GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
EAL - EAL domain
Pfam: PF00563 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 236
Sequences: 12630
Seq/Len: 53.52
HH_delta: -0.032 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
23_L228_I2.462223.693
64_D98_S2.080153.120
177_G181_R2.018913.028
144_R171_D1.936062.904
65_R107_W1.887262.831
17_F74_Q1.790532.686
122_V172_Y1.785452.678
109_S146_L1.75172.627
69_E113_Q1.720782.581
14_E38_K1.656382.484
22_D25_S1.630772.446
214_E218_E1.60112.401
219_L223_L1.598442.397
200_K226_D1.559082.338
151_A172_Y1.453732.180
3_Q39_D1.439152.159
217_L233_F1.424292.136
213_S216_Q1.366172.049
39_D43_G1.333352.000
217_L228_I1.280041.920
54_A63_L1.279871.920
166_A188_A1.267091.900
211_V228_I1.262161.893
70_Q73_K1.248571.873
20_I227_Y1.247411.871
193_Q201_S1.232491.849
74_Q78_W1.225191.838
122_V151_A1.20681.810
66_W70_Q1.203581.805
172_Y207_I1.172051.758
177_G210_G1.169361.754
189_Q219_L1.13611.704
21_V233_F1.132911.699
140_L150_I1.126931.690
111_L114_Y1.11841.677
11_N70_Q1.115211.673
20_I172_Y1.105071.657
35_L67_I1.087061.630
70_Q74_Q1.083511.625
184_S215_E1.080831.621
89_P149_R1.073881.611
14_E44_L1.073461.610
38_K44_L1.069211.604
72_L111_L1.049381.574
217_L221_K1.036251.554
149_R171_D1.035161.553
214_E232_L1.033481.550
193_Q223_L1.021611.532
15_L67_I1.019641.529
117_P120_R1.013621.520
6_Q10_N0.991281.487
20_I122_V0.987491.481
173_I199_A0.98651.480
16_Y44_L0.973411.460
29_I227_Y0.972151.458
231_Y236_P0.971441.457
217_L232_L0.963641.445
13_L35_L0.962181.443
208_A225_V0.957471.436
39_D42_G0.953491.430
205_K226_D0.950931.426
94_I104_F0.940071.410
184_S189_Q0.939461.409
69_E111_L0.921511.382
205_K227_Y0.92091.381
184_S216_Q0.920581.381
69_E114_Y0.919811.380
196_I223_L0.913471.370
196_I225_V0.910131.365
112_L148_F0.904241.356
89_P122_V0.895291.343
94_I123_L0.881921.323
15_L66_W0.876741.315
12_K39_D0.860111.290
112_L118_P0.859741.289
152_L170_P0.855191.283
75_L116_L0.854271.281
193_Q197_N0.853951.281
20_I30_G0.846381.269
122_V149_R0.819611.229
228_I233_F0.803391.205
61_D101_D0.797221.196
110_N113_Q0.793021.189
183_L219_L0.786191.179
35_L63_L0.779131.169
137_L167_S0.774761.162
91_F122_V0.774621.162
184_S219_L0.759591.139
183_L192_L0.758421.138
184_S213_S0.749711.124
71_A90_L0.746011.119
172_Y205_K0.742641.114
20_I91_F0.740071.110
12_K37_W0.729771.095
73_K114_Y0.727451.091
218_E221_K0.727151.091
166_A182_D0.723741.086
218_E222_E0.715691.073
170_P204_I0.715441.073
141_R145_S0.714241.071
109_S142_R0.709781.065
75_L90_L0.705871.059
185_D188_A0.70291.054
199_A206_V0.698641.048
32_E93_N0.696841.045
132_N135_E0.690791.036
69_E73_K0.686831.030
123_L148_F0.684471.027
139_N142_R0.683211.025
22_D27_R0.682681.024
