GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Fe-ADH - Iron-containing alcohol dehydrogenase
Pfam: PF00465 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0224
Length: 366
Sequences: 5776
Seq/Len: 15.78
HH_delta: 0.041 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
281_R319_R0.958373.579
72_E76_K0.911423.403
219_P324_S0.8973.349
220_R227_D0.850923.177
65_E146_E0.743712.777
39_D43_D0.743632.777
224_D227_D0.739192.760
70_A97_V0.684032.554
209_Q212_R0.661132.469
217_N233_N0.649652.426
23_R51_E0.649442.425
82_I94_A0.639432.388
9_G169_E0.638152.383
8_R169_E0.618192.308
13_E16_E0.612612.288
24_V81_C0.605832.262
172_A228_L0.572882.139
320_A324_S0.566612.116
166_L235_A0.565532.112
91_M126_A0.561852.098
190_A210_A0.561472.097
57_G69_E0.555352.074
39_D42_L0.547852.046
42_L46_E0.547322.044
181_S270_E0.544422.033
337_D340_D0.53862.011
186_A214_I0.537252.006
31_S35_S0.525581.963
330_R333_D0.513691.918
187_L211_I0.51071.907
177_R270_E0.509721.903
257_S271_A0.506051.890
59_G66_D0.501061.871
274_I334_L0.484851.810
176_P180_A0.482831.803
15_G44_A0.482671.802
84_A94_A0.482651.802
69_E72_E0.472221.763
179_T231_R0.471511.761
53_Q77_F0.466461.742
74_A122_L0.462461.727
323_R329_T0.458061.710
316_D320_A0.45151.686
10_A13_E0.444521.660
43_D47_E0.443491.656
73_Q77_F0.443221.655
312_D316_D0.433931.620
46_E52_V0.428811.601
17_E20_R0.419021.565
281_R312_D0.417241.558
67_V93_A0.417021.557
40_R169_E0.411331.536
220_R224_D0.410131.531
74_A79_A0.408831.527
12_E40_R0.407761.523
18_L81_C0.405911.516
27_V97_V0.405721.515
343_E346_E0.401111.498
71_A100_L0.399081.490
215_F298_L0.395741.478
74_A101_L0.391121.460
229_E233_N0.387351.446
171_T235_A0.386761.444
256_L275_L0.385841.441
66_D69_E0.382161.427
73_Q76_K0.381761.426
317_E320_A0.37721.408
33_S56_D0.374491.398
53_Q73_Q0.372941.393
183_G218_L0.371971.389
145_D148_G0.371921.389
24_V83_I0.370431.383
171_T231_R0.366011.367
343_E347_A0.363181.356
280_L318_L0.359441.342
8_R228_L0.359191.341
123_P162_D0.357191.334
266_V271_A0.350091.307
67_V143_I0.350091.307
9_G167_D0.348811.302
319_R323_R0.347311.297
84_A124_L0.346411.294
59_G63_T0.34571.291
340_D343_E0.344521.286
220_R229_E0.344381.286
27_V58_V0.343731.284
30_P34_K0.342231.278
219_P223_A0.341871.277
81_C125_I0.339591.268
184_L322_L0.339391.267
41_V85_I0.334581.249
169_E172_A0.334391.249
217_N220_R0.333891.247
25_L79_A0.333851.247
8_R172_A0.333341.245
131_A179_T0.332111.240
179_T221_A0.330881.236
227_D230_A0.329381.230
53_Q79_A0.327551.223
64_L68_D0.327531.223
183_G234_L0.326951.221
18_L125_I0.324261.211
174_L178_L0.324121.210
346_E350_A0.324011.210
125_I163_A0.322791.205
214_I234_L0.321781.202
43_D46_E0.320721.198
4_I239_T0.313351.170
253_A272_V0.311971.165
42_L52_V0.310931.161
179_T225_P0.310731.160
