GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
FA_desaturase - Fatty acid desaturase
Pfam: PF00487 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 257
Sequences: 3905
Seq/Len: 15.19
HH_delta: 0.948 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
37_W41_L0.377762.629
234_N237_E0.318632.217
36_R40_D0.31782.212
230_V238_A0.312542.175
35_S38_L0.298562.078
144_A147_A0.294372.048
236_P240_P0.27971.946
240_P243_K0.278791.940
217_G236_P0.274141.908
27_A32_F0.262631.828
41_L45_L0.262061.824
143_L147_A0.261591.820
14_G167_I0.260651.814
61_H65_H0.249071.733
237_E240_P0.241061.678
138_L142_L0.239891.669
241_I244_E0.239411.666
97_F101_F0.233751.627
137_L141_L0.231571.611
43_G54_Y0.22681.578
221_H225_H0.224811.564
133_I137_L0.222641.549
101_F104_S0.221311.540
139_L143_L0.220521.535
8_L12_L0.21421.491
134_L138_L0.212831.481
223_E242_L0.207141.441
57_W179_E0.205571.431
13_L164_P0.202951.412
156_W159_L0.200621.396
155_W159_L0.199711.390
37_W40_D0.194911.356
134_L137_L0.194691.355
25_H29_H0.194531.354
135_A138_L0.191891.335
33_F39_N0.187941.308
212_N220_Y0.185611.292
146_L150_F0.18561.292
141_L144_A0.183951.280
143_L146_L0.181731.265
99_F103_L0.181331.262
136_A140_A0.1811.260
63_R66_H0.180161.254
29_H224_H0.181.253
55_S58_R0.179911.252
100_R103_L0.177641.236
221_H224_H0.177391.234
163_L167_I0.177371.234
9_A13_L0.176881.231
114_F118_K0.176741.230
142_L146_L0.176491.228
147_A150_F0.173821.210
13_L17_F0.173661.208
158_L162_L0.17321.205
95_R99_F0.172461.200
144_A148_A0.172411.200
41_L44_R0.171711.195
150_F155_W0.171141.191
35_S41_L0.169411.179
239_H243_K0.168451.172
18_A175_V0.168391.172
134_L141_L0.168341.171
152_F155_W0.168061.170
140_A143_L0.166751.160
61_H64_H0.16591.154
205_V208_S0.165341.151
212_N217_G0.165261.150
100_R104_S0.165231.150
28_G62_N0.165181.149
215_T219_N0.164541.145
26_D31_A0.16391.141
96_R100_R0.163391.137
106_F109_I0.162831.133
7_L10_L0.162081.128
18_A22_G0.161531.124
209_W213_W0.160771.119
155_W158_L0.160561.117
121_M124_R0.159781.112
140_A144_A0.159761.112
33_F38_L0.159371.109
96_R99_F0.158881.106
115_F118_K0.158131.100
154_P158_L0.157961.099
212_N219_N0.157721.098
27_A43_G0.156611.090
29_H65_H0.156591.090
193_D196_Y0.155921.085
14_G45_L0.155761.084
227_F230_V0.1551.079
40_D58_R0.154541.075
24_A28_G0.153811.070
223_E230_V0.153571.069
237_E241_I0.151891.057
22_G232_W0.151841.057
235_L239_H0.151571.055
29_H61_H0.151021.051
39_N127_R0.150791.049
219_N222_I0.150181.045
103_L107_F0.149851.043
53_P56_S0.149341.039
57_W68_T0.149031.037
240_P244_E0.148621.034
134_L142_L0.147871.029
35_S39_N0.147681.028
239_H242_L0.146031.016
24_A47_G0.1461.016
179_E218_L0.1461.016
76_D223_E0.144861.008
212_N215_T0.143841.001
124_R127_R0.143711.000
231_P234_N0.143190.996
29_H225_H0.143060.996
43_G58_R0.141880.987
65_H224_H0.141130.982
135_A146_L0.140780.980
98_L101_F0.140730.979
142_L145_L0.140490.978
223_E239_H0.139530.971
57_W178_L0.139460.970
22_G218_L0.139280.969
132_L136_A0.139110.968
11_L15_L0.138720.965
152_F156_W0.138470.964
136_A139_L0.138140.961
220_Y223_E0.1380.960
208_S211_L0.137650.958
108_P115_F0.137130.954
34_R37_W0.136880.953
15_L215_T0.135620.944
148_A155_W0.135160.941
138_L141_L0.13490.939
122_R125_R0.134860.938
112_F115_F0.134190.934
179_E221_H0.13340.928
153_S156_W0.133350.928
107_F111_Y0.13310.926
45_L79_T0.132710.924
119_R123_R0.132460.922
136_A146_L0.132450.922
20_L218_L0.132350.921
43_G47_G0.132030.919
97_F104_S0.131650.916
108_P112_F0.131620.916
146_L149_L0.131550.915
161_F165_F0.131350.914
14_G41_L0.131130.913
205_V211_L0.131060.912
168_G171_F0.131010.912
29_H221_H0.130960.911
21_F60_S0.130880.911
147_A151_F0.130760.910
190_D193_D0.130650.909
26_D69_N0.130330.907
192_R196_Y0.130270.907
17_F20_L0.130180.906
105_L109_I0.128970.897
139_L144_A0.128550.895
169_S173_A0.128460.894
