GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
FGGY_N - FGGY family of carbohydrate kinases N-terminal domain
Pfam: PF00370 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0108
Length: 245
Sequences: 5710
Seq/Len: 23.31
HH_delta: 0.019 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
190_E200_E1.333733.949
18_D22_K1.198543.549
106_E141_E1.197763.546
14_A55_A0.998112.955
109_E141_E0.904752.679
92_L146_I0.879222.603
181_Y206_I0.87562.593
208_P211_E0.841872.493
182_D189_D0.821332.432
182_D185_T0.801782.374
29_R54_E0.796472.358
49_W163_K0.792612.347
46_D163_K0.789242.337
86_D149_K0.786882.330
5_I52_I0.781112.313
34_Y94_P0.764372.263
93_R143_E0.763262.260
27_A58_E0.762162.257
11_S28_S0.746712.211
161_A235_G0.744942.206
236_G241_A0.743112.200
187_Q200_E0.736222.180
16_L59_L0.735432.178
122_K189_D0.725792.149
3_L14_A0.714572.116
29_R58_E0.714542.116
87_K151_A0.70612.091
7_I12_V0.687442.035
193_L200_E0.681032.016
212_I233_I0.659581.953
152_K168_A0.640351.896
165_T232_V0.618061.830
46_D90_K0.61631.825
190_E194_E0.615021.821
167_R205_E0.614531.820
37_E40_W0.609261.804
32_P47_E0.584811.732
122_K191_E0.583121.727
137_L141_E0.566291.677
83_V156_L0.557271.650
207_V211_E0.548571.624
3_L56_L0.541061.602
212_I215_T0.536721.589
79_G237_G0.534041.581
118_E121_E0.533891.581
118_E122_K0.525071.555
1_Y24_V0.523921.551
159_Y163_K0.487991.445
58_E62_Q0.487741.444
87_K152_K0.485361.437
49_W53_C0.4781.415
89_G162_Y0.472251.398
172_Y186_G0.467151.383
138_W142_N0.465771.379
105_E109_E0.464651.376
169_A207_V0.462361.369
16_L63_A0.458921.359
109_E113_E0.453171.342
218_P228_E0.45131.336
108_E112_E0.447041.324
84_L139_L0.444091.315
1_Y16_L0.443611.313
85_L154_L0.442961.312
118_E191_E0.440671.305
12_V52_I0.439771.302
25_A59_L0.438371.298
161_A169_A0.43831.298
81_G95_A0.437771.296
212_I231_P0.433971.285
12_V51_A0.433641.284
145_E148_E0.432661.281
193_L203_L0.430391.274
106_E137_L0.429131.271
140_K147_F0.425761.261
86_D90_K0.418761.240
215_T229_G0.418271.238
84_L202_L0.417731.237
165_T214_G0.413591.225
34_Y47_E0.413531.224
46_D50_E0.411741.219
27_A55_A0.411221.218
44_D47_E0.410981.217
5_I56_L0.408811.210
80_H177_R0.403831.196
50_E54_E0.401111.188
111_N116_P0.399921.184
31_Y51_A0.39881.181
48_I156_L0.398541.180
118_E195_A0.398141.179
107_A127_L0.3971.175
161_A213_I0.395481.171
117_E121_E0.393641.166
44_D94_P0.391651.160
41_A99_M0.390411.156
172_Y181_Y0.390251.155
181_Y185_T0.384271.138
5_I14_A0.384171.137
60_L63_A0.383791.136
101_T128_S0.383791.136
54_E58_E0.383581.136
25_A63_A0.38121.129
59_L63_A0.381161.129
66_D69_Q0.377741.118
27_A59_L0.376961.116
199_P202_L0.375041.110
104_A108_E0.373831.107
1_Y69_Q0.366451.085
102_R138_W0.366031.084
25_A62_Q0.365031.081
207_V213_I0.364061.078
17_F23_I0.363331.076
115_S195_A0.361521.070
227_P230_T0.356121.054
145_E149_K0.354171.049
147_F150_A0.352741.044
