GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
PI-PLC-X - Phosphatidylinositol-specific phospholipase C X domain
Pfam: PF00388 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0384
Length: 146
Sequences: 1613
Seq/Len: 11.05
HH_delta: 0.179 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
77_R115_R0.510663.095
85_S138_G0.442262.680
68_T71_D0.413372.505
45_L57_V0.366742.222
33_R37_E0.343032.079
43_L76_I0.334042.024
69_F73_L0.324041.964
106_E110_E0.319051.933
57_V72_V0.303431.839
33_R75_D0.301021.824
31_S34_E0.29951.815
134_G137_R0.295821.793
132_T135_E0.294391.784
33_R79_F0.287741.744
37_E79_F0.279311.693
20_G26_K0.249371.511
92_L108_L0.248721.507
70_E74_N0.248481.506
49_D97_S0.24621.492
37_E82_E0.239551.452
8_D12_S0.239291.450
77_R81_F0.239081.449
5_G8_D0.238971.448
76_I140_I0.235611.428
69_F104_L0.234711.422
77_R112_L0.233371.414
36_L41_R0.231891.405
47_V69_F0.231781.405
85_S137_R0.229471.391
46_R59_H0.22151.342
73_L90_L0.221181.340
36_L39_G0.219951.333
5_G14_H0.219941.333
46_R93_K0.219741.332
73_L108_L0.217341.317
19_T31_S0.212781.289
78_D82_E0.210751.277
49_D55_L0.211.273
87_P133_L0.209831.272
108_L112_L0.205911.248
13_S16_T0.204231.238
8_D14_H0.201031.218
109_K118_Q0.198751.204
10_I13_S0.198481.203
45_L72_V0.196331.190
102_N106_E0.196171.189
5_G10_I0.195631.186
112_L140_I0.194921.181
74_N78_D0.192611.167
108_L142_L0.192451.166
58_Y62_T0.191621.161
73_L112_L0.18671.131
47_V104_L0.18541.124
74_N111_I0.182881.108
47_V96_Y0.176551.070
8_D11_S0.175831.066
71_D74_N0.17531.062
33_R78_D0.175211.062
70_E110_E0.173881.054
103_K107_I0.173561.052
81_F84_P0.169881.029
47_V57_V0.167951.018
5_G12_S0.166511.009
103_K106_E0.166021.006
15_N59_H0.165881.005
36_L88_V0.165341.002
17_Y46_R0.163860.993
30_W34_E0.163250.989
73_L107_I0.163150.989
4_P7_H0.163030.988
84_P88_V0.161010.976
42_Y91_S0.16070.974
53_G90_L0.160390.972
70_E103_K0.158380.960
58_Y66_G0.158270.959
8_D16_T0.157630.955
45_L90_L0.156630.949
117_Y121_P0.156290.947
113_G116_L0.155810.944
129_N135_E0.154560.937
107_I111_I0.154270.935
31_S35_Q0.153820.932
80_L84_P0.153660.931
19_T28_Q0.153590.931
126_Q135_E0.152960.927
12_S42_Y0.150840.914
86_E133_L0.150650.913
91_S95_E0.150610.913
52_D74_N0.148180.898
126_Q129_N0.147760.895
81_F114_D0.147710.895
75_D78_D0.14730.893
21_G24_W0.146870.890
80_L86_E0.145730.883
11_S14_H0.145420.881
44_D93_K0.145370.881
50_G56_V0.144590.876
35_Q40_I0.144490.876
6_T130_L0.144150.874
17_Y44_D0.144050.873
138_G141_V0.143380.869
27_T46_R0.143150.867
90_L93_K0.142850.866
7_H135_E0.142410.863
56_V68_T0.141360.857
57_V69_F0.141220.856
50_G53_G0.140210.850
34_E37_E0.140110.849
47_V55_L0.139690.847
4_P8_D0.139650.846
128_N135_E0.139470.845
50_G100_Q0.138780.841
12_S16_T0.138490.839
117_Y139_K0.138030.836
53_G103_K0.1380.836
44_D95_E0.137930.836
132_T136_L0.136210.825
36_L43_L0.136080.825
10_I16_T0.135390.820
43_L94_H0.134520.815
56_V65_S0.13450.815
29_S75_D0.134250.814
27_T64_T0.133570.809
14_H59_H0.132640.804
29_S67_I0.132430.803
8_D15_N0.132350.802
104_L107_I0.131770.799
139_K142_L0.131410.796
105_A109_K0.131380.796
10_I14_H0.13120.795
92_L104_L0.130990.794
43_L121_P0.128680.780
89_I138_G0.128650.780
86_E134_G0.128530.779
13_S18_L0.127880.775
7_H11_S0.127320.772
30_W38_S0.127120.770
30_W71_D0.126910.769
89_I136_L0.126790.768
110_E121_P0.126110.764
28_Q86_E0.125850.763
106_E109_K0.125610.761
98_P102_N0.125360.760
53_G127_E0.125170.759
17_Y20_G0.124880.757
118_Q121_P0.124480.754
87_P93_K0.124270.753
35_Q38_S0.124250.753
58_Y83_H0.12330.747
76_I88_V0.123180.746
75_D79_F0.123160.746
43_L90_L0.121760.738
37_E83_H0.121450.736
37_E78_D0.121130.734
49_D96_Y0.120940.733
8_D27_T0.120870.732
17_Y22_Q0.120720.732
20_G25_S0.120310.729
15_N93_K0.120150.728
93_K100_Q0.119910.727
51_N56_V0.119910.727
61_I141_V0.119770.726
5_G13_S0.119540.724
58_Y65_S0.119090.722
69_F108_L0.118930.721
32_I36_L0.118030.715
32_I72_V0.117960.715
13_S17_Y0.117850.714
79_F86_E0.11710.710
109_K119_P0.116980.709
102_N105_A0.115440.700
120_P126_Q0.115130.698
78_D99_E0.114290.693
88_V140_I0.113630.689
38_S43_L0.113460.688
12_S15_N0.113430.687
8_D13_S0.113130.686
48_W101_Q0.112940.684
122_D127_E0.112780.683
5_G16_T0.112540.682
25_S62_T0.112410.681
37_E115_R0.112130.680
18_L27_T0.111760.677
87_P116_L0.111630.676
83_H138_G0.111530.676
8_D46_R0.11120.674
106_E137_R0.110870.672
32_I45_L0.110540.670
46_R95_E0.110380.669
21_G34_E0.110170.668
70_E107_I0.109710.665
99_E106_E0.109640.664
138_G142_L0.109430.663
52_D127_E0.10930.662
111_I115_R0.109220.662
14_H17_Y0.108810.659
82_E139_K0.10880.659
11_S18_L0.108650.658
46_R94_H0.108280.656
28_Q35_Q0.107670.652
58_Y64_T0.107640.652
32_I67_I0.107430.651
50_G55_L0.107160.649
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
4gnkB11000.179
2zkmX11000.184
1djxA0.98631000.191
3qr0A11000.205
4i90A0.96581000.212
3v1hA0.96581000.213
3ea1A0.95211000.219
3ohmB11000.225
2plcA0.95211000.23
3h4xA0.952199.90.323

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