GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Hexokinase_1 - Hexokinase
Pfam: PF00349 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0108
Length: 206
Sequences: 2544
Seq/Len: 12.35
HH_delta: 0.226 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
81_E85_N0.628523.772
172_E176_D0.40412.425
169_D172_E0.363792.183
93_E123_E0.35362.122
111_D177_A0.348972.094
66_L117_I0.343762.063
48_M54_T0.334512.008
93_E119_E0.324051.945
192_V197_G0.313891.884
171_V175_Q0.310081.861
50_P53_V0.29991.800
20_Q23_E0.298061.789
192_V196_V0.293751.763
135_L178_L0.291091.747
118_A122_K0.281011.686
38_K59_G0.275691.655
77_V120_F0.268851.613
132_K183_L0.267561.606
114_A177_A0.262181.573
49_L54_T0.261961.572
144_E150_S0.260241.562
174_L189_V0.259071.555
69_D193_N0.257661.546
16_L21_L0.25331.520
67_A136_G0.252431.515
18_D22_Q0.249931.500
10_L21_L0.248131.489
138_T197_G0.244461.467
195_T198_T0.244411.467
77_V116_C0.240471.443
48_M53_V0.235191.411
136_G197_G0.232991.398
63_G133_L0.231741.391
47_K53_V0.225271.352
91_E123_E0.224641.348
47_K50_P0.22331.340
143_V151_G0.223281.340
25_S37_A0.222661.336
67_A78_A0.219881.320
140_S194_D0.218081.309
116_C119_E0.217891.308
178_L182_G0.217841.307
174_L178_L0.216821.301
39_S42_S0.212731.277
69_D73_T0.211171.267
79_L120_F0.208221.250
71_G140_S0.206461.239
173_L176_D0.20611.237
9_K13_Q0.203531.221
49_L53_V0.202561.216
68_L117_I0.202191.213
74_N94_K0.202071.213
144_E152_T0.201371.209
49_L52_Y0.199891.200
67_A138_T0.197371.185
118_A129_R0.193831.163
69_D138_T0.193821.163
60_N85_N0.192321.154
106_G165_V0.192051.153
76_R94_K0.189441.137
170_V191_I0.185051.111
142_P156_W0.184911.110
156_W161_D0.184141.105
165_V168_K0.182071.093
33_E37_A0.180551.084
64_D131_E0.179221.076
137_F174_L0.177891.068
61_E81_E0.177191.063
68_L135_L0.176591.060
112_F116_C0.175321.052
48_M52_Y0.174491.047
72_G194_D0.174251.046
78_A92_Q0.174011.044
17_S201_A0.17311.039
37_A40_S0.173071.039
114_A178_L0.172671.036
109_L165_V0.171761.031
18_D23_E0.171441.029
71_G76_R0.17051.023
34_K39_S0.170271.022
69_D76_R0.170171.021
37_A42_S0.169731.019
46_L50_P0.168411.011
105_S108_E0.167281.004
116_C120_F0.167061.003
21_L25_S0.166771.001
9_K12_Q0.165940.996
72_G140_S0.165480.993
46_L49_L0.165010.990
50_P54_T0.164920.990
71_G74_N0.164880.990
120_F124_H0.164730.989
18_D26_D0.164590.988
177_A182_G0.164390.987
171_V191_I0.163910.984
36_L62_K0.162720.977
18_D25_S0.162680.976
68_L77_V0.162430.975
48_M51_S0.161620.970
27_R41_S0.160590.964
51_S196_V0.160410.963
193_N196_V0.159850.959
139_F143_V0.159710.958
23_E27_R0.159610.958
139_F153_L0.159380.957
37_A41_S0.158390.951
64_D81_E0.157880.948
64_D79_L0.157530.945
77_V95_Y0.157040.942
175_Q182_G0.155610.934
16_L20_Q0.155170.931
64_D90_I0.155030.930
178_L183_L0.154590.928
75_L97_I0.154580.928
105_S111_D0.154460.927
17_S20_Q0.153580.922
14_F21_L0.152690.916
63_G69_D0.152350.914
64_D126_L0.151060.907
46_L53_V0.15090.906
144_E151_G0.147890.888
69_D74_N0.14730.884
66_L79_L0.147230.884
93_E116_C0.147020.882
