GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Inositol_P - Inositol monophosphatase family
Pfam: PF00459 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0171
Length: 270
Sequences: 5362
Seq/Len: 19.86
HH_delta: 0.033 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
228_L233_G1.329134.534
123_Y130_L0.987533.369
236_T259_H0.938373.201
85_Y113_V0.871722.974
138_G230_E0.789922.695
225_M229_E0.789752.694
124_D127_L0.785252.679
134_S137_Q0.779092.658
84_E114_N0.771762.633
15_E56_A0.73782.517
12_A56_A0.734732.507
237_D241_K0.683222.331
19_I52_L0.644512.199
17_G123_Y0.623262.126
44_E48_A0.602262.055
61_F64_H0.591432.018
88_V112_L0.587932.006
50_E68_G0.578961.975
116_E135_R0.577011.968
13_A109_I0.56691.934
226_L230_E0.564851.927
209_A262_L0.561141.914
122_I200_A0.560921.914
51_K55_E0.553721.889
31_E47_L0.550281.877
105_F126_F0.547551.868
160_V207_A0.54311.853
30_V33_K0.538241.836
120_G226_L0.528551.803
86_T112_L0.521511.779
133_A230_E0.515091.757
52_L56_A0.506291.727
56_A59_K0.505351.724
113_V118_V0.504771.722
89_I109_I0.504661.722
54_I66_I0.503981.719
112_L117_P0.496141.693
131_Y204_E0.493421.683
85_Y111_L0.484841.654
20_I92_I0.484591.653
200_A227_I0.483941.651
43_T99_V0.479131.635
132_Y140_F0.471571.609
87_W111_L0.471511.609
23_R45_A0.471351.608
129_E206_R0.469241.601
116_E229_E0.453331.547
110_A222_A0.452211.543
64_H85_Y0.450811.538
54_I58_R0.441071.505
57_L64_H0.439281.499
136_G230_E0.43891.497
124_D197_L0.437971.494
260_E264_A0.431451.472
9_A87_W0.430121.467
8_I12_A0.429571.465
21_R126_F0.425241.451
20_I49_A0.423311.444
141_L204_E0.42221.440
108_S196_A0.419321.431
10_I132_Y0.409761.398
13_A121_V0.404721.381
140_F145_R0.403911.378
53_I89_I0.403121.375
64_H87_W0.401051.368
153_P156_N0.400391.366
24_F105_F0.399331.362
84_E113_V0.396911.354
49_A92_I0.389941.330
106_A196_A0.387221.321
8_I61_F0.385581.315
133_A226_L0.38431.311
53_I109_I0.383711.309
261_K264_A0.381641.302
123_Y128_G0.374721.278
135_R229_E0.373951.276
234_I260_E0.367641.254
135_R230_E0.360951.231
6_L132_Y0.358391.223
14_R130_L0.356151.215
139_A146_I0.351931.201
50_E71_D0.350681.196
46_D70_E0.349641.193
253_A259_H0.347611.186
129_E204_E0.347151.184
41_F96_R0.344481.175
234_I256_P0.344351.175
8_I60_A0.342851.170
201_L206_R0.342141.167
190_R193_G0.338521.155
102_L192_M0.337251.151
49_A53_I0.335231.144
237_D240_G0.333041.136
11_R60_A0.33281.135
54_I68_G0.332261.134
54_I71_D0.331071.129
55_E59_K0.328711.121
129_E141_L0.327691.118
43_T95_T0.326721.115
88_V222_A0.325311.110
47_L51_K0.323841.105
67_I86_T0.320651.094
10_I14_R0.318841.088
199_L228_L0.318681.087
199_L224_G0.316851.081
21_R105_F0.315731.077
48_A51_K0.315561.077
119_A134_S0.315261.076
41_F99_V0.314721.074
199_L252_A0.31281.067
117_P225_M0.311051.061
110_A117_P0.311031.061
97_N190_R0.308671.053
20_I98_F0.308181.051
110_A226_L0.305821.043
11_R15_E0.305551.042
229_E242_P0.305211.041
10_I130_L0.305151.041
148_V231_A0.299721.022
