GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Peptidase_M24 - Metallopeptidase family M24
Pfam: PF00557 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 207
Sequences: 8192
Seq/Len: 39.57
HH_delta: 0.026 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
178_P207_E1.838493.714
122_L205_V1.344882.717
117_A138_V1.24142.508
104_Q195_G1.236732.498
20_A33_A1.183362.390
16_A37_A1.159142.341
97_V100_P1.146272.315
117_A120_E1.113132.249
136_R140_E1.10712.236
105_R109_E1.097832.218
12_A42_H1.080662.183
109_E113_E1.058122.137
139_L188_L1.048092.117
5_K8_R1.032112.085
110_A142_Y1.004812.030
102_P106_R0.990232.000
26_T70_R0.983821.987
101_T104_Q0.973351.966
2_C86_D0.956431.932
3_M181_V0.949571.918
138_V142_Y0.943051.905
13_A37_A0.917791.854
16_A19_E0.888821.795
37_A42_H0.876521.771
189_Y196_G0.866671.751
112_R116_E0.862811.743
10_A92_I0.846661.710
36_R41_R0.842891.703
156_I202_T0.835781.688
28_Y68_D0.831881.680
32_A36_R0.831131.679
33_A36_R0.830131.677
129_S173_D0.816231.649
57_P69_R0.813611.643
113_E117_A0.80591.628
113_E142_Y0.787931.592
127_T130_D0.787621.591
114_A138_V0.783551.583
137_E141_E0.782131.580
123_R126_V0.779471.575
16_A33_A0.776581.569
132_Y136_R0.774111.564
133_E137_E0.770251.556
116_E120_E0.766021.547
118_A135_V0.762431.540
121_A134_A0.760121.535
23_P73_E0.758061.531
5_K85_Y0.757191.530
176_L182_F0.74281.500
103_E106_R0.734761.484
103_E194_W0.730081.475
37_A41_R0.717761.450
18_M96_F0.711871.438
35_E40_R0.705661.425
102_P105_R0.69841.411
72_Q75_D0.694111.402
8_R12_A0.684241.382
4_R8_R0.673531.361
33_A37_A0.668231.350
26_T29_E0.66511.344
121_A126_V0.663361.340
119_I203_V0.658321.330
108_Y199_F0.656261.326
22_R25_M0.648571.310
114_A139_L0.646711.306
80_D91_D0.645881.305
124_P178_P0.642661.298
16_A20_A0.627231.267
69_R75_D0.626041.265
17_A34_I0.62361.260
97_V108_Y0.61871.250
106_R142_Y0.612091.236
84_R89_H0.607661.227
88_Y158_L0.605451.223
176_L205_V0.602141.216
111_A197_V0.595381.203
31_A35_E0.594041.200
28_Y32_A0.593551.199
127_T175_V0.591461.195
91_D200_E0.588261.188
10_A90_A0.581361.174
107_A195_G0.579411.170
7_A202_T0.570931.153
115_L119_I0.570761.153
25_M33_A0.562021.135
15_E19_E0.561111.133
181_V204_L0.559921.131
113_E138_V0.558481.128
115_L201_D0.555411.122
80_D200_E0.55351.118
118_A131_V0.540741.092
5_K86_D0.540351.092
10_A83_P0.539981.091
109_E112_R0.538761.088
129_S171_G0.537921.087
107_A197_V0.534181.079
122_L184_I0.532591.076
9_I85_Y0.532311.075
184_I203_V0.5321.075
21_L30_I0.531921.074
183_A202_T0.530061.071
191_I194_W0.529041.069
12_A37_A0.528061.067
130_D133_E0.523941.058
126_V130_D0.521281.053
36_R40_R0.520071.051
9_I83_P0.519071.049
110_A138_V0.508321.027
106_R110_A0.508241.027
76_I104_Q0.507741.026
71_L98_V0.506881.024
55_S77_V0.50231.015
152_L166_N0.499061.008
177_E180_M0.497971.006
118_A134_A0.497351.005
3_M7_A0.497111.004
148_Y189_Y0.496161.002
163_P166_N0.495571.001
100_P105_R0.49440.999
48_A89_H0.492880.996
35_E44_G0.492640.995
126_V134_A0.490120.990
6_A90_A0.487360.984
89_H160_F0.481390.972
122_L176_L0.476980.964
55_S71_L0.473820.957
7_A11_D0.46910.948
63_H161_H0.465730.941
25_M29_E0.463210.936
14_M96_F0.461150.932
117_A121_A0.458580.926
53_V77_V0.45640.922
126_V131_V0.450110.909
94_R201_D0.446950.903
78_I93_A0.444050.897
117_A134_A0.442950.895
135_V152_L0.442820.894
122_L131_V0.442570.894
30_I71_L0.442490.894
2_C5_K0.439260.887
156_I181_V0.434770.878
106_R109_E0.431220.871
101_T195_G0.43110.871
29_E32_A0.429750.868
21_L98_V0.428780.866
30_I53_V0.426280.861
34_I53_V0.425810.860
121_A124_P0.419750.848
133_E170_P0.415530.839
5_K9_I0.411690.832
14_M81_F0.409630.827
14_M92_I0.409280.827