222_V326_G0.310391.159
223_A324_S0.309371.155
263_R343_E0.303621.134
30_P56_D0.302211.128
208_L212_R0.302061.128
25_L74_A0.30181.127
184_L327_L0.300881.124
5_I13_E0.297281.110
3_K17_E0.297241.110
84_A91_M0.296311.106
254_H268_H0.295561.104
212_R216_E0.294881.101
27_V94_A0.294121.098
169_E228_L0.293411.096
7_G13_E0.29321.095
30_P57_G0.292981.094
216_E233_N0.291941.090
72_E75_R0.289821.082
278_H281_R0.289231.080
82_I98_A0.28881.078
313_D316_D0.288691.078
84_A126_A0.286941.071
176_P222_V0.286631.070
205_A209_Q0.284461.062
19_K48_A0.28291.056
14_L41_V0.282361.054
23_R78_G0.282091.053
46_E51_E0.28161.052
67_V97_V0.281221.050
33_S38_V0.280431.047
68_D72_E0.278941.042
188_A276_L0.278511.040
17_E163_A0.278321.039
94_A124_L0.277921.038
25_L73_Q0.277661.037
14_L127_I0.277451.036
40_R43_D0.27681.034
217_N230_A0.27671.033
8_R232_E0.274581.025
193_A244_A0.273821.022
31_S34_K0.272341.017
32_L35_S0.270461.010
190_A241_A0.270311.009
140_Y155_R0.26831.002
23_R53_Q0.267460.999
342_D346_E0.266950.997
311_A314_A0.26650.995
69_E73_Q0.266430.995
5_I17_E0.266020.993
208_L297_A0.264950.989
131_A235_A0.264360.987
11_L40_R0.26420.987
256_L344_I0.263120.983
11_L170_L0.261980.978
204_D207_A0.261430.976
16_E48_A0.261250.976
236_L240_L0.260210.972
273_A327_L0.259070.967
199_A204_D0.258750.966
263_R347_A0.256120.956
221_A225_P0.255920.956
195_L280_L0.255590.954
180_A222_V0.255580.954
61_N265_G0.254740.951
91_M128_P0.254540.950
24_V50_I0.254260.949
139_P157_P0.253960.948
23_R77_F0.2530.945
210_A241_A0.250670.936
220_R223_A0.250070.934
257_S261_G0.249080.930
328_P334_L0.248490.928
98_A122_L0.247470.924
91_M135_S0.247280.923
221_A230_A0.247190.923
37_L85_I0.245410.916
345_A348_A0.24480.914
125_I165_I0.244730.914
193_A204_D0.2430.907
63_T66_D0.242070.904
13_E17_E0.24090.900
177_R181_S0.240750.899
5_I165_I0.240.896
168_P232_E0.239650.895
55_F70_A0.239630.895
191_I211_I0.239580.895
277_P322_L0.239450.894
191_I314_A0.239320.894
194_Y208_L0.239090.893
9_G12_E0.239010.892
3_K20_R0.238450.890
329_T333_D0.238390.890
59_G69_E0.238330.890
225_P231_R0.238020.889
253_A276_L0.237820.888
181_S267_P0.237590.887
26_V38_V0.237530.887
184_L273_A0.236750.884
12_E44_A0.236320.882
63_T265_G0.236170.882
99_L156_S0.235890.881
10_A165_I0.235760.880
217_N229_E0.235380.879
209_Q213_L0.23530.879
12_E169_E0.235170.878
24_V52_V0.234910.877
187_L214_I0.232680.869
38_V42_L0.232240.867
215_F317_E0.231420.864
29_D32_L0.231390.864
63_T146_E0.230830.862
7_G10_A0.230590.861
213_L217_N0.23030.860
193_A207_A0.22950.857
11_L169_E0.229480.857
64_L146_E0.229060.855
252_A279_V0.228950.855
229_E232_E0.228850.855
40_R44_A0.228760.854
137_V239_T0.228260.852
46_E49_G0.227970.851
45_L50_I0.22790.851
205_A212_R0.226550.846
215_F219_P0.226060.844