180_L262_L0.295881.009
118_V135_R0.29581.009
20_I105_F0.295471.008
146_I204_E0.295091.007
111_L119_A0.294421.004
122_I227_I0.2910.993
19_I22_E0.289650.988
9_A13_A0.287280.980
57_L61_F0.286790.978
195_S216_L0.28560.974
67_I88_V0.283950.969
15_E52_L0.283540.967
117_P226_L0.281650.961
56_A60_A0.28060.957
15_E18_E0.280430.957
157_A258_L0.279780.954
50_E54_I0.279170.952
23_R44_E0.279020.952
251_I263_L0.2770.945
14_R123_Y0.276170.942
175_S178_R0.276070.942
13_A107_I0.275740.941
16_A107_I0.272250.929
122_I224_G0.269410.919
178_R182_S0.269010.918
149_S208_D0.267980.914
50_E72_G0.267930.914
256_P260_E0.26750.913
11_R56_A0.267070.911
9_A121_V0.265660.906
21_R128_G0.264630.903
8_I57_L0.264530.902
175_S179_K0.264050.901
12_A52_L0.263770.900
46_D69_E0.263560.899
225_M235_V0.261630.893
12_A53_I0.260770.890
42_V47_L0.260640.889
139_A227_I0.260570.889
70_E95_T0.257960.880
240_G263_L0.256790.876
46_D95_T0.25590.873
6_L119_A0.253870.866
256_P259_H0.252290.861
90_D95_T0.251840.859
111_L118_V0.251230.857
70_E90_D0.250240.854
29_S44_E0.250210.854
197_L201_L0.248760.849
199_L235_V0.247790.845
157_A208_D0.247090.843
65_P83_D0.246870.842
194_S197_L0.246330.840
24_F126_F0.245580.838
69_E95_T0.245070.836
135_R138_G0.244810.835
19_I23_R0.243240.830
12_A16_A0.242940.829
107_I121_V0.242840.828
13_A17_G0.240.819
133_A139_A0.239990.819
49_A52_L0.239260.816
195_S212_S0.238110.812
18_E21_R0.23740.810
67_I219_W0.23730.810
97_N198_D0.236980.808
30_V99_V0.236870.808
68_G71_D0.236650.807
141_L146_I0.235890.805
65_P86_T0.235620.804
129_E201_L0.23530.803
259_H263_L0.234780.801
52_L55_E0.233340.796
139_A230_E0.232970.795
202_V207_A0.232550.793
14_R17_G0.232470.793
110_A120_G0.231910.791
51_K71_D0.231540.790
216_L221_I0.231430.790
228_L252_A0.230970.788
108_S122_I0.230760.787
236_T263_L0.230540.786
104_E201_L0.230320.786
140_F143_G0.229180.782
83_D114_N0.227650.777
7_K11_R0.227210.775
164_S167_S0.226170.772
177_I181_L0.225550.769
254_S257_E0.225290.769
45_A49_A0.224990.768
6_L121_V0.224950.767
162_S212_S0.224850.767
88_V110_A0.223790.763
24_F101_G0.222870.760
131_Y200_A0.222790.760
85_Y118_V0.221340.755
253_A256_P0.221110.754
108_S224_G0.220490.752
46_D90_D0.220460.752
166_S169_P0.219970.750
87_W119_A0.219840.750
258_L261_K0.219390.748
106_A194_S0.218770.746
9_A64_H0.218520.745
86_T115_G0.217990.744
183_L265_L0.217150.741
109_I121_V0.216750.739
234_I259_H0.215830.736
20_I45_A0.21550.735
150_K257_E0.215120.734
16_A20_I0.214430.732
210_Y216_L0.214090.730
224_G227_I0.213280.728
69_E90_D0.212480.725
7_K10_I0.21130.721
179_K265_L0.211280.721
17_G21_R0.210690.719
251_I262_L0.210580.718
57_L87_W0.209790.716
70_E91_P0.209760.716
11_R14_R0.20950.715
48_A52_L0.209440.715
22_E26_R0.209230.714
196_A224_G0.208970.713
26_R44_E0.20840.711
104_E197_L0.20830.711
91_P95_T0.207310.707
106_A124_D0.207250.707
10_I121_V0.207240.707
119_A133_A0.205940.703
17_G130_L0.205030.699
146_I231_A0.20490.699
15_E19_I0.204870.699