69_D142_P0.146590.880
197_G204_Y0.146420.879
146_T150_S0.145810.875
135_L183_L0.145240.872
175_Q189_V0.144360.866
114_A118_A0.144060.865
106_G168_K0.142110.853
196_V200_L0.141280.848
74_N139_F0.139940.840
9_K37_A0.139920.840
152_T169_D0.139480.837
114_A174_L0.138640.832
69_D195_T0.13850.831
133_L136_G0.137930.828
65_F198_T0.137640.826
126_L129_R0.137460.825
63_G76_R0.137340.824
59_G63_G0.137210.823
107_E111_D0.137190.823
59_G62_K0.13640.819
194_D197_G0.136120.817
119_E123_E0.136110.817
169_D173_L0.13610.817
70_L109_L0.136020.816
28_F34_K0.1350.810
16_L24_I0.134730.809
115_D119_E0.134550.807
107_E173_L0.134390.807
96_K130_D0.134230.806
142_P145_Q0.133830.803
110_F114_A0.133580.802
110_F151_G0.132830.797
134_P190_A0.131210.787
192_V199_L0.129580.778
70_L84_G0.12790.768
19_E23_E0.127780.767
137_F170_V0.127080.763
95_Y116_C0.126880.761
145_Q151_G0.126570.760
151_G191_I0.126390.759
142_P194_D0.126290.758
140_S156_W0.126260.758
9_K39_S0.126260.758
62_K131_E0.126240.758
77_V113_I0.126090.757
153_L198_T0.125840.755
173_L177_A0.125730.755
19_E22_Q0.125690.754
176_D182_G0.125110.751
68_L106_G0.124470.747
118_A177_A0.124250.746
164_G168_K0.123670.742
67_A134_P0.123630.742
162_I194_D0.123360.740
115_D123_E0.123270.740
78_A194_D0.12240.735
28_F126_L0.122340.734
182_G189_V0.121780.731
10_L96_K0.121270.728
60_N115_D0.121140.727
100_E123_E0.120960.726
23_E26_D0.120940.726
68_L113_I0.120720.724
13_Q173_L0.120710.724
10_L14_F0.120530.723
75_L113_I0.120260.722
189_V192_V0.119620.718
66_L135_L0.119450.717
78_A136_G0.11940.717
67_A81_E0.11920.715
22_Q25_S0.118960.714
39_S205_Q0.118850.713
91_E120_F0.118290.710
168_K173_L0.118240.710
11_L22_Q0.1180.708
28_F202_G0.117890.708
11_L24_I0.117670.706
200_L203_A0.117080.703
118_A123_E0.116360.698
95_Y119_E0.116010.696
17_S161_D0.115790.695
65_F133_L0.115680.694
36_L39_S0.115330.692
85_N115_D0.115030.690
106_G173_L0.114890.690
60_N83_S0.114880.689
70_L75_L0.114440.687
72_G142_P0.113970.684
46_L52_Y0.113950.684
40_S92_Q0.113610.682
19_E198_T0.11360.682
66_L132_K0.113490.681
142_P163_S0.113140.679
119_E122_K0.112990.678
11_L20_Q0.112890.678
122_K129_R0.112780.677
33_E42_S0.112560.676
125_N131_E0.112210.673
69_D72_G0.11220.673
134_P141_F0.112130.673
38_K61_E0.112050.672
86_G131_E0.111830.671
27_R189_V0.111410.669
110_F136_G0.111360.668
105_S164_G0.111310.668
22_Q69_D0.11130.668
37_A85_N0.111260.668
197_G200_L0.111190.667
34_K37_A0.111140.667
91_E131_E0.111120.667
138_T198_T0.110990.666
66_L170_V0.110930.666
51_S153_L0.110920.666
72_G195_T0.11090.666
20_Q25_S0.110710.664
142_P195_T0.110590.664
39_S51_S0.110280.662
34_K131_E0.110130.661
107_E176_D0.109930.660
11_L25_S0.109540.657
72_G80_V0.109420.657
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
1bdgA0.98541000.226
1z05A0.86891000.235
2hoeA0.87381000.239
4ijaA0.85441000.241
1z6rA0.87381000.243
3o8mA0.98061000.243
3f9mA0.99031000.254
1czaN0.985499.90.266
1czaN0.985499.90.272
3hm8A0.961299.90.292

Page generated in 0.0577 seconds.