176_P223_A0.225890.843
220_R230_A0.225750.843
25_L53_Q0.224970.840
137_V164_A0.22450.838
342_D345_A0.224230.837
74_A97_V0.224020.837
345_A349_L0.223980.836
26_V42_L0.223230.834
40_R170_L0.223010.833
82_I122_L0.222910.832
328_P333_D0.22260.831
320_A323_R0.222360.830
126_A164_A0.2220.829
316_D319_R0.221790.828
338_E341_L0.221740.828
222_V325_L0.221560.827
175_P178_L0.22120.826
149_G265_G0.221170.826
71_A75_R0.220860.825
277_P319_R0.220710.824
23_R80_D0.220310.823
176_P225_P0.220080.822
33_S42_L0.219510.820
206_L240_L0.218680.817
259_A347_A0.218030.814
216_E220_R0.216450.808
347_A350_A0.216380.808
93_A97_V0.216370.808
65_E147_E0.216030.807
68_D71_A0.215910.806
71_A97_V0.215750.806
55_F69_E0.21470.802
11_L41_V0.213620.798
185_D268_H0.211350.789
75_R101_L0.211010.788
55_F66_D0.210850.787
245_I250_T0.209570.783
126_A161_P0.209330.782
16_E19_K0.209190.781
15_G47_E0.209020.780
32_L38_V0.208770.780
11_L127_I0.207940.776
26_V52_V0.207470.775
44_A47_E0.207030.773
99_L159_L0.206330.770
11_L167_D0.206320.770
198_K249_G0.206210.770
300_V313_D0.206160.770
17_E21_L0.205640.768
84_A90_V0.205540.768
58_V93_A0.205150.766
17_E165_I0.204970.765
49_G52_V0.204950.765
88_G254_H0.204650.764
6_F232_E0.204620.764
274_I277_P0.204380.763
67_V96_A0.204120.762
217_N221_A0.203730.761
33_S54_V0.203380.759
260_L271_A0.203340.759
27_V70_A0.20270.757
19_K50_I0.202480.756
171_T179_T0.201870.754
133_T138_T0.201370.752
96_A141_A0.201260.752
37_L40_R0.200910.750
101_L122_L0.200730.750
33_S39_D0.200730.750
180_A327_L0.199520.745
71_A101_L0.198980.743
257_S272_V0.198610.742
174_L182_G0.198180.740
281_R315_I0.197980.739
201_P236_L0.197790.739
280_L314_A0.196760.735
88_G268_H0.195170.729
187_L191_I0.194330.726
65_E69_E0.194320.726
28_T90_V0.194050.725
83_I125_I0.193760.724
267_P270_E0.193080.721
248_A276_L0.192480.719
280_L315_I0.192180.718
59_G265_G0.191760.716
281_R316_D0.191680.716
172_A226_E0.190640.712
28_T298_L0.190140.710
188_A272_V0.190080.710
217_N234_L0.190070.710
128_P166_L0.189220.707
29_D35_S0.189110.706
256_L348_A0.188740.705
61_N89_S0.188570.704
70_A93_A0.188180.703
6_F166_L0.187630.701
211_I215_F0.187460.700
264_Y340_D0.18740.700
272_V275_L0.185280.692
96_A100_L0.184850.690
96_A154_I0.184560.689
270_E327_L0.18440.689
67_V71_A0.184380.688
252_A255_A0.184110.687
74_A77_F0.183940.687
138_T242_G0.183820.686
23_R28_T0.18370.686
215_F321_L0.183690.686
319_R329_T0.183590.686
81_C123_P0.183130.684
12_E47_E0.183090.684
251_G297_A0.182190.680
139_P246_S0.182130.680
22_G80_D0.181420.677
28_T297_A0.181390.677
5_I10_A0.181110.676
131_A171_T0.181070.676
15_G19_K0.180920.676
251_G283_N0.180480.674
185_D254_H0.180140.673
258_H353_R0.180090.672
14_L44_A0.179910.672
188_A253_A0.179530.670
213_L237_A0.179510.670
15_G50_I0.179240.669
