GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
PP2C - Protein phosphatase 2C
Pfam: PF00481 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0238
Length: 254
Sequences: 4953
Seq/Len: 19.5
HH_delta: 0.094 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
104_T123_A1.132194.282
122_R138_D0.846913.203
127_R201_D0.759962.874
134_Q217_N0.759652.873
42_H100_G0.642292.429
115_V123_A0.618082.338
207_A212_W0.598262.263
112_K196_D0.591672.238
219_E248_R0.577682.185
205_V220_I0.573112.168
211_L241_L0.56642.142
51_A173_L0.562652.128
218_E222_D0.559022.114
139_H191_D0.535412.025
126_C131_I0.522041.974
151_R154_G0.509961.929
244_E248_R0.500651.894
79_F105_V0.486021.838
148_E152_K0.476731.803
51_A101_S0.474441.794
112_K194_E0.471111.782
137_R143_N0.471061.782
106_A115_V0.469091.774
106_A206_L0.464031.755
106_A204_L0.463631.753
104_T206_L0.454761.720
117_N136_T0.453651.716
50_Y54_N0.446011.687
84_D179_K0.442771.675
216_S219_E0.442581.674
122_R217_N0.437321.654
223_I244_E0.437061.653
106_A113_L0.433181.638
39_F101_S0.428721.621
143_N146_E0.419891.588
79_F116_A0.415781.573
105_V116_A0.403521.526
126_C221_V0.398391.507
235_Q239_E0.398281.506
55_L173_L0.395491.496
246_I250_S0.394191.491
114_Y194_E0.393611.489
113_L195_V0.392861.486
39_F103_A0.389221.472
127_R198_T0.3861.460
102_T121_S0.385221.457
58_F86_S0.378451.431
85_E89_S0.377311.427
79_F103_A0.375611.421
35_L56_P0.37241.408
76_R189_E0.371791.406
147_R151_R0.366581.386
81_A86_S0.362461.371
137_R146_E0.362311.370
72_E76_R0.354871.342
62_N81_A0.353381.337
122_R136_T0.349911.323
58_F83_T0.347371.314
212_W220_I0.346641.311
120_D209_D0.346541.311
135_L193_S0.340421.288
154_G157_V0.337661.277
101_S121_S0.336531.273
42_H45_S0.336091.271
148_E151_R0.334891.267
245_A250_S0.334191.264
125_L201_D0.331991.256
54_N57_E0.330911.252
71_I114_Y0.326011.233
115_V193_S0.324441.227
72_E194_E0.32311.222
162_R165_G0.322561.220
203_F224_V0.319251.207
59_L78_A0.318771.206
13_E49_E0.317671.201
146_E149_R0.3171.199
243_D247_A0.315011.191
127_R130_G0.315011.191
87_L173_L0.313151.184
9_G246_I0.312751.183
220_I241_L0.312431.182
150_I155_G0.310411.174
207_A211_L0.309221.170
84_D87_L0.306241.158
102_T209_D0.306151.158
75_L116_A0.305521.156
113_L197_L0.305441.155
73_E77_Q0.298951.131
151_R155_G0.298921.131
124_V212_W0.297961.127
86_S89_S0.295961.119
37_G105_V0.292771.107
58_F61_E0.291921.104
117_N193_S0.289481.095
144_P148_E0.289141.094
139_H171_R0.288151.090
47_A87_L0.287181.086
125_L132_I0.285561.080
124_V220_I0.285471.080
19_L39_F0.283351.072
205_V224_V0.281931.066
125_L204_L0.278891.055
150_I158_S0.278671.054
39_F56_P0.278471.053
215_L220_I0.278171.052
114_Y192_I0.277761.051
215_L244_E0.277381.049
48_A51_A0.276541.046
104_T117_N0.27641.045
113_L204_L0.274861.040
62_N77_Q0.27431.037
238_A242_V0.272351.030
78_A83_T0.268311.015
103_A173_L0.267881.013
122_R134_Q0.267331.011
172_A175_D0.267321.011
244_E247_A0.266561.008
171_R191_D0.266221.007
118_V190_P0.266141.007
104_T136_T0.26591.006
108_I113_L0.264811.002
74_A78_A0.261220.988
124_V221_V0.260770.986
219_E222_D0.259190.980
227_S240_K0.259090.980
70_D73_E0.257920.975
117_N123_A0.254140.961
126_C203_F0.253680.959
236_E240_K0.253440.959
239_E243_D0.252730.956
240_K243_D0.252460.955
40_D120_D0.249180.942
33_V109_D0.248650.940
238_A245_A0.247440.936
44_G48_A0.246690.933
42_H48_A0.246480.932
171_R190_P0.246340.932
53_Q57_E0.245660.929
126_C224_V0.245620.929
42_H175_D0.245150.927
37_G56_P0.244320.924
55_L83_T0.243660.922
17_R49_E0.243430.921
17_R52_S0.242670.918
211_L245_A0.24160.914
10_V246_I0.241370.913
215_L248_R0.240790.911
76_R80_L0.240780.911
131_I224_V0.240720.910
102_T120_D0.24030.909
242_V246_I0.238980.904
73_E76_R0.238110.901
40_D209_D0.237590.899
47_A96_S0.236190.893
7_M242_V0.236010.893
163_V166_V0.232510.879
240_K244_E0.232220.878
19_L35_L0.231730.876
214_V250_S0.231490.876
50_Y87_L0.231030.874
63_L74_A0.230390.871
154_G158_S0.230350.871
198_T201_D0.229570.868