100_L131_P0.682331.023
17_F33_V0.680731.021
107_W111_L0.680021.020
3_Q42_G0.67811.017
6_Q12_K0.672981.009
31_Y88_L0.665890.999
108_L143_L0.664340.996
35_L66_W0.663220.995
40_P43_G0.662480.994
22_D29_I0.662480.994
137_L141_R0.657190.986
23_L217_L0.656280.984
87_D120_R0.651190.977
196_I206_V0.649960.975
22_D226_D0.648410.973
154_D209_E0.64820.972
33_V90_L0.645260.968
124_E174_K0.645230.968
13_L66_W0.640620.961
74_Q77_S0.639390.959
9_R62_E0.637960.957
42_G49_Q0.630790.946
190_S201_S0.628290.942
30_G89_P0.621010.931
105_L109_S0.61920.929
108_L123_L0.617050.925
24_R221_K0.615980.924
17_F31_Y0.613920.921
96_P128_N0.611820.918
20_I207_I0.609650.914
57_T61_D0.608030.912
207_I227_Y0.606740.910
59_L62_E0.606490.910
194_S201_S0.60580.909
197_N201_S0.60440.907
11_N69_E0.601570.902
55_E60_S0.597430.896
196_I200_K0.597420.896
4_L54_A0.596520.895
105_L139_N0.594180.891
214_E217_L0.592360.888
133_D168_L0.590730.886
5_R59_L0.590650.886
220_L225_V0.589130.884
24_R226_D0.586950.880
135_E139_N0.586550.880
26_G221_K0.586390.880
172_Y227_Y0.580.870
106_D142_R0.57690.865
107_W110_N0.575420.863
15_L33_V0.566740.850
219_L222_E0.565060.848
68_L111_L0.563850.846
61_D98_S0.559760.840
105_L142_R0.555820.834
181_R216_Q0.554310.831
39_D45_L0.554150.831
11_N66_W0.553890.831
91_F172_Y0.550630.826
15_L71_A0.550340.825
20_I89_P0.549920.825
7_A12_K0.549880.825
62_E65_R0.549170.824
138_E142_R0.547290.821
138_E141_R0.54620.819
68_L108_L0.542720.814
4_L13_L0.539590.809
89_P120_R0.53850.808
76_A115_G0.538330.807
208_A220_L0.538330.807
188_A216_Q0.536390.805
200_K206_V0.53540.803
231_Y235_P0.533330.800
54_A58_G0.532950.799
3_Q41_D0.532180.798
197_N200_K0.532160.798
76_A114_Y0.531880.798
149_R205_K0.530990.796
85_D88_L0.53080.796
15_L35_L0.529970.795
4_L7_A0.528520.793
48_E177_G0.521760.783
182_D188_A0.520210.780
142_R145_S0.519910.780
7_A13_L0.516960.775
211_V217_L0.516110.774
149_R172_Y0.511490.767
6_Q9_R0.509640.764
126_S154_D0.509120.764
127_E156_G0.508650.763
54_A60_S0.504840.757
65_R111_L0.503940.756
73_K77_S0.502060.753
51_L60_S0.501450.752
104_F108_L0.499610.749
152_L164_Y0.499460.749
190_S193_Q0.498210.747
211_V220_L0.493420.740
12_K40_P0.486360.729
101_D107_W0.484940.727
99_L139_N0.481340.722
72_L114_Y0.480990.721
68_L92_V0.479950.720
106_D110_N0.478370.717
72_L121_L0.478360.717
123_L150_I0.477250.716
180_V208_A0.473830.711
103_E107_W0.469780.705
19_P234_S0.469050.704
141_R169_P0.465930.699
196_I220_L0.46510.698
65_R69_E0.463260.695
21_V28_I0.462390.694
189_Q193_Q0.462360.693
182_D185_D0.46170.692
26_G217_L0.457140.686
198_L202_L0.456660.685
34_L93_N0.456280.684
173_I204_I0.455660.683
42_G45_L0.45560.683
180_V183_L0.454590.682
38_K43_G0.45090.676
93_N153_D0.44910.674