279_V283_N0.178810.668
133_T136_E0.178490.666
256_L259_A0.178390.666
255_A353_R0.17820.665
15_G18_L0.178160.665
74_A82_I0.178050.665
134_G138_T0.177860.664
331_L336_I0.177440.663
150_R153_S0.177320.662
218_L321_L0.177250.662
98_A124_L0.177120.661
178_L181_S0.177050.661
273_A322_L0.177010.661
219_P321_L0.176610.659
171_T174_L0.176470.659
178_L182_G0.176410.659
151_K254_H0.176030.657
315_I319_R0.175870.657
134_G238_S0.175360.655
100_L104_P0.175130.654
32_L37_L0.174940.653
32_L85_I0.174650.652
128_P238_S0.174620.652
41_V44_A0.174350.651
232_E236_L0.17370.649
251_G258_H0.173280.647
24_V80_D0.173150.647
214_I218_L0.172630.645
92_D268_H0.172530.644
242_G245_I0.171580.641
258_H351_D0.171240.639
127_I165_I0.170820.638
140_Y245_I0.170710.637
72_E77_F0.16980.634
82_I97_V0.169590.633
38_V54_V0.169460.633
73_Q79_A0.169010.631
23_R79_A0.168770.630
39_D46_E0.168280.628
12_E43_D0.167980.627
217_N237_A0.167620.626
15_G48_A0.167590.626
92_D269_G0.166820.623
28_T56_D0.166760.623
88_G92_D0.166650.622
176_P326_G0.166550.622
35_S38_V0.166480.622
216_E219_P0.166270.621
3_K157_P0.165320.617
260_L275_L0.165230.617
141_A154_I0.16450.614
61_N261_G0.164470.614
27_V90_V0.16410.613
214_I237_A0.163740.611
68_D100_L0.163280.610
183_G186_A0.163280.610
21_L125_I0.163090.609
18_L83_I0.162910.608
137_V243_L0.162850.608
300_V314_A0.162730.608
124_L162_D0.162710.608
148_G152_L0.162580.607
4_I164_A0.162250.606
263_R344_I0.161890.605
297_A300_V0.161820.604
260_L331_L0.161740.604
250_T283_N0.161070.601
211_I214_I0.160870.601
12_E16_E0.160770.600
219_P222_V0.160710.600
14_L165_I0.16060.600
332_S338_E0.160080.598
250_T353_R0.159960.597
27_V82_I0.159630.596
239_T243_L0.159360.595
188_A257_S0.159340.595
29_D34_K0.159210.595
214_I217_N0.159120.594
188_A251_G0.15870.593
209_Q240_L0.158660.592
314_A318_L0.158440.592
187_L318_L0.158430.592
200_N203_S0.158020.590
321_L325_L0.157660.589
266_V334_L0.156930.586
318_L322_L0.15610.583
28_T33_S0.155550.581
142_V185_D0.155470.581
153_S258_H0.155250.580
10_A14_L0.155160.579
96_A143_I0.155130.579
14_L18_L0.15480.578
205_A240_L0.153430.573
74_A81_C0.153390.573
323_R333_D0.153310.572
70_A73_Q0.152620.570
270_E328_P0.152470.569
92_D254_H0.152350.569
11_L14_L0.152310.569
191_I276_L0.15210.568
221_A224_D0.15210.568
53_Q76_K0.151960.567
81_C84_A0.151680.566
6_F236_L0.151350.565
99_L154_I0.150930.564
68_D75_R0.15090.563
184_L325_L0.150640.563
199_A203_S0.14990.560
2_T160_Y0.14960.559
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3ox4A0.99731000.041
4fr2A0.99731000.042
3bfjA0.99731000.084
1rrmA0.99181000.097
1vljA0.98911000.106
1oj7A0.98631000.127
3jzdA0.89891000.138
3hl0A0.89071000.144
3iv7A0.89071000.146
1o2dA0.9291000.172

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