146_I149_K0.352681.044
215_T231_P0.348781.033
72_A233_I0.346531.026
57_K61_S0.345691.024
52_I56_L0.343041.016
3_L16_L0.342741.015
186_G208_P0.341681.012
33_Y43_Q0.340991.010
60_L67_P0.339151.004
84_L136_L0.338811.003
150_A202_L0.330770.979
105_E108_E0.329410.975
172_Y206_I0.329330.975
191_E194_E0.328830.974
154_L168_A0.328470.973
73_I230_T0.326110.966
16_L70_I0.325290.963
7_I51_A0.324290.960
143_E146_I0.32350.958
137_L197_G0.319710.947
7_I52_I0.319290.945
169_A213_I0.318640.943
133_L196_L0.318050.942
60_L70_I0.316870.938
86_D92_L0.315340.934
115_S118_E0.313610.929
82_L153_F0.313410.928
45_P83_V0.311870.923
119_I179_G0.310310.919
75_I161_A0.308430.913
187_Q205_E0.306790.908
53_C57_K0.306410.907
47_E50_E0.305940.906
150_A153_F0.302140.895
52_I160_L0.301840.894
106_E142_N0.301750.893
27_A62_Q0.301510.893
73_I232_V0.300390.889
79_G174_N0.299720.887
93_R146_I0.295070.874
107_A134_A0.2950.873
2_Y72_A0.294680.873
170_T204_P0.294260.871
136_L153_F0.293740.870
80_H98_W0.292430.866
121_E184_R0.288690.855
167_R207_V0.28780.852
181_Y186_G0.286440.848
31_Y43_Q0.285220.844
45_P94_P0.283850.840
9_T97_L0.282760.837
7_I160_L0.282680.837
93_R139_L0.28170.834
89_G168_A0.281630.834
188_W203_L0.279460.827
216_L230_T0.279130.826
92_L149_K0.278680.825
84_L150_A0.278280.824
119_I127_L0.277990.823
215_T218_P0.27680.820
96_I102_R0.276150.818
139_L146_I0.275440.816
77_G174_N0.275380.815
6_D9_T0.274740.813
75_I164_L0.274710.813
58_E61_S0.274680.813
137_L147_F0.272520.807
85_L159_Y0.270020.799
172_Y208_P0.269650.798
8_G13_K0.268380.795
29_R55_A0.266920.790
85_L152_K0.266560.789
110_L134_A0.264540.783
133_L179_G0.264280.782
12_V31_Y0.26420.782
80_H237_G0.263860.781
42_E94_P0.263810.781
106_E109_E0.263060.779
111_N127_L0.262410.777
3_L70_I0.262070.776
213_I234_A0.261780.775
4_G74_G0.261660.775
72_A231_P0.261020.773
133_L180_L0.260930.773
144_P148_E0.259820.769
209_P235_G0.259570.769
166_G217_T0.259410.768
239_Q243_A0.258660.766
83_V95_A0.258110.764
125_L131_Y0.257810.763
74_G233_I0.257550.763
107_A129_P0.256660.760
170_T175_A0.255940.758
136_L180_L0.255730.757
237_G240_A0.255530.757
36_P40_W0.255130.755
158_D170_T0.25470.754
43_Q97_L0.254440.753
155_T178_T0.254060.752
108_E111_N0.252740.748
18_D24_V0.252530.748
19_E71_K0.251830.746
53_C56_L0.251380.744
187_Q190_E0.250540.742
169_A205_E0.249580.739
152_K162_Y0.248150.735
137_L140_K0.247930.734
14_A59_L0.246970.731
109_E112_E0.246390.730
193_L198_I0.245410.727
85_L89_G0.243220.720
41_A97_L0.241710.716
157_S235_G0.240070.711
189_D192_L0.239670.710
84_L92_L0.237220.702
78_Q98_W0.237160.702
70_I230_T0.236420.700
170_T206_I0.236210.699
183_I206_I0.236180.699
103_A134_A0.234420.694
29_R51_A0.234160.693
89_G151_A0.234120.693
15_V23_I0.233290.691
194_E197_G0.232790.689
207_V234_A0.231250.685
174_N237_G0.229820.680
151_A201_E0.229430.679
157_S174_N0.229030.678
157_S170_T0.227830.675