145_D158_S0.229030.866
96_S99_S0.22490.851
16_D210_G0.222560.842
126_C225_R0.222510.842
62_N65_F0.22210.840
83_T87_L0.221370.837
54_N86_S0.220440.834
157_V170_S0.219490.830
227_S237_A0.21690.820
35_L107_L0.215730.816
55_L101_S0.215260.814
37_G59_L0.214980.813
137_R191_D0.214250.810
140_K213_D0.213740.808
219_E244_E0.213650.808
155_G158_S0.213470.807
138_D217_N0.211840.801
229_N236_E0.211650.800
75_L105_V0.211110.798
101_S173_L0.210870.798
84_D88_Y0.20980.793
211_L215_L0.209540.793
171_R175_D0.208880.790
223_I237_A0.208090.787
109_D114_Y0.207820.786
218_E221_V0.20630.780
140_K170_S0.206260.780
15_E213_D0.206120.780
171_R174_G0.205640.778
9_G250_S0.203090.768
41_G44_G0.202790.767
38_V104_T0.202650.766
169_V172_A0.202370.765
236_E239_E0.201190.761
162_R166_V0.200760.759
241_L245_A0.200280.757
20_I36_F0.200140.757
45_S49_E0.19970.755
72_E192_I0.199320.754
75_L114_Y0.19910.753
41_G209_D0.198450.751
111_N196_D0.198140.749
217_N220_I0.197320.746
36_F206_L0.195850.741
19_L37_G0.195220.738
150_I157_V0.195170.738
123_A193_S0.194850.737
35_L105_V0.194550.736
124_V217_N0.194060.734
149_R153_A0.193440.732
16_D40_D0.193250.731
104_T121_S0.192580.728
150_I154_G0.192350.727
128_N198_T0.191520.724
49_E53_Q0.191350.724
123_A135_L0.191090.723
242_V245_A0.191060.723
117_N139_H0.190970.722
220_I237_A0.189860.718
77_Q81_A0.189260.716
80_L189_E0.18920.716
7_M10_V0.188930.715
243_D246_I0.188670.714
127_R195_V0.188160.712
124_V207_A0.187870.711
151_R158_S0.186490.705
54_N90_D0.186270.704
141_P168_A0.185560.702
121_S209_D0.185510.702
222_D226_E0.185060.700
114_Y117_N0.185060.700
37_G103_A0.184710.699
16_D41_G0.18410.696
125_L135_L0.183840.695
55_L59_L0.183810.695
126_C129_G0.182870.692
61_E65_F0.181860.688
128_N200_D0.181770.687
57_E61_E0.181160.685
86_S90_D0.18110.685
223_I240_K0.180570.683
11_R43_G0.178520.675
90_D96_S0.17790.673
223_I227_S0.177630.672
11_R14_M0.177590.672
36_F108_I0.176850.669
131_I221_V0.17680.669
83_T86_S0.176490.668
61_E86_S0.1760.666
118_V179_K0.175910.665
88_Y179_K0.175470.664
124_V138_D0.175240.663
100_G103_A0.175210.663
16_D209_D0.175140.662
144_P147_R0.174530.660
120_D210_G0.174520.660
81_A85_E0.173930.658
221_V225_R0.17330.655
79_F192_I0.173020.654
15_E102_T0.17110.647
115_V136_T0.169790.642
141_P170_S0.169730.642
22_Q36_F0.169730.642
151_R157_V0.168540.637
84_D118_V0.168360.637
47_A51_A0.167970.635
128_N226_E0.167770.635
55_L87_L0.167170.632
48_A52_S0.16690.631
134_Q138_D0.166780.631
224_V237_A0.166770.631
54_N58_F0.165760.627
49_E52_S0.165170.625
109_D197_L0.165020.624
42_H209_D0.164010.620
19_L22_Q0.163470.618
48_A101_S0.163170.617
173_L179_K0.162950.616
203_F237_A0.162720.615
58_F62_N0.162610.615
239_E242_V0.162530.615
110_G197_L0.160820.608
8_Q14_M0.160460.607
35_L39_F0.160430.607
129_G225_R0.160190.606
63_L67_D0.160020.605
44_G100_G0.15960.604
40_D210_G0.159290.602
79_F190_P0.158380.599
9_G14_M0.157190.595
161_G164_N0.156840.593
15_E209_D0.156380.591
116_A190_P0.156270.591
140_K168_A0.156270.591
148_E158_S0.156190.591
40_D44_G0.155410.588
19_L60_K0.155350.588
143_N191_D0.155170.587
33_V107_L0.154870.586
207_A220_I0.15480.585
71_I109_D0.15430.584
108_I197_L0.153670.581
47_A50_Y0.153090.579
51_A83_T0.152810.578
234_P237_A0.15240.576
125_L195_V0.152310.576
79_F83_T0.152040.575
178_L208_S0.15160.573
18_H208_S0.150970.571
43_G169_V0.150720.570
209_D213_D0.150240.568
89_S93_N0.150140.568
145_D148_E0.150130.568
127_R131_I0.149860.567
11_R44_G0.149680.566
67_D77_Q0.14930.565
14_M48_A0.149040.564
235_Q243_D0.14840.561
142_S158_S0.148320.561
36_F204_L0.147490.558
72_E80_L0.147340.557
178_L190_P0.147110.556
162_R179_K0.146630.555
117_N138_D0.14590.552
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
2i0oA0.96851000.094
2p8eA0.98031000.099
1a6qA0.98031000.101
3qn1B0.97641000.105
4jndA0.97241000.112
3kdjB0.95671000.118
2j4oA0.96851000.123
4da1A0.93311000.129
2irmA0.96061000.133
3d8kA0.9371000.136

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