GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
ECH - Enoyl-CoA hydrataseisomerase family
Pfam: PF00378 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0127
Length: 245
Sequences: 13585
Seq/Len: 55.45
HH_delta: -0.04 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
174_E184_E2.117453.212
119_E177_P2.035793.088
122_K160_P2.00963.049
184_E187_E1.977062.999
117_A172_V1.921542.915
95_A112_C1.784932.708
10_T186_L1.704972.587
38_E90_P1.654992.511
120_D178_D1.613922.448
159_E191_R1.539582.336
162_S165_E1.504852.283
165_E168_E1.451832.203
153_E159_E1.432922.174
129_R195_K1.423252.159
19_R53_K1.403362.129
214_S217_E1.386142.103
35_D85_R1.385672.102
119_E164_E1.363432.068
150_R169_L1.342712.037
96_A185_A1.319772.002
102_V124_G1.303451.977
116_I176_V1.268951.925
180_E183_E1.266521.921
96_A182_D1.247541.893
19_R54_A1.232181.869
25_E29_E1.224411.857
14_N51_G1.179011.789
155_L203_T1.178881.788
7_G44_K1.177191.786
46_V89_F1.138781.728
164_E168_E1.131251.716
153_E173_D1.12191.702
165_E169_L1.120031.699
9_A37_A1.104361.675
119_E178_D1.094471.660
4_I9_A1.092751.658
49_S98_N1.080881.640
10_T49_S1.073681.629
109_A115_R1.071991.626
117_A123_F1.071621.626
31_E85_R1.067911.620
116_I188_L1.051411.595
148_P152_R1.050891.594
12_T51_G1.045711.586
159_E165_E1.037421.574
153_E174_E1.034311.569
152_R208_N1.033761.568
37_A46_V1.024961.555
152_R156_L1.015651.541
186_L190_K1.015411.540
115_R145_L1.015111.540
4_I40_D1.014261.539
113_D204_K1.010911.534
36_E40_D1.009831.532
6_D190_K1.004671.524
115_R149_S0.997821.514
12_T49_S0.99651.512
180_E184_E0.98691.497
128_V158_G0.986011.496
9_A43_V0.972191.475
38_E85_R0.971761.474
176_V184_E0.955171.449
152_R207_L0.940321.427
118_A178_D0.925311.404
167_L175_V0.924451.402
13_L26_M0.918431.393
5_E186_L0.916381.390
97_V101_A0.90621.375
86_L93_T0.905731.374
11_I33_A0.904971.373
98_N120_D0.90041.366
154_L161_I0.900341.366
23_N26_M0.897981.362
5_E190_K0.893231.355
98_N118_A0.89091.352
34_L89_F0.884251.341
106_F125_F0.883451.340
10_T182_D0.878251.332
45_V189_A0.869771.319
181_L185_A0.855141.297
205_K209_R0.848061.287
150_R153_E0.847161.285
97_V109_A0.846281.284
47_V185_A0.837831.271
182_D185_A0.837671.271
124_G160_P0.836781.269
118_A181_L0.831171.261
31_E35_D0.82731.255
53_K98_N0.815721.237
24_P63_E0.814141.235
87_A141_R0.809891.229
18_K62_K0.80871.227
28_D78_R0.805921.223
29_E33_A0.804911.221
15_R18_K0.803341.219
189_A193_A0.797431.210
182_D186_L0.796251.208
213_Q217_E0.773271.173
150_R165_E0.765641.162
46_V91_K0.758551.151
84_S88_N0.757271.149
100_H122_K0.754551.145
149_S173_D0.748731.136
163_A175_V0.739241.121
5_E10_T0.738941.121
237_E241_A0.731.107
147_G150_R0.725261.100
114_F188_L0.712441.081
84_S216_E0.710971.079
15_R60_D0.710691.078
198_S234_D0.707811.074
195_K200_L0.705591.070
49_S182_D0.703721.068
142_L146_I0.689341.046
146_I150_R0.687721.043
192_L200_L0.686731.042
32_E36_E0.679611.031