16_Y38_K0.448640.673
8_I63_L0.445560.668
121_L148_F0.442820.664
186_E189_Q0.440030.660
190_S194_S0.437120.656
72_L116_L0.436060.654
46_P49_Q0.43450.652
126_S209_E0.43440.652
26_G214_E0.433530.650
28_I234_S0.432620.649
63_L67_I0.432130.648
8_I66_W0.431360.647
137_L169_P0.429360.644
133_D136_L0.428130.642
19_P28_I0.426780.640
157_S179_L0.426270.639
155_F195_L0.425810.639
206_V226_D0.42580.639
191_L198_L0.425730.639
93_N174_K0.425190.638
220_L228_I0.424290.636
212_E231_Y0.416610.625
32_E174_K0.415180.623
48_E52_P0.414950.622
51_L126_S0.411070.617
4_L37_W0.41080.616
183_L189_Q0.410580.616
33_V71_A0.409380.614
166_A191_L0.408640.613
57_T60_S0.407870.612
140_L169_P0.407840.612
135_E138_E0.407540.611
164_Y167_S0.407310.611
92_V121_L0.406650.610
192_L208_A0.405770.609
53_I56_R0.403940.606
93_N124_E0.40340.605
194_S198_L0.402860.604
71_A92_V0.402260.603
4_L59_L0.397020.595
32_E153_D0.396360.594
133_D137_L0.395620.593
174_K229_Q0.393880.591
16_Y36_R0.393460.590
118_P148_F0.38910.584
38_K42_G0.388970.583
116_L121_L0.386530.580
64_D95_S0.386150.579
45_L49_Q0.38590.579
5_R9_R0.385820.579
65_R110_N0.385120.578
106_D109_S0.385030.577
186_E190_S0.384990.577
21_V26_G0.38460.577
55_E128_N0.382940.574
47_P50_F0.382140.573
164_Y168_L0.382120.573
67_I92_V0.381390.572
5_R62_E0.381270.572
166_A185_D0.380280.570
34_L231_Y0.379150.569
30_G91_F0.37910.569
139_N143_L0.379050.569
212_E216_Q0.378990.568
75_L120_R0.377560.566
35_L50_F0.376630.565
215_E218_E0.376440.565
134_A138_E0.376290.564
103_E106_D0.374720.562
183_L220_L0.373860.561
64_D67_I0.373420.560
31_Y90_L0.371720.558
94_I98_S0.371570.557
3_Q6_Q0.370170.555
194_S197_N0.368270.552
175_L225_V0.367880.552
141_R144_R0.366790.550
108_L111_L0.36660.550
180_V192_L0.365850.549
29_I89_P0.365370.548
105_L146_L0.362230.543
124_E209_E0.361460.542
102_P135_E0.361090.542
157_S178_S0.360880.541
134_A167_S0.359740.540
195_L199_A0.358750.538
16_Y236_P0.358580.538
55_E95_S0.357370.536
7_A37_W0.357240.536
31_Y234_S0.356630.535
60_S97_E0.356020.534
37_W50_F0.355850.534
108_L148_F0.355710.534
160_S164_Y0.355570.533
30_G88_L0.355460.533
34_L154_D0.355420.533
142_R146_L0.353630.530
133_D167_S0.353350.530
51_L55_E0.353040.530
96_P129_D0.352550.529
88_L120_R0.351940.528
61_D65_R0.351260.527
15_L70_Q0.35110.527
189_Q223_L0.349550.524
99_L129_D0.348150.522
65_R103_E0.347420.521
221_K228_I0.346670.520
125_I140_L0.34260.514
116_L120_R0.341720.513
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
4hjfA1100-0.032
2r6oA1100-0.029
3hvbA0.9873100-0.028
4hu4A0.9915100-0.027
3hv8A0.9873100-0.006
4f3hA0.9831100-0.002
3pjxA0.9661100-0.001
4fojA0.9831100-0.001
3sy8A0.98731000.005
3s83A11000.007

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