54_G64_Y0.408470.825
107_A144_L0.408070.824
73_E99_G0.405450.819
129_S133_E0.404560.817
113_E141_E0.404090.816
134_A137_E0.400270.809
91_D185_E0.400070.808
4_R204_L0.399440.807
128_G176_L0.395710.799
18_M94_R0.39560.799
155_G165_P0.395560.799
178_P206_T0.393980.796
12_A16_A0.392550.793
128_G167_I0.390210.788
146_E189_Y0.390140.788
131_V134_A0.389830.787
35_E51_P0.379690.767
124_P206_T0.375770.759
112_R199_F0.372590.753
124_P207_E0.366090.740
51_P65_T0.365860.739
117_A137_E0.362180.732
78_I198_R0.362080.731
138_V141_E0.361970.731
155_G162_E0.361710.731
122_L203_V0.361010.729
9_I44_G0.360810.729
168_A171_G0.360750.729
56_G75_D0.358010.723
80_D154_H0.356870.721
79_I96_F0.354150.715
107_A111_A0.352590.712
6_A85_Y0.351630.710
174_T180_M0.351480.710
50_P65_T0.348360.704
113_E116_E0.347720.702
93_A198_R0.346650.700
91_D154_H0.345540.698
183_A198_R0.344930.697
12_A15_E0.344150.695
55_S69_R0.343040.693
95_T199_F0.341620.690
131_V176_L0.340660.688
44_G83_P0.340340.687
185_E200_E0.340020.687
108_Y112_R0.339980.687
15_E18_M0.339840.686
167_I182_F0.338070.683
110_A139_L0.337670.682
134_A138_V0.337460.682
13_A83_P0.336490.680
82_G90_A0.334760.676
7_A90_A0.333310.673
128_G174_T0.332540.672
154_H185_E0.331860.670
15_E94_R0.330820.668
16_A41_R0.329610.666
156_I183_A0.328590.664
132_Y152_L0.327120.661
28_Y51_P0.32690.660
80_D185_E0.326540.660
76_I97_V0.32630.659
34_I39_L0.325990.659
69_R72_Q0.324810.656
182_F205_V0.324320.655
118_A121_A0.321280.649
58_N61_L0.321170.649
100_P104_Q0.319060.645
189_Y198_R0.318650.644
110_A113_E0.318280.643
16_A42_H0.318030.642
119_I184_I0.317580.642
93_A183_A0.31720.641
114_A118_A0.316640.640
10_A13_A0.316190.639
13_A17_A0.314860.636
175_V178_P0.311610.629
58_N75_D0.310930.628
34_I81_F0.310680.628
115_L199_F0.310440.627
127_T173_D0.310060.626
2_C88_Y0.309740.626
130_D134_A0.309140.624
162_E165_P0.308760.624
55_S75_D0.307920.622
179_G204_L0.307530.621
13_A39_L0.306780.620
154_H200_E0.305670.617
8_R11_D0.302470.611
60_D192_P0.301770.610
74_G98_V0.301750.610
9_I87_G0.299430.605
58_N69_R0.298080.602
157_G162_E0.297660.601
33_A41_R0.297560.601
110_A114_A0.295820.598
124_P177_E0.295760.597
13_A34_I0.295750.597
124_P205_V0.29310.592
20_A25_M0.292510.591
58_N64_Y0.29240.591
139_L144_L0.288830.583
17_A20_A0.287070.580
7_A204_L0.286330.578
181_V202_T0.286250.578
187_G198_R0.285050.576
55_S98_V0.284650.575
23_P70_R0.284550.575
91_D161_H0.2840.574
57_P77_V0.283840.573
107_A110_A0.282180.570
21_L96_F0.282120.570
10_A81_F0.281810.569
97_V104_Q0.281310.568
11_D15_E0.281170.568
107_A191_I0.280260.566
35_E39_L0.279360.564
183_A186_P0.279080.564
161_H185_E0.278840.563
29_E41_R0.278570.563
43_G85_Y0.278480.563
12_A41_R0.277150.560
24_G70_R0.276980.560
20_A37_A0.276220.558
128_G180_M0.275220.556
49_F82_G0.274420.554
14_M18_M0.273880.553
6_A10_A0.272740.551
135_V148_Y0.270250.546
7_A92_I0.269990.545
54_G59_T0.269330.544
118_A184_I0.269130.544
73_E98_V0.26820.542
179_G206_T0.268040.541
110_A144_L0.267010.539
154_H161_H0.265290.536
23_P98_V0.265250.536
43_G86_D0.264940.535
82_G89_H0.263180.532
121_A131_V0.262540.530
159_E162_E0.260160.526
92_I202_T0.259880.525
28_Y31_A0.259270.524
83_P90_A0.258120.521
151_G187_G0.257610.520
21_L77_V0.257340.520
111_A188_L0.257150.519
107_A188_L0.256940.519
30_I77_V0.256090.517
158_L162_E0.255760.517
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
2zsgA0.98071000.026
3q6dA0.98071000.028
4fkcA0.98551000.032
4egeA0.97581000.034
1wn1A0.97581000.035
1wy2A0.98071000.039
2v3zA0.98551000.071
3s6bA0.98551000.072
3ig4A0.96621000.074
4iu6A0.98551000.074

Page generated in 0.0288 seconds.