_P81_R1.637783.085
31_R61_Q1.445492.723
9_E29_R1.443672.720
79_R135_E1.376992.594
87_D118_G1.347212.538
79_R131_Q1.285042.421
60_I76_V1.266872.386
129_V154_F1.188652.239
79_R132_F1.128082.125
9_E27_T1.123592.117
31_R65_I1.120852.111
35_R65_I1.095352.063
150_S155_I1.084632.043
1_R145_N1.067172.010
50_V75_I1.037311.954
150_S154_F1.035031.950
5_I37_L1.018791.919
80_L132_F0.996151.877
120_E128_R0.992051.869
61_Q64_E0.990031.865
25_P57_R0.987911.861
25_P61_Q0.967271.822
51_I63_A0.92381.740
91_R99_K0.922861.738
11_E27_T0.906671.708
48_I147_L0.892451.681
121_S124_D0.891281.679
5_I147_L0.886231.669
51_I67_A0.88281.663
49_D144_E0.881451.660
5_I66_I0.856791.614
55_P78_P0.822951.550
115_R124_D0.818471.542
32_E35_R0.81641.538
34_A62_T0.816031.537
28_E31_R0.804161.515
49_D145_N0.798181.504
11_E15_E0.794691.497
21_D81_R0.791091.490
3_Y48_I0.785531.480
3_Y145_N0.775131.460
31_R35_R0.758621.429
32_E36_Q0.755721.424
60_I64_E0.754031.420
29_R33_Q0.743781.401
77_D132_F0.74061.395
36_Q39_E0.723951.364
66_I149_V0.722821.362
52_Y132_F0.712411.342
39_E69_G0.703631.325
92_P95_E0.685111.291
27_T30_G0.683131.287
110_D113_F0.673031.268
113_F123_E0.671721.265
123_E127_Q0.667431.257
91_R95_E0.660351.244
130_K134_D0.659181.242
9_E14_A0.657171.238
29_R32_E0.647891.220
124_D127_Q0.647321.219
21_D84_D0.640071.206
77_D135_E0.63761.201
53_S76_V0.631651.190
12_F17_R0.628131.183
132_F148_I0.615461.159
64_E68_E0.61221.153
4_L155_I0.609671.148
54_S151_H0.583291.099
50_V144_E0.574011.081
38_G65_I0.572881.079
53_S74_I0.562361.059
63_A149_V0.561271.057
35_R68_E0.561141.057
12_F24_P0.55621.048
129_V158_L0.553821.043
105_E109_S0.549431.035
57_R61_Q0.544271.025
10_S13_N0.540631.018
82_E152_G0.537731.013
28_E32_E0.535951.010
8_G26_L0.535581.009
35_R69_G0.533971.006
9_E33_Q0.530991.000
3_Y46_I0.529280.997
12_F19_Q0.528660.996
80_L148_I0.528460.995
22_S89_E0.528340.995
52_Y141_R0.524490.988
54_S59_C0.524090.987
125_F154_F0.523980.987
39_E42_A0.520130.980
78_P81_R0.517870.976
132_F136_L0.515740.972
126_Q130_K0.509450.960
48_I145_N0.508290.958
84_D89_E0.506750.955
55_P76_V0.504450.950
53_S59_C0.502570.947
10_S19_Q0.501450.945
100_F103_E0.498630.939
125_F129_V0.495350.933
52_Y75_I0.48570.915
125_F157_A0.48290.910
26_L30_G0.479460.903
134_D138_A0.479450.903
56_L81_R0.478730.902
94_D98_E0.476420.897
127_Q131_Q0.476220.897
53_S60_I0.474280.893
126_Q157_A0.469920.885
91_R96_I0.46290.872
7_H151_H0.460680.868
30_G34_A0.451070.850
88_W96_I0.436350.822
19_Q24_P0.432620.815
51_I147_L0.43180.813
95_E98_E0.431130.812
38_G42_A0.430410.811
136_L148_I0.426220.803
57_R60_I0.425280.801
59_C151_H0.422850.797