31_E81_E0.678141.029
43_V91_K0.677181.027
56_C105_G0.675471.025
167_L172_V0.67411.023
29_E32_E0.673621.022
202_A228_E0.671811.019
235_F239_I0.670351.017
177_P180_E0.670081.017
236_Q240_A0.668931.015
13_L56_C0.668631.014
62_K243_L0.668051.013
185_A189_A0.666881.012
161_I169_L0.662941.006
3_E12_T0.661341.003
88_N216_E0.658070.998
41_P91_K0.657710.998
164_E167_L0.654410.993
119_E175_V0.652780.990
114_F173_D0.652550.990
24_P28_D0.651810.989
183_E187_E0.649750.986
38_E89_F0.646160.980
139_T222_E0.645830.980
93_T112_C0.63930.970
10_T47_V0.636760.966
238_G241_A0.635650.964
107_E138_G0.635130.964
97_V123_F0.631230.958
239_I243_L0.624530.947
19_R57_A0.623350.946
97_V115_R0.619230.939
8_V45_V0.615830.934
98_N181_L0.612960.930
103_G126_P0.612160.929
217_E220_E0.606490.920
54_A100_H0.602940.915
107_E127_E0.599060.909
37_A43_V0.594190.901
40_D43_V0.592680.899
197_P201_R0.588780.893
147_G151_A0.587080.891
4_I36_E0.582370.883
196_P234_D0.581590.882
146_I154_L0.58150.882
49_S96_A0.579430.879
35_D39_A0.57880.878
106_F123_F0.577730.876
94_I189_A0.571490.867
145_L149_S0.567340.861
68_D71_E0.56630.859
116_I185_A0.564440.856
116_I174_E0.560380.850
237_E240_A0.560040.850
187_E191_R0.559050.848
213_Q221_F0.558610.847
110_L171_L0.558170.847
46_V93_T0.554060.841
90_P201_R0.5480.831
172_V175_V0.545050.827
96_A181_L0.540390.820
122_K162_S0.538330.817
166_A171_L0.537270.815
44_K197_P0.535490.812
15_R21_A0.535190.812
186_L189_A0.530530.805
221_F225_L0.527140.800
183_E186_L0.526390.799
102_V126_P0.524770.796
89_F93_T0.524420.796
234_D238_G0.523920.795
128_V203_T0.523260.794
28_D32_E0.522810.793
176_V181_L0.52090.790
190_K194_A0.520860.790
33_A36_E0.518790.787
97_V121_A0.517430.785
3_E10_T0.516810.784
4_I42_D0.510080.774
215_L219_L0.508840.772
11_I37_A0.508580.772
38_E91_K0.505440.767
11_I46_V0.50540.767
89_F92_P0.502690.763
155_L207_L0.502340.762
209_R221_F0.502260.762
157_T188_L0.498340.756
15_R23_N0.495870.752
163_A172_V0.495040.751
224_D228_E0.493620.749
107_E135_G0.492170.747
225_L228_E0.492010.746
4_I43_V0.491070.745
27_L82_L0.491050.745
150_R167_L0.489730.743
95_A115_R0.489170.742
8_V193_A0.488950.742
45_V193_A0.488710.741
174_E188_L0.488610.741
104_G107_E0.485140.736
7_G42_D0.484840.736
8_V47_V0.48290.733
221_F224_D0.478180.725
129_R160_P0.477920.725
140_F218_A0.477210.724
102_V160_P0.475820.722
124_G158_G0.474670.720
47_V96_A0.473420.718
22_L26_M0.46980.713
203_T206_A0.469250.712
146_I151_A0.468860.711
233_E236_Q0.467440.709
11_I48_I0.467350.709
206_A225_L0.466450.708
48_I93_T0.466070.707
240_A243_L0.465590.706
77_R81_E0.464980.705
47_V186_L0.464720.705
202_A229_C0.464460.705
40_D91_K0.463750.704
54_A98_N0.463440.703
33_A37_A0.454950.690
25_E28_D0.454370.689
107_E141_R0.45040.683
191_R194_A0.448760.681
34_L46_V0.447760.679
198_S232_S0.44760.679
154_L169_L0.445040.675
114_F192_L0.443380.673
148_P207_L0.443080.672
11_I34_L0.442450.671