90_D94_G0.203920.696
148_V233_G0.203130.693
212_S216_L0.202870.692
69_E220_D0.202780.692
253_A262_L0.202510.691
152_P257_E0.202160.690
46_D220_D0.200790.685
112_L222_A0.200650.685
229_E234_I0.200350.683
191_S198_D0.200330.683
191_S212_S0.20010.683
93_D220_D0.199910.682
120_G227_I0.198450.677
66_I89_I0.19840.677
108_S199_L0.197310.673
28_L33_K0.197140.673
177_I180_L0.197070.672
95_T220_D0.196090.669
108_S200_A0.195890.668
90_D93_D0.195620.667
69_E93_D0.195490.667
154_L159_S0.195210.666
194_S198_D0.195090.666
46_D91_P0.19470.664
18_E22_E0.194180.662
60_A64_H0.193460.660
147_R150_K0.193440.660
108_S223_A0.193270.659
134_S230_E0.19250.657
200_A224_G0.192460.657
261_K265_L0.192150.656
141_L144_R0.192140.655
195_S210_Y0.192050.655
250_L254_S0.192030.655
141_L206_R0.190450.650
121_V130_L0.190260.649
192_M201_L0.190170.649
6_L12_A0.189020.645
198_D210_Y0.188880.644
19_I48_A0.188220.642
106_A122_I0.188090.642
173_D176_L0.187830.641
250_L253_A0.187590.640
132_Y143_G0.187570.640
9_A16_A0.187080.638
14_R128_G0.186970.638
138_G145_R0.186910.638
135_R226_L0.186740.637
33_K43_T0.186640.637
96_R100_R0.186210.635
124_D131_Y0.186170.635
228_L235_V0.186110.635
221_I243_L0.185740.634
43_T46_D0.184670.630
154_L157_A0.184420.629
6_L134_S0.184060.628
46_D50_E0.183250.625
236_T240_G0.181520.619
198_D207_A0.179850.614
95_T219_W0.179530.612
104_E192_M0.179410.612
159_S209_A0.179160.611
247_S250_L0.178890.610
151_A157_A0.178890.610
253_A258_L0.177110.604
49_A107_I0.176740.603
180_L184_V0.176730.603
98_F105_F0.176340.602
262_L265_L0.176190.601
179_K182_S0.176170.601
153_P261_K0.175960.600
69_E91_P0.175190.598
47_L50_E0.175190.598
234_I242_P0.174510.595
133_A138_G0.17450.595
73_D76_P0.174470.595
12_A15_E0.173980.594
14_R18_E0.173890.593
165_Y168_Q0.17370.593
238_L249_G0.173510.592
57_L60_A0.173090.590
106_A197_L0.172560.589
131_Y201_L0.172490.588
44_E47_L0.172050.587
180_L265_L0.171990.587
43_T219_W0.16960.579
260_E263_L0.169110.577
13_A16_A0.168460.575
61_F87_W0.167940.573
28_L99_V0.167630.572
88_V117_P0.167620.572
162_S191_S0.16730.571
23_R48_A0.167110.570
20_I23_R0.166820.569
216_L219_W0.166660.569
166_S171_I0.165760.565
50_E66_I0.165370.564
184_V188_G0.164720.562
243_L250_L0.164590.561
129_E142_N0.164390.561
11_R18_E0.164160.560
19_I49_A0.163910.559
227_I231_A0.163670.558
201_L204_E0.162320.554
57_L111_L0.162320.554
96_R158_S0.161970.553
195_S199_L0.161570.551
180_L183_L0.161010.549
223_A227_I0.159770.545
54_I89_I0.159530.544
55_E58_R0.159360.544
234_I263_L0.159290.543
122_I223_A0.158520.541
195_S220_D0.158450.541
253_A257_E0.158360.540
97_N102_L0.158080.539
27_Q31_E0.157850.539
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3lv0A0.95931000.033
2bjiA0.97781000.046
2fvzA0.97411000.052
3rydA0.94441000.058
3t0jA0.95931000.06
2pcrA0.94441000.06
2q74A0.98151000.065
2p3nA0.92591000.075
2qflA0.95561000.08
1g0hA0.90741000.111

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