50_V146_V0.42090.793
67_A74_I0.418710.789
10_S27_T0.417880.787
8_G62_T0.411730.776
24_P27_T0.411160.775
42_A69_G0.40990.772
46_I145_N0.407650.768
4_L158_L0.4050.763
8_G33_Q0.40490.763
34_A38_G0.404340.762
20_G89_E0.40290.759
52_Y77_D0.400430.754
35_R39_E0.396270.746
21_D55_P0.395890.746
63_A74_I0.393390.741
26_L34_A0.392540.739
23_D57_R0.390850.736
85_F89_E0.386660.728
4_L148_I0.385010.725
14_A29_R0.381660.719
104_F108_W0.381320.718
125_F153_G0.378910.714
51_I72_I0.376790.710
7_H82_E0.372210.701
65_I68_E0.370020.697
17_R92_P0.369170.695
13_N19_Q0.366530.690
65_I69_G0.365690.689
30_G33_Q0.36370.685
107_W111_P0.363330.684
9_E13_N0.363110.684
64_E74_I0.361640.681
7_H58_R0.357360.673
11_E24_P0.3570.673
11_E25_P0.355480.670
134_D137_I0.353090.665
133_L158_L0.349080.658
36_Q40_Y0.348360.656
86_G119_G0.345140.650
135_E138_A0.344940.650
83_I122_W0.344770.649
94_D97_E0.343660.647
5_I149_V0.343470.647
49_D147_L0.342170.645
52_Y136_L0.341230.643
18_V93_F0.339340.639
12_F22_S0.338210.637
54_S58_R0.335410.632
88_W116_P0.333970.629
35_R38_G0.333530.628
42_A45_D0.333170.628
51_I70_L0.332260.626
87_D117_P0.332020.625
53_S63_A0.331980.625
16_G94_D0.331570.625
51_I74_I0.329850.621
95_E99_K0.326140.614
152_G156_R0.322680.608
16_G93_F0.319310.602
38_G66_I0.319220.601
14_A27_T0.318650.600
34_A37_L0.314860.593
122_W157_A0.313340.590
58_R151_H0.312050.588
61_Q65_I0.310220.584
38_G69_G0.30920.582
21_D56_L0.308920.582
132_F135_E0.306270.577
10_S59_C0.306210.577
8_G30_G0.305690.576
83_I125_F0.302440.570
97_E105_E0.299720.565
22_S90_G0.299160.564
141_R144_E0.297510.560
37_L40_Y0.296590.559
111_P114_Y0.290780.548
41_L46_I0.290560.547
48_I51_I0.28990.546
55_P77_D0.289450.545
50_V141_R0.289270.545
34_A65_I0.28740.541
85_F122_W0.286510.540
83_I153_G0.285890.539
52_Y80_L0.279940.527
103_E106_A0.277080.522
108_W111_P0.276340.521
136_L146_V0.275320.519
19_Q22_S0.27390.516
2_I133_L0.273240.515
56_L59_C0.272780.514
45_D48_I0.270510.510
67_A72_I0.269820.508
80_L136_L0.268760.506
115_R121_S0.268480.506
75_I140_K0.267820.505
47_Q70_L0.266530.502
47_Q145_N0.265490.500
61_Q68_E0.264890.499
11_E14_A0.264160.498
27_T33_Q0.263240.496
52_Y146_V0.263040.496
135_E140_K0.262210.494
46_I49_D0.261940.493
10_S85_F0.261690.493
107_W114_Y0.261610.493
56_L82_E0.260990.492
122_W156_R0.25860.487
58_R82_E0.257860.486
67_A70_L0.256660.483
24_P57_R0.256570.483
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
4ij5A0.9811000.05
1h2eA0.9811000.057
3kkkA11000.071
2hhjA11000.074
3gp3A11000.074
1riiA11000.074
1fztA0.99371000.075
4embA11000.076
4gpzA11000.077
3d8hA11000.079

Page generated in 0.0267 seconds.