134_P203_T0.441950.670
127_E135_G0.439960.667
162_S168_E0.438530.665
47_V182_D0.437930.664
19_R100_H0.436830.663
133_F206_A0.436250.662
90_P205_K0.436170.662
115_R172_V0.435070.660
163_A167_L0.434240.659
187_E190_K0.434090.659
118_A179_E0.433660.658
123_F172_V0.432910.657
26_M29_E0.432050.655
45_V94_I0.427450.648
206_A221_F0.427270.648
4_I7_G0.427190.648
140_F143_P0.4270.648
140_F144_R0.426170.647
234_D241_A0.425180.645
48_I112_C0.425060.645
157_T192_L0.425060.645
128_V195_K0.423960.643
134_P155_L0.422890.642
167_L174_E0.422160.640
116_I184_E0.420320.638
153_E157_T0.420180.637
8_V189_A0.418920.636
102_V127_E0.417220.633
34_L86_L0.416890.632
135_G138_G0.415880.631
107_E125_F0.415140.630
75_F79_F0.414490.629
116_I181_L0.413530.627
202_A225_L0.413460.627
164_E175_V0.412980.627
184_E188_L0.411530.624
154_L157_T0.411450.624
37_A91_K0.411050.624
235_F238_G0.41060.623
43_V46_V0.40890.620
100_H160_P0.407190.618
114_F157_T0.403830.613
148_P211_L0.402420.610
134_P137_G0.400590.608
204_K208_N0.400260.607
223_Q227_A0.398970.605
104_G127_E0.397870.604
31_E82_L0.397680.603
156_L200_L0.397610.603
8_V186_L0.397340.603
209_R213_Q0.397170.603
8_V190_K0.397170.603
234_D237_E0.394770.599
32_E35_D0.394640.599
85_R89_F0.394050.598
94_I188_L0.393760.597
44_K193_A0.393730.597
103_G125_F0.392150.595
47_V94_I0.388990.590
127_E134_P0.388780.590
36_E39_A0.385590.585
73_R77_R0.385590.585
69_E73_R0.383040.581
21_A57_A0.380850.578
34_L93_T0.380420.577
120_D163_A0.378660.574
191_R195_K0.377270.572
106_F110_L0.377190.572
117_A175_V0.376320.571
96_A189_A0.375630.570
91_K197_P0.371560.564
157_T191_R0.371450.564
104_G136_A0.371310.563
25_E63_E0.370870.563
161_I171_L0.370450.562
146_I169_L0.370370.562
161_I166_A0.370150.562
98_N121_A0.369550.561
216_E220_E0.36670.556
125_F155_L0.366360.556
152_R204_K0.365030.554
16_P20_N0.363760.552
120_D164_E0.363670.552
98_N178_D0.362650.550
143_P147_G0.362260.550
18_K21_A0.361780.549
133_F229_C0.361180.548
126_P130_L0.359530.545
150_R168_E0.359480.545
128_V200_L0.359390.545
27_L31_E0.3590.545
219_L222_E0.358760.544
109_A112_C0.358620.544
123_F161_I0.35670.541
165_E174_E0.356030.540
143_P151_A0.355990.540
74_E78_R0.355870.540
192_L195_K0.355330.539
61_L239_I0.354930.538
215_L222_E0.354270.537
61_L130_L0.351950.534
106_F171_L0.351920.534
180_E187_E0.351760.534
101_A106_F0.35080.532
131_G196_P0.350290.531
30_L48_I0.349890.531
145_L173_D0.349540.530
220_E224_D0.348430.529
76_F79_F0.347780.528
117_A121_A0.347430.527
202_A205_K0.34730.527
213_Q218_A0.346690.526
18_K60_D0.346460.526
127_E226_F0.346260.525
143_P207_L0.344650.523
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3hrxA0.9959100-0.04
4fzwC1100-0.032
4fzwA0.9918100-0.025
4jcsA1100-0.014
4jfcA1100-0.01
3qreA1100-0.008
3kqfA1100-0.006
3hinA0.9918100-0.004
3qmjA1100-0.004
3lkeA1100-0.003

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