121_M127_R0.127840.890
218_L221_H0.127370.886
218_L222_I0.127370.886
14_G214_L0.127290.886
140_A152_F0.127290.886
33_F42_L0.127030.884
27_A42_L0.126960.883
139_L142_L0.126770.882
115_F120_R0.126760.882
97_F100_R0.126710.882
110_W114_F0.12640.880
47_G54_Y0.126340.879
151_F154_P0.126050.877
140_A146_L0.125980.877
158_L163_L0.125660.874
135_A145_L0.125550.874
220_Y236_P0.12540.873
111_Y115_F0.125380.873
65_H225_H0.124810.869
191_T195_Y0.124480.866
10_L163_L0.124290.865
30_G39_N0.124140.864
109_I112_F0.123940.862
208_S212_N0.123930.862
104_S107_F0.12340.859
11_L14_G0.12320.857
19_R216_G0.122050.849
10_L159_L0.121950.849
172_L176_T0.121510.846
57_W215_T0.121510.846
64_H74_D0.121240.844
12_L15_L0.121170.843
16_S20_L0.120860.841
95_R103_L0.120640.840
178_L208_S0.120490.838
173_A176_T0.120290.837
209_W212_N0.120280.837
172_L175_V0.120270.837
179_E228_P0.120240.837
189_E193_D0.120170.836
20_L46_L0.120.835
65_H180_H0.119790.834
238_A241_I0.119590.832
61_H180_H0.119570.832
141_L148_A0.119480.831
223_E226_L0.119460.831
23_L46_L0.119340.830
135_A139_L0.119310.830
194_F198_Q0.119010.828
8_L140_A0.11890.827
132_L140_A0.118810.827
231_P235_L0.118620.825
149_L154_P0.118430.824
132_L147_A0.117980.821
195_Y198_Q0.117610.818
208_S221_H0.117380.817
157_A160_L0.117160.815
100_R106_F0.116910.814
218_L235_L0.116850.813
210_W213_W0.11650.811
206_H209_W0.116390.810
96_R101_F0.116230.809
134_L143_L0.116170.808
33_F41_L0.116150.808
230_V241_I0.115790.806
220_Y239_H0.115560.804
53_P134_L0.115330.803
164_P169_S0.115290.802
37_W147_A0.114890.800
65_H74_D0.114860.799
155_W161_F0.11470.798
7_L156_W0.114630.798
113_I117_R0.114610.798
69_N76_D0.114530.797
104_S116_F0.114350.796
96_R104_S0.114310.795
13_L16_S0.114110.794
7_L11_L0.114010.793
147_A152_F0.113940.793
104_S108_P0.113890.793
99_F104_S0.113750.792
21_F32_F0.113730.791
15_L209_W0.113730.791
61_H224_H0.113630.791
36_R39_N0.11350.790
149_L152_F0.113410.789
69_N77_S0.112740.785
24_A57_W0.112680.784
101_F106_F0.112550.783
57_W227_F0.112370.782
133_I146_L0.112290.781
216_G232_W0.111870.778
25_H224_H0.111630.777
27_A33_F0.111560.776
76_D219_N0.11150.776
17_F49_P0.11140.775
56_S60_S0.111280.774
74_D227_F0.111190.774
116_F119_R0.111070.773
205_V215_T0.111050.773
45_L49_P0.111010.773
133_I143_L0.110450.769
72_D189_E0.110350.768
111_Y114_F0.110060.766
133_I144_A0.109950.765
68_T76_D0.109940.765
184_D188_N0.109920.765
161_F197_R0.109810.764
34_R49_P0.109740.764
103_L108_P0.109680.763
119_R146_L0.109660.763
36_R41_L0.109560.762
141_L145_L0.109530.762
99_F105_L0.109510.762
67_Y70_N0.109310.761
108_P111_Y0.109110.759
26_D216_G0.109040.759
105_L108_P0.108740.757
230_V240_P0.108660.756
148_A158_L0.108590.756
44_R55_S0.10840.754
117_R121_M0.108240.753
13_L216_G0.10810.752
153_S157_A0.107730.750
211_L214_L0.107580.749
222_I239_H0.107540.748
74_D228_P0.107470.748
61_H74_D0.107310.747
145_L151_F0.10720.746
26_D231_P0.1070.745
34_R39_N0.106940.744
57_W218_L0.106830.743
212_N232_W0.106680.742
175_V211_L0.106590.742
50_I169_S0.106550.741
180_H221_H0.106240.739
174_F178_L0.105610.735
136_A147_A0.10550.734
95_R98_L0.105440.734
22_G32_F0.105360.733
154_P160_L0.104770.729
12_L171_F0.104670.728
97_F103_L0.104540.727
177_Y221_H0.104360.726
121_M154_P0.104320.726
11_L133_I0.104140.725
58_R62_N0.104070.724
150_F154_P0.103890.723
151_F156_W0.103840.723
25_H76_D0.103550.721
121_M126_K0.103070.717
150_F153_S0.102990.717
171_F214_L0.102330.712
207_N212_N0.102130.711
150_F158_L0.101980.710
221_H232_W0.10190.709
14_G162_L0.101880.709
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
2l8sA0.1868130.948
3mlfA0.1479110.949
1uj8A0.15958.90.951
3v5wG0.1448.30.952
1vk8A0.167360.954
4e04A0.25294.90.956
3r31A0.26464.60.957
2kvuA0.15564.60.957
3k2yA0.24124.40.957
2fgxA0.252940.958
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