162_Y168_A0.227750.674
113_E195_A0.226970.672
217_T229_G0.22630.670
158_D168_A0.226180.670
46_D91_P0.225530.668
5_I75_I0.22550.668
73_I216_L0.223710.662
173_S240_A0.222950.660
161_A165_T0.222590.659
109_E137_L0.222580.659
84_L153_F0.221480.656
2_Y71_K0.221110.655
175_A188_W0.219930.651
180_L203_L0.219570.650
9_T98_W0.219510.650
85_L168_A0.217610.644
134_A179_G0.216910.642
77_G156_L0.216310.640
48_I95_A0.215770.639
173_S209_P0.214320.635
79_G156_L0.213250.631
90_K163_K0.212010.628
86_D151_A0.211660.627
172_Y209_P0.211440.626
119_I123_T0.210660.624
54_E57_K0.21050.623
79_G177_R0.21050.623
122_K182_D0.208840.618
177_R237_G0.208680.618
105_E141_E0.208610.618
152_K202_L0.208580.618
132_P155_T0.20830.617
35_T41_A0.207920.616
47_E51_A0.206760.612
192_L196_L0.206610.612
155_T174_N0.204970.607
26_S62_Q0.204760.606
154_L162_Y0.204280.605
67_P70_I0.204160.604
43_Q78_Q0.203960.604
75_I160_L0.20380.603
83_V91_P0.203310.602
82_L132_P0.20320.602
89_G227_P0.201980.598
46_D159_Y0.201970.598
194_E199_P0.201730.597
228_E231_P0.201210.596
50_E57_K0.200650.594
239_Q242_A0.20050.594
156_L174_N0.199940.592
16_L24_V0.199840.592
226_L230_T0.199050.589
173_S236_G0.198560.588
180_L188_W0.198120.587
216_L226_L0.196930.583
182_D187_Q0.196410.582
13_K28_S0.19550.579
98_W239_Q0.194810.577
166_G219_E0.194730.577
90_K149_K0.194030.574
155_T158_D0.193990.574
81_G98_W0.193460.573
80_H174_N0.193290.572
130_G135_K0.193260.572
124_G135_K0.193170.572
123_T179_G0.192160.569
78_Q237_G0.191830.568
198_I202_L0.190920.565
174_N177_R0.190230.563
107_A179_G0.190040.563
140_K197_G0.190010.563
80_H132_P0.189490.561
102_R142_N0.189120.560
101_T129_P0.188630.559
105_E142_N0.187620.556
81_G237_G0.187170.554
56_L59_L0.186710.553
215_T228_E0.185860.550
78_Q95_A0.185610.550
180_L198_I0.18510.548
214_G217_T0.184980.548
64_G67_P0.18470.547
40_W138_W0.184310.546
116_P120_Y0.1840.545
46_D49_W0.183780.544
32_P44_D0.183580.544
141_E147_F0.183540.543
69_Q227_P0.183160.542
50_E53_C0.182970.542
117_E120_Y0.182610.541
63_A67_P0.181010.536
77_G80_H0.180460.534
96_I139_L0.180440.534
161_A232_V0.179880.533
81_G177_R0.179610.532
218_P229_G0.178940.530
137_L196_L0.178920.530
53_C163_K0.178530.529
56_L60_L0.17840.528
18_D21_G0.178270.528
191_E195_A0.178230.528
23_I26_S0.177910.527
80_H130_G0.177350.525
81_G130_G0.177210.525
91_P94_P0.176380.522
68_E227_P0.175610.520
42_E102_R0.175560.520
43_Q98_W0.175450.519
184_R187_Q0.174960.518
29_R50_E0.174930.518
6_D10_T0.174930.518
123_T192_L0.174670.517
99_M240_A0.174640.517
52_I57_K0.174240.516
13_K76_S0.173660.514
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3ll3A0.98781000.019
3hz6A0.99591000.021
3ifrA11000.026
4bc3A0.99591000.06
3jvpA0.99591000.066
2p3rA0.98371000.077
3h3nX0.98371000.079
3i8bA0.95511000.083
3g25A0.98371000.087
2itmA0.